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EP0711339A1 - Culture media additives for bioreactors - Google Patents

Culture media additives for bioreactors

Info

Publication number
EP0711339A1
EP0711339A1 EP94922694A EP94922694A EP0711339A1 EP 0711339 A1 EP0711339 A1 EP 0711339A1 EP 94922694 A EP94922694 A EP 94922694A EP 94922694 A EP94922694 A EP 94922694A EP 0711339 A1 EP0711339 A1 EP 0711339A1
Authority
EP
European Patent Office
Prior art keywords
bioreactors
culture media
media additives
hollow fiber
culture medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94922694A
Other languages
German (de)
French (fr)
Inventor
Randal A. Goffe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UniSyn Technologies Inc
Original Assignee
UniSyn Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UniSyn Technologies Inc filed Critical UniSyn Technologies Inc
Publication of EP0711339A1 publication Critical patent/EP0711339A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A hollow fiber bioreactor culture medium which contains a stabilized hemoglobin or a perfluorochemical emulsion is described. The culture medium mediates oxygen demand and utilization. Efficiency of the bioreactor is enhanced so that novel hollow fiber and stirred tank cell culture system configurations, equipment and methods are enabled.
EP94922694A 1994-04-01 1994-07-26 Culture media additives for bioreactors Withdrawn EP0711339A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US1994/003613 WO1995027040A1 (en) 1994-04-01 1994-04-01 Culture media additives for hollow fiber bioreactors
WOPCT/US94/03613 1994-04-01
PCT/US1994/008295 WO1995027041A1 (en) 1994-04-01 1994-07-26 Culture media additives for bioreactors

Publications (1)

Publication Number Publication Date
EP0711339A1 true EP0711339A1 (en) 1996-05-15

Family

ID=22242416

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94922694A Withdrawn EP0711339A1 (en) 1994-04-01 1994-07-26 Culture media additives for bioreactors

Country Status (6)

Country Link
EP (1) EP0711339A1 (en)
JP (1) JPH08511173A (en)
AU (2) AU6766994A (en)
CA (1) CA2163618A1 (en)
NO (1) NO954854L (en)
WO (2) WO1995027040A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255109B1 (en) * 1998-06-24 2001-07-03 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Nitric oxide-scavenging system for culturing oocytes, embryos, or other cells
GB9915413D0 (en) 1999-07-01 1999-09-01 Glaxo Group Ltd Propagation method
AUPQ319199A0 (en) * 1999-09-30 1999-10-28 Unisearch Limited Method and apparatus for culturing cells
AU781265B2 (en) * 1999-09-30 2005-05-12 Unisearch Limited Method and apparatus for culturing cells
CA2422230C (en) * 2000-09-13 2011-03-15 Csir Bio-reactor device
DE10136912A1 (en) * 2001-07-30 2003-02-20 Wolfgang Fege Providing oxygen to cell or tissue cultures, useful e.g. for growing organs for transplantation, comprises using substances that bind oxygen reversibly
DK2463297T3 (en) 2006-05-22 2017-01-09 Univ California Oxygen Compositions and Methods
WO2010122080A1 (en) * 2009-04-23 2010-10-28 Hemarina Bioreactor using oxygen-carrying molecules
EP2427483B1 (en) * 2009-05-07 2015-03-11 Hemarina Novel heamoglobin and uses thereof
WO2012048298A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
WO2016049421A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled feed
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11629332B2 (en) 2017-03-31 2023-04-18 Terumo Bct, Inc. Cell expansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3997396A (en) * 1973-07-02 1976-12-14 Monsanto Company Method for the in vitro propagation and maintenance of cells
US5223428A (en) * 1982-12-14 1993-06-29 Baxter International Inc. Method for in vitro culture of mammalian cells
US5180676A (en) * 1984-06-14 1993-01-19 Teijin Limited Method of cultivating animal or plant cells
DE3786213T2 (en) * 1986-09-19 1993-09-30 Shimadzu Corp Pressure incubator.
DE3871206D1 (en) * 1987-03-24 1992-06-25 Grace W R & Co BASIC MEDIUM FOR A CELL CULTURE.
US5264555A (en) * 1992-07-14 1993-11-23 Enzon, Inc. Process for hemoglobin extraction and purification

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9527041A1 *

Also Published As

Publication number Publication date
AU7371394A (en) 1995-10-23
AU6766994A (en) 1995-10-23
WO1995027040A1 (en) 1995-10-12
WO1995027041A1 (en) 1995-10-12
JPH08511173A (en) 1996-11-26
CA2163618A1 (en) 1995-10-12
NO954854D0 (en) 1995-11-29
NO954854L (en) 1995-11-29

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19951121

AK Designated contracting states

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Designated state(s): CH DE FR GB IT LI NL

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19980203