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EP0706391A4 - Complexes au gallium pour le traitement des maladies induites par les radicaux libres - Google Patents

Complexes au gallium pour le traitement des maladies induites par les radicaux libres

Info

Publication number
EP0706391A4
EP0706391A4 EP94921320A EP94921320A EP0706391A4 EP 0706391 A4 EP0706391 A4 EP 0706391A4 EP 94921320 A EP94921320 A EP 94921320A EP 94921320 A EP94921320 A EP 94921320A EP 0706391 A4 EP0706391 A4 EP 0706391A4
Authority
EP
European Patent Office
Prior art keywords
treatment
free radical
induced diseases
gallium complexes
gallium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94921320A
Other languages
German (de)
English (en)
Other versions
EP0706391A1 (fr
Inventor
Mordechai Chevion
Eduard Berenshtein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Yissum Research Development Co of Hebrew University of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Research Development Co of Hebrew University of Jerusalem filed Critical Yissum Research Development Co of Hebrew University of Jerusalem
Publication of EP0706391A1 publication Critical patent/EP0706391A1/fr
Publication of EP0706391A4 publication Critical patent/EP0706391A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP94921320A 1993-06-18 1994-06-17 Complexes au gallium pour le traitement des maladies induites par les radicaux libres Withdrawn EP0706391A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL10606493 1993-06-18
IL106064A IL106064A (en) 1993-06-18 1993-06-18 Gallium complexes for the treatment of free radical-induced diseases
PCT/US1994/006878 WO1995000140A1 (fr) 1993-06-18 1994-06-17 Complexes au gallium pour le traitement des maladies induites par les radicaux libres

Publications (2)

Publication Number Publication Date
EP0706391A1 EP0706391A1 (fr) 1996-04-17
EP0706391A4 true EP0706391A4 (fr) 1997-07-30

Family

ID=11064963

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94921320A Withdrawn EP0706391A4 (fr) 1993-06-18 1994-06-17 Complexes au gallium pour le traitement des maladies induites par les radicaux libres

Country Status (4)

Country Link
EP (1) EP0706391A4 (fr)
AU (1) AU7209394A (fr)
IL (1) IL106064A (fr)
WO (1) WO1995000140A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955111A (en) * 1996-10-08 1999-09-21 Hartford Hospital Methods and compositions for inducing production of stress proteins
WO2004060490A1 (fr) * 2003-01-07 2004-07-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Composition comprenant un complexe desferrioxamine-metal, et son utilisation pour le traitement de dommages causes aux tissus consecutivement a une exposition a des agents chimiques de combat
EP3189836B1 (fr) 2009-08-19 2024-01-17 Mordechai Chevion Complexes desferrioxamine-métal pour le traitement de troubles liés à l'immunité
US20190022103A1 (en) * 2014-12-22 2019-01-24 Mordechai Chevion New metal complexes of nocardamine and their use in pharmaceutical compositions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0325559A2 (fr) * 1988-01-20 1989-07-26 Ciba-Geigy Ag Procédé pour la préparation de composés complexes
WO1993009088A1 (fr) * 1991-10-30 1993-05-13 University Of Florida Procede ameliore destine a la synthese de desferrioxamine b, ainsi que d'analogues et d'homologues de celle-ci

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX12394A (es) * 1987-07-23 1993-12-01 Ciba Geigy Ag Procedimiento par la obtencion de carbamatos de polietilenglicol.
IL91047A (en) * 1989-07-19 1993-06-10 Yissum Res Dev Co Zinc complexes for the treatment of free radical- induced diseases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0325559A2 (fr) * 1988-01-20 1989-07-26 Ciba-Geigy Ag Procédé pour la préparation de composés complexes
WO1993009088A1 (fr) * 1991-10-30 1993-05-13 University Of Florida Procede ameliore destine a la synthese de desferrioxamine b, ainsi que d'analogues et d'homologues de celle-ci

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE MEDLINE US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; SAJI H ET AL: "[Enhancement of 67Ga tumor-to-blood ratios by chelating agent (author's transl)]", XP002031699 *
NAGAMACHI S ET AL: "Gallium-67 scintigraphy in patients with hemochromatosis treated by deferoxamine.", ANN NUCL MED, MAY 1988, 2 (1) P35-9, JAPAN, XP000653965 *
RADIOISOTOPES, JAN 1980, 29 (1) P7-12, JAPAN *
See also references of WO9500140A1 *

Also Published As

Publication number Publication date
IL106064A0 (en) 1993-10-20
EP0706391A1 (fr) 1996-04-17
IL106064A (en) 1997-11-20
AU7209394A (en) 1995-01-17
WO1995000140A1 (fr) 1995-01-05

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19951211

AK Designated contracting states

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Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 19970616

AK Designated contracting states

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Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

17Q First examination report despatched

Effective date: 19971022

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20000106