EP0766685A4 - MACROLIDES ARYLES, ALKYLES, ALCENYLES ET ALCYNYLES - Google Patents

MACROLIDES ARYLES, ALKYLES, ALCENYLES ET ALCYNYLES

Info

Publication number: EP0766685A4
Authority: EP; European Patent Office
Prior art keywords: alcynyles; alcenyles; aryles; alkyles; macrolides
Prior art date: 1994-06-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP95923827A

Other languages

German (de)

French (fr)

Other versions

EP0766685A1 (en

Inventor

Helen M Organ

Mark A Holmes

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck and Co Inc

Original Assignee

Merck and Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-15

Filing date

1995-06-12

Publication date

1997-07-16

1995-06-12 Application filed by Merck and Co Inc filed Critical Merck and Co Inc

1997-04-09 Publication of EP0766685A1 publication Critical patent/EP0766685A1/en

1997-07-16 Publication of EP0766685A4 publication Critical patent/EP0766685A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

EP95923827A 1994-06-15 1995-06-12 MACROLIDES ARYLES, ALKYLES, ALCENYLES ET ALCYNYLES Withdrawn EP0766685A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/259,831 US5880280A (en)	1994-06-15	1994-06-15	Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity
US259831		1994-06-15
PCT/US1995/007476 WO1995034568A1 (en)	1994-06-15	1995-06-12	Aryl, alkyl, alkenyl, and alkynylmacrolides

Publications (2)

Publication Number	Publication Date
EP0766685A1 EP0766685A1 (en)	1997-04-09
EP0766685A4 true EP0766685A4 (en)	1997-07-16

Family

ID=22986583

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP95923827A Withdrawn EP0766685A4 (en)	1994-06-15	1995-06-12	MACROLIDES ARYLES, ALKYLES, ALCENYLES ET ALCYNYLES

Country Status (6)

Country	Link
US (1)	US5880280A (en)
EP (1)	EP0766685A4 (en)
JP (1)	JPH10502058A (en)
AU (1)	AU692571B2 (en)
CA (1)	CA2192338A1 (en)
WO (1)	WO1995034568A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030129186A1 (en)	2001-07-25	2003-07-10	Biomarin Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
AU2007237187B2 (en) *	2002-07-16	2010-08-05	Biotica Technology Limited	Production of polyketides
US20110104186A1 (en)	2004-06-24	2011-05-05	Nicholas Valiante	Small molecule immunopotentiators and assays for their detection
US7851658B2 (en) *	2004-08-17	2010-12-14	President And Fellows Of Harvard College	Palladium-catalyzed carbon-carbon bond forming reactions
CN101287411B (en)	2005-04-28	2013-03-06	普罗秋斯生物医学公司	Drug Information System and Its Use
WO2007011722A2 (en)	2005-07-15	2007-01-25	President And Fellows Of Harvard College	Reaction discovery system
WO2008036682A2 (en)	2006-09-18	2008-03-27	Raptor Pharmaceutical Inc.	Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
EP2427178B1 (en)	2009-05-06	2023-01-04	Laboratory Skin Care, Inc.	Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0184162A2 (en) *	1984-12-03	1986-06-11	Fujisawa Pharmaceutical Co., Ltd.	Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
WO1991013889A1 (en) *	1990-03-13	1991-09-19	Fisons Plc	Immunosuppressive macrocyclic compounds
WO1992020688A1 (en) *	1991-05-13	1992-11-26	Merck & Co., Inc.	Amino o-aryl, o-alkyl, o-alkenyl and o-alkynyl macrolides
WO1993004680A1 (en) *	1991-09-05	1993-03-18	Abbott Laboratories	Macrocyclic immunomodulators
WO1995015328A1 (en) *	1993-11-30	1995-06-08	Abbott Laboratories	Macrocyclic immunomodulators with novel cyclohexyl ring replacements

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3244592A (en) *	1962-06-09	1966-04-05	Arai Tadashi	Ascomycin and process for its production
EP0346427B1 (en) *	1987-12-09	1995-03-29	FISONS plc	Macrocyclic compounds
EP0427680B1 (en) *	1989-11-09	1995-08-23	Sandoz Ltd.	Heteroatoms-containing tricyclic compounds
US5296489A (en) *	1990-03-13	1994-03-22	Fisons	Immunosuppressive macrocyclic compounds
GB2244991A (en) *	1990-06-11	1991-12-18	Fujisawa Pharmaceutical Co	Tricyclo compounds
US5190950A (en) *	1990-06-25	1993-03-02	Merck & Co., Inc.	Antagonists of immunosuppressive macrolides
GB9014136D0 (en) *	1990-06-25	1990-08-15	Fujisawa Pharmaceutical Co	Tricyclo compounds,a process for their production and a pharmaceutical composition containing the same
GB2245891A (en) *	1990-07-09	1992-01-15	Fujisawa Pharmaceutical Co	Tricyclo compounds
US5143918A (en) *	1990-10-11	1992-09-01	Merck & Co., Inc.	Halomacrolides and derivatives having immunosuppressive activity
US5162334A (en) *	1991-05-13	1992-11-10	Merck & Co., Inc.	Amino O-alkyl, O-alkenyl and O-alkynlmacrolides having immunosuppressive activity
US5262533A (en) *	1991-05-13	1993-11-16	Merck & Co., Inc.	Amino O-aryl macrolides having immunosuppressive activity
US5250678A (en) *	1991-05-13	1993-10-05	Merck & Co., Inc.	O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
US5189042A (en) *	1991-08-22	1993-02-23	Merck & Co. Inc.	Fluoromacrolides having immunosuppressive activity
US5208241A (en) *	1991-09-09	1993-05-04	Merck & Co., Inc.	N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity
US5247076A (en) *	1991-09-09	1993-09-21	Merck & Co., Inc.	Imidazolidyl macrolides having immunosuppressive activity
US5252732A (en) *	1991-09-09	1993-10-12	Merck & Co., Inc.	D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity

1994
- 1994-06-15 US US08/259,831 patent/US5880280A/en not_active Expired - Fee Related
1995
- 1995-06-12 AU AU28254/95A patent/AU692571B2/en not_active Ceased
- 1995-06-12 WO PCT/US1995/007476 patent/WO1995034568A1/en not_active Ceased
- 1995-06-12 EP EP95923827A patent/EP0766685A4/en not_active Withdrawn
- 1995-06-12 JP JP8502401A patent/JPH10502058A/en not_active Ceased
- 1995-06-12 CA CA002192338A patent/CA2192338A1/en not_active Abandoned

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0184162A2 (en) *	1984-12-03	1986-06-11	Fujisawa Pharmaceutical Co., Ltd.	Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
US4894366A (en) *	1984-12-03	1990-01-16	Fujisawa Pharmaceutical Company, Ltd.	Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
WO1991013889A1 (en) *	1990-03-13	1991-09-19	Fisons Plc	Immunosuppressive macrocyclic compounds
WO1992020688A1 (en) *	1991-05-13	1992-11-26	Merck & Co., Inc.	Amino o-aryl, o-alkyl, o-alkenyl and o-alkynyl macrolides
WO1993004680A1 (en) *	1991-09-05	1993-03-18	Abbott Laboratories	Macrocyclic immunomodulators
WO1995015328A1 (en) *	1993-11-30	1995-06-08	Abbott Laboratories	Macrocyclic immunomodulators with novel cyclohexyl ring replacements

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9534568A1 *

Also Published As

Publication number	Publication date
JPH10502058A (en)	1998-02-24
AU692571B2 (en)	1998-06-11
EP0766685A1 (en)	1997-04-09
AU2825495A (en)	1996-01-05
US5880280A (en)	1999-03-09
WO1995034568A1 (en)	1995-12-21
CA2192338A1 (en)	1995-12-21

Publication	Publication Date	Title
DE69636353D1 (en)	2006-08-24	Datenübetragungsvorrichtung.
FI950715A0 (en)	1995-02-17	Ytmikromekanisk, symmetrisk tryckskillnadsgivare
NO980016D0 (en)	1998-01-02	Macrolides
DE69821009D1 (en)	2004-02-12	6,9-BRIDGED ERYTHROMYCIN DERIVATIVES
ATE239750T1 (en)	2003-05-15	6,11-BRIDGED ERYTHROMYCIN DERIVATIVES
TR199500945A1 (en)	1996-10-21	Substituted biphenyloxazolines.
NO960499D0 (en)	1996-02-07	Antineurodegeneratively-active 10-aminoalipatyldibenz [b, foxepins
LV11898A (en)	1997-12-20	Erythromycin derivatives
EP0766685A4 (en)	1997-07-16	MACROLIDES ARYLES, ALKYLES, ALCENYLES ET ALCYNYLES
DK0874814T3 (en)	2003-09-22	25-hydroxy-16-ene-26,27-bishomo-cholecalciferoler
EP0684299A3 (en)	1997-04-16	Dihydrofarnesal.
FI1592U1 (en)	1994-10-26	Spruta, foeretraedesvis injectionspruta
TR28915A (en)	1997-08-06	Naftoquinone derivatives.
ES1032571Y (en)	1996-11-01	GAFA,
FR2714950B3 (en)	1996-06-28	Reducer-variator.
IT234659Y1 (en)	2000-03-13	SOTTOSELLA.
FR2720962B1 (en)	1996-08-23	Baguetteuse.
FR2720961B1 (en)	1996-08-23	Baguetteuse.
FI945785A0 (en)	1994-12-09	Pimpelspoe, fiskeredokap
FIU940180U0 (en)	1994-03-25	Baotstege, kaerra, landgaong
FI944648A0 (en)	1994-10-05	Bromsmekanism Foer fordon, saerskilt Foer en cykel
FI952416A0 (en)	1995-05-18	Distributionanordning Foer vetska, speciellt tvaettvaetska Foer vindrutor
FI950956A0 (en)	1995-03-01	Luftkabel, saosom haengspiralkabel
FI1391U1 (en)	1994-06-16	Utrymme, saosom bastu av elementkonstruktion
FI954956A0 (en)	1995-10-18	Taecklist Foer foensterkarmar, till skydd deras ytteryta

Legal Events

Date	Code	Title	Description
1997-02-21	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1997-04-09	17P	Request for examination filed	Effective date: 19970115
1997-04-09	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
1997-07-16	A4	Supplementary search report drawn up and despatched	Effective date: 19970604
1997-07-16	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
1997-10-22	17Q	First examination report despatched	Effective date: 19970908
1999-05-03	GRAG	Despatch of communication of intention to grant	Free format text: ORIGINAL CODE: EPIDOS AGRA
1999-08-24	GRAG	Despatch of communication of intention to grant	Free format text: ORIGINAL CODE: EPIDOS AGRA
1999-08-24	GRAH	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOS IGRA
2000-07-21	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2000-09-06	18D	Application deemed to be withdrawn	Effective date: 19991207