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EP0757558A4 - Procedes de criblage des agents modulateurs des inflammations tegumentaires - Google Patents

Procedes de criblage des agents modulateurs des inflammations tegumentaires

Info

Publication number
EP0757558A4
EP0757558A4 EP95917009A EP95917009A EP0757558A4 EP 0757558 A4 EP0757558 A4 EP 0757558A4 EP 95917009 A EP95917009 A EP 95917009A EP 95917009 A EP95917009 A EP 95917009A EP 0757558 A4 EP0757558 A4 EP 0757558A4
Authority
EP
European Patent Office
Prior art keywords
integumental
screening methods
modulating agents
inflammation modulating
inflammation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95917009A
Other languages
German (de)
English (en)
Other versions
EP0757558A1 (fr
Inventor
Vivien Mak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adolor Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Priority to EP99201333A priority Critical patent/EP0937460A3/fr
Publication of EP0757558A1 publication Critical patent/EP0757558A1/fr
Publication of EP0757558A4 publication Critical patent/EP0757558A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/275Nitriles; Isonitriles
    • A61K31/277Nitriles; Isonitriles having a ring, e.g. verapamil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/4174Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/44221,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/451Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • A61K31/522Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP95917009A 1994-04-12 1995-04-11 Procedes de criblage des agents modulateurs des inflammations tegumentaires Withdrawn EP0757558A4 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP99201333A EP0937460A3 (fr) 1994-04-12 1995-04-11 Utilisation d'un antidiarrhéique pour la préparation d'un médicament pour le traitement des inflammations

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US22599194A 1994-04-12 1994-04-12
US225991 1994-04-12
US27128794A 1994-07-06 1994-07-06
US271287 1994-07-06
US40023495A 1995-03-03 1995-03-03
US400234 1995-03-03
PCT/US1995/004677 WO1995027510A1 (fr) 1994-04-12 1995-04-11 Procedes de criblage des agents modulateurs des inflammations tegumentaires

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP99201333A Division EP0937460A3 (fr) 1994-04-12 1995-04-11 Utilisation d'un antidiarrhéique pour la préparation d'un médicament pour le traitement des inflammations

Publications (2)

Publication Number Publication Date
EP0757558A1 EP0757558A1 (fr) 1997-02-12
EP0757558A4 true EP0757558A4 (fr) 1999-06-16

Family

ID=27397548

Family Applications (2)

Application Number Title Priority Date Filing Date
EP99201333A Withdrawn EP0937460A3 (fr) 1994-04-12 1995-04-11 Utilisation d'un antidiarrhéique pour la préparation d'un médicament pour le traitement des inflammations
EP95917009A Withdrawn EP0757558A4 (fr) 1994-04-12 1995-04-11 Procedes de criblage des agents modulateurs des inflammations tegumentaires

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP99201333A Withdrawn EP0937460A3 (fr) 1994-04-12 1995-04-11 Utilisation d'un antidiarrhéique pour la préparation d'un médicament pour le traitement des inflammations

Country Status (4)

Country Link
EP (2) EP0937460A3 (fr)
JP (1) JPH10500669A (fr)
AU (1) AU2385795A (fr)
WO (1) WO1995027510A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2185699A1 (fr) * 1994-04-04 1995-10-12 William R. Freeman Emploi de nucleosides de phosphonylemethoxyalkyle pour traiter la pression intra-oculaire elevee
HU226195B1 (hu) 1995-12-21 2008-06-30 Nestle Sa Javított immortalizált humán bõrsejtvonalak és szérrummentes tápközeg elõállításukra
US5798093A (en) * 1997-03-14 1998-08-25 Adolor Corporation Spray formulations of antihyperalgesic opiates and method of treating topical hyperalgesic conditions and pruritus therewith
US6353004B1 (en) 1997-07-14 2002-03-05 Adolor Coporation Peripherally acting anti-pruritic opiates
US5849762A (en) * 1997-07-14 1998-12-15 Adolor Corporation Peripherally acting anti-pruritic opiates
AUPP646498A0 (en) 1998-10-12 1998-11-05 Australian National University, The A method of modulating ion channel functional activity
DE19948126A1 (de) * 1999-10-06 2001-04-12 Max Delbrueck Centrum Pharmazeutisches Mittel zur Behandlung von Kachexie und/oder kardiogenem Schock
WO2002009683A2 (fr) * 2000-07-27 2002-02-07 Pharmacia Corporation Therapie anti-aldosterones destinee a prevenir ou traiter les troubles lies a une inflammation
US6697668B2 (en) * 2001-01-25 2004-02-24 Iomed, Inc. Ocular iontophoretic device and method for using the same
EP1469884A1 (fr) * 2002-01-30 2004-10-27 Pharmacia Corporation Therapie combinant un antagoniste d'aldosterone et un agent anti-inflammatoire et destinee a prevenir ou a traiter les troubles cardio-vasculaires
EP2377532A1 (fr) * 2004-08-18 2011-10-19 Ace ApS Compositions cosmétiques et pharmaceutiques comportant des inhibiteurs ACE et/ou antagonistes de récepteur d'angiotensine II pour le traitement de troubles dermatologiques
WO2008007131A2 (fr) * 2006-07-14 2008-01-17 Medical Research Council Traitement d'une maladie démyélinisante
JP2008222603A (ja) * 2007-03-09 2008-09-25 Institute Of Physical & Chemical Research 神経変性疾患の予防・治療剤
CA3133733A1 (fr) * 2019-04-30 2020-11-05 Xin-Yuan Fu Compose pour le traitement de maladies cutanees auto-immunes causees par une inflammation, et son utilisation
AU2021257466A1 (en) 2020-04-17 2022-12-08 Biolectrics Llc Systems and methods for oral iontophoresis
WO2022253910A1 (fr) * 2021-06-02 2022-12-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Nouveau procédé pour traiter une maladie cutanée inflammatoire
CN119746028B (zh) * 2024-11-06 2025-11-25 北京生命科技研究院有限公司 一种多肽在治疗银屑病中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002497A1 (fr) * 1989-08-21 1991-03-07 Beth Israel Hospital Association Nifedipine topique pour le traitement de l'hypersensibilite cutanee, oculaire et de la muqueuse, ainsi que d'etats inflammatoires et hyperproliferatifs
DD297062A5 (de) * 1990-08-23 1992-01-02 Tks Optimum Gmbh,Dd Verfahren zur herstellung eines neuartigen topischen dermatikums mit antientzuendlicher wirkung
US5202130A (en) * 1989-08-31 1993-04-13 The Johns Hopkins University Suppression of eczematous dermatitis by calcium transport inhibition

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4384000A (en) * 1980-08-07 1983-05-17 Lanier Earl W Method for treatment of various dermatological conditions
GB8806224D0 (en) * 1988-03-16 1988-04-13 Johnson Matthey Plc Platinum chemotherapeutic product
US5116847A (en) * 1991-01-25 1992-05-26 The Procter & Gamble Company Use of loperamide and related compounds for treatment of respiratory disease symptoms

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002497A1 (fr) * 1989-08-21 1991-03-07 Beth Israel Hospital Association Nifedipine topique pour le traitement de l'hypersensibilite cutanee, oculaire et de la muqueuse, ainsi que d'etats inflammatoires et hyperproliferatifs
US5202130A (en) * 1989-08-31 1993-04-13 The Johns Hopkins University Suppression of eczematous dermatitis by calcium transport inhibition
DD297062A5 (de) * 1990-08-23 1992-01-02 Tks Optimum Gmbh,Dd Verfahren zur herstellung eines neuartigen topischen dermatikums mit antientzuendlicher wirkung

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
EVANS CH ET AL.: "Inhibition, by lanthanides, of neutral proteinases secreted by human rheumatoid synovium", EUR.J.BIOCHEM., vol. 151, 1985, pages 29 - 32, XP002098132 *
GANGAROSA L P ET AL: "CONDUCTIVITY OF DRUGS USED FOR IONTOPHORESIS", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 67, no. 10, October 1978 (1978-10-01), pages 1439 - 1443, XP002055803 *
J.INVESTIG.DERMATOL., vol. 93, no. 3, 1989, pages 322 - 326, XP002098133 *
See also references of WO9527510A1 *

Also Published As

Publication number Publication date
EP0937460A2 (fr) 1999-08-25
WO1995027510A1 (fr) 1995-10-19
EP0937460A3 (fr) 2000-04-05
JPH10500669A (ja) 1998-01-20
EP0757558A1 (fr) 1997-02-12
AU2385795A (en) 1995-10-30

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