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EP0754062A1 - Produit destine a l'absorption intestinale de constituants de denrees alimentaires et procede de fabrication de ce type de produit - Google Patents

Produit destine a l'absorption intestinale de constituants de denrees alimentaires et procede de fabrication de ce type de produit

Info

Publication number
EP0754062A1
EP0754062A1 EP95916553A EP95916553A EP0754062A1 EP 0754062 A1 EP0754062 A1 EP 0754062A1 EP 95916553 A EP95916553 A EP 95916553A EP 95916553 A EP95916553 A EP 95916553A EP 0754062 A1 EP0754062 A1 EP 0754062A1
Authority
EP
European Patent Office
Prior art keywords
starch
product
plasticized
mass
fatty acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95916553A
Other languages
German (de)
English (en)
Inventor
Johann Friedrich Desaga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP0754062A1 publication Critical patent/EP0754062A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Definitions

  • the invention relates to a product for enteral supply with food ingredients, in which the food ingredients are present masked.
  • the invention further relates to a method for producing such a product for enteral nutrition.
  • Food ingredients that do not appear in the usual diet or only in a small amount can be enriched in food to prevent diseases (so-called "functional food”).
  • An example of such substances are highly unsaturated fatty acids such as the 6 3-fatty acids found in vegetable oils or in fish oil. These can be reluctant or even ingestion Trigger Uiibeknörnerscheinkeiten so that a supply can not be carried out for a long time. There is therefore a search for ways to mask these substances in such a way that they are imperceptible to the senses.
  • the substance to be absorbed should be as finely divided as possible by binding to a carrier substance. Gelatin, gum arabic and hydrocolloids have proven ineffective for this purpose.
  • the invention has set itself the goal of encapsulating fatty acids, in particular unsaturated fatty acids, as well as the 6J3 fatty acids, and also amino acids in such a way that they are imperceptible to the senses.
  • the procedure according to the invention first makes it easy to influence the rate of disruption and thus the absorption site in the gastrointestinal tract, the release of the substances which are perceived as unpleasant only taking place after being absorbed by the encapsulation. when they can no longer cause aversion reactions.
  • the fatty acid is a ( ⁇ 3-fatty acid.
  • metabolic disorders can be prevented or they can be treated without physical or psychological defense reactions of the patient.
  • the fatty acid can be equally advantageous Short-chain fatty acid
  • the essential amino acids are preferably used as amino acids.
  • the product according to the invention can advantageously contain one or more flavoring substances and / or coloring agents, fat-soluble substances, substances having an antioxidant effect, substances having a pharmacological effect or the like.
  • the starch carrier can be a starch from cereals, tubers or legumes or a cereal meal or a flour from potatoes, tapioca or legumes. If the formation of inclusion complexes is to be favored, a starch with an increased amylose content is preferably used.
  • a process for producing a multicomponent product for enteral supply with food ingredients in which a starchy material and at least one food ingredient are intimately mixed with one another, characterized in that a multicomponent prepared extrudate is added to and mixed with a plasticized starch mass is at least a part of the added food ingredient or the added food ingredients complexed at least in sections with the amylose of starch and the remaining part is included in the starch matrix.
  • the plasticized mixture is advantageously pressed through a nozzle.
  • a method for producing a multicomponent product for enteral supply with food ingredients in which a starchy material and at least one food ingredient are intimately mixed and extruded together before or during an extrusion, characterized in that at least part of the added food ingredient or the added food ingredients are at least partially complexed with the amylose of the starch and the remaining part is included in the starch matrix.
  • the components of the product are first premixed dry and then in one Extruder are metered in that they are intimately mixed, heated above the gelatinization temperature of the starch or starch-containing material and plasticized, whereby they are output as a plasticized mass from the extruder.
  • the components from the extruder are further advantageously discharged from one or more extruder openings as a continuous plastic strand.
  • the mixed components can be converted into an unexpanded plastic mass which is cut into a pastille shape, the pastilles having a diameter of 4-5 mm, for example.
  • the starch material is plasticized so that the pastilles of the end product have a glass-like character.
  • lozenges can be administered orally directly.
  • the mass should be dried.
  • the mass can be processed further by means of various measures, for example the mass cut into a lozenge shape or shaped in another way by the action of heat, for example exposure to hot air, microwaves, hot oil or by baking, and / or pressure drop which does not inflate mixed components can be granulated or ground to a predeterminable degree of fineness. All of these measures preserve the sensory masking. So that the "products can normal 11 foods are added without their typical properties and in particular to influence their taste.
  • the swelling process provides a grain-like process Product that can be consumed alone or in combination with other products.
  • the granules or flour can be mixed into pastries, bread, sauces, soups, pasta, dairy foods, etc.
  • the plasticized and optionally dried mass can also be flattened, rolled, embossed, cut and / or punched or shaped in some other way, so that a variant-rich product is available for enteral nutrition.
  • the lozenges can also be stored, especially when antioxidant substances are added, and storage periods of several months are easily possible.
  • the different grain size distribution and structure achieved by further processing enables the absorption rates in the organism to be influenced further.
  • a starch with a high amylose content is cook-extruded with water and oil.
  • the starch is gelatinized by the energy introduced and forms a plastic mass.
  • part of the lipids is stored in the amylose helix, the remaining part is finely dispersed in the plasticized mass.
  • the extrudate, which emerges continuously as a strand, is cut into pastilles by rotating cutting knives, cooled and then dried.
  • the initially soft, plastic mass is transferred into a glass-like matrix. The pastilles are tasteless.
  • Wheat bran is used in a proportion of 40 - 45%
  • Potato starch also mixed in a proportion of 40 - 45%.
  • Oil is added as the remaining portion, preferably in an amount of 10% or more. Then proceed as in Example 1. Even with the mixture according to Example 2, the lipids of the oil can be incorporated into the amylose helix and the starch mass of wheat bran and potato starch to a degree that the extrudate is tasteless.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

L'invention concerne un produit destiné à l'absorption intestinale de constituants de denrées alimentaires, dans lequel lesdits constituants sont masqués. Ce produit est caractérisé en ce qu'au moins un des constituants des denrées alimentaires est un acide gras ou une substance contenant des acide gras et/ou un acide aminé ou une substance contenant des acides aminés, liés sous forme finement dispersée dans une matrice d'amidon plastifié. Au moins une partie de l'acide gras (des acides gras) et/ou de l'acide aminé (des acides aminés) est intégrée dans au moins des portions d'une hélice d'amylose. L'invention concerne également un procédé de fabrication de ce type de produit.
EP95916553A 1994-04-01 1995-04-01 Produit destine a l'absorption intestinale de constituants de denrees alimentaires et procede de fabrication de ce type de produit Withdrawn EP0754062A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4411414A DE4411414C1 (de) 1994-04-01 1994-04-01 Produkt zur enteralen Versorgung mit Fettsäuren und/oder Aminosäuren sowie Verfahren zur Herstellung eines derartigen Produktes
DE4411414 1994-04-01
PCT/DE1995/000446 WO1995026752A1 (fr) 1994-04-01 1995-04-01 Produit destine a l'absorption intestinale de constituants de denrees alimentaires et procede de fabrication de ce type de produit

Publications (1)

Publication Number Publication Date
EP0754062A1 true EP0754062A1 (fr) 1997-01-22

Family

ID=6514462

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95916553A Withdrawn EP0754062A1 (fr) 1994-04-01 1995-04-01 Produit destine a l'absorption intestinale de constituants de denrees alimentaires et procede de fabrication de ce type de produit

Country Status (3)

Country Link
EP (1) EP0754062A1 (fr)
DE (1) DE4411414C1 (fr)
WO (1) WO1995026752A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0935523B1 (fr) 1996-10-28 2004-09-29 Inc. General Mills Inclusion et encapsulation de particules a liberation controlee
EP1342548B1 (fr) 1996-10-28 2015-12-23 General Mills, Inc. Inclusion et encapsulation de particules à libération contrôlée et produit encapsulé
US7201923B1 (en) 1998-03-23 2007-04-10 General Mills, Inc. Encapsulation of sensitive liquid components into a matrix to obtain discrete shelf-stable particles
PT1065936E (pt) 1998-03-23 2009-09-24 Gen Mills Inc Encapsulação de componentes em produtos comestíveis
US6500463B1 (en) 1999-10-01 2002-12-31 General Mills, Inc. Encapsulation of sensitive components into a matrix to obtain discrete shelf-stable particles
US6436453B1 (en) 2000-06-16 2002-08-20 General Mills, Inc. Production of oil encapsulated minerals and vitamins in a glassy matrix
US6468568B1 (en) 2000-06-16 2002-10-22 General Mills, Inc. Oligosaccharide encapsulated mineral and vitamin ingredients
US6558718B1 (en) 2000-06-19 2003-05-06 General Mills, Inc. Nutrient clusters for food products and methods of preparation
AT414205B (de) * 2000-06-20 2006-10-15 Vis Vitalis Lizenz & Handels Verfahren zur herstellung von ungesättigtem fettsäure-trockenkonzentrat
US7431986B2 (en) 2002-07-24 2008-10-07 General Mills, Inc. Encapsulation of sensitive components using pre-emulsification
US7803413B2 (en) 2005-10-31 2010-09-28 General Mills Ip Holdings Ii, Llc. Encapsulation of readily oxidizable components
EP2717708A1 (fr) 2011-06-07 2014-04-16 SPAI Group Ltd. Compositions et procédés pour améliorer la stabilité et l'extension de la durée de conservation d'additifs alimentaires sensibles et produits alimentaires de ceux-ci
US9560877B2 (en) 2012-03-13 2017-02-07 General Mills, Inc. Cereal-based product with improved eating quality fortified with dietary fiber and/or calcium
BR102022016500A2 (pt) * 2022-08-18 2024-02-27 Universidade Estadual De Campinas Processo de obtenção de composições à base de compostos multifuncionais, composições à base de compostos multifuncionais assim obtidas e seu uso

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3962416A (en) * 1971-01-25 1976-06-08 Sol Katzen Preserved nutrients and products
US3786123A (en) * 1971-01-25 1974-01-15 S Katzen Method for stabilizing and preserving nutrients and products
US4562082A (en) * 1984-03-15 1985-12-31 General Foods Corporation Extruded shrimp analog formed from vegetable protein and starch complex
JPS6227040A (ja) * 1985-07-26 1987-02-05 Sapporo Breweries Ltd 物質を澱粉に吸着あるいは包接させる方法
JPH0451870A (ja) * 1990-06-14 1992-02-20 Terumo Corp 抗肥満性食品およびその製造方法
US5183690A (en) * 1990-06-25 1993-02-02 The United States Of America, As Represented By The Secretary Of Agriculture Starch encapsulation of biologically active agents by a continuous process
JPH0463563A (ja) * 1990-07-03 1992-02-28 Terumo Corp 抗肥満性食品およびその製造方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9526752A1 *

Also Published As

Publication number Publication date
DE4411414C1 (de) 1995-11-30
WO1995026752A1 (fr) 1995-10-12

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