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EP0698025B1 - Antagonistes de l'acide amp et procedes de traitement a l'aide de ceux-ci - Google Patents

Antagonistes de l'acide amp et procedes de traitement a l'aide de ceux-ci Download PDF

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Publication number
EP0698025B1
EP0698025B1 EP94917602A EP94917602A EP0698025B1 EP 0698025 B1 EP0698025 B1 EP 0698025B1 EP 94917602 A EP94917602 A EP 94917602A EP 94917602 A EP94917602 A EP 94917602A EP 0698025 B1 EP0698025 B1 EP 0698025B1
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Prior art keywords
compound
alkyl
formula
set forth
pharmaceutically acceptable
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German (de)
English (en)
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EP0698025A1 (fr
Inventor
Frank Wätjen
Jorgen Drejer
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NTG Nordic Transport Group AS
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Neurosearch AS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Definitions

  • the present invention relates to novel ring fused glutamate antagonists, a method of treatment therewith, pharmaceutical compositions comprising the compounds and to a method of preparing the novel compounds of the invention.
  • Another object of the present invention is to provide a method of treating disorders or diseases of mammals, including a human, responsive to the blockade of glutamic and aspartic acid receptors which comprises administering to a mammal in need thereof a compound of the invention.
  • a third object of the present invention is to provide novel pharmaceutical compositions for the treatment of disorders or diseases of mammals, including a human, responsive to the blockade of glutamic and aspartic acid receptors.
  • EAA excitatory amino acids
  • NMDA N-methyl-D-aspartate
  • AMPA alfa-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid
  • This excitotoxic action is responsible for the loss of neurons in cerebrovascular disorders such as cerebral ischemia or cerebral infarction resulting from a range of conditions, such as thromboembolic or haemorrhagic stroke, cerebral vasospasm, hypoglycaemia, cardiac arrest, status epilepticus, perinatal asphyxia, anoxia such as from near-drowning, pulmonary surgery and cerebral trauma as well as lathyrism, Alzheimer's, and Huntington's diseases.
  • cerebrovascular disorders such as cerebral ischemia or cerebral infarction resulting from a range of conditions, such as thromboembolic or haemorrhagic stroke, cerebral vasospasm, hypoglycaemia, cardiac arrest, status epilepticus, perinatal asphyxia, anoxia such as from near-drowning, pulmonary surgery and cerebral trauma as well as lathyrism, Alzheimer's, and Huntington's diseases.
  • the compounds of the present invention may also be useful in the treatment of Amyotrophic Lateral Sclerosis (ALS), schizophrenia, Parkinsonism, epilepsy, anxiety, pain and drug addiction.
  • ALS Amyotrophic Lateral Sclerosis
  • schizophrenia schizophrenia, Parkinsonism, epilepsy
  • anxiety anxiety, pain and drug addiction.
  • EP-A1-529 636 relates to indole-2,3-dione oxime derivatives having excitatory amino acid antagonising properties.
  • EP-A1-283 959 and WO-A1-94/09000 relates to quinoxaline derivatives also having excitatory amino acid antagonising properties.
  • the compounds of the present invention differs from the compounds disclosed in the above patent applications by having an aryl group or a heteroaryl group attached in position 5 or 6.
  • the invention then, inter alia, comprises the following, alone or in combination:
  • A is a ring of five to seven atoms fused with the benzo ring at the positions marked a and b, and formed by the following bivalent radicals: a-NR 12 -CH 2 -CH 2 -b a-CH 2 -CH 2 -NR 12 -b a-CH 2 -NR 12 -CH 2 -b, a-CH 2 -CH 2 -NR 12 -CH 2 -b, a-CH 2 -NR 12 -CH 2 -CH 2 -b, a-CH 2 -CH 2 -CH 2 -NR 12 -b, a-NR 12 -CH 2 -CH 2 -CH 2 -b, a-CH 2 -CH 2 -NR 12 -CH 2 -CH 2 -b, a-CH 2 -CH 2 -NR 12 -CH 2 -CH 2 -b, a-CH 2 -CH 2 -CH 2 -NR 12 -CH 2 -b, a-CH 2
  • Examples of pharmaceutically acceptable addition salts include inorganic and organic acid addition salts such as the hydrochloride, hydrobromide, phosphate, nitrate, perchlorate, sulphate, citrate, lactate, tartrate, maleate, fumarate, mandelate, benzoate, ascorbate, cinnamate, benzenesulfonate, methanesulfonate, stearate, succinate, glutamate, glycollate, toluene-p-sulphonate, formate, malonate, naphthalene-2-sulphonate, salicylate and the acetate.
  • Such salts are formed by procedures well known in the art.
  • acids such as oxalic acid, while not in themselves pharmaceutically acceptable, may be useful in the preparation of salts useful as intermediates in obtaining compounds of the invention and their pharmaceutically acceptable acid addition salts.
  • Halogen is fluorine, chlorine, bromine, or iodine.
  • Alkyl means a straight chained or branched chain of from one to six carbon atoms or cyclic alkyl of from three to seven carbon atoms, including but not limited to, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, t-butyl, pentyl, hexyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl; methyl, ethyl, propyl and isopropyl are preferred groups.
  • Alkoxy is O-alkyl, wherein alkyl is as defined above.
  • Amino is NH 2 or NH-alkyl or N-(alkyl) 2 , wherein alkyl is as defined above.
  • the compounds of this invention may exist in unsolvated as well as in solvated forms with pharmaceutically acceptable solvents such as water, ethanol and the like.
  • pharmaceutically acceptable solvents such as water, ethanol and the like.
  • the solvated forms are considered equivalent to the unsolvated forms for the purposes of this invention.
  • Racemic forms can be resolved into the optical antipodes by known methods, for example, by separation of diastereomeric salts thereof, with an optically active acid, and liberating the optically active amine compound by treatment with a base. Another method for resolving racemates into the optical antipodes is based upon chromatography on an optical active matrix. Racemic compounds of the present invention can thus be resolved into their optical antipodes, e.g., by fractional crystallization of d- or I- (tartrates, mandelates, or camphorsulphonate) salts for example.
  • the compounds of the present invention may also be resolved by the formation of diastereomeric amides by reaction of the compounds of the present invention with an optically active activated carboxylic acid such as that derived from (+) or (-) phenylalanine, (+) or (-) phenylglycine, (+) or (-) camphanic acid or by the formation of diastereomeric carbamates by reaction of the compounds of the present invention with an optically active chloroformate or the like.
  • an optically active activated carboxylic acid such as that derived from (+) or (-) phenylalanine, (+) or (-) phenylglycine, (+) or (-) camphanic acid
  • the compounds of the invention exhibit valuable biological properties because of their strong excitatory amino acid (EAA) antagonizing properties at the AMPA ((RS)-alfa-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) binding site.
  • EAA excitatory amino acid
  • the compounds of the present invention exhibit binding affinity for the AMPA receptor as described by T. Honoré et al., Neuroscience Letters 54 , 27-32 (1985) with IC 50 values from the nanomolar to the lower micro molar range.
  • Table 1 Compound IC 50 Compound 3 0.6 ⁇ M Compound 9 0.2 ⁇ M Compound 10 0.15 ⁇ M Compound 13 0.1 ⁇ M
  • compounds of the present invention when adminestered i.v. or i.p. in the in vivo AMPA seizure test as described below inhibit the clonic seizures induced by AMPA.
  • a compound of the invention may be administered as the raw chemical, it is preferable to present the active ingredient as a pharmaceutical formulation.
  • the invention thus further provides pharmaceutical formulations comprising a compound of the invention or a pharmaceutically acceptable salt or derivative thereof together with one or more pharmaceutically acceptable carriers therefor and, optionally, other therapeutic and/or prophylactic ingredients.
  • the carrier(s) must be "acceptable” in the sense of being compatible with the other ingredients of the formulation and not deleterious to the recipient thereof.
  • compositions include those suitable for oral, rectal, nasal, topical (including buccal and sub-lingual), vaginal or parenteral (including intramuscular, sub-cutaneous and intravenous) administration or in a form suitable for administration by inhalation or insufflation.
  • compositions and unit dosages thereof may be placed into the form of pharmaceutical compositions and unit dosages thereof, and in such form may be employed as solids, such as tablets or filled capsules, or liquids such as solutions, suspensions, emulsions, elixirs, or capsules filled with the same, all for oral use, in the form of suppositories for rectal administration; or in the form of sterile injectable solutions for parenteral (including subcutaneous) use.
  • Such pharmaceutical compositions and unit dosage forms thereof may comprise conventional ingredients in conventional proportions, with or without additional active compounds or principles, and such unit dosage forms may contain any suitable effective amount of the active ingredient commensurate with the intended daily dosage range to be employed.
  • Formulations containing ten (10) milligrams of active ingredient or, more broadly, 0.1 to one hundred (100) milligrams, per tablet, are accordingly suitable representative unit dosage forms.
  • the compounds of the present invention can be administrated in a wide variety of oral and parenteral dosage forms. It will be obvious to those skilled in the art that the following dosage forms may comprise, as the active component, either a compound of the invention or a pharmaceutically acceptable salt of a compound of the invention.
  • pharmaceutically acceptable carriers can be either solid or liquid.
  • Solid form preparations include powders, tablets, pills, capsules, cachets, suppositories, and dispersible granules.
  • a solid carrier can be one or more substances which may also act as diluents, flavouring agents, solubilizers, lubricants, suspending agents, binders, preservatives, tablet disintegrating agents, or an encapsulating material.
  • the carrier is a finely divided solid which is in a mixture with the finely divided active component.
  • the active component is mixed with the carrier having the necessary binding capacity in suitable proportions and compacted in the shape and size desired.
  • the powders and tablets preferably contain from five or ten to about seventy percent of the active compound.
  • Suitable carriers are magnesium carbonate, magnesium stearate, talc, sugar, lactose, pectin, dextrin, starch, gelatin, tragacanth, methylcellulose, sodium carboxymethylcellulose, a low melting wax, cocoa butter, and the like.
  • the term "preparation" is intended to include the formulation of the active compound with encapsulating material as carrier providing a capsule in which the active component, with or without carriers, is surrounded by a carrier, which is thus in association with it.
  • cachets and lozenges are included. Tablets, powders, capsules, pills, cachets, and lozenges can be used as solid forms suitable for oral administration.
  • a low melting wax such as admixture of fatty acid glycerides or cocoa butter
  • the active component is dispersed homogeneously therein, as by stirring.
  • the molten homogenous mixture is then poured into convenient sized molds, allowed to cool, and thereby to solidify.
  • Formulations suitable for vaginal administration may be presented as pessaries, tampons, creams, gels, pastes, foams or sprays containing in addition to the active ingredient such carriers as are known in the art to be appropriate.
  • Liquid form preparations include solutions, suspensions, and emulsions, for example, water or water-propylene glycol solutions.
  • parenteral injection liquid preparations can be formulated as solutions in aqueous polyethylene glycol solution.
  • the compounds according to the present invention may thus be formulated for parenteral administration (e.g. by injection, for example bolus injection or continuous infusion) and may be presented in unit dose form in ampoules, pre-filled syringes, small volume infusion or in multi-dose containers with an added preservative.
  • the compositions may take such forms as suspensions, solutions, or emulsions in oily or aqueous vehicles, and may contain formulatory agents such as suspending, stabilising and/or dispersing agents.
  • the active ingredient may be in powder form, obtained by aseptic isolation of sterile solid or by lyophilisation from solution, for constitution with a suitable vehicle, e.g. sterile, pyrogen-free water, before use.
  • Aqueous solutions suitable for oral use can be prepared by dissolving the active component in water and adding suitable colorants, flavours, stabilizing and thickening agents, as desired.
  • Aqueous suspensions suitable for oral use can be made by dispersing the finely divided active component in water with viscous material, such as natural or synthetic gums, resins, methylcellulose, sodium carboxymethylcellulose, or other well known suspending agents.
  • viscous material such as natural or synthetic gums, resins, methylcellulose, sodium carboxymethylcellulose, or other well known suspending agents.
  • solid form preparations which are intended to be converted, shortly before use, to liquid form preparations for oral administration.
  • liquid forms include solutions, suspensions, and emulsions.
  • These preparations may contain, in addition to the active component, colorants, flavours, stabilizers, buffers, artificial and natural sweeteners, dispersants, thickeners, solubilizing agents, and the like.
  • the compounds according to the invention may be formulated as ointments, creams or lotions, or as a transdermal patch.
  • Ointments and creams may, for example, be formulated with an aqueous or oily base with the addition of suitable thickening and/or gelling agents.
  • Lotions may be formulated with an aqueous or oily base and will in general also contain one or more emulsifying agents, stabilising agents, dispersing agents, suspending agents, thickening agents, or colouring agents.
  • Formulations suitable for topical administration in the mouth include lozenges comprising the active agent in a flavoured base, usually sucrose and acacia or tragacanth; pastilles comprising the active ingredient in an inert base such as gelatin and glycerin or sucrose and acacia; and mouthwashes comprising the active ingredient in a suitable liquid carrier.
  • Solutions or suspensions are applied directly to the nasal cavity by conventional means, for example with a dropper, pipette or spray.
  • the formulations may be provided in single or multidose form. In the latter case of a dropper or pipette, this may be achieved by the patient administering an appropriate, predetermined volume of the solution or suspension. In the case of a spray, this may be achieved for example by means of a metering atomising spray pump.
  • Administration to the respiratory tract may also be achieved by means of an aerosol formulation in which the active ingredient is provided in a pressurized pack with a suitable propellant such as a chlorofluorocarbon (CFC) for example dichlorodifluoromethane, trichlorofluoromethane, or dichlorotetrafluoroethane, carbon dioxide, or other suitable gas.
  • a suitable propellant such as a chlorofluorocarbon (CFC) for example dichlorodifluoromethane, trichlorofluoromethane, or dichlorotetrafluoroethane, carbon dioxide, or other suitable gas.
  • CFC chlorofluorocarbon
  • the aerosol may conveniently also contain a surfactant such as lecithin.
  • the dose of drug may be controlled by provision of a metered valve.
  • the active ingredients may be provided in the form of a dry powder, for example a powder mix of the compound in a suitable powder base such as lactose, starch, starch derivatives such as hydroxypropylmethyl cellulose and polyvinylpyrrolidone (PVP).
  • a powder base such as lactose, starch, starch derivatives such as hydroxypropylmethyl cellulose and polyvinylpyrrolidone (PVP).
  • PVP polyvinylpyrrolidone
  • the powder carrier will form a gel in the nasal cavity.
  • the powder composition may be presented in unit dose form for example in capsules or cartridges of, e.g., gelatin, or blister packs from which the powder may be administered by means of an inhaler.
  • the compound In formulations intended for administration to the respiratory tract, including intranasal formulations, the compound will generally have a small particle size for example of the order of 5 microns or less. Such a particle size may be obtained by means known in the art, for example by micronization.
  • formulations adapted to give sustained release of the active ingredient may be employed.
  • the pharmaceutical preparations are preferably in unit dosage forms.
  • the preparation is subdivided into unit doses containing appropriate quantities of the active component.
  • the unit dosage form can be a packaged preparation, the package containing discrete quantities of preparation, such as packeted tablets, capsules, and powders in vials or ampoules.
  • the unit dosage form can be a capsule, tablet, cachet, or lozenge itself, or it can be the appropriate number of any of these in packaged form.
  • Tablets or capsules for oral administration and liquids for intravenous administration are preferred compositions.
  • the compounds of this invention are extremely useful in the treatment of central nervous system disorders related to their biological activity.
  • the compounds of this invention may accordingly be administered to a subject, including a human, in need of treatment, alleviation, or elimination of a disorder or disease associated with the biological activity of the compounds.
  • excitatory amino acid dependent including glutamate and/or aspartate dependent psychosis, excitatory amino acid dependent, including glutamate and/or aspartate dependent anoxia, excitatory amino acid dependent, including glutamate and/or aspartate dependent ischemia, excitatory amino acid dependent, including glutamate and/or aspartate dependent Parkinsonism, excitatory amino acid dependent, including glutamate and/or aspartate dependent convulsions and excitatory amino acid dependent, including glutamate and/or aspartate dependent migraine as well as ALS.
  • excitatory amino acid dependent including glutamate and/or aspartate dependent psychosis
  • excitatory amino acid dependent including glutamate and/or aspartate dependent anoxia
  • excitatory amino acid dependent including glutamate and/or aspartate dependent ischemia
  • excitatory amino acid dependent including glutamate and/or aspartate dependent Parkinsonism
  • excitatory amino acid dependent including glutamate and/or aspartate dependent convulsions
  • excitatory amino acid dependent
  • Suitable dosage ranges are 0.1 to 1000 milligrams daily, 10-500 milligrams daily, and especially 30-100 milligrams daily, dependent as usual upon the exact mode of administration, form in which administered, the indication toward which the administration is directed, the subject involved and the body weight of the subject involved, and further the preference and experience of the physician or veterinarian in charge.
  • the isoquinoline salt (3.9 mmol) was dissolved in acetic acid (10 mL) and sodium borohydride (0.15 g, 3.97 mmol) was added. After stirring for 24 h, the reaction mixture was diluted with a mixture of ethyl acetate and water and potassium carbonate was added portionwise to neutralize the acetic acid. The aqueous layer was extracted with ethyl acetate (2x), washed with saturated NaCI, dried over MgSO 4 , filtered and evaporated.
  • N-ethyl-5-bromo-8-nitro-1,2,3,4-tetrahydroisoquinoline was prepared according to the same procedure. M.p. 52-53°C.

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Claims (10)

  1. Composé ayant la formule
    Figure imgb0035
     ou un sel de celui-ci pharmaceutiquement acceptable dans laquelle
    R1 est un atome d'hydrogène, un radical alkyle ou un radical benzyle ;
    X est O ou NOR2, où R2 est un atome d'hydrogène, un radical alkyle ou un radical benzyle ;
    Y est N-R4 où R4 est un atome d'hydrogène, OH ou un radical alkyle ;
    n est 0 ou 1 ;
    R6 est
    un radical phényle,
    un radical naphtyle,
    un radical thiényle,
    un radical pyridyle,
    dont tous peuvent être substitués, une ou plusieurs fois, par les substituants choisis dans le groupe constitué d'un halogène, d'un groupe CF3, d'un groupe NO2, d'un groupe amino, d'un groupe alkyle, d'un groupe alcoxyle et d'un groupe phényle ;
    A est un cycle de cinq à sept atomes condensé avec le cycle benzoïque aux positions désignées par a et b et formé par les radicaux bivalents suivants :

            a-NR12-CH2-CH2-b



            a-CH2-CH2-NR12-b



            a-CH2-NR12-CH2-b,



            a-CH2-CH2-NR12-CH2-b,



            a-CH2-NR12-CH2-CH2-b,



            a-CH2-CH2-CH2-NR12-b,



            a-NR12-CH2-CH2-CH2-b,



            a-CH2-CH2-NR12-CH2-CH2-b,



            a-CH2-CH2-CH2-NR12-CH2-b,



            a-CH2-NR12-CH2-CH2-CH2-b,



            a-CH2-CH2-CH2-CH2-NR12-b,



            a-NR12-CH2-CH2-CH2-CH2-b,

    dans lesquels
       R12 est un atome d'hydrogène, un radical CH2CH2OH ou un radical alkyle.
  2. Composé, selon la revendication 1 ayant la formule
    Figure imgb0036
     ou un sel de celui-ci pharmaceutiquement acceptable ;
    dans laquelle X, Y, n, R1, R6 et R12 ont les significations énoncées à la revendication 1.
  3. Composé selon la revendication 1 ayant la formule
    Figure imgb0037
     ou un sel de celui-ci pharmaceutiquement acceptable ;
    dans laquelle X, Y, n, R1, R6 et R12 ont les significations énoncées à la revendication 1.
  4. Composé selon la revendication 1 ayant la formule
    Figure imgb0038
     ou un sel de celui-ci pharmaceutiquement acceptable ;
    dans laquelle X, Y, n, R1, R6 et R12 ont les significations énoncées à la revendication 1.
  5. Composé selon la revendication 1 ayant la formule
    Figure imgb0039
     ou un sel de celui-ci pharmaceutiquement acceptable ;
    dans laquelle X, Y, n, R1, R6 et R12 ont les significations énoncées à la revendication 1.
  6. Composé selon la revendication 1 destiné à être utilisé comme médicament.
  7. Composition pharmaceutique comprenant une quantité thérapeutiquement efficace d'un composé selon la revendication 1 en association avec un porteur pharmaceutiquement acceptable.
  8. Utilisation d'un composé selon la revendication 1 pour la fabrication d'un médicament destiné au traitement d'un dysfonctionnement ou d'une maladie chez un mammifère, y compris un être humain, lequel dysfonctionnement ou maladie est sensible au blocage des récepteurs de l'acide glutamique et/ou de l'acide aspartique.
  9. Utilisation selon la revendication 8, dans laquelle le dysfonctionnement ou la maladie d'un mammifère est le lathyrisme, la maladie d'Alzheimer, les maladies de Huntington, l'ALS, la schizophrénie, la maladie de Parkinson, l'épilepsie, l'anxiété, la douleur, la toxicomanie ou les maladies cérébrovasculaires.
  10. Procédé de préparation d'un composé selon la revendication 1, comprenant l'étape consistant à :
    a) faire réagir un composé ayant la formule
    Figure imgb0040
     dans laquelle A, a, b, R1 et R6 ont les significations énoncées à la revendication 1, avec le composé NH2OR2, dans lequel R2 a la signification énoncée à la revendication 1, ou avec l'un de ses dérivés réactifs, pour former un composé selon la revendication 1 ; ou
    b) faire réagir un composé ayant la formule
    Figure imgb0041
     dans laquelle A, a, b, R1 et R6 ont les significations précédemment énoncées, avec de l'acide oxalique ou avec l'un de ses dérivés réactifs, pour former un composé selon la revendication 1.
EP94917602A 1993-05-13 1994-05-09 Antagonistes de l'acide amp et procedes de traitement a l'aide de ceux-ci Expired - Lifetime EP0698025B1 (fr)

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DK55893A DK55893D0 (da) 1993-05-13 1993-05-13 Nye receptoraktive forbindelser, deres fremstilling og anvendelse
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PCT/EP1994/001492 WO1994026747A1 (fr) 1993-05-13 1994-05-09 Antagonistes de l'acide amp et procedes de traitement a l'aide de ceux-ci

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WO1999049864A1 (fr) * 1998-03-31 1999-10-07 Neurosearch A/S Derives d'indol-2,3-dione-3-oxime destines a un usage therapeutique
US6096744A (en) * 1998-05-04 2000-08-01 Warner-Lambert Company Sulfonamide derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
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JPH08510221A (ja) 1996-10-29
CA2161783A1 (fr) 1994-11-24
NO305287B1 (no) 1999-05-03
FI954965L (fi) 1995-11-10
NZ267081A (en) 1997-11-24
FI954965A7 (fi) 1995-11-10
DE69407407T2 (de) 1998-04-09
NO954576L (no) 1996-01-15
CA2161783C (fr) 2006-08-15
DK0698025T3 (da) 1998-08-24
AU679075B2 (en) 1997-06-19
FI954965A0 (fi) 1995-10-18
NO954576D0 (no) 1995-11-13
AU6926494A (en) 1994-12-12
WO1994026747A1 (fr) 1994-11-24
EP0698025A1 (fr) 1996-02-28
JP3439215B2 (ja) 2003-08-25

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