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EP0694498A1 - Procédé et dispositif pour prélever un liquide d'une ampoule en verre fermée - Google Patents

Procédé et dispositif pour prélever un liquide d'une ampoule en verre fermée Download PDF

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Publication number
EP0694498A1
EP0694498A1 EP95890104A EP95890104A EP0694498A1 EP 0694498 A1 EP0694498 A1 EP 0694498A1 EP 95890104 A EP95890104 A EP 95890104A EP 95890104 A EP95890104 A EP 95890104A EP 0694498 A1 EP0694498 A1 EP 0694498A1
Authority
EP
European Patent Office
Prior art keywords
ampoule
glass
glass ampoule
liquid
cannula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP95890104A
Other languages
German (de)
English (en)
Other versions
EP0694498B1 (fr
Inventor
Horst Dipl.-Ing.Dr. Rüther
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AVL Medical Instruments AG
Original Assignee
AVL Medical Instruments AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AVL Medical Instruments AG filed Critical AVL Medical Instruments AG
Publication of EP0694498A1 publication Critical patent/EP0694498A1/fr
Application granted granted Critical
Publication of EP0694498B1 publication Critical patent/EP0694498B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67B—APPLYING CLOSURE MEMBERS TO BOTTLES JARS, OR SIMILAR CONTAINERS; OPENING CLOSED CONTAINERS
    • B67B7/00—Hand- or power-operated devices for opening closed containers
    • B67B7/92—Hand- or power-operated devices for opening closed containers by breaking, e.g. for ampoules
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T225/00—Severing by tearing or breaking
    • Y10T225/30—Breaking or tearing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T225/00—Severing by tearing or breaking
    • Y10T225/30—Breaking or tearing apparatus
    • Y10T225/371—Movable breaking tool

Definitions

  • the invention relates to a method and a device for removing a liquid from a sealed glass ampoule, the glass ampoule being held in an upright position, the bottom of the ampoule pointing upward.
  • an automatic injection device has become known from US Pat. No. 3,892,237, in which a glass ampoule is held in an upright position, the bottom of the ampoule pointing upwards.
  • the tip of the glass ampoule can be broken with a mechanically actuated device, the gas-containing content of which reaches a deformable plastic ampoule.
  • a mechanically actuated device the gas-containing content of which reaches a deformable plastic ampoule.
  • the force of a prestressed spring deforms the plastic ampoule and, at the same time, an injection needle is ejected from the injection device to an adjustable injection depth.
  • such a device is not suitable for automated use in laboratory devices.
  • the object of the invention is to propose a method and a device for the automatic removal of a liquid from a closed container, in particular the removal of quality control liquids from glass ampoules.
  • this object is achieved in that the bottom of the glass ampoule is mechanically destroyed by the insertion of a removal element and in that liquid is sucked out of a fragment-free area of the glass ampoule.
  • the glass ampoule is automatically removed from a reservoir containing a large number of glass ampoules.
  • a device according to the invention for removing a liquid from a sealed glass ampoule is characterized in that a removal element which can be inserted through the bottom of the glass ampoule is provided and has a cannula for aspirating the liquid from a splinter-free area of the glass ampoule.
  • the removal element is designed as a rigid-walled cannula, the rigidity of which is sufficient to mechanically destroy the bottom of the glass ampoule.
  • a separate part of the removal element can also be provided for the destruction of the ampoule base.
  • the removal element can have an elastic membrane in the area of its tip, the outer diameter of which is adapted to the inner diameter of the glass ampoule.
  • the glass surface of the ampoules could be coated with an elastomer in order to retain the glass fragments in the ampoule area.
  • the bottom of the glass ampoule and the adjoining shaft area are encased by an elastomer part.
  • the elastomer parts of several glass ampoules can form a disposable carrier element for ampoule transport or ampoule storage.
  • the adhesion of the elastomer part means that less glass fragments fall into the ampoule.
  • the glass fragments remain in the ampoule area and are not scattered around.
  • the fracture area remains covered except for an inlet opening of the removal device.
  • no residual liquid can flow out of the glass ampoule after the removal process even if the head of the ampoule is turned upwards.
  • the removal opening can close automatically after the removal process. This also significantly reduces the odor nuisance caused by aging liquids.
  • the device has a holder 1 in which a glass ampoule 2 is held, preferably elastically by means of a sealing ring 3.
  • the glass ampoule 2 consisting of bottom 4, shaft area 5, neck area 6 and head area 7 contains a liquid 8 (calibration or quality control liquid or also medicinal product), the surface of which is designated by 9.
  • a removal device 10 Due to the upright position of the ampoule, the base 4 pointing upwards, the ampoule can be opened by inserting a removal device 10 through the base 4, this being mechanically destroyed.
  • the glass fragments that occur during the destruction sometimes sink into the neck or head area 6, 7 of the glass ampoule 2 or float - due to the surface tension of the liquid 8 - on its surface 9.
  • a splinter-free area 11 thus arises between the neck area 6 and the surface 9 of the liquid, from which liquid through the cannula 12 arranged in the removal device 10 can be suctioned off.
  • an elastic membrane 13 can be arranged on the removal device 10, which presses the glass particles under the surface 9 after immersion in the liquid 8.
  • the bottom 4 and the shaft area 5 of the glass ampoule 2 adjoining the bottom are enveloped by an elastomer part 14, which holds the glass fragments that occur in the ampoule area.
  • the elastomer parts 14 of several glass ampoules 2 can be combined to form a disposable carrier element 15.
  • a blunt, hard object to open the ampoule e.g. B. the thick-walled cannula 12, no significant wear is expected in operation.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
EP95890104A 1994-07-28 1995-06-06 Procédé et dispositif pour prélever un liquide d'une ampoule en verre fermée Expired - Lifetime EP0694498B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT1497/94 1994-07-28
AT0149794A AT404827B (de) 1994-07-28 1994-07-28 Verfahren und vorrichtung zur entnahme einer flüssigkeit aus einer verschlossenen glasampulle

Publications (2)

Publication Number Publication Date
EP0694498A1 true EP0694498A1 (fr) 1996-01-31
EP0694498B1 EP0694498B1 (fr) 1997-08-20

Family

ID=3515127

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95890104A Expired - Lifetime EP0694498B1 (fr) 1994-07-28 1995-06-06 Procédé et dispositif pour prélever un liquide d'une ampoule en verre fermée

Country Status (5)

Country Link
US (1) US5628353A (fr)
EP (1) EP0694498B1 (fr)
JP (1) JP2929575B2 (fr)
AT (1) AT404827B (fr)
DE (1) DE59500528D1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0919215A1 (fr) 1997-11-24 1999-06-02 AVL Medical Instruments AG Ampoule en verre pour contenir du liquide
AT406014B (de) * 1997-12-22 2000-01-25 Avl List Gmbh Vorrichtung zur entnahme einer flüssigkeit aus einer glasampulle
DE19841722C2 (de) * 1998-09-12 2002-08-08 Rossendorf Forschzent Vorrichtung zum Öffnen von Glasampullen
WO2010069960A1 (fr) * 2008-12-19 2010-06-24 F. Hoffmann-La Roche Ag Dispositif et procédé pour l'exécution automatique d'une vérification de l'étalonnage d'un analyseur
DE102011112516A1 (de) * 2011-09-07 2013-03-07 Aap Biomaterials Gmbh Flüssigkeitsbehälter mit Sollbruchstelle
US9186635B2 (en) 2009-03-17 2015-11-17 Stryker Ireland Limited Vacuum mixing device for bone cement and method for mixing bone cement in said device

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136607A (en) * 1995-11-02 2000-10-24 Bayer Corporation Multi-analyte reference solutions with stable pO2 in zero headspace containers
US5800113A (en) * 1997-03-27 1998-09-01 Kabushiki Kaisha Yuyama Seisakusho Device for separating series-connected plastic ampules
US6340097B1 (en) * 1998-10-22 2002-01-22 Closure Medical Corporation Applicator with protective barrier
US7946461B2 (en) * 2006-06-05 2011-05-24 Watson Laboratories, Inc. Ampoule opener and associated methods
WO2008000030A1 (fr) * 2006-06-27 2008-01-03 Glen Stanley Riverstone Dispositif et procédé pour ouvrir des ampoules
WO2010012114A1 (fr) * 2008-07-29 2010-02-04 Medmix Systems Ag Dispositif pour ouvrir un récipient de fluide fermé
CN102424344B (zh) * 2011-08-19 2012-12-26 姜秀娟 固定式安瓿自动开启器
US10532157B2 (en) 2016-04-08 2020-01-14 University Of Washington Ampule autoinjector systems and methods
EP3476418B1 (fr) 2017-10-30 2025-10-29 Eurotrol B.V. Dispositif d'extraction d'un fluide à partir d'une ampoule

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR721646A (fr) * 1930-11-14 1932-03-05 Negoce Et Ind Ampoule destinée à contenir de l'anhydride sulfureux ou tout autre gaz liquéfié sous pression. et appareil pour briser cette ampoule et diffuser le gaz qu'elle contient dans un liquide quelconque
US3892237A (en) 1973-07-17 1975-07-01 Maurice Steiner Self-injecting syringe
EP0079279A1 (fr) * 1981-11-05 1983-05-18 Millipore S.A. Procédé pour l'ouverture aseptique et anti-particulaire d'enceintes en verre scellé et dispositif et appareil mettant en oeuvre ce procédé
EP0472457A1 (fr) * 1990-08-20 1992-02-26 Cogema Compagnie Generale Des Matieres Nucleaires Appareil de vidange et de rinçage de flacons non récupérables contenant un produit toxique

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1680616A (en) * 1922-06-06 1928-08-14 Horst Friedrich Wilhelm Sealed package
US3380636A (en) * 1966-01-13 1968-04-30 Ushkow Meyer Ampul stand and opener
AR204599A1 (es) * 1975-08-21 1976-02-12 Ims Ltd Novedosa herramienta de mano para la rotura manual o digital de ampolletas de vidrio selladas
US4506817A (en) * 1981-12-23 1985-03-26 Parker Andrew E Device for opening ampoules
US4497349A (en) * 1982-02-08 1985-02-05 Loma Linda University Medical Center Solution dispenser
ES530426A0 (es) * 1983-03-10 1985-04-16 Dehais Claude Perfeccionamientos en las maquinas para elaborar ampollas farmaceuticas y similares y anpolla obtenida.
US4808381A (en) * 1983-05-13 1989-02-28 E. I. Du Pont De Nemours And Company Fluid transfer device
US5041267A (en) * 1986-12-30 1991-08-20 Air Products And Chemicals, Inc. Ultra high purity reagent container with large breakseal
DE8808138U1 (de) * 1988-06-24 1988-10-27 Ballies, Uwe, Dr. med., 2300 Kiel Vorrichtung zum Abscheiden des durch Zentrifugation eines Probenröhrchens von dem Blutkuchen separierten Serums
US5012845A (en) * 1988-08-18 1991-05-07 Dynatech Precision Sampling Corporation Fluid injector
DE4025717A1 (de) * 1990-08-14 1992-02-20 Hoechst Ag Spritzengestell
DK200890D0 (da) * 1990-08-22 1990-08-22 Ulf Nonboe Metode til bestemmelse af lugtende svinekoed
GB9107258D0 (en) * 1991-04-06 1991-05-22 Chromacol Ltd Apparatus for use in analytical instruments
US5179024A (en) * 1991-05-30 1993-01-12 Harald Dahms Sealed vials containing improved karl fischer solutions, and process for water determination using these vials
US5221311A (en) * 1992-01-10 1993-06-22 Rising Peter E Evacuated sampling vial

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR721646A (fr) * 1930-11-14 1932-03-05 Negoce Et Ind Ampoule destinée à contenir de l'anhydride sulfureux ou tout autre gaz liquéfié sous pression. et appareil pour briser cette ampoule et diffuser le gaz qu'elle contient dans un liquide quelconque
US3892237A (en) 1973-07-17 1975-07-01 Maurice Steiner Self-injecting syringe
EP0079279A1 (fr) * 1981-11-05 1983-05-18 Millipore S.A. Procédé pour l'ouverture aseptique et anti-particulaire d'enceintes en verre scellé et dispositif et appareil mettant en oeuvre ce procédé
EP0472457A1 (fr) * 1990-08-20 1992-02-26 Cogema Compagnie Generale Des Matieres Nucleaires Appareil de vidange et de rinçage de flacons non récupérables contenant un produit toxique

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0919215A1 (fr) 1997-11-24 1999-06-02 AVL Medical Instruments AG Ampoule en verre pour contenir du liquide
US5948366A (en) * 1997-11-24 1999-09-07 Avl Medical Instruments Ag Glass ampoule for holding a drug a calibration liquid or a quality control liquid
AT406014B (de) * 1997-12-22 2000-01-25 Avl List Gmbh Vorrichtung zur entnahme einer flüssigkeit aus einer glasampulle
US6099510A (en) * 1997-12-22 2000-08-08 Avl Medical Instruments Ag Device for withdrawing a liquid from a sealed glass ampoule
DE19841722C2 (de) * 1998-09-12 2002-08-08 Rossendorf Forschzent Vorrichtung zum Öffnen von Glasampullen
WO2010069960A1 (fr) * 2008-12-19 2010-06-24 F. Hoffmann-La Roche Ag Dispositif et procédé pour l'exécution automatique d'une vérification de l'étalonnage d'un analyseur
US9186635B2 (en) 2009-03-17 2015-11-17 Stryker Ireland Limited Vacuum mixing device for bone cement and method for mixing bone cement in said device
US9999459B2 (en) 2009-03-17 2018-06-19 Stryker European Holdings I, Llc Vacuum mixing device for bone cement and method for mixing bone cement in said device
WO2013034302A2 (fr) 2011-09-07 2013-03-14 Aap Biomaterials Gmbh Contenant pour liquides à point de rupture théorique
WO2013034302A3 (fr) * 2011-09-07 2013-05-30 Aap Biomaterials Gmbh Contenant pour liquides à point de rupture théorique
DE102011112516A1 (de) * 2011-09-07 2013-03-07 Aap Biomaterials Gmbh Flüssigkeitsbehälter mit Sollbruchstelle
US9642774B2 (en) 2011-09-07 2017-05-09 Stryker European Holdings I, Llc Liquid container with predetermined breaking point
DE102011112516B4 (de) 2011-09-07 2024-02-29 Stryker European Operations Holdings Llc Gebinde mit einem Behälter zur Aufnahme einer Flüssigkeit und einer Flüssigkeitsentnahmeeinrichtung

Also Published As

Publication number Publication date
EP0694498B1 (fr) 1997-08-20
JPH08322907A (ja) 1996-12-10
US5628353A (en) 1997-05-13
ATA149794A (de) 1998-07-15
DE59500528D1 (de) 1997-09-25
AT404827B (de) 1999-03-25
JP2929575B2 (ja) 1999-08-03

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