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EP0650358A4 - 17-acyl-4-aza-steroid-3-one as 5-alpha-reductase inhibitors. - Google Patents

17-acyl-4-aza-steroid-3-one as 5-alpha-reductase inhibitors.

Info

Publication number
EP0650358A4
EP0650358A4 EP93916878A EP93916878A EP0650358A4 EP 0650358 A4 EP0650358 A4 EP 0650358A4 EP 93916878 A EP93916878 A EP 93916878A EP 93916878 A EP93916878 A EP 93916878A EP 0650358 A4 EP0650358 A4 EP 0650358A4
Authority
EP
European Patent Office
Prior art keywords
aza
steroid
acyl
alpha
reductase inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93916878A
Other versions
EP0650358A1 (en
Inventor
Dennis Alan Holt
Mark Alan Levy
Hye-Ja Oh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0650358A1 publication Critical patent/EP0650358A1/en
Publication of EP0650358A4 publication Critical patent/EP0650358A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
EP93916878A 1992-06-30 1993-06-30 17-acyl-4-aza-steroid-3-one as 5-alpha-reductase inhibitors. Withdrawn EP0650358A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB929213901A GB9213901D0 (en) 1992-06-30 1992-06-30 Compounds
GB9213901 1992-06-30
PCT/US1993/006233 WO1994000121A1 (en) 1992-06-30 1993-06-30 17-acyl-4-aza-steroid-3-one as 5-alpha-reductase inhibitors

Publications (2)

Publication Number Publication Date
EP0650358A1 EP0650358A1 (en) 1995-05-03
EP0650358A4 true EP0650358A4 (en) 1995-06-07

Family

ID=10717969

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93916878A Withdrawn EP0650358A4 (en) 1992-06-30 1993-06-30 17-acyl-4-aza-steroid-3-one as 5-alpha-reductase inhibitors.

Country Status (4)

Country Link
EP (1) EP0650358A4 (en)
JP (1) JPH07508524A (en)
GB (1) GB9213901D0 (en)
WO (1) WO1994000121A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
US5595996A (en) * 1994-10-25 1997-01-21 Merck & Co., Inc. 7-substituted 4-aza cholanic acid derivatives and their use
GB201102913D0 (en) 2011-02-18 2011-04-06 Univ Birmingham Novel therapeutic

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0277002A2 (en) * 1987-01-28 1988-08-03 Smithkline Beecham Corporation Steroid-5-alpha-reductase inhibitors
WO1992000010A1 (en) * 1990-06-27 1992-01-09 Smithkline Beecham Corporation Method of treating human prostatic adenocarcinoma

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4377584A (en) * 1978-04-13 1983-03-22 Merck & Co., Inc. 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
US4760071A (en) * 1984-02-27 1988-07-26 Merck & Co., Inc. 17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors
US4859681A (en) * 1984-02-27 1989-08-22 Merck & Co., Inc. 17 α-Acyl-4-aza-5a-androst-1-en-3-ones as 5 alpha-reductase inhibitors
US5049562A (en) * 1984-02-27 1991-09-17 Merck & Co., Inc. 17β-acyl-4-aza-5α-androst-1-ene-3-ones as 5α-reductase inhibitors
GB8505862D0 (en) * 1985-03-07 1985-04-11 Erba Farmitalia Steroidic 5alpha-reductase inhibitors
US5110939A (en) * 1987-01-28 1992-05-05 Smithkline Beecham Corporation Intermediates in the preparation of steriod 5-alpha-reductase inhibitors
US4910226A (en) * 1987-04-29 1990-03-20 Smithkline Beckman Corporation Steroid 5-alpha-reductase inhibitors
US5116983A (en) * 1988-04-18 1992-05-26 Merck & Co., Inc. Dehydrogenation process intermediates
US4882319A (en) * 1988-12-23 1989-11-21 Smithkline Beckman Corporation Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5-α-reductase
US5098908A (en) * 1990-06-20 1992-03-24 Merck & Co., Inc. 17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones as testosterone reductase inhibitors
US5061803A (en) * 1990-09-24 1991-10-29 Merck & Co., Inc. Process for making 17-beta alkanoyl 3-oxo-4-aza-5-α-androst-1-enes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0277002A2 (en) * 1987-01-28 1988-08-03 Smithkline Beecham Corporation Steroid-5-alpha-reductase inhibitors
WO1992000010A1 (en) * 1990-06-27 1992-01-09 Smithkline Beecham Corporation Method of treating human prostatic adenocarcinoma

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9400121A1 *

Also Published As

Publication number Publication date
EP0650358A1 (en) 1995-05-03
WO1994000121A1 (en) 1994-01-06
JPH07508524A (en) 1995-09-21
GB9213901D0 (en) 1992-08-12

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19950112

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): BE CH DE FR GB IT LI NL

A4 Supplementary search report drawn up and despatched
AK Designated contracting states

Kind code of ref document: A4

Designated state(s): BE CH DE FR GB IT LI NL

RHK1 Main classification (correction)

Ipc: C07J 73/00

17Q First examination report despatched

Effective date: 19970804

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19971216