EP0648128A4 - DNA ENCODING THE INTERLEUKIN PRECURSOR 1-g (b) CONVERSION ENZYME. - Google Patents

DNA ENCODING THE INTERLEUKIN PRECURSOR 1-g (b) CONVERSION ENZYME.

Info

Publication number: EP0648128A4
Authority: EP; European Patent Office
Prior art keywords: dna encoding; conversion enzyme; interleukin; precursor; interleukin precursor
Prior art date: 1992-06-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP93916529A

Other languages

German (de)

French (fr)

Other versions

EP0648128A1 (en

Inventor

Andrew D Howard

Susan M Molineaux

Michael J Tocci

Jimmy R Calaycay

Douglas K Miller

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck and Co Inc

Original Assignee

Merck and Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-24

Filing date

1993-06-14

Publication date

1995-07-26

1993-06-14 Application filed by Merck and Co Inc filed Critical Merck and Co Inc

1995-04-19 Publication of EP0648128A1 publication Critical patent/EP0648128A1/en

1995-07-26 Publication of EP0648128A4 publication Critical patent/EP0648128A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6472—Cysteine endopeptidases (3.4.22)
- C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Saccharide Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

EP93916529A 1992-06-24 1993-06-14 DNA ENCODING THE INTERLEUKIN PRECURSOR 1-g (b) CONVERSION ENZYME. Withdrawn EP0648128A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US90639292A	1992-06-24	1992-06-24
PCT/US1993/005687 WO1994000154A1 (en)	1992-06-24	1993-06-14	DNA ENCODING PRECURSOR INTERLEUKIN 1β CONVERTING ENZYME
US906392		2001-07-16

Publications (2)

Publication Number	Publication Date
EP0648128A1 EP0648128A1 (en)	1995-04-19
EP0648128A4 true EP0648128A4 (en)	1995-07-26

Family

ID=25422367

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP93916529A Withdrawn EP0648128A4 (en)	1992-06-24	1993-06-14	DNA ENCODING THE INTERLEUKIN PRECURSOR 1-g (b) CONVERSION ENZYME.

Country Status (5)

Country	Link
EP (1)	EP0648128A4 (en)
JP (1)	JPH08500242A (en)
AU (1)	AU4634993A (en)
CA (1)	CA2136981A1 (en)
WO (1)	WO1994000154A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6008217A (en) *	1995-12-20	1999-12-28	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β converting enzyme
US5874424A (en) *	1995-12-20	1999-02-23	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β converting enzyme
US6204261B1 (en)	1995-12-20	2001-03-20	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β Converting enzyme inhibitors
US6420522B1 (en)	1995-06-05	2002-07-16	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β converting enzyme
US5856116A (en) *	1994-06-17	1999-01-05	Vertex Pharmaceuticals, Incorporated	Crystal structure and mutants of interleukin-1 beta converting enzyme
AU733479B2 (en) *	1994-06-17	2001-05-17	Vertex Pharmaceuticals Incorporated	Crystal structure and mutants of interleukin-1beta converting enzyme
US5847135A (en) *	1994-06-17	1998-12-08	Vertex Pharmaceuticals, Incorporated	Inhibitors of interleukin-1β converting enzyme
US5756466A (en) *	1994-06-17	1998-05-26	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1β converting enzyme
US5716929A (en) *	1994-06-17	1998-02-10	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1β converting enzyme
EP0786007A1 (en) *	1994-10-14	1997-07-30	Basf Aktiengesellschaft	Transgenic nonhuman animal having functionally disrupted interleukin-1-beta converting enzyme gene
WO1996026280A1 (en) *	1995-02-21	1996-08-29	Basf Aktiengesellschaft	NOVEL CYSTEINE PROTEASE RELATED TO INTERLEUKIN-1β CONVERTING ENZYME
US5869315A (en) *	1995-12-18	1999-02-09	Basf Aktiengesellschaft	Modified interleukin-1β converting enzyme with increased stability
US5843904A (en) *	1995-12-20	1998-12-01	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1βconverting enzyme
US6288037B1 (en)	1996-01-29	2001-09-11	Basf Aktiengesellschaft	Substrates and inhibitors for cysteine protease ICH-1
US6180402B1 (en) *	1996-11-20	2001-01-30	Qlt Inc.	Method for inhibiting apoptosis induced by photodynamic therapy using a cysteine or serine protease inhibitor
GB2324529A (en) *	1997-02-21	1998-10-28	Merck & Co Inc	A combinatorial library based on a tetrapeptide substituted with aminomethylcoumarin for characterizing proteases
DE69925581T2 (en)	1998-03-09	2006-04-27	Vertex Pharmaceuticals Inc., Cambridge	1,2-DIAZEPANDERIVATE AS INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME
ID27002A (en)	1998-03-19	2001-02-22	Vertex Pharma	CASASAGE OBSERVERS
PE20011350A1 (en)	2000-05-19	2002-01-15	Vertex Pharma	PROPHARMAC OF AN INHIBITOR OF INTERLEUKIN-1ß CONVERTER ENZYME (ICE)
CA2383392A1 (en) *	2001-04-27	2002-10-27	Matsushita Electric Industrial Co., Ltd.	Bio-device, and quantitative measurement apparatus and method using the same
GB0411056D0 (en)	2004-05-18	2004-06-23	Novartis Ag	Organic compounds
EP2295054A1 (en)	2004-05-27	2011-03-16	Vertex Pharmaceuticals Incorporated	Ice inhibitors for the treatment of autoinflammatory diseases
WO2019226649A1 (en) *	2018-05-22	2019-11-28	Nantkwest, Inc.	Optimization of nk-92 cell growth using poloxamer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0533350A1 (en) *	1991-08-16	1993-03-24	Merck & Co. Inc.	DNA encoding precursor interleukin 1B converting enzyme

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IN150740B (en) *	1978-11-24	1982-12-04	Hoffmann La Roche

1993
- 1993-06-14 JP JP6502418A patent/JPH08500242A/en active Pending
- 1993-06-14 EP EP93916529A patent/EP0648128A4/en not_active Withdrawn
- 1993-06-14 CA CA 2136981 patent/CA2136981A1/en not_active Abandoned
- 1993-06-14 AU AU46349/93A patent/AU4634993A/en not_active Abandoned
- 1993-06-14 WO PCT/US1993/005687 patent/WO1994000154A1/en not_active Ceased

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0533350A1 (en) *	1991-08-16	1993-03-24	Merck & Co. Inc.	DNA encoding precursor interleukin 1B converting enzyme

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
D CERRETTI ET AL: "Molecular cloning of the interleukin 1beta converting enzyme", SCIENCE, vol. 256, 3 April 1992 (1992-04-03), pages 97 - 100, XP002930919, DOI: doi:10.1126/science.1373520 *
N. THORNBERRY: "A novel heterodimeric cysteine protease is requiered for interleukin-1beta processing in monocytes", NATURE, vol. 356, 30 April 1992 (1992-04-30), LONDON GB, pages 768 - 774 *
See also references of WO9400154A1 *

Also Published As

Publication number	Publication date
CA2136981A1 (en)	1994-01-06
EP0648128A1 (en)	1995-04-19
WO1994000154A1 (en)	1994-01-06
JPH08500242A (en)	1996-01-16
AU4634993A (en)	1994-01-24

Publication	Publication Date	Title
EP0648128A4 (en)	1995-07-26	DNA ENCODING THE INTERLEUKIN PRECURSOR 1-g (b) CONVERSION ENZYME.
NO884170D0 (en)	1988-09-20	CATALYTIC CONVERSION PROCESS.
MA24511A1 (en)	1998-12-31	INTERLEUKIN 1B CONVERSION ENZYME INHIBITORS
DE3854748D1 (en)	1996-01-18	Differential / single-ended converter.
DE59007688D1 (en)	1994-12-15	Piezoelectric converter.
DE69015722D1 (en)	1995-02-16	Catalytic converter.
NO167240C (en)	1991-10-16	PARTY WITH MORE FREEDOMS.
FI893018A0 (en)	1989-06-20	KOMMUNIKATION MELLAN ROEK- OCH ELDDETEKTIONSSYSTEM.
EP0643204A3 (en)	1995-08-02	Ceramic honeycomb catalytic converter.
DE3583071D1 (en)	1991-07-11	ANALOG-DIGITAL CONVERSION.
FR2618134B1 (en)	1993-12-31	OZONE CRACKING CATALYST
GB2198475B (en)	1990-09-26	Muffler with flow director plates
EP0645622A3 (en)	1996-01-03	DNA bases analyzer.
FI873865A7 (en)	1988-03-09	Catalytic converter.
NO884172D0 (en)	1988-09-20	CATALYTIC CONVERSION PROCESS.
GR3015387T3 (en)	1995-06-30	Molluscicides.
DE3584573D1 (en)	1991-12-12	CATALYTIC CRACKING.
DE3870641D1 (en)	1992-06-11	PERFORMANCE CONVERTER.
DE3769811D1 (en)	1991-06-13	METALLURGICAL TUBE.
DE3877808D1 (en)	1993-03-11	IRON OXIDE CATALYST AND PRODUCTION THEREOF.
GB2204641B (en)	1991-06-12	Muffler with reverse flow passages
FI853138A0 (en)	1985-08-15	FLEXIBEL PAOSE MED INRE STABILISERANDE MELLANVAEGG.
DE3867770D1 (en)	1992-02-27	FREQUENCY CONVERTER FOR THE MIDDLE INFRARED AREA.
DE3574616D1 (en)	1990-01-11	PRESSURE CONVERTER.
IT8420466A0 (en)	1984-04-10	COMPOUNDS WITH CARDIOTROPHIC ACTIVITY.

Legal Events

Date	Code	Title	Description
1995-03-03	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1995-04-19	17P	Request for examination filed	Effective date: 19950124
1995-04-19	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
1995-06-07	RHK1	Main classification (correction)	Ipc: C12N 15/57
1995-07-26	A4	Supplementary search report drawn up and despatched
1995-07-26	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
2003-09-24	17Q	First examination report despatched	Effective date: 20030808
2004-07-10	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2004-08-25	18D	Application deemed to be withdrawn	Effective date: 20040219