EP0531530A4 - - Google Patents

Info

Publication number: EP0531530A4
Authority: EP; European Patent Office
Prior art keywords: secreted; incubation; signal peptide; earlier stage; host
Prior art date: 1990-05-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP19910920978

Other languages

English (en)

French (fr)

Other versions

EP0531530A1 (en

Inventor

Tamotsu¸ Hashimoto

Atsushi¸ Tsujimura

Juzo 1-24-3 Uesono-Cho Meito-Ku Udaka

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi Aventis KK

Original Assignee

Hoechst Japan Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-11

Filing date

1991-05-10

Publication date

1994-04-06

1991-05-10 Application filed by Hoechst Japan Ltd filed Critical Hoechst Japan Ltd

1993-03-17 Publication of EP0531530A1 publication Critical patent/EP0531530A1/en

1994-04-06 Publication of EP0531530A4 publication Critical patent/EP0531530A4/xx

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
- C12N9/2411—Amylases
- C12N9/2414—Alpha-amylase (3.2.1.1.)
- C12N9/2417—Alpha-amylase (3.2.1.1.) from microbiological source
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/832—Bacillus
- Y10S435/833—Bacillus brevis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Engineering & Computer Science (AREA)
Toxicology (AREA)
Microbiology (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)

EP91920978A 1990-05-11 1991-05-10 Process for producing protein Withdrawn EP0531530A1 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP12216690		1990-05-11
JP122166/90		1990-05-11
JP334575/90		1990-11-30
JP2334575A JPH04126084A (ja)	1990-05-11	1990-11-30	蛋白質の製造法

Publications (2)

Publication Number	Publication Date
EP0531530A1 EP0531530A1 (en)	1993-03-17
EP0531530A4 true EP0531530A4 (ja)	1994-04-06

Family

ID=26459349

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP91920978A Withdrawn EP0531530A1 (en)	1990-05-11	1991-05-10	Process for producing protein

Country Status (11)

Country	Link
US (1)	US5232841A (ja)
EP (1)	EP0531530A1 (ja)
JP (1)	JPH04126084A (ja)
AU (1)	AU643793B2 (ja)
CA (1)	CA2082637A1 (ja)
CS (1)	CS135591A2 (ja)
IE (1)	IE911607A1 (ja)
IL (1)	IL98095A0 (ja)
NZ (1)	NZ238095A (ja)
PT (1)	PT97623A (ja)
WO (1)	WO1991018101A1 (ja)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5714346A (en) *	1993-02-22	1998-02-03	Sumitomo Pharmaceuticals Company, Limited	Process for production of human growth hormone using Bacillus Brevis
JP3406244B2 (ja) *	1999-04-30	2003-05-12	伊藤ハム株式会社	新規な融合蛋白質からの組み換えインスリンの製造方法
JP5020487B2 (ja) *	2005-07-22	2012-09-05	ヒゲタ醤油株式会社	融合タンパク質発現用新規ｄｎａ及び該ｄｎａを用いたタンパク質の製造方法
WO2007137300A2 (en)	2006-05-23	2007-11-29	Bellicum Pharmaceuticals, Inc.	Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods
US8097422B2 (en)	2007-06-20	2012-01-17	Salk Institute For Biological Studies	Kir channel modulators
US20090280103A1 (en) *	2008-04-04	2009-11-12	Martin Flueck	Regulation of muscle repair
SG176970A1 (en)	2009-07-02	2012-02-28	Verdezyne Inc	Biological methods for preparing adipic acid
CA2767259A1 (en) *	2009-07-09	2011-01-13	Verdezyne, Inc.	Engineered microorganisms with enhanced fermentation activity
US8889394B2 (en) *	2009-09-07	2014-11-18	Empire Technology Development Llc	Multiple domain proteins
US8343752B2 (en)	2011-05-03	2013-01-01	Verdezyne, Inc.	Biological methods for preparing adipic acid
US8728798B2 (en)	2011-05-03	2014-05-20	Verdezyne, Inc.	Biological methods for preparing adipic acid
MY184871A (en)	2011-07-06	2021-04-28	Radici Chimica S P A	Biological methods for preparing a fatty dicarboxylic acid
US9850493B2 (en)	2012-12-19	2017-12-26	Verdezyne, Inc.	Biological methods for preparing a fatty dicarboxylic acid
JP2016501040A (ja)	2012-12-19	2016-01-18	ヴェルデザイン，インコーポレーテッド	脂肪族ジカルボン酸を調製するための生物学的方法
US10513706B2 (en)	2014-04-09	2019-12-24	The Scripps Research Institute	Import of unnatural or modified nucleoside triphosphates into cells via nucleic acid triphosphate transporters
US20180148744A1 (en)	2015-03-20	2018-05-31	Verdezyne, Inc.	Biological methods for preparing 3-hydroxypropionic acid
CA3069321A1 (en)	2017-07-11	2019-01-17	Synthorx, Inc.	Incorporation of unnatural nucleotides and methods thereof
EP3652300A4 (en)	2017-07-13	2021-06-23	Radici Chimica S.p.A.	BIOLOGICAL PROCEDURES FOR MODIFYING CELLULAR CARBON FLOW
US20200181220A1 (en)	2017-08-03	2020-06-11	Synthorx, Inc.	Cytokine conjugates for the treatment of proliferative and infectious diseases
WO2020060948A1 (en)	2018-09-17	2020-03-26	Levadura Biotechnology, Inc.	Production of cannabinoids in yeast using a fatty acid feedstock
US20200246467A1 (en)	2019-02-06	2020-08-06	Synthorx, Inc.	Il-2 conjugates and methods of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0326046A3 (en) *	1988-01-25	1990-06-13	Takeda Chemical Industries, Ltd.	Production of human epidermal growth factor

1990
- 1990-11-30 JP JP2334575A patent/JPH04126084A/ja active Pending
1991
- 1991-05-08 CS CS911355A patent/CS135591A2/cs unknown
- 1991-05-09 IL IL98095A patent/IL98095A0/xx unknown
- 1991-05-09 NZ NZ238095A patent/NZ238095A/en unknown
- 1991-05-09 US US07/696,551 patent/US5232841A/en not_active Expired - Fee Related
- 1991-05-09 PT PT97623A patent/PT97623A/pt not_active Application Discontinuation
- 1991-05-10 WO PCT/JP1991/000626 patent/WO1991018101A1/ja not_active Ceased
- 1991-05-10 AU AU77626/91A patent/AU643793B2/en not_active Ceased
- 1991-05-10 CA CA002082637A patent/CA2082637A1/en not_active Abandoned
- 1991-05-10 EP EP91920978A patent/EP0531530A1/en not_active Withdrawn
- 1991-05-10 IE IE160791A patent/IE911607A1/en unknown

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *

Also Published As

Publication number	Publication date
NZ238095A (en)	1992-10-28
AU643793B2 (en)	1993-11-25
EP0531530A1 (en)	1993-03-17
WO1991018101A1 (en)	1991-11-28
IL98095A0 (en)	1992-06-21
JPH04126084A (ja)	1992-04-27
PT97623A (pt)	1992-02-28
AU7762691A (en)	1991-12-10
CA2082637A1 (en)	1991-11-12
CS135591A2 (en)	1991-12-17
IE911607A1 (en)	1991-11-20
US5232841A (en)	1993-08-03

Publication	Publication Date	Title
EP0531530A4 (ja)	1994-04-06
Vernet et al.	1990	Secretion of functional papain precursor from insect cells. Requirement for N-glycosylation of the pro-region.
AU6132294A (en)	1994-08-29	Fusion proteins including a cleavage site recognized by a plant virus protease
EP1502952A3 (en)	2005-05-11	Process for the production of protein products in Aspergillus oryzae and a promoter for use in Aspergillus
AU7449400A (en)	2001-04-30	Process for producing transglutaminase
EP1000160B1 (en)	2004-04-14	CLONING OF THE PROLYL-DIPEPTIDYL-PEPTIDASE FROM $i(ASPERGILLUS ORYZAE)
IE872455L (en)	1988-03-12	Improved recombinant expression
CA2346797A1 (en)	2000-05-04	Process for recovering heterologous polypeptides from bacterial cells
AU7149691A (en)	1991-08-21	Process for enzymatical cleavage of recombinant proteins by means of iga proteases
DK1117808T3 (da)	2005-04-25	Transformaationssystem inden jfjor området filamentöse svampeværter: I chrysosporium
HUP0001272A1 (hu)	2000-08-28	Peptidek expressziója közvetlenül a tápközegbe
CA2087261A1 (en)	1992-01-17	Purification directed cloning of peptides
Ohnishi et al.	1994	Involvement of the COOH-terminal pro-sequence of Serratia marcescens serine protease in the folding of the mature enzyme
ATE317398T1 (de)	2006-02-15	Modifiziertes e.coli enterotoxin ii signalpeptid sowie ein mikroorganismus der ein fusionsprotein sowie ein heterologes protein exprimiert
AU1003888A (en)	1988-09-01	Pancreatic secretory trypsin inhibitor and variants thereof produced by a recombinant host, process, expression vector and recombinant host therefore and pharmaceutical use thereof
WO2002040697A3 (en)	2003-03-13	Metabolic rate shifts in fermentations expressing recombinant proteins
NZ534259A (en)	2006-05-26	A protein with homology to cysteine-rich secretory protein (CRISP) inhibitor
Creemers et al.	1993	Proprotein processing activity and cleavage site selectivity of the Kex2‐like endoprotease PACE4
AU3634697A (en)	1998-02-10	Systems for the mass production of proteins or peptides by microorganisms of the genus (humicola)
AU2003237061A1 (en)	2004-01-19	Hansenula polymorpha yapsin deficient mutant strain and process for the preparation of recombinant proteins using the same
MX9708689A (es)	1998-02-28	Promotores de la expresion de genes.
AU7057098A (en)	1998-11-24	Improved prokaryotic expression of protein
HU9203434D0 (en)	1993-01-28	Biosythetic process for producing chemical products
KR930702528A (ko)	1993-09-09	스트렙토마이세스 리비단으로부터 분리하고 정제한 단백질 가수분해 효소 x를 암호화하는 dna 시퀸스
EP1546302A4 (en)	2006-08-16	PROCESS FOR PRODUCING MAMMALIAN TRYPSIN

Legal Events

Date	Code	Title	Description
1993-01-29	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1993-03-17	17P	Request for examination filed	Effective date: 19921030
1993-03-17	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE
1994-04-06	A4	Supplementary search report drawn up and despatched	Effective date: 19931209
1994-04-06	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE
1996-03-13	17Q	First examination report despatched	Effective date: 19960126
1996-04-12	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN
1996-05-29	18W	Application withdrawn	Withdrawal date: 19960327
2007-08-08	RIN1	Information on inventor provided before grant (corrected)	Inventor name: UDAKA, JUZO,1 Inventor name: HASHIMOTO, TAMOTSU Inventor name: TSUJIMURA, ATSUSHI