EP0522007A4 - A fonctionalized complexand - Google Patents

A fonctionalized complexand

Info

Publication number: EP0522007A4
Authority: EP; European Patent Office
Prior art keywords: fonctionalized; complexand; fonctionalized complexand
Prior art date: 1990-03-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP19910907128

Other versions

EP0522007A1 (en

Inventor

Martin W. Brechbiel

Otto A. Gansow

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

United States Department of Commerce

Original Assignee

United States Department of Commerce

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-26

Filing date

1991-03-14

Publication date

1993-06-16

1991-03-14 Application filed by United States Department of Commerce filed Critical United States Department of Commerce

1993-01-13 Publication of EP0522007A1 publication Critical patent/EP0522007A1/en

1993-06-16 Publication of EP0522007A4 publication Critical patent/EP0522007A4/en

Status Withdrawn legal-status Critical Current

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
- A61K49/16—Antibodies; Immunoglobulins; Fragments thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Radiology & Medical Imaging (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Physics & Mathematics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Organic Chemistry (AREA)
Food Science & Technology (AREA)
Cell Biology (AREA)
Microbiology (AREA)
Pharmacology & Pharmacy (AREA)
Optics & Photonics (AREA)
Biotechnology (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP19910907128 1990-03-26 1991-03-14 A fonctionalized complexand Withdrawn EP0522007A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US49832090A	1990-03-26	1990-03-26
US498320		1990-03-26

Publications (2)

Publication Number	Publication Date
EP0522007A1 EP0522007A1 (en)	1993-01-13
EP0522007A4 true EP0522007A4 (en)	1993-06-16

Family

ID=23980564

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP19910907128 Withdrawn EP0522007A4 (en)	1990-03-26	1991-03-14	A fonctionalized complexand

Country Status (4)

Country	Link
EP (1)	EP0522007A4 (en)
AU (1)	AU7587091A (en)
CA (1)	CA2079206A1 (en)
WO (1)	WO1991014458A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6120768A (en) *	1993-05-17	2000-09-19	Immunomedics, Inc.	Dota-biotin derivatives
US6565828B2 (en)	2000-04-07	2003-05-20	Bristol-Myers Squibb Company	Macrocyclic chelants for metallopharmaceuticals
US6517814B2 (en)	2001-01-09	2003-02-11	Bristol-Myers Squibb Pharma Company	Macrocyclic chelants useful for metallopharmaceuticals
IL157444A0 (en)	2001-02-23	2004-03-28	Bristol Myers Squibb Pharma Co	Labeled macrophase scavenger receptor antagonists and diagnostic and pharmaceutical compositions containing the same
CN113533273B (en) *	2021-06-26	2024-06-04	浙江工商大学	Marking method for improving time-resolved fluorescence signal intensity and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0038546A2 (en) *	1980-04-17	1981-10-28	The Massachusetts General Hospital	99m Tc labeled diagnostic compositions and method for making the same
EP0255471A1 (en) *	1986-07-28	1988-02-03	Schering Aktiengesellschaft	1,4,7,10-Tetraazacyclododecane-derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4472509A (en) *	1982-06-07	1984-09-18	Gansow Otto A	Metal chelate conjugated monoclonal antibodies
US4885363A (en) *	1987-04-24	1989-12-05	E. R. Squibb & Sons, Inc.	1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US4994560A (en) *	1987-06-24	1991-02-19	The Dow Chemical Company	Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies
GB8719041D0 (en) *	1987-08-12	1987-09-16	Parker D	Conjugate compounds

1991
- 1991-03-14 WO PCT/US1991/001637 patent/WO1991014458A1/en not_active Ceased
- 1991-03-14 EP EP19910907128 patent/EP0522007A4/en not_active Withdrawn
- 1991-03-14 AU AU75870/91A patent/AU7587091A/en not_active Withdrawn
- 1991-03-14 CA CA002079206A patent/CA2079206A1/en not_active Abandoned

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0038546A2 (en) *	1980-04-17	1981-10-28	The Massachusetts General Hospital	99m Tc labeled diagnostic compositions and method for making the same
EP0255471A1 (en) *	1986-07-28	1988-02-03	Schering Aktiengesellschaft	1,4,7,10-Tetraazacyclododecane-derivatives

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ACTA CHEM SCAND., VOL. 44, NO. 7, PAGE(S) 698-706, August 1990, FOSSHEIM R ET AL. 'MOLECULAR STRUCTURE AND DYNAMICS OF AMINOPOLYCARBOXYLATES AND THEIR LANTHANIDE ION COMPLEXES.' *
ANGEWANDTE CHEMIE. INTERNATIONAL EDITION vol. 15, no. 11, 1976, WEINHEIM DE page 686 H. STETTER & W. FRANK 'Complex Formation with Tetraazacycloalkane-N,N',N'',N'''-tet raacetic Acids as a Function of Ring Size' *
BIOCONJUG CHEM, VOL. 1, NO. 5, PAGE(S) 345-9, 1990, RUSER G ET AL. 'Synthesis and evaluation of two new bifunctional carboxymethylated tetraazamacrocyclic chelating agents for protein labeling with indium-111.' *
EIGHTH ANNUAL MEETING OF THE SOCIETY FOR MAGNETIC RESONANCE IMAGING, WASHINGTON, D.C., USA, FEBRUARY 24-28, 1990. MAGN RESON IMAGING, VOL. 8, SUPP. 1, 1990, page 47 RUNGE V M ET AL. 'CLINICAL EFFICACY OF GADOLINIUM HP-DO3A A NON-IONIC GADOLINIUM CRYPTELATE.' *
NUCL. MED. BIOL. INT. J. RADIAT. APPL. INSTRUM. PART. B., VOL. 16, NO. 6, PAGE(S) 561-567, 1989, RUNGE V M ET AL. 'Experimental trials with Gd(DO3A). A nonionic magnetic resonance contrast agent.' *
See also references of WO9114458A1 *

Also Published As

Publication number	Publication date
WO1991014458A1 (en)	1991-10-03
CA2079206A1 (en)	1991-09-27
EP0522007A1 (en)	1993-01-13
AU7587091A (en)	1991-10-21

Publication	Publication Date	Title
AU113313S (en)	1992-02-21	A cookpot
GB2245202B (en)	1994-03-23	A vice
GB2299156B (en)	1996-12-11	A dearmer
GB2241531B (en)	1994-02-16	A keep
AU114360S (en)	1992-06-18	A case
EP0472025A3 (en)	1993-08-11	A microprocessor
GB9007244D0 (en)	1990-05-30	A flicker-effect device
EP0522007A4 (en)	1993-06-16	A fonctionalized complexand
AU112161S (en)	1991-09-23	A section
GB2251667B (en)	1993-05-26	A framework
GB2243157B (en)	1994-05-18	A spread
GB9004519D0 (en)	1990-04-25	A boss
AU108807S (en)	1990-08-30	A playstructure
AU109221S (en)	1990-10-22	a gamesboard
AU108986S (en)	1990-09-17	A Gamesboard
AU111069S (en)	1991-05-22	A sweat-shirt
AU113578S (en)	1992-03-27	A section
AU111790S (en)	1991-08-09	A section
AU111499S (en)	1991-07-11	A section
AU111414S (en)	1991-07-02	A section
GB9026023D0 (en)	1991-01-16	A structure
AU110592S (en)	1991-03-21	A brief case
GB2256357B (en)	1995-02-08	A panti-hose
AU111462S (en)	1991-07-05	A block
AU111446S (en)	1991-07-05	A block

Legal Events

Date	Code	Title	Description
1992-11-27	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1993-01-13	17P	Request for examination filed	Effective date: 19921009
1993-01-13	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE
1993-05-12	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN
1993-06-16	A4	Supplementary search report drawn up and despatched	Effective date: 19930423
1993-06-16	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE
1993-06-30	18W	Application withdrawn	Withdrawal date: 19930507