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EP0591452A4 - Multiple emulsions and methods of preparation - Google Patents

Multiple emulsions and methods of preparation

Info

Publication number
EP0591452A4
EP0591452A4 EP19920915365 EP92915365A EP0591452A4 EP 0591452 A4 EP0591452 A4 EP 0591452A4 EP 19920915365 EP19920915365 EP 19920915365 EP 92915365 A EP92915365 A EP 92915365A EP 0591452 A4 EP0591452 A4 EP 0591452A4
Authority
EP
European Patent Office
Prior art keywords
preparation
methods
multiple emulsions
water
oil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP19920915365
Other versions
EP0591452B1 (en
EP0591452A1 (en
Inventor
Robert L Hunter
Carol Elizabeth Bennett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emory University
Original Assignee
Emory University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emory University filed Critical Emory University
Publication of EP0591452A1 publication Critical patent/EP0591452A1/en
Publication of EP0591452A4 publication Critical patent/EP0591452A4/en
Application granted granted Critical
Publication of EP0591452B1 publication Critical patent/EP0591452B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/064—Water-in-oil emulsions, e.g. Water-in-silicone emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/066—Multiple emulsions, e.g. water-in-oil-in-water
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/90—Block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Colloid Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

Abstract

The present invention relates to water-in-oil and water-in-oil multiple emulsions and methods of preparation for use in numerous applications including vaccine adjuvants, pharmaceuticals, cosmetics, foods, and various household and industrial applications.
EP92915365A 1991-06-27 1992-06-25 Multiple emulsions and methods of preparation Expired - Lifetime EP0591452B1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US72181091A 1991-06-27 1991-06-27
US86982292A 1992-04-15 1992-04-15
US869822 1992-04-15
US89739092A 1992-06-18 1992-06-18
US897390 1992-06-18
PCT/US1992/005419 WO1993000160A1 (en) 1991-06-27 1992-06-25 Multiple emulsions and methods of preparation
US721810 1996-09-27

Publications (3)

Publication Number Publication Date
EP0591452A1 EP0591452A1 (en) 1994-04-13
EP0591452A4 true EP0591452A4 (en) 1994-07-20
EP0591452B1 EP0591452B1 (en) 1998-05-06

Family

ID=27419028

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92915365A Expired - Lifetime EP0591452B1 (en) 1991-06-27 1992-06-25 Multiple emulsions and methods of preparation

Country Status (12)

Country Link
EP (1) EP0591452B1 (en)
JP (1) JPH06508555A (en)
CN (2) CN1042198C (en)
AT (1) ATE165749T1 (en)
AU (1) AU2316892A (en)
CA (1) CA2112356A1 (en)
DE (1) DE69225404T2 (en)
DK (1) DK0591452T3 (en)
ES (1) ES2116340T3 (en)
IE (2) IE922095A1 (en)
IL (2) IL102317A0 (en)
WO (1) WO1993000160A1 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0640348A1 (en) * 1993-07-26 1995-03-01 Akzo Nobel N.V. Oil-based and water-based adjuvant mixture
US5433953A (en) * 1994-01-10 1995-07-18 Minnesota Mining And Manufacturing Microcapsules and methods for making same
US5656280A (en) * 1994-12-06 1997-08-12 Helene Curtis, Inc. Water-in-oil-in-water compositions
US5589177A (en) * 1994-12-06 1996-12-31 Helene Curtis, Inc. Rinse-off water-in-oil-in-water compositions
GB9626865D0 (en) * 1996-12-24 1997-02-12 Cyanamid Websters Pty Limited Veterinary vaccines
SE9801288D0 (en) 1998-04-14 1998-04-14 Astra Ab Vaccine delivery system and method of production
AU5068999A (en) * 1998-07-31 2000-02-21 Korea Institute Of Science And Technology Lipid emulsion and solid lipid nanoparticle as a gene or drug carrier
KR100342835B1 (en) * 1998-07-31 2002-07-02 박호군 Lipid emulsion as a gene or drug carrier, formulation, and method for preparating thereof
FR2808703B1 (en) * 2000-05-09 2002-08-02 Centre Nat Rech Scient PROCESS FOR THE PREPARATION OF A DOUBLE MONODISPERSE EMULSION
US6995209B2 (en) * 2001-03-21 2006-02-07 Madash Llc Thermally reversible water in oil in water emulsions
JP2005515197A (en) * 2001-12-03 2005-05-26 ドー バイオファーマ インコーポレイテッド Stabilized reverse micelle composition and use thereof
US8802116B2 (en) 2003-02-27 2014-08-12 Novasel Australia Pty. Ltd. Poloxamer emulsion preparations
DE10351644A1 (en) * 2003-11-05 2005-06-09 Bayer Technology Services Gmbh Process for the preparation of storage-stable multiple emulsions
EP1598060A1 (en) 2004-05-18 2005-11-23 Nestec S.A. Oil-in-water emulsion for delivery
EP1850938B1 (en) 2005-02-25 2017-08-16 Cytec Technology Corp. Water-in-oil-in water emulsions of hydroxamated polymers and methods for using the same
US20070292521A1 (en) * 2006-06-20 2007-12-20 Schwitzer Co., Ltd Oral Encapsulated Preparation for Aquatic Animals
US20100190695A1 (en) 2007-09-10 2010-07-29 Ryo Akamatsu Liquid crystal emulsion type pharmaceutical composition containing cyclosporine, and therepeutic method of treating cutaneous disease therewith
US8741325B2 (en) * 2008-12-18 2014-06-03 The Hong Kong University Of Science And Technology Material for forming a multi-level antimicrobial surface coating and its preparation
US9352289B2 (en) * 2010-12-28 2016-05-31 Conopco, Inc. Method for production of an emulsion
FR3002454B1 (en) 2013-02-26 2015-04-10 Commissariat Energie Atomique IMMUNOGENIC COMPOSITION IN THE FORM OF EMULSION
US9968673B2 (en) 2013-02-26 2018-05-15 Commissariat á l'ènergie atomique et aux ènergies alternatives Immunogenic composition in emulsion form comprising two dispersed phases, one comprising an antigen and the other comprising an immunostimulating agent
CN103223164B (en) * 2013-04-15 2014-08-20 华南农业大学 Water-in-oil-in-water adjuvant vaccine and preparation method thereof
FR3043558B1 (en) * 2015-11-18 2017-12-29 Commissariat Energie Atomique IMMUNOGENIC EMULSION COMPOSITION COMPRISING TWO DISPERSED PHASES, ONE COMPRISING ANTIGEN AND THE OTHER COMPRISING AN IMMUNOSTIMULANT AGENT
EP3377114B1 (en) * 2015-11-18 2020-07-08 Commissariat à l'Énergie Atomique et aux Énergies Alternatives Immunogenic composition in the form of an emulsion comprising two dispersed phases, one comprising an antigen and the other comprising an immunostimulating agent
CN106821774A (en) * 2017-02-23 2017-06-13 韩后化妆品股份有限公司 Micro-capsule compound and the application of parcel essential oil and rice ferment filtrate
CN108578688B (en) * 2018-04-03 2022-02-11 武汉轻工大学 Preparation method of multiple nanoemulsion vaccine adjuvant
BR102020010237A2 (en) * 2020-05-22 2021-12-07 Ouro Fino Saúde Animal Ltda PLATFORM FOR FLAVOR MAKING

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4384974A (en) * 1979-07-27 1983-05-24 Revlon, Inc. Stable water-in-oil emulsions
US4446044A (en) * 1981-04-09 1984-05-01 E. I. Du Pont De Nemours And Company Aqueous water-in-oil cleaning emulsion
US4606918A (en) * 1983-08-22 1986-08-19 Syntex (U.S.A.) Inc. Polyoxypropylene-polyoxyethylene block polymer based adjuvants
JPS60199833A (en) * 1984-03-26 1985-10-09 Meiji Milk Prod Co Ltd Manufacturing method of W/O/W type composite emulsion for pharmaceuticals, cosmetics, etc.
US4808334A (en) * 1986-07-11 1989-02-28 Fuji Oil Company, Ltd. Production of sterile composite emulsion
GB8813161D0 (en) * 1988-06-03 1988-07-06 Unilever Plc Emulsions
US5061688A (en) * 1988-08-19 1991-10-29 Illinois Institute Of Technology Hemoglobin multiple emulsion

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *

Also Published As

Publication number Publication date
WO1993000160A1 (en) 1993-01-07
HK1010450A1 (en) 1999-06-17
CN1096224A (en) 1994-12-14
DE69225404D1 (en) 1998-06-10
EP0591452B1 (en) 1998-05-06
EP0591452A1 (en) 1994-04-13
IE67066B1 (en) 1996-02-21
CN1042198C (en) 1999-02-24
DK0591452T3 (en) 1999-01-25
JPH06508555A (en) 1994-09-29
IE922095A1 (en) 1992-12-30
AU2316892A (en) 1993-01-25
CN1073889A (en) 1993-07-07
ATE165749T1 (en) 1998-05-15
DE69225404T2 (en) 1998-12-17
IL102317A0 (en) 1993-01-14
CA2112356A1 (en) 1993-01-07
ES2116340T3 (en) 1998-07-16
IL107262A0 (en) 1994-01-25

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