EP0585399A4 - Treatment of colorectal carcinoma with antisense oligonucleotides to c-myb proto-oncogene - Google Patents

Treatment of colorectal carcinoma with antisense oligonucleotides to c-myb proto-oncogene

Info

Publication number: EP0585399A4
Authority: EP; European Patent Office
Prior art keywords: oncogene; treatment; antisense oligonucleotides; colorectal carcinoma; myb proto
Prior art date: 1991-05-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP92913962A

Other languages

English (en)

Other versions

EP0585399A1 (fr

Inventor

Bruno Calabretta

Alan M Gewirtz

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Temple Univ School of Medicine

Original Assignee

Temple Univ School of Medicine

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-23

Filing date

1992-05-22

Publication date

1995-11-15

1992-05-22 Application filed by Temple Univ School of Medicine filed Critical Temple Univ School of Medicine

1994-03-09 Publication of EP0585399A1 publication Critical patent/EP0585399A1/fr

1995-11-15 Publication of EP0585399A4 publication Critical patent/EP0585399A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/312—Phosphonates
- C12N2310/3125—Methylphosphonates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Biophysics (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Zoology (AREA)
Oncology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)

EP92913962A 1991-05-23 1992-05-22 Treatment of colorectal carcinoma with antisense oligonucleotides to c-myb proto-oncogene Withdrawn EP0585399A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US70486291A	1991-05-23	1991-05-23
US704862		1991-05-23

Publications (2)

Publication Number	Publication Date
EP0585399A1 EP0585399A1 (fr)	1994-03-09
EP0585399A4 true EP0585399A4 (en)	1995-11-15

Family

ID=24831149

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP92913962A Withdrawn EP0585399A4 (en)	1991-05-23	1992-05-22	Treatment of colorectal carcinoma with antisense oligonucleotides to c-myb proto-oncogene

Country Status (4)

Country	Link
EP (1)	EP0585399A4 (fr)
JP (1)	JPH06508130A (fr)
CA (1)	CA2109829A1 (fr)
WO (1)	WO1992020348A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5646042A (en) *	1992-08-26	1997-07-08	Ribozyme Pharmaceuticals, Inc.	C-myb targeted ribozymes
US5658780A (en) *	1992-12-07	1997-08-19	Ribozyme Pharmaceuticals, Inc.	Rel a targeted ribozymes
AU685074B2 (en) *	1992-12-14	1998-01-15	Start Technology Partnership	Administration of oligonucleotides antisense to dopamine receptor MRNA for diagnosis and treatment of neurological pathologies
DE4338704A1 (de)	1993-11-12	1995-05-18	Hoechst Ag	Stabilisierte Oligonucleotide und deren Verwendung
DE19502912A1 (de) *	1995-01-31	1996-08-01	Hoechst Ag	G-Cap Stabilisierte Oligonucleotide
US5994320A (en) *	1995-02-06	1999-11-30	Regents Of The University Of Minnesota	Antisense oligonucleotides and methods for treating central nervous system tumors
GB9504598D0 (en)	1995-03-03	1995-04-26	Imp Cancer Res Tech	Method of nucleic acid analysis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990005445A1 (fr) *	1988-11-07	1990-05-31	Temple University Of The Commonwealth System Of Higher Education	Oligonucleotides non codants du proto-oncogene c-myb et leurs emplois

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4740463A (en) *	1984-04-13	1988-04-26	Massachusetts Institute Of Technology	Methods and artificial genes for antagonizing the function of an oncogene

1992
- 1992-05-22 CA CA002109829A patent/CA2109829A1/fr not_active Abandoned
- 1992-05-22 WO PCT/US1992/004318 patent/WO1992020348A1/fr not_active Ceased
- 1992-05-22 JP JP5500313A patent/JPH06508130A/ja active Pending
- 1992-05-22 EP EP92913962A patent/EP0585399A4/en not_active Withdrawn

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990005445A1 (fr) *	1988-11-07	1990-05-31	Temple University Of The Commonwealth System Of Higher Education	Oligonucleotides non codants du proto-oncogene c-myb et leurs emplois
US5098890A (en) *	1988-11-07	1992-03-24	Temple University-Of The Commonwealth System Of Higher Education	Antisence oligonucleotides to c-myb proto-oncogene and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MELANI, C. ET AL.: "C-MYB EXPRESSION IN HUMAN COLON CARCINOMA CELL LINES AND EFFECT OF C- MYB ANTISENSE OLIGONUCLEOTIDE ON CELL PROLIFERATION.", PROC AM ASSOC CANCER RES ANNU MEET 32 (0), 428;, March 1991 (1991-03-01) *
MELANI, C. ET AL.: "INHIBITION OF PROLIFERATION BY C- MYB ANTISENSE OLIGODEOXYNUCLEOTIDES IN COLON ADENOCARCINOMA CELL LINES THAT EXPRESS C-MYB.", CANCER RES 51 (11), 2897-2901., 1 June 1991 (1991-06-01) *
See also references of WO9220348A1 *

Also Published As

Publication number	Publication date
CA2109829A1 (fr)	1992-11-26
WO1992020348A1 (fr)	1992-11-26
EP0585399A1 (fr)	1994-03-09
JPH06508130A (ja)	1994-09-14

Publication	Publication Date	Title
GB9307747D0 (en)	1993-06-09	Treating formations using alternate flowpaths
NZ287827A (en)	1999-02-25	Substituted purinyl derivatives, medicaments thereof and use to treat immune deficiencies or control cancer growth
IL108367A0 (en)	1994-04-12	Antisense polynzcleotide inhibition of human growth factor-sensitive cancer cells
EP0594677A4 (en)	1997-09-17	Antiviral liponucleosides: treatment of hepatitis b
EP0666923A4 (fr)	1995-01-20	Apport cible de polynucleotides ou d'oligonucleotides a des cellules.
GB9019946D0 (en)	1990-10-24	Treatment of nucleotide material
EP0172721A3 (en)	1988-11-30	Use of phlorizin or its derivatives in the treatment of cancer
GB9113971D0 (en)	1991-08-14	Treatment of water
EP0585399A4 (en)	1995-11-15	Treatment of colorectal carcinoma with antisense oligonucleotides to c-myb proto-oncogene
EP0489846A4 (en)	1992-06-24	Antisense oligonucleotides to c-abl proto-oncogene
EP0580795A4 (en)	1995-11-15	Antisense oligonucleotides to c-kit proto-oncogene and uses thereof
GB9106170D0 (en)	1991-05-08	New compounds for use in the treatment of cancer
EP0572563A4 (en)	1993-12-29	Treatment of esophageal cancer
GB9218711D0 (en)	1992-10-21	Skin cancer treatment
ZA925385B (en)	1993-03-31	Seed treatment
GB9026874D0 (en)	1991-01-30	Soil treatment
GB2253946B (en)	1995-02-15	Treatment of fluids
GB9012630D0 (en)	1990-07-25	Improvements in or relating to treatment of sewage
AU5136693A (en)	1994-04-26	Antisense oligonucleotides to b myb proto-oncogene
ZA899631B (en)	1991-08-28	Cancer treatment
GB9108799D0 (en)	1991-06-12	Disposable chamber pots
GB9117210D0 (en)	1991-09-25	Treatment of cancer
GB9112528D0 (en)	1991-07-31	Anti-corrosion treatment
GB9026737D0 (en)	1991-01-30	Cancer treatment
GB9008524D0 (en)	1990-06-13	Treatment of cancer

Legal Events

Date	Code	Title	Description
1994-01-21	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1994-03-09	17P	Request for examination filed	Effective date: 19931028
1994-03-09	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE
1995-11-15	A4	Supplementary search report drawn up and despatched	Effective date: 19950929
1995-11-15	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE
1996-08-16	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN
1996-10-02	18W	Application withdrawn	Withdrawal date: 19960802