EP0493533A4 - Inhibition of cell growth by keratan sulfate, chondroitin sulfate, dermatan sulfate and other glycans - Google Patents

Inhibition of cell growth by keratan sulfate, chondroitin sulfate, dermatan sulfate and other glycans

Info

Publication number: EP0493533A4
Authority: EP; European Patent Office
Prior art keywords: sulfate; glycans; inhibition; cell growth; keratan
Prior art date: 1989-10-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP19900917627

Other languages

English (en)

Other versions

EP0493533A1 (fr

Inventor

Diane M. Snow

Jerry Silver

Adrian Harel

Dikla Roufa

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Case Western Reserve University

Gliatech Inc

Original Assignee

Case Western Reserve University

Gliatech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-27

Filing date

1990-10-26

Publication date

1992-10-28

1990-10-26 Application filed by Case Western Reserve University, Gliatech Inc filed Critical Case Western Reserve University

1992-07-08 Publication of EP0493533A1 publication Critical patent/EP0493533A1/fr

1992-10-28 Publication of EP0493533A4 publication Critical patent/EP0493533A4/en

Status Withdrawn legal-status Critical Current

Links

SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 title 1
229920001287 Chondroitin sulfate Polymers 0.000 title 1
229920000045 Dermatan sulfate Polymers 0.000 title 1
229920000288 Keratan sulfate Polymers 0.000 title 1
229940059329 chondroitin sulfate Drugs 0.000 title 1
AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 title 1
229940051593 dermatan sulfate Drugs 0.000 title 1
KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 title 1
230000017095 negative regulation of cell growth Effects 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Wood Science & Technology (AREA)
Public Health (AREA)
Biochemistry (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Immunology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP19900917627 1989-10-27 1990-10-26 Inhibition of cell growth by keratan sulfate, chondroitin sulfate, dermatan sulfate and other glycans Withdrawn EP0493533A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US42837489A	1989-10-27	1989-10-27
US428374		1999-10-28

Publications (2)

Publication Number	Publication Date
EP0493533A1 EP0493533A1 (fr)	1992-07-08
EP0493533A4 true EP0493533A4 (en)	1992-10-28

Family

ID=23698624

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP19900917627 Withdrawn EP0493533A4 (en)	1989-10-27	1990-10-26	Inhibition of cell growth by keratan sulfate, chondroitin sulfate, dermatan sulfate and other glycans

Country Status (4)

Country	Link
EP (1)	EP0493533A4 (fr)
AU (1)	AU6872691A (fr)
CA (1)	CA2071898A1 (fr)
WO (1)	WO1991006303A1 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5605938A (en)	1991-05-31	1997-02-25	Gliatech, Inc.	Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
US7008783B1 (en)	1992-09-22	2006-03-07	Maruha Corporation	Gene encoding chondroitinase ABC and uses therefor
US6140071A (en) *	1994-01-27	2000-10-31	Somatogen, Inc.	Proteins with mutations to decrease N-terminal methylation
HUT77134A (hu) *	1994-12-01	1998-03-02	Seikagaku Corporation	Keratán-szulfát-oligoszacharid frakciók és ilyet tartalmazó gyógyszerkészítmények és eljárás a fenti oligoszaharidok előállítására
EP0747470A1 (fr)	1995-06-08	1996-12-11	The Procter & Gamble Company	Compositions de nettoyage contenant du kératanase
EP0747469A1 (fr) *	1995-06-08	1996-12-11	The Procter & Gamble Company	Compositions de nettoyage contenant du chondroitinase
FR2787329B1 (fr) *	1998-12-17	2001-02-09	Aventis Pharma Sa	Nouvelle application therapeutique des heparines de bas poids moleculaire
AU6557299A (en)	1999-01-07	2000-07-13	Seikagaku Corporation	Method for producing oligosaccharide, and novel oligosaccharide and pharaceutical composition containing the same
US6083933A (en) *	1999-04-19	2000-07-04	Stellar International Inc.	Treatment of cystitis-like symptoms with chondroitin sulfate following administration of a challenge solution
EP1074260B1 (fr)	1999-07-21	2004-02-18	Seikagaku Corporation	Inhibiteur de la production de Il-12
WO2002060471A2 (fr) *	2001-01-30	2002-08-08	Ich Productions Limited	Ligands des proteines tyrosine phosphatases de type recepteur
IL160188A0 (en)	2001-08-13	2004-07-25	Univ Florida	Materials and methods to promote repair of nerve tissue
GB0205022D0 (en) *	2002-03-04	2002-04-17	Univ Cambridge Tech	Materials and methods for the treatment of cns damage
DE60336341D1 (de)	2002-05-04	2011-04-21	Acorda Therapeutics Inc	Zusammensetzungen und verfahren zur förderung des neuronalen wachstums
US20040161476A1 (en)	2003-02-19	2004-08-19	Hahn Sungtack Samuel	Cystitis treatment with high dose chondroitin sulfate
US7511026B2 (en)	2003-03-25	2009-03-31	Seikagaku Corporation	Therapeutic agent for nerve damage
MX348062B (es)	2003-05-16	2017-05-26	Acorda Therapeutics Inc	Mutantes que degradan proteoglicanos para tratamiento del snc.
US7959914B2 (en)	2003-05-16	2011-06-14	Acorda Therapeutics, Inc.	Methods of reducing extravasation of inflammatory cells
WO2005112986A2 (fr)	2004-05-18	2005-12-01	Acorda Therapeutics, Inc.	Procedes de purification de la chondroitinase et formulations stables de cette derniere
WO2006111348A1 (fr) *	2005-04-18	2006-10-26	Abbott Gmbh & Co. Kg	Utilisation d'heparine ou de derives de l'heparine pour la modulation du recepteur nogo controlant la croissance des neurites
AU2006294755B2 (en)	2005-09-26	2012-04-19	Acorda Therapeutics, Inc.	Compositions and methods of using chondroitinase ABCI mutants
CA3009034C (fr)	2006-10-10	2020-08-18	Acorda Therapeutics, Inc.	Compositions et procedes d'utilisation de mutants des chondroitinases abci
WO2009005033A1 (fr)	2007-06-29	2009-01-08	National University Corporation Nagoya University	Agent d'améliorer d'un dysfonctionnement dû à une neuropathie et inhibiteur de l'activation de la rho kinase
WO2010003023A2 (fr) *	2008-07-01	2010-01-07	Zacharon Pharmaceuticals, Inc.	Inhibiteurs d'héparane sulfate
WO2011082175A2 (fr) *	2009-12-31	2011-07-07	Zacharon Pharmaceuticals, Inc.	Inhibiteurs de glycosaminoglycane
AU2016369595B2 (en) *	2015-12-18	2022-11-24	Tega Therapeutics, Inc.	Cellular glycosaminoglycan compositions and methods of making and using

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3441835A1 (de) *	1984-11-15	1986-05-22	Luitpold-Werk Chemisch-pharmazeutische Fabrik GmbH & Co, 8000 München	Blutstillungsmittel
EP0257003A2 (fr) *	1986-07-09	1988-02-24	Kabi Pharmacia AB	Composition d'enzyme capable de dégrader le glycosaminoglycane, et méthode de production de cette composition
WO1988001280A1 (fr) *	1986-08-21	1988-02-25	Board Of Regents, The University Of Texas System	Derives de glycosaminoglycane et leur utilisation comme inhibiteurs de l'invasion tumorale ou proliferation metastatique
WO1990006755A1 (fr) *	1988-12-15	1990-06-28	Glycomed Incorporated	Fragments d'heparine utilises comme inhibiteurs de la proliferation de cellules musculaires lisses

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5299207A (en) *	1976-02-16	1977-08-19	Kaken Pharmaceut Co Ltd	Remedy for cattle diarrhea
US4640912A (en) *	1983-06-09	1987-02-03	Hausman Marvin S	Administration of "active" chondroitin sulfate A and "active" chondroitin sulfate C or mixtures thereof to mammals including humans
SE8304836D0 (sv) *	1983-09-09	1983-09-09	Pharmacia Ab	Sett att bestemma forendringar i ledbrosk
US4745098A (en) *	1984-02-24	1988-05-17	The Regents Of The University Of California	Compositions and method for improving wound healing
US4808570A (en) *	1984-02-24	1989-02-28	University Of California	Compositions and method for improving wound healing
US4710493A (en) *	1984-08-14	1987-12-01	Albert Landsberger	Therapeutic agent for the use in cancer treatment
IT1208509B (it) *	1985-03-13	1989-07-10	Mediolanum Farmaceutici Srl	Processo per la produzione di eparan solfato e dermatan solfato naturali sostanzialmente puri eloro impiego farmaceutico.
SE8501723L (sv) *	1985-04-09	1986-10-10	Pharmacia Ab	Preparation att anvendas vid behandling av ledinflammation
US4829000A (en) *	1985-08-30	1989-05-09	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Reconstituted basement membrane complex with biological activity
US4696816A (en) *	1985-11-07	1987-09-29	Brown Mark D	Method for treating intervertebral disc displacement with enzymes
US4956348A (en) *	1986-02-19	1990-09-11	Eye Research Institute Of Retina Foundation	Stimulation of tear secretion with cyclic nucleotides
US4760131A (en) *	1986-04-23	1988-07-26	Collagen Corporation	Wound-healing composition
US4945086A (en) *	1988-05-03	1990-07-31	The Board Of Trustees Of The Leland Stanford Junior University	Smooth muscle cell growth inhibitor

1990
- 1990-10-26 EP EP19900917627 patent/EP0493533A4/en not_active Withdrawn
- 1990-10-26 WO PCT/US1990/006189 patent/WO1991006303A1/fr not_active Ceased
- 1990-10-26 CA CA002071898A patent/CA2071898A1/fr not_active Abandoned
- 1990-10-26 AU AU68726/91A patent/AU6872691A/en not_active Abandoned

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3441835A1 (de) *	1984-11-15	1986-05-22	Luitpold-Werk Chemisch-pharmazeutische Fabrik GmbH & Co, 8000 München	Blutstillungsmittel
EP0257003A2 (fr) *	1986-07-09	1988-02-24	Kabi Pharmacia AB	Composition d'enzyme capable de dégrader le glycosaminoglycane, et méthode de production de cette composition
WO1988001280A1 (fr) *	1986-08-21	1988-02-25	Board Of Regents, The University Of Texas System	Derives de glycosaminoglycane et leur utilisation comme inhibiteurs de l'invasion tumorale ou proliferation metastatique
WO1990006755A1 (fr) *	1988-12-15	1990-06-28	Glycomed Incorporated	Fragments d'heparine utilises comme inhibiteurs de la proliferation de cellules musculaires lisses

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
DEVELOPMENT BIOLOGY, vol. 138, no. 2, April 1990, pages 359-376; D.M. SNOW et al.: "Molecular and cellular characterization on the glial roof plate of the spinal cord and optic tectum: A possible role for a proteoglycan in the development of an axon barrier" *
EXPERIMENTAL CELL RESEARCH, vol. 175, no. 2, April 1988, pages 229-247; G. MUGNAI et al.: "Ganglioside-dependent adhesion events of human neuroblastoma cells regulated by the RGDS-dependent fibronectin receptor anf proteoglycans" *
EXPERIMENTAL NEUROLOGY, vol. 109, no. 1, July 1990, pages 111-130; D.M. SNOW et al.: "Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro" *
FEDERATION PROCEEDINGS, vol. 44, no. 2, February 1985, pages 386-393; B. CATERSON et al.: "Production and characterization of monoclonal antibodies directed against connective tissue proteoglycans" *
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, vol. 7, no. 2, 1989, pages 133-143; G.M. GILAD et al.: "Effects of glycosaminoglycans and proteinase inhibitors on astroglia-induced detachment of cultured rat cerebellar neurons" *
JOURNAL OF CELLULAR PHYSIOLOGY, vol. 135, no. 2, May 1988, pages 293-300; D.H. DAMON et al.: "Sulfated glycosaminoglycans modify growth factor-induced neurite outgrowth in PC12 cells" *
JOURNAL OF NEUROSCIENCE RESEARCH, vol. 19, no. 4, April 1988, pages 428-439; N.G. CARRI et al.: "Differential outgrowth of retinal neurites on purified extracellular matrix molecules" *
See also references of WO9106303A1 *
THE JOURNAL OF CELL BILLOGY, vol. 105, no. 6, part 1, December 1987, pages 2511-2521; PERRIS et al.: "Amphibian neural crest cell migration on purified extracellular matrix components: A chondroitin sulfate proteoglycan inhibits locomotion on fibronectin substrates" *
THE JOURNAL OF CELL BIOLOGY, vol. 101, 1985, pages 53-59; M. ZANETTI et al.: "Two subpopulations of differentiated chondrocytes identified with a monoclonal antibody to keretan sulfate" *
THE JOURNAL OF CELL BIOLOGY, vol. 105, no. 6, part 1, December 1987, pages 2511-2521; PERRIS et al.: "Amphibian neural crest cell migration on purified extracellular matrix components: A chondroitin sulfate proteoglycan inhibits locomotion on fibronectin substrates" *
THE JOURNAL OF NEUROSCIENCE, vol. 3, no. 11, November 1983, pages 2324-2335; S. CARBONETTO et al.: "Nerve fiber growth in culture on fibronectin, collagen, and glycosaminoglycan substrates" *

Also Published As

Publication number	Publication date
AU6872691A (en)	1991-05-31
EP0493533A1 (fr)	1992-07-08
CA2071898A1 (fr)	1991-04-28
WO1991006303A1 (fr)	1991-05-16

Publication	Publication Date	Title
EP0493533A4 (en)	1992-10-28	Inhibition of cell growth by keratan sulfate, chondroitin sulfate, dermatan sulfate and other glycans
AU6387590A (en)	1991-04-18	Door hinge
AU582138B2 (en)	1989-03-16	Refrigerator door hinge
AU6107790A (en)	1992-02-13	Casement hinge
AU2561792A (en)	1993-04-05	Cell-type specific heparan sulfate proteoglycans and their uses
GB2239284B (en)	1993-12-01	Single sliding sash
GB2244298B (en)	1994-01-26	Structural assemblies and cavity closers
GB2229766B (en)	1993-05-19	Door hinge system
GB2260452B (en)	1993-07-21	Access closure allowing passage of elongate members
AU5915790A (en)	1992-01-23	Synthetic chondroitin sulfate proteoglycan and process for producing the same
GB9022010D0 (en)	1990-11-21	Access closure allowing passage of elongate members
GB8806244D0 (en)	1988-04-13	Cupboard door manufacture
GB2231616B (en)	1993-09-22	Casement fastener
GB2238827B (en)	1994-03-30	Hinge
GB8815032D0 (en)	1988-08-03	Doors & methods of ensuring their security
GB2248877B (en)	1994-09-07	Door closer and method of making the door closer
GB8912016D0 (en)	1989-07-12	Hinge
GB2216592B (en)	1992-05-06	Casement fastener
GB2228283B (en)	1992-11-25	Doors
GB9005160D0 (en)	1990-05-02	Hinge
AP9000210A0 (en)	1990-10-31	Solid thiocarbonates and methods of
CS446088A1 (en)	1989-04-14	Adjustable door hinge
CA62235S (en)	1989-01-03	Doorstop
GB2174751B (en)	1988-04-07	Hinges for doors and the like
HUT57361A (en)	1991-11-28	Door and window structure particularly workshop- or garage-door

Legal Events

Date	Code	Title	Description
1992-05-22	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1992-07-08	17P	Request for examination filed	Effective date: 19920422
1992-07-08	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE
1992-10-28	A4	Supplementary search report drawn up and despatched	Effective date: 19920908
1992-10-28	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE
1994-02-02	17Q	First examination report despatched	Effective date: 19931220
1995-08-09	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
1995-09-27	18D	Application deemed to be withdrawn	Effective date: 19950411