[go: up one dir, main page]

EP0461202A1 - Composition contenant une enzyme pour le nettoyage de verres de contact et methode pour un tel nettoyage - Google Patents

Composition contenant une enzyme pour le nettoyage de verres de contact et methode pour un tel nettoyage

Info

Publication number
EP0461202A1
EP0461202A1 EP19900906421 EP90906421A EP0461202A1 EP 0461202 A1 EP0461202 A1 EP 0461202A1 EP 19900906421 EP19900906421 EP 19900906421 EP 90906421 A EP90906421 A EP 90906421A EP 0461202 A1 EP0461202 A1 EP 0461202A1
Authority
EP
European Patent Office
Prior art keywords
polymer
terpolymer
membrane
composition according
hydrogen peroxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19900906421
Other languages
German (de)
English (en)
Inventor
Lennart Frigren
Christiane Persson
Annika Brantvik
Claes Franzen
Staffan Waxegard
Lennart Wenngren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Health AB
Original Assignee
DIB Ltd
Pharmacia AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DIB Ltd, Pharmacia AB filed Critical DIB Ltd
Publication of EP0461202A1 publication Critical patent/EP0461202A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/12—Non-macromolecular oxygen-containing compounds, e.g. hydrogen peroxide or ozone
    • A61L12/124—Hydrogen peroxide; Peroxy compounds
    • A61L12/126—Hydrogen peroxide; Peroxy compounds neutralised with catalase or peroxidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres

Definitions

  • Disinfection of contact lenses is mainly carried out by treat ⁇ ing the lenses once a day (or up to once a week) with an aqueous hydrogen peroxide (3 %) solution.
  • the killing effect depends on the concentration of the hydrogen peroxide solu- tion and the time during which the lenses are in contact with the solution. Minimum 1,5 % during minimum 20 minutes is regarded to give a sufficiently killing effect.
  • the removal of the hydrogen peroxide can be carried out in different ways.
  • The-most common way is the use of platinum as a catalyst for the decomposition of hydrogen peroxide and the use of the enzyme catalase for the same purpose.
  • the method based on platinum is carried out in such a way that a plate of platinum is mounted on the bottom of the di ⁇ sinfection vessel.
  • a plate of platinum is mounted on the bottom of the di ⁇ sinfection vessel.
  • the solution of hydrogen peroxide is added the decomposition process starts immediately.
  • Each plate of platinum is intended for three months daily use.
  • a new plate gives a rapid decomposition process, which can je- opardize the killing effect, whereas a plate, which has been used for some time, gives a remarkably reduced decomposition effect with big risk for remaining high concentrations of hydrogen peroxide after the recommended treating time, 6 h. Accordingly the risk of damages on the eye is big.
  • the advantage of the method with the decomposition with pla ⁇ tinum is that it is regarded as easy to use by the user be ⁇ cause disinfection and decomposition is started at the same time and the user needs not do anything with the lenses un- til after 6 h when the process is ready.
  • catalase for the decomposi ⁇ tion of hydrogen peroxide is carried out in such a way that catalase is added either as a solution or in the form of a tablet approximately, 20-30 minutes after the lenses have been placed in 3 % hydrogen .peroxide.
  • the decomposition then starts immediately and goes very rapidly and completely.
  • the disadvantage of the method is that the users consider the method more complicated to use than the method with platinum due to the fact that it requires two operations by the user at two different occasions.
  • An ideal tablet preparation of a hydrogen peroxide inactiva- tor shall thus be able to give a slow decomposition at the beginning and a rapid decomposition after the disinfection is completed.
  • This invention is intended to fulfil the following requirements:
  • a disinfection-process for contact lenses, which when initiated by the user does not require any further acti ⁇ on until the process is complete and the lenses are rea ⁇ dy for use.
  • a predetermined concentration of hydrogen peroxide shall be maintained during a specific period of time in order to secure a complete disinfection.
  • the decomposition rate shall be increased in order to secure that no hydrogen peroxide remains after the desired period of time (during the night).
  • the invention comprises that tablet cores containing a cata ⁇ lytic substance such as catalase, is coated with a membrane, which consists of a water insoluble polymer which contains water soluble particles of a defined size and amount. The particles will be dissolved by the hydrogen peroxide solu ⁇ tion and a macroporous membrane is formed. Hydrogen peroxide penetrates through this membrane and a reaction starts bet- ween the hydrogen peroxide and catalase, whereby hydrogen pe ⁇ roxide decomposes for oxygen and water.
  • a cata ⁇ lytic substance such as catalase
  • the decomposition of the hydrogen peroxide is initially slow, but concurrently with the formation of more oxygen the membrane is expanded by the gas pressure and the penetration capacity of the mem ⁇ brane is increased, whereby catalase is released to the sur ⁇ rounding hydrogen peroxide solution and the reaction rate and the decomposition will increase.
  • the polymer forming Jhe membrane should have good funifor ⁇ ming and adhesive properties and should be easily soluble in organic solvents, such as acetone and methylene chloride.
  • Suitable polymers are derivatives of cellulose, acrylpoly- mers and vinylpolymers.
  • the coating polymer is a polymer, which contains 80-95 per cent by weight of vinyl chloride, 1-19 per cent by weight vinylacetate and 0-10 per cent vinylalcohol.
  • the coating should also preferably include a plastisizer.
  • the amount of the p astisizer may vary between 30 and 150 per cent by weight of the polymer coating.
  • suitable plastisizers are acetyltributylcitrate, polyethylene glycol , blown castor oil and glyceryltriacetate.
  • the coating can al ⁇ so include sodium bicarbonate as a stabilizing agent.
  • the poreforming substance which is used according to tfie in ⁇ vention should be very water soluble, insoluble in the sol ⁇ vent, which is used for the coating, and toxicologically acceptable in the amounts used.
  • perfered are sugars, such as sucrose and lactose and salts, such as sodium chloride.
  • the particle size of the poreforming substance may vary bet ⁇ ween 0,1 and 100, preferably between 0,5 and 50 urn.
  • the ra- tio between the amount of porecreating substance and coating polymer depends on the desired property. Usually this ratio should exceed 5 and preferably be between 10 and 30.
  • the co ⁇ ating comprises a terpolymer of
  • the amount of plasticizer exceeds 30 per cent by weight of the terpolymer.
  • the amount of plasticizer varies between 50 and 150 per cent by weight of the terpolymer.
  • the ratio porecreating agent to terpolymer should preferably exceed 5. Most preferably this ratio should vary between 10 and 30.
  • the coating thickness depends also on the desired property. It can vary between 5 and 300 ⁇ , preferably between 10 and 200 ⁇ m.
  • the coating procedure according to the invention can prefer ⁇ ably be carried out in the folowing manner:
  • a terpolymer containing (w/w%) 80-95 '/. VC (vinyl- chloride), 1-19 % VAC (vinylacetate), and 1-10 % V0H (vlnylalcohol) is dissolved in a solvent, e.g. acetone, methylenechloride, methylethylketone, or mixtures aceto ⁇ ne and ethanol , acetone and methylenechloride, or the like.
  • a solvent e.g. acetone, methylenechloride, methylethylketone, or mixtures aceto ⁇ ne and ethanol , acetone and methylenechloride, or the like.
  • a suspension of the pore-creating substance is produced as fol ows:
  • the pore-creating particles are ground either by dry milling in a ball mill or by wet-milling in a glass bead milling device to a defined particle size, preferably between 0,5 urn and 50 ⁇ m.
  • the particles are dispersed in solvents or mixtures of solvents, such as those previ ⁇ ously mentioned, and mixed with the terpolymer solution.
  • the ratio between pore-creating substance and terpolymer in the coating fluid is as previously described for the ratio in the coating.
  • the coating fluid may, as previ ⁇ ously stated, include a plasticizer and sodium bicarbonate.
  • the coating fluid in the form of a suspension, is then applied on cores by conventional coating procedure.
  • coating procedures are pan coating, manual or spray-coating, W ⁇ rster coating, and other fluid-bed coating procedures.
  • Coloring matter can also be incorporated in the coating fluid, and insoluble co ⁇ loring materials are preferred.
  • Example 1 The following examples further illustrate the invention but should not be construed as limiting the invention.
  • Example 1 The following examples further illustrate the invention but should not be construed as limiting the invention.
  • Tablets including catalase (commercially available from Allergan) in a sufficient amount for decomposition of 10 ml hydrogen peroxide (3 %) were coated according to the proce ⁇ dure described above with a membrane consisting of 1 mg ter ⁇ polymer of vinylchloride, vinylacetate and vinylalcohol as a water insoluble membrane, 0,2 mg acetyltributylcitrate, 0,1 mg blown castor oil, 5,6 mg saccharose and 0,2 mg sodium bicarbonate. Acetone' as used as a solvent for the coating.
  • the catalase containing tablets from Allergan were coated by a coating fluid having the following composition:

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Eyeglasses (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Oxygen, Ozone, And Oxides In General (AREA)
  • Catalysts (AREA)

Abstract

L'invention concerne une composition comprenant un noyau doté d'une matière catalytique pour la décomposition du peroxyde d'hydrogène en oxygène et eau. Ladite composition est caractérisée par le fait que le noyau est entouré d'une membrane, qui peut s'étendre en milieu aqueux et qui comprend un polymère insoluble dans l'eau et une matière porogène soluble dans l'eau, distribuée de manière aléatoire dans le polymère, permettant l'augmentation de la perméabilité de la membrane vis à vis de la matière catalytique au fur et à mesure que la membrane s'étend dans le milieu aqueux.
EP19900906421 1989-04-10 1990-04-05 Composition contenant une enzyme pour le nettoyage de verres de contact et methode pour un tel nettoyage Withdrawn EP0461202A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8901279 1989-04-10
SE8901279A SE8901279D0 (sv) 1989-04-10 1989-04-10 Komposition

Publications (1)

Publication Number Publication Date
EP0461202A1 true EP0461202A1 (fr) 1991-12-18

Family

ID=20375626

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19900906421 Withdrawn EP0461202A1 (fr) 1989-04-10 1990-04-05 Composition contenant une enzyme pour le nettoyage de verres de contact et methode pour un tel nettoyage

Country Status (5)

Country Link
EP (1) EP0461202A1 (fr)
JP (1) JPH04506159A (fr)
AU (1) AU5528490A (fr)
SE (1) SE8901279D0 (fr)
WO (1) WO1990011786A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2026714A1 (fr) * 1989-11-03 1991-05-04 Peter Gyulai Composes detruisant le peroxyde d'hydrogene et methode d'utilisation
JPH05504496A (ja) * 1990-02-27 1993-07-15 アラーガン、インコーポレイテッド 過酸化水素分解組成物およびその使用方法
DK0517758T3 (da) * 1990-02-27 1999-08-09 Allergan Inc Hydrogenperoxid-destruerende sammensætninger og fremgangsmåder til fremstilling og anvendelse af samme
US5145644A (en) 1990-12-20 1992-09-08 Allergan, Inc. Hydrogen peroxide destroying compositions and methods of making and using same
ES2041561B1 (es) * 1991-05-07 1994-06-01 Dirygesa Sl Procedimiento para desinfectar y limpiar lentes de contacto.
JPH08507700A (ja) * 1992-12-28 1996-08-20 ボシュ アンド ロム インコーポレイテッド 水性媒体内に活性物質を制御放出する組成物
JP3381172B2 (ja) 1993-01-26 2003-02-24 アラーガン、インコーポレイテッド コンタクトレンズ消毒用組成物および方法
US5362647A (en) * 1993-02-12 1994-11-08 Allergan, Inc. Compositions and methods for destroying hydrogen peroxide
JP2002508530A (ja) 1997-12-12 2002-03-19 シュノプティク アクティーゼルスカブ 物質の定時解放のための容器

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8332489D0 (en) * 1983-12-06 1984-01-11 Contactasol Ltd Contact lenses
DE3666914D1 (en) * 1985-07-10 1989-12-21 Ciba Geigy Ag Cleaning set for contact lenses
DE3524659C2 (de) * 1985-07-10 1999-02-18 Novartis Ag Kontaktlinsenpflegesatz
EP0265253A3 (fr) * 1986-10-24 1990-01-10 Kingston Technologies, Inc. Enzyme dispersé stabilisé
DE3721574A1 (de) * 1987-06-30 1989-01-12 Kettelhack Riker Pharma Gmbh Arzneimittel in form von pellets mit enzymatisch kontrollierter arzneistoff-freisetzung

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9011786A1 *

Also Published As

Publication number Publication date
AU5528490A (en) 1990-11-05
SE8901279D0 (sv) 1989-04-10
WO1990011786A1 (fr) 1990-10-18
JPH04506159A (ja) 1992-10-29

Similar Documents

Publication Publication Date Title
US4585482A (en) Long-acting biocidal compositions and method therefor
EP0461202A1 (fr) Composition contenant une enzyme pour le nettoyage de verres de contact et methode pour un tel nettoyage
NO169996C (no) Fremgangsmaate ved fremstilling av et farmasoeytisk preparat med kontrollert utskillelse av virkestoff
JPH02111715A (ja) 合成メラニン凝集体
HK80892A (en) Cleaning set for contact lenses
Schultz et al. A new multiparticulate delayed release system.: Part II: Coating formulation and properties of free films
JPS57158209A (en) Production of bead-form highly water-absorbing polymer
DE2305320A1 (de) Durch einschluss in ein wasserloesliches, hydrophiles polymer stabilisierte enzymkoerper
AU8199787A (en) Spheroids
JPS6470409A (en) Skin treatment composition
EP0677322B1 (fr) Méthode pour préparer des émulsions aqueuses pour revêtir des préparations pharmaceutiques solides
CH633975A5 (de) Verfahren zur inkorporierung von wirkstoffen in siliciumdioxidhaltige traegermaterialien.
EP0527946B1 (fr) Vehicule a liberation regulee
Boros et al. Oxygen free radical-induced histamine release during intestinal ischemia and reperfusion
JPS6418440A (en) Micro-capsule
US5556480A (en) Procedure for disinfecting and cleaning contact lenses
ATE173639T1 (de) Wasserstoffperoxid zersetzende zusammensetzungen und verfahren zur herstellung und verwendung derselben
JP3222136B2 (ja) 微生物中における液体の封入
NZ237394A (en) Pharmaceutical germicidal composition comprising an aqueous solution of iodine, at least one organic substance which reacts with iodine and a source of iodate ions
Braverman et al. The influence of dietary sodium chloride on in vitro renin release from rat kidney slices
Dakin et al. A handbook of antiseptics
FI84521C (fi) Skoetseltillbehoer foer kontaktglas.
GB1377618A (en) Composition and device for impelementing the delivery storage and use of microorganisms
JP2567427B2 (ja) 浸透分配経口投与製剤
JPH08507700A (ja) 水性媒体内に活性物質を制御放出する組成物

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19911007

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: KABI PHARMACIA AB

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: DIB LIMITED

17Q First examination report despatched

Effective date: 19931109

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19940322