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EP0460064A4 - Therapeutic aerosol formulations - Google Patents

Therapeutic aerosol formulations

Info

Publication number
EP0460064A4
EP0460064A4 EP19900904101 EP90904101A EP0460064A4 EP 0460064 A4 EP0460064 A4 EP 0460064A4 EP 19900904101 EP19900904101 EP 19900904101 EP 90904101 A EP90904101 A EP 90904101A EP 0460064 A4 EP0460064 A4 EP 0460064A4
Authority
EP
European Patent Office
Prior art keywords
aerosol formulations
therapeutic aerosol
therapeutic
formulations
aerosol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19900904101
Other versions
EP0460064A1 (en
Inventor
George Robert 1485 Ashford Avenue Felt
Mark Peter Warchol
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rorer International Holdings Inc
Original Assignee
Rorer International Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rorer International Holdings Inc filed Critical Rorer International Holdings Inc
Publication of EP0460064A1 publication Critical patent/EP0460064A1/en
Publication of EP0460064A4 publication Critical patent/EP0460064A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP19900904101 1989-02-23 1990-02-21 Therapeutic aerosol formulations Withdrawn EP0460064A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31460589A 1989-02-23 1989-02-23
US314605 1994-09-28

Publications (2)

Publication Number Publication Date
EP0460064A1 EP0460064A1 (en) 1991-12-11
EP0460064A4 true EP0460064A4 (en) 1992-04-01

Family

ID=23220626

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19900904101 Withdrawn EP0460064A4 (en) 1989-02-23 1990-02-21 Therapeutic aerosol formulations

Country Status (6)

Country Link
EP (1) EP0460064A4 (en)
JP (1) JPH05508616A (en)
AU (1) AU5194990A (en)
CA (1) CA2050905A1 (en)
FI (1) FI913899A0 (en)
WO (1) WO1990009781A1 (en)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2097932A1 (en) * 1991-10-11 1993-04-12 Shojiro Yamazaki Antibody containing composition
CA2127877A1 (en) * 1992-01-21 1993-07-22 Robert M. Platz Improved process for preparing micronized polypeptide drugs
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US5698672A (en) * 1995-04-04 1997-12-16 Zymogenetics, Inc. Synthetic calcitonin mimetics
GB9612297D0 (en) * 1996-06-11 1996-08-14 Minnesota Mining & Mfg Medicinal aerosol formulations
DE19733651A1 (en) * 1997-08-04 1999-02-18 Boehringer Ingelheim Pharma Aqueous aerosol preparations containing biologically active marrow molecules and processes for producing corresponding aerosols
GB9807232D0 (en) * 1998-04-03 1998-06-03 Univ Cardiff Aerosol composition
US6458338B1 (en) 1998-09-22 2002-10-01 Aeropharm Technology Incorporated Amino acid stabilized medicinal aerosol formulations
US6136294C1 (en) * 1998-09-22 2002-09-24 Aeropharm Technology Inc Amino acid stabilized medical aerosol formulation
US6540983B1 (en) 2000-01-25 2003-04-01 Aeropharm Technology Incorporated Medical aerosol formulation
US6540982B1 (en) 2000-01-25 2003-04-01 Aeropharm Technology Incorporated Medical aerosol formulation
US6585957B1 (en) 2000-01-25 2003-07-01 Aeropharm Technology Incorporated Medicinal aerosol formulation
US6464959B1 (en) 2000-05-01 2002-10-15 Aeropharm Technology Incorporated Non-aqueous aerosol suspension comprising troglitazone, a fluid propellant, and an amino acid stabilizer
US6565833B1 (en) 2000-05-01 2003-05-20 Aeropharm Technology Incorporated Medicinal aerosol formulation
US6548049B1 (en) 2000-05-01 2003-04-15 Aeropharm Technology Incorporated Medicinal aerosol formulation
US6468507B1 (en) 2000-05-01 2002-10-22 Aeropharm Technology, Inc. Non-aqueous aerosol formulation comprising rosiglitazone maleate, a non-aqueous carrier, and an amino acid stabilizer
US6749845B2 (en) 2001-02-15 2004-06-15 Aeropharm Technology, Inc. Modulated release particles for lung delivery
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
CN101861311A (en) 2007-07-21 2010-10-13 阿尔巴尼分子研究公司 The indazole that the 5-pyridone replaces
CA2722611A1 (en) 2007-11-21 2009-05-28 Decode Genetics Ehf Biaryl pde4 inhibitors for treating pulmonary and cardiovascular disorders
EP2077132A1 (en) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device, storage device and method for dispensing a formulation
CA2727055C (en) 2008-01-11 2016-12-20 Albany Molecular Research, Inc. (1-azinone) -substituted pyridoindoles as mch antagonists
US8297305B2 (en) 2008-01-28 2012-10-30 Kohler Co. Valve assembly having an improved flow path
WO2010059836A1 (en) 2008-11-20 2010-05-27 Decode Genetics Ehf Substituted aza-bridged bicyclics for cardiovascular and cns disease
CN102361876B (en) 2009-01-26 2015-02-04 以色列生物研究所 Bicyclic heterocyclic spiro compounds
WO2010112358A2 (en) 2009-03-31 2010-10-07 Boehringer Ingelheim International Gmbh Method for coating a surface of a component
EP3508239B1 (en) 2009-05-18 2020-12-23 Boehringer Ingelheim International GmbH Adapter, inhalant apparatus and atomizer
AU2010323220B2 (en) 2009-11-25 2015-04-23 Boehringer Ingelheim International Gmbh Nebulizer
WO2011064163A1 (en) 2009-11-25 2011-06-03 Boehringer Ingelheim International Gmbh Nebulizer
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
EP2694220B1 (en) 2011-04-01 2020-05-06 Boehringer Ingelheim International GmbH Medical device comprising a container
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
WO2013152894A1 (en) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Atomiser with coding means
JP6643231B2 (en) 2013-08-09 2020-02-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Nebulizer
ES2836977T3 (en) 2013-08-09 2021-06-28 Boehringer Ingelheim Int Nebulizer
SG11201608891RA (en) 2014-05-07 2016-11-29 Boehringer Ingelheim Int Nebulizer, indicator device and container
EP3139979B1 (en) 2014-05-07 2023-07-05 Boehringer Ingelheim International GmbH Unit, nebulizer and method
US10722666B2 (en) 2014-05-07 2020-07-28 Boehringer Ingelheim International Gmbh Nebulizer with axially movable and lockable container and indicator
AU2019240065A1 (en) 2018-03-20 2020-09-24 Icahn School Of Medicine At Mount Sinai Kinase inhibitor compounds and compositions and methods of use
JP2021536467A (en) 2018-09-06 2021-12-27 インノファーマスクリーン インコーポレイテッド Methods and compositions for the treatment of asthma or Parkinson's disease
EP3906233B1 (en) 2018-12-31 2024-01-31 Icahn School of Medicine at Mount Sinai Kinase inhibitor compounds and compositions and methods of use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB837465A (en) * 1957-01-31 1960-06-15 Riker Laboratories Inc Self-propelling, powder-dispensing compositions
GB994734A (en) * 1962-10-30 1965-06-10 Riker Laboratories Inc Self-propelling powder-dispensing compositions
EP0302772A1 (en) * 1987-08-03 1989-02-08 Asahi Kasei Kogyo Kabushiki Kaisha Calcitonin composition for nasal administration

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4241051A (en) * 1977-11-04 1980-12-23 Christie Robert B Calcitonin
JPS61267528A (en) * 1984-11-26 1986-11-27 Yamanouchi Pharmaceut Co Ltd Transnasal calcitonin agent containing absorbefacient
DE3686025T2 (en) * 1985-05-22 1993-01-07 Liposome Technology Inc METHOD AND SYSTEM FOR INHALING LIPOSOMES.
HUT44794A (en) * 1985-12-04 1988-04-28 Sandoz Ag Process for production of calcitonine-derivatives and medical preparatives containing such compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB837465A (en) * 1957-01-31 1960-06-15 Riker Laboratories Inc Self-propelling, powder-dispensing compositions
GB994734A (en) * 1962-10-30 1965-06-10 Riker Laboratories Inc Self-propelling powder-dispensing compositions
EP0302772A1 (en) * 1987-08-03 1989-02-08 Asahi Kasei Kogyo Kabushiki Kaisha Calcitonin composition for nasal administration

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
K. PARKITT et al.: "MARTINDALE - THE EXTRA PHARMACOPOEIA", Twenty-ninth edition, edited by J.E.F. Reynolds, January 1989, The Pharmaceutical Press, London, GB; *
PATENT ABSTRACTS OF JAPAN, vol. 9, no. 331 (C-321)(2054), 25th December 1985; & JP-A-60 161 924 (FUJISAWA YAKUHIN KOGYO K.K.) 23-08-1985 *
See also references of WO9009781A1 *

Also Published As

Publication number Publication date
FI913899A7 (en) 1991-08-19
EP0460064A1 (en) 1991-12-11
AU5194990A (en) 1990-09-26
FI913899A0 (en) 1991-08-19
WO1990009781A1 (en) 1990-09-07
JPH05508616A (en) 1993-12-02
CA2050905A1 (en) 1990-08-24

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Legal Events

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