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EP0362911A1 - Bouteille pour dispenser de manière contrôlable un liquide goutte à goutte - Google Patents

Bouteille pour dispenser de manière contrôlable un liquide goutte à goutte Download PDF

Info

Publication number
EP0362911A1
EP0362911A1 EP89202150A EP89202150A EP0362911A1 EP 0362911 A1 EP0362911 A1 EP 0362911A1 EP 89202150 A EP89202150 A EP 89202150A EP 89202150 A EP89202150 A EP 89202150A EP 0362911 A1 EP0362911 A1 EP 0362911A1
Authority
EP
European Patent Office
Prior art keywords
bottle
liquid
drops
insert element
tip portion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP89202150A
Other languages
German (de)
English (en)
Inventor
Leonid Bunin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0362911A1 publication Critical patent/EP0362911A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0272—Dropper bottles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Rigid or semi-rigid containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material or by deep-drawing operations performed on sheet material
    • B65D1/02—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents
    • B65D1/08—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents adapted to discharge drops

Definitions

  • This invention relates to a bottle for dispensing liquid contents by individual drops and, more particularly, to a bottle having a dispensing tip portion formed to include an insert having a bore of predetermined cross sectional area and length to regulate the flow to generate liquid drops within a predetermined size range.
  • a liquid material is most advantageously dispensed in the form of drops, preferably drops that are predictably within a predetermined size range.
  • Such applications include the provision of medications such as eye drops to patients' eyes, in the dispensation of which an overdose of medication must be avoided.
  • the bottle containing liquid contents is uncapped, typically by the detachment of a screw-on cap, whereafter the user gently squeezes the bottle to dispense from a distal tip end thereof one or more drops of medication intended to be deposited at a selected location, e.g., an eye.
  • Such bottles typically, are made of a flexible plastic material and the tip generally has an outer conical elongate shape with an aperture at which individual drops are formed before they separate from the bottle for deposition at the intended site.
  • thermoplastics that are safe and convenient for use of the type at issue are thermoplastics and, when the tip ends of such bottles are molded, the provision of the fine orifice through which the liquid contents must flow to the tip end of the bottle requires the disposition of a core of very small diameter. The core must be subsequently removed without damaging the resulting molded part.
  • such orifices must have diameters in the range 130-150 microns and numerous attempts have been made utilizing metal wires of this diameter as cores to generate such orifices.
  • Unfortunately because of high molding temperatures and the forces with which the material and various elements have to be manipulated, too often the core wire tends to break and remains within the orifice from which it must be extracted. As a consequence, serious quality control problems are presented to the manufacturer, not the least of which is to inspect each such tip to insure that the core wire has been effectively removed without damaging the remaining tip.
  • Another object of this invention is to provide a bottle having a delivery tip portion that is easily manufactured of plastics material and ensures regulation of the flow of liquid contents from the bottle to be released as drops delivered within a predetermined size range.
  • a bottle for controllably dispensing liquid contents therefrom as drops that are delivered within a predetermined size range
  • a delivery tip portion is formed internally as an elongate frustro-conical outwardly opening passage having a wide end for forming individual liquid drops thereat and a narrow end for receiving a regulated flow of liquid from the bottle contents, and a liquid flow regulating insert element having an internal bore of predetermined cross sectional area and length, the insert element being located at a narrow end of the tip portion to regulate flow of the liquid from the bottle into the tip portion.
  • a bottle 10, formed according to a preferred embodiment of this invention has toward an open end thereof a shoulder portion 12, which may be externally threaded for receiving a closure cap (not shown) when the bottle is not in use so as to protect liquid contents of the bottle from contamination by ambient dirt, bacteria and the like.
  • the delivery end of such a bottle 10 may conveniently be formed as an elongate portion 14 having an end 16 from which liquid contents 18 of the bottle may be expelled in the form of drops 20 that each form a neck 22 immediately prior to separation from the bottle.
  • Such bottles considering cost, manufacturing convenience, amenability to sterilization so as to contain sensitive medications, flexibility for convenience of transportation, handling, and use, inter alia , are usually made of flexible plastics materials. As a practical matter, manufacture of such bottles, especially the tip end portions thereof, involves various aspects of the molding of thermoplastics material.
  • FIG. 2 is a vertical cross-sectional view along an axial plane of a typical bottle according to preferred embodiment of this invention.
  • an upper portion 24 of the internal volume of bottle 10 that contains, most likely, some air over an upper surface of liquid contents 18.
  • a small amount 118 of the liquid contents of the bottle that have been expelled towards the tip end 16 may be expected to remain within an elongate frustro-conical tapered base defined by a wall 26 and ending in a base 28 if the bottle has been used at least once.
  • the wider end of the frustro-conical surface 26 is towards the outermost portion of the tip end of the bottle, i.e., the end adjacent the end surface 16 thereof.
  • annular recess defined by an outer cylindrical surface 30 of a diameter "D" and a depth "d” may be formed as illustrated in Figure 2.
  • An opening, not numbered in order to avoid confusion, is formed in the base 28 of a diameter sufficient to receive tightly therewithin an insert element 32 to be described more fully hereinafter.
  • the outer surface of insert element 32 may be made rough or otherwise amenable to sealing/bonding with the bottle material being molded therearound.
  • Figure 2 illustrates the length "L” as being somewhat greater than the thickness "d" of the base 28 of the body tip portion, this is not essential. Persons skilled in the art can easily visualize techniques that will permit other dimensional relationships.
  • bore 34 is shown as a straight cylindrical portion, even this is not absolutely essential.
  • bore 34 provides the desired regulation of flow rate of liquid contents 18 from the bottle 10 therethrough.
  • insert element 32 may be merely a small length of a uniform cylindrical tubing having an internal bore "x" and cut to a suitable length "L”.
  • Known techniques for locating a core may be utilized, especially since the outer dimension of insert element 32 is bound to be larger than that of an otherwise necessary core wire having an outer diameter comparable to "x".
  • the details of how the bottle tip portion is molded around insert element 32 are not critical to an appreciation of the advantages of the present invention.
  • a drop determined in size by the diameter "D" and the depth "d" of recess 30 will form as drop 20, eventually neck at 22, and be released as the drop of predetermined size, i.e., at least within an acceptable range of diameter size.
  • bore 34 presents a flow impedance of known magnitude, which is selected with attention paid to the viscosity and other relevant parameters pertaining to the liquid contents 18, there is intentional avoidance of either an uncontrolled squirting of the liquid or a rapid succession of drops from the bottle.
  • the present invention provides a very definite, inexpensive and easy-to-manufacture structure to controllably dispense a liquid in individual drops within a predetermined size range.
  • a distinct advantage of the structure according to the preferred embodiment is that different bottles all having the same general shape and size may be utilized to contain and dispense different liquid contents having different viscosities and flow characteristics, simply by selecting for inclusion therein different internal diameters "x" and/or bore lengths "L" of insert elements having the same external diameter so that they can be molded utilizing the same equipment. Assume that there are two bottles having the same internal size and external shape, to be used to dispense two different liquid contents which must be released in drops of different size or, even if the drops are to be of the same size, the liquids have different viscosities.
  • One simple solution would be to have one or more separately produced tip elements that can be integrated with any individual bottle body in known manner, such a tip element typically being calibrated to provide the desired flow of a selected fluid.
  • a tip portion would have essentially the same geometry of structure as that of the delivery end portion of the bottle of Figs. 1 and 2.
  • the manufacturer need select merely the right internally sized insert 32 while using exactly the same molding equipment otherwise.
  • Conventional techniques would require the provision of different core wires that may differ only slightly in external diameter and yet may each be subject to breakage and consequent problems as adverted to earlier.
  • the combination of the insert element 32 and otherwise conventional bottle tip portion 14, according to this invention enables a wide range of deliveries, for different types of liquids, to be realized merely by changing insert elements that have essentially the same external shape and size.

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ceramic Engineering (AREA)
  • Mechanical Engineering (AREA)
  • Closures For Containers (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
EP89202150A 1988-09-01 1989-08-25 Bouteille pour dispenser de manière contrôlable un liquide goutte à goutte Withdrawn EP0362911A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23929188A 1988-09-01 1988-09-01
US239291 1988-09-01

Publications (1)

Publication Number Publication Date
EP0362911A1 true EP0362911A1 (fr) 1990-04-11

Family

ID=22901508

Family Applications (1)

Application Number Title Priority Date Filing Date
EP89202150A Withdrawn EP0362911A1 (fr) 1988-09-01 1989-08-25 Bouteille pour dispenser de manière contrôlable un liquide goutte à goutte

Country Status (2)

Country Link
EP (1) EP0362911A1 (fr)
JP (1) JPH02139347A (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5158213A (en) * 1989-10-26 1992-10-27 Laboratoires Merck Sharp & Dohme-Chibret Dispensing bottle with internal flow rate restriction system
US5373964A (en) * 1993-06-23 1994-12-20 Moore; Sidney D. Eyedrop dispenser with focusing liquid lens
US7503909B2 (en) * 2001-10-31 2009-03-17 Santen Pharmaceutical Co., Ltd. Instillation container with level-difference portion
EP2050501A1 (fr) * 2007-10-19 2009-04-22 Lifescan Scotland Ltd Embout de distribution de liquide avec réservoir
EP1928394A4 (fr) * 2005-09-29 2010-03-17 Hanmi Pharm Ind Co Ltd Embout compte-gouttes doseur pour solution medicinale
KR101247688B1 (ko) * 2010-12-31 2013-04-01 나성식 액체용기
EP2597044A1 (fr) 2011-11-25 2013-05-29 Hoffmann Neopac AG Insert compte-gouttes et récipient avec insert compte-gouttes
ITMI20130424A1 (it) * 2013-03-20 2014-09-21 Uni Degli Studi Di Bergamo Utensile per la formazione e il distacco di gocce di fluido in condizioni supercritiche
US10220988B2 (en) 2008-03-27 2019-03-05 Nemera La Verpillière Device for dispensing a liquid in the form of drops

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0451950U (fr) * 1990-09-06 1992-05-01
CA2557720C (fr) * 2004-03-09 2012-08-14 Santen Pharmaceutical Co., Ltd. Recipient de liquide
JP4592451B2 (ja) * 2004-03-09 2010-12-01 参天製薬株式会社 液体容器
JP2009261453A (ja) * 2008-04-22 2009-11-12 Hanshin Kasei Kogyo Kk 滴下ノズル

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2188802A (en) * 1939-01-06 1940-01-30 Beckett Lloyd Stanley Cap and dropper
DE825501C (de) * 1950-12-07 1951-12-20 Paul Freiherr Von Pechmann Fluessigkeitsbehaelter mit engem Ausgabekanal zur tropfenweisen Ausgabe seines Inhalts durch Schuetteln
US3276639A (en) * 1964-12-21 1966-10-04 Cooke Engineering Company Metered drop dispenser
US3276847A (en) * 1961-08-31 1966-10-04 Cooke Engineering Company Tubular dropper for micro-titration

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2188802A (en) * 1939-01-06 1940-01-30 Beckett Lloyd Stanley Cap and dropper
DE825501C (de) * 1950-12-07 1951-12-20 Paul Freiherr Von Pechmann Fluessigkeitsbehaelter mit engem Ausgabekanal zur tropfenweisen Ausgabe seines Inhalts durch Schuetteln
US3276847A (en) * 1961-08-31 1966-10-04 Cooke Engineering Company Tubular dropper for micro-titration
US3276639A (en) * 1964-12-21 1966-10-04 Cooke Engineering Company Metered drop dispenser

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5158213A (en) * 1989-10-26 1992-10-27 Laboratoires Merck Sharp & Dohme-Chibret Dispensing bottle with internal flow rate restriction system
US5373964A (en) * 1993-06-23 1994-12-20 Moore; Sidney D. Eyedrop dispenser with focusing liquid lens
WO1995000407A1 (fr) * 1993-06-23 1995-01-05 Moore Sidney D Distributeur de gouttes oculaires a lentille liquide de focalisation
US7503909B2 (en) * 2001-10-31 2009-03-17 Santen Pharmaceutical Co., Ltd. Instillation container with level-difference portion
EP1928394A4 (fr) * 2005-09-29 2010-03-17 Hanmi Pharm Ind Co Ltd Embout compte-gouttes doseur pour solution medicinale
WO2009052243A1 (fr) * 2007-10-19 2009-04-23 Lifescan Scotland, Ltd Embout de distribution de liquide avec réservoir
EP2050501A1 (fr) * 2007-10-19 2009-04-22 Lifescan Scotland Ltd Embout de distribution de liquide avec réservoir
CN101903106A (zh) * 2007-10-19 2010-12-01 生命扫描苏格兰有限公司 具有贮存器的液体分配头
US10220988B2 (en) 2008-03-27 2019-03-05 Nemera La Verpillière Device for dispensing a liquid in the form of drops
US10640268B2 (en) 2008-03-27 2020-05-05 Nemera La Verpillière Device for dispensing a liquid in the form of drops
US11155391B2 (en) 2008-03-27 2021-10-26 Nemera La Verpillière Device for dispensing a liquid in the form of drops
US11524822B2 (en) 2008-03-27 2022-12-13 Nemera La Verpillière Device for dispensing a liquid in the form of drops
KR101247688B1 (ko) * 2010-12-31 2013-04-01 나성식 액체용기
EP2597044A1 (fr) 2011-11-25 2013-05-29 Hoffmann Neopac AG Insert compte-gouttes et récipient avec insert compte-gouttes
ITMI20130424A1 (it) * 2013-03-20 2014-09-21 Uni Degli Studi Di Bergamo Utensile per la formazione e il distacco di gocce di fluido in condizioni supercritiche

Also Published As

Publication number Publication date
JPH02139347A (ja) 1990-05-29

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