EP0204989A3 - Use of penicillamine in the treatment of immune deficiency diseases - Google Patents
Use of penicillamine in the treatment of immune deficiency diseases Download PDFInfo
- Publication number
- EP0204989A3 EP0204989A3 EP86106646A EP86106646A EP0204989A3 EP 0204989 A3 EP0204989 A3 EP 0204989A3 EP 86106646 A EP86106646 A EP 86106646A EP 86106646 A EP86106646 A EP 86106646A EP 0204989 A3 EP0204989 A3 EP 0204989A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- penicillamine
- immune deficiency
- treatment
- deficiency diseases
- diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LJRDOKAZOAKLDU-UDXJMMFXSA-N (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-[(2r,3s,4r,5s)-5-[(1r,2r,3s,5r,6s)-3,5-diamino-2-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric ac Chemical compound OS(O)(=O)=O.N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO LJRDOKAZOAKLDU-UDXJMMFXSA-N 0.000 title abstract 2
- 229960001639 penicillamine Drugs 0.000 title abstract 2
- 208000003669 immune deficiency disease Diseases 0.000 title 1
- 208000030507 AIDS Diseases 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT86106646T ATE73995T1 (en) | 1985-06-08 | 1986-05-15 | USE OF PENICILLAMIN TO TREAT IMMUNE DEFICIENCY DISEASES. |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3520624 | 1985-06-08 | ||
| DE3520624 | 1985-06-08 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP0204989A2 EP0204989A2 (en) | 1986-12-17 |
| EP0204989A3 true EP0204989A3 (en) | 1989-12-20 |
| EP0204989B1 EP0204989B1 (en) | 1992-03-25 |
Family
ID=6272806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP86106646A Expired - Lifetime EP0204989B1 (en) | 1985-06-08 | 1986-05-15 | Use of penicillamine in the treatment of immune deficiency diseases |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4847297A (en) |
| EP (1) | EP0204989B1 (en) |
| JP (1) | JPS61286325A (en) |
| AT (1) | ATE73995T1 (en) |
| AU (1) | AU584551B2 (en) |
| CA (1) | CA1283859C (en) |
| DE (1) | DE3684514D1 (en) |
| ZA (1) | ZA864263B (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5192788A (en) * | 1988-05-23 | 1993-03-09 | Georgia State University Foundation, Inc. | Porphyrin antiviral compositions |
| US5109016A (en) * | 1988-05-23 | 1992-04-28 | Georgia State University Foundation, Inc. | Method for inhibiting infection or replication of human immunodeficiency virus with porphyrin and phthalocyanine antiviral compositions |
| US5061700A (en) * | 1989-11-16 | 1991-10-29 | Gordon Jay Dow | Glyceryl acetate ointment vehicles |
| US5554655A (en) * | 1991-09-30 | 1996-09-10 | Jess G. Thoene | Method of treating HIV infection |
| MX9205549A (en) * | 1991-09-30 | 1993-05-01 | Jess G Thoene | METHOD FOR THE TREATMENT OF HIV. |
| US6764693B1 (en) | 1992-12-11 | 2004-07-20 | Amaox, Ltd. | Free radical quenching composition and a method to increase intracellular and/or extracellular antioxidants |
| US5725870A (en) * | 1993-10-15 | 1998-03-10 | Thoene; Jess G. | Methods, composites and articles for contraception |
| CA2173964A1 (en) * | 1993-10-15 | 1995-04-20 | Jess G. Thoene | Prevention of hiv infection |
| US6541517B1 (en) | 1999-09-03 | 2003-04-01 | Donald M. Murphy | Treatment of skin disorders |
| US6117904A (en) * | 1999-09-03 | 2000-09-12 | Murphy; Donald M. | Treatment of pruritus |
| US20070134277A1 (en) * | 2005-12-09 | 2007-06-14 | Children's Medical Center Corporation | Pharmaceutical formulation for sulfur-containing drugs in liquid dosage forms |
| US20100166833A1 (en) * | 2007-05-07 | 2010-07-01 | Technion Research & Development Foundation Ltd. | Compositions, articles and methods for preventing or reducing tobacco-associated damage |
| US20190282519A1 (en) * | 2018-03-19 | 2019-09-19 | Cronus Research Labs Private Limited | Pencillamine oral composition |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB585413A (en) * | 1944-06-19 | 1947-02-06 | Wellcome Found | Improved method for the resolution of penicillamine |
| GB1424432A (en) * | 1972-03-25 | 1976-02-11 | Degussa | Pharmaceutical compositions |
| CH588887A5 (en) * | 1974-07-19 | 1977-06-15 | Battelle Memorial Institute | |
| US4487780A (en) * | 1979-09-18 | 1984-12-11 | Scheinberg Israel H | Method of treatment of rheumatoid arthritis |
-
1986
- 1986-05-15 DE DE8686106646T patent/DE3684514D1/en not_active Expired - Lifetime
- 1986-05-15 AT AT86106646T patent/ATE73995T1/en active
- 1986-05-15 EP EP86106646A patent/EP0204989B1/en not_active Expired - Lifetime
- 1986-06-05 JP JP61129362A patent/JPS61286325A/en active Granted
- 1986-06-06 ZA ZA864263A patent/ZA864263B/en unknown
- 1986-06-06 CA CA000511011A patent/CA1283859C/en not_active Expired - Lifetime
- 1986-06-06 AU AU58440/86A patent/AU584551B2/en not_active Ceased
-
1988
- 1988-03-16 US US07/170,638 patent/US4847297A/en not_active Expired - Fee Related
Non-Patent Citations (7)
| Title |
|---|
| Arzneimittelforsch./Drug Res., Band 36, Nr. 2, Februar 1986, Aulendorf, DE, P. CHANDRA et al.: "Selective inhibition of replication of the AIDS-associated virus HTLV-III/LAV by synthetic D-penicillamine, Ganze Dokument. * |
| Boletino Soc. Italiana Biologica Sperimentale, Band 43, 1967, Seiten 645-647, Napoli, IT, P. MAZZUCATO et al.: "Attivita antivirale della guanidina E della D-penicillamina. II. Studio comparato degli antagonisti della guanidina E della D-penicillamina", Seite 645; Figur 2. * |
| Concours Medical, Band 100, 23. Dezember 1978, Seiten 7845-7850, Paris, FR, V. LEMAIRE: "Les traitements a visée immunologique en rhumatologie", Seite 7850: "Immuno-stimulation". * |
| Int. Journal of Immunotherapy, Band I, Nr. 2, 1985, Seiten 79-83, Bioscience Ediprint Inc., CH, Y. SHIOKAWA: "Progress in new immunomodulator research", Ganze Dokument, Insbes. Tabelle IV. * |
| Nouvelle Presse Medicale, Band 1, Nr. 14, Seiten 953-958, 1972, Paris, FR, G.H. WERNER: "La multiplication des virus. 2. Perspectives d'avenir de la chimiotherapie antivirale", Seiten 953-954; conclusions. * |
| Postgraduate Med. J., Suppl., Band 50, 1974, Seiten 50-55, London, GB, I.A. JAFFE et al.: "Further studies of the anti-viral effect of D-penicillamine", Zusammenfassung; Introduction. * |
| The Merck Manual of Diagnosis and Therapy, R. BERKOW, M.D. Editor; 14. Auflage, 1982, MSD Research Lab. Rahway, NJ, US, Seiten 288-304. * |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE73995T1 (en) | 1992-04-15 |
| EP0204989B1 (en) | 1992-03-25 |
| ZA864263B (en) | 1987-02-25 |
| CA1283859C (en) | 1991-05-07 |
| JPS61286325A (en) | 1986-12-16 |
| EP0204989A2 (en) | 1986-12-17 |
| AU584551B2 (en) | 1989-05-25 |
| JPH0380772B2 (en) | 1991-12-26 |
| DE3684514D1 (en) | 1992-04-30 |
| US4847297A (en) | 1989-07-11 |
| AU5844086A (en) | 1986-12-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| OA08581A (en) | Treatment of diseases caused by retroviruses. | |
| NO883007D0 (en) | PROCEDURE FOR THE PREPARATION OF BENZOPYRANE DERIVATIVES. | |
| AU1256288A (en) | Treatment of human viral infections by dsrna combined with viral inhibitors | |
| ZW22687A1 (en) | Treatment of diseases caused by viruses | |
| FI884095A7 (en) | DOSERINGSVENTIL MED HOPFAELLBAR CHAMBER. | |
| EP0204989A3 (en) | Use of penicillamine in the treatment of immune deficiency diseases | |
| NO882388D0 (en) | PROCEDURE FOR THE PREPARATION OF CONTAMINATED MINERALS. | |
| GR3006674T3 (en) | ||
| GR3019860T3 (en) | R-(-)-1-(5-hydroxyhexyl)-3-methyl-7-propylxanthin, process for its preparation and medicines containing it | |
| NO881636D0 (en) | PROCEDURE FOR THE MANUFACTURE OF FIBER-CONTAINED SOY MILK. | |
| GB2179858B (en) | Compositions for treating viral skin diseases. | |
| ZA884262B (en) | Pharmaceutical composition for the treatment of tumors | |
| IT8721560A0 (en) | PROCEDURE FOR THE PURIFICATION OF INTERFERON. | |
| AU3660284A (en) | (-)-1,7-diphenyl-3-methylaza-7-cyano-8-methylnonane | |
| NO880292D0 (en) | PROCEDURE FOR HUMAN TREATMENT. | |
| ZA929879B (en) | Compositions for the treatment of mammalian diseases. | |
| NO873727L (en) | PROCEDURE FOR THE PREPARATION OF BENZOCSAZONE RELATIONS WITH THERAPEUTIC ACTIVITY. | |
| NO164972C (en) | ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE GEM-DIHALO-1,8-DIAMINO-4-AZA OCTANES. | |
| ZA875676B (en) | The use of 15-deoxyspergualine as a pharmaceutical | |
| NO884792L (en) | PROCEDURE FOR THE PREPARATION OF ALFA-OLEPHINE POLYMES. | |
| IT8719427A0 (en) | PROCEDURE FOR THE PREPARATION OF AGENTS FOR THE TREATMENT OF GASEOUS COMBUSTION PRODUCTS. | |
| NO884635L (en) | PROCEDURE FOR TREATMENT OF FEEDS. | |
| GR3005231T3 (en) | ||
| EP0245368A4 (en) | Treatment of demyelinating diseases. | |
| AU7398587A (en) | Treatment of soybeans |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 19860515 |
|
| AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE |
|
| RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: ASTA PHARMA AKTIENGESELLSCHAFT |
|
| PUAL | Search report despatched |
Free format text: ORIGINAL CODE: 0009013 |
|
| AK | Designated contracting states |
Kind code of ref document: A3 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE |
|
| 17Q | First examination report despatched |
Effective date: 19901015 |
|
| ITF | It: translation for a ep patent filed | ||
| GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
| RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: ASTA MEDICA AKTIENGESELLSCHAFT |
|
| AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE |
|
| REF | Corresponds to: |
Ref document number: 73995 Country of ref document: AT Date of ref document: 19920415 Kind code of ref document: T |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: SE Payment date: 19920410 Year of fee payment: 7 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: GB Payment date: 19920429 Year of fee payment: 7 |
|
| REF | Corresponds to: |
Ref document number: 3684514 Country of ref document: DE Date of ref document: 19920430 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: CH Payment date: 19920508 Year of fee payment: 7 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: AT Effective date: 19920515 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: BE Payment date: 19920526 Year of fee payment: 7 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: LU Payment date: 19920527 Year of fee payment: 7 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: NL Payment date: 19920531 Year of fee payment: 7 |
|
| ET | Fr: translation filed | ||
| GBT | Gb: translation of ep patent filed (gb section 77(6)(a)/1977) | ||
| EPTA | Lu: last paid annual fee | ||
| PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
| 26N | No opposition filed | ||
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 19930515 Ref country code: GB Effective date: 19930515 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SE Effective date: 19930516 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: FR Payment date: 19930528 Year of fee payment: 8 |
|
| ITTA | It: last paid annual fee | ||
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LI Effective date: 19930531 Ref country code: CH Effective date: 19930531 Ref country code: BE Effective date: 19930531 |
|
| BERE | Be: lapsed |
Owner name: ASTA MEDICA A.G. Effective date: 19930531 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: NL Effective date: 19931201 |
|
| GBPC | Gb: european patent ceased through non-payment of renewal fee |
Effective date: 19930515 |
|
| NLV4 | Nl: lapsed or anulled due to non-payment of the annual fee | ||
| REG | Reference to a national code |
Ref country code: CH Ref legal event code: PL |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: DE Payment date: 19941221 Year of fee payment: 9 |
|
| EUG | Se: european patent has lapsed |
Ref document number: 86106646.2 Effective date: 19931210 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: FR Effective date: 19950131 |
|
| REG | Reference to a national code |
Ref country code: FR Ref legal event code: ST |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: DE Effective date: 19960201 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES;WARNING: LAPSES OF ITALIAN PATENTS WITH EFFECTIVE DATE BEFORE 2007 MAY HAVE OCCURRED AT ANY TIME BEFORE 2007. THE CORRECT EFFECTIVE DATE MAY BE DIFFERENT FROM THE ONE RECORDED. Effective date: 20050515 |