EP0280215A1 - Lentille intraoculaire - Google Patents
Lentille intraoculaire Download PDFInfo
- Publication number
- EP0280215A1 EP0280215A1 EP88102485A EP88102485A EP0280215A1 EP 0280215 A1 EP0280215 A1 EP 0280215A1 EP 88102485 A EP88102485 A EP 88102485A EP 88102485 A EP88102485 A EP 88102485A EP 0280215 A1 EP0280215 A1 EP 0280215A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- diamond
- intraocular lens
- carbon film
- light
- lens
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000000695 crystalline len Anatomy 0.000 claims abstract description 69
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 34
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 33
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 19
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 19
- 239000011347 resin Substances 0.000 claims description 19
- 229920005989 resin Polymers 0.000 claims description 19
- 239000010408 film Substances 0.000 description 30
- 230000005540 biological transmission Effects 0.000 description 11
- 210000001508 eye Anatomy 0.000 description 10
- 238000002834 transmittance Methods 0.000 description 6
- 208000002177 Cataract Diseases 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000000354 decomposition reaction Methods 0.000 description 4
- 238000007737 ion beam deposition Methods 0.000 description 3
- 210000001525 retina Anatomy 0.000 description 3
- 230000035807 sensation Effects 0.000 description 3
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- 206010007269 Carcinogenicity Diseases 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 210000005252 bulbus oculi Anatomy 0.000 description 2
- 231100000260 carcinogenicity Toxicity 0.000 description 2
- 230000007670 carcinogenicity Effects 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 238000001659 ion-beam spectroscopy Methods 0.000 description 2
- 210000001328 optic nerve Anatomy 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- -1 carbon ions Chemical class 0.000 description 1
- 239000003575 carbonaceous material Substances 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 230000002393 scratching effect Effects 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
- A61F2/16—Intraocular lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/303—Carbon
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- G02B1/041—Lenses
- G02B1/043—Contact lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2002/16965—Lens includes ultraviolet absorber
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00574—Coating or prosthesis-covering structure made of carbon, e.g. of pyrocarbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
Definitions
- the present invention relates to an intraocular lens which is to be implanted in place of the natural eye's crystalline lens that has been removed in surgical operations on cataract and so on.
- PMMA resins polymethyl methacrylate resins
- Such an intraocular lens is implanted in a location that is close to the place where the natural eye's crystalline lens was positioned so that the state of an image focused on the retina is very close to that attained by the normal eye. Accordingly, the intraocular lens is particularly suitable for use as artificial crystalline lenses from the viewpoint of the restoration of the patient's vision after operation. Also, the intraocular lenses require no daily care and are preferred for aged people who are frequent victims of cataract.
- intraocular lenses made of PMMA resins is increasing today and further improvements in their properties such as biocompatibility and transparency are needed.
- Fig. 3 shows the transmittance characteristics of a prior art intraocular lens made of PMMA resin.
- the conventional intraocular lens transmits ultraviolet rays at wavelengths below 250 nm and its transmittance of light in the near ultraviolet range longer than 250 nm is sharply increased to at least 90%. If such as intraocular lens is implanted in a patient's eye, his eyeball, in particular, the optic nerve may be damaged by ultraviolet radiation. There also is a problem in association with visual sensation; that is, the eye fitted with this lens which transmits light in the ultraviolet and near ultraviolet regions produces a more bluish sensation than the normal eyeball.
- An object, therefore, of the present invention is to provide a highly biocompatible intraocular lens that does not transmit any of the rays in the ultraviolet and near ultraviolet regions and which yet retains high transmittance of visible rays of light.
- the present inventors conducted intensive studies in order to develop an intraocular lens that is free from the aforementioned problems with the prior art products and which is most close to the normal eye's crystalline lens.
- the present invention has been accomplished as a result of these efforts and solves the problems by coating a diamond-like carbon film on the surface of an artificial crystalline lens made of such a material as a PMMA resin.
- an intraocular lens having the surface of an artificial crystalline lens coated with a diamond-like carbon film.
- the artificial crystalline lens is preferably made of a polymethyl methacrylate.
- the diamond-like carbon film coated on the surface of the artificial crystalline lens preferably has a thickness in the range of 10 - 100 nm.
- the diamond-like carbon film according to the present invention is preferably formed by some suitable method such as ion beam deposition, sputtering or RF decomposition that are capable of forming a diamond-like carbon film at low temperatures.
- An artificial crystalline lens made of such a material as PMMA resin which is coated with a diamond-like carbon film on its surface in accordance with the present invention has the ability to block the transmission of light in the ultraviolet and near ultraviolet regions, while permitting light in the visible range to be transmitted. Further, the surface coating which is made of a carbon material has only a small irritating effect on living tissues and good biocompatibility to the tissues so that the intraocular lens of the present invention is highly advantageous as a biomaterial.
- Fig. 1 is a graph showing the light transmittance of an intraocular lens having a diamond-like carbon film coated in a thickness of 20 nm on the surface of an artificial crystalline lens made of a PMMA resin. As shown in Fig. 1, the intraocular lens furnished with the diamond-like carbon film is transparent only to the light in the visible and infrared regions.
- the quantity of light in the shorter wavelength range that is transmitted through the intraocular lens of the present invention can be adjusted by controlling the thickness of the diamond-like carbon film. If the thickness of the film is less than 10 nm, light transmission is increased on the shorter wavelength side. Furthermore, pinholes in the thin film will permit some transmission of near ultraviolet light. Accordingly, the diamond-like carbon film is unable to exhibit its intended effect, i.e., blocking the light in the ultraviolet and near ultraviolet regions. If, on the other hand, the film thickness exceeds 100 nm, the intraocular lens will absorb not only undesired light but also the visible light which should be transmitted. In addition, the cost of forming the diamond-like carbon film is increased. Therefore, according to the present invention, a film thickness that is effective for the purpose of admitting desired visible light while blocking undesired light in the near ultraviolet region may be determined within the range of 10 - 100 nm.
- the thickness of the diamond-like carbon film formed on the intraocular lens of the present invention is to be determined within the range of 10 - 100 nm.
- the diamond-like carbon film is preferably formed by low-temperature processes such as ion beam deposition, sputtering and RF decomposition.
- ion beam deposition method carbon ions produced by sputtering a carbon electrode is accelerated by such a mechanism as the difference in pressure or magnetic field and driven toward the surface of a PMMA resin so as to deposit diamond-like carbon on the resin surface.
- RF decomposition method a plasma is produced by applying an electric field oscillating at high frequency between electrodes and a negative voltage is superposed on the deposition side, that is, on the electrode where the artificial crystalline lens is disposed.
- a mixture of hydrogen gas and a hydrocarbon gas is supplied between the electrodes, the hydrocarbon is ionized by the plasma and the resulting ion is accelerated toward the negative electrode to deposit diamond-like carbon on the artificial crystalline lens.
- the carbon film thus formed is essentially in the form of a amorphous matrix in which diamond-like crystals are dispersed.
- This diamond-like carbon film has a high degree of biocompatibility and presents no problem of carcinogenicity. Furthermore, this diamond-like carbon film has a high degree of hardness and displays high transmittance of light in both visible and infrared regions.
- the artificial crystalline lens of the intraocular lens of the present invention is preferably made of a PMMA resin. It should, however, be noted that the material of the artificial crystalline lens is in no way limited to PMMA resins and that the present invention also includes within its scope those intraocular lenses having a diamond-like carbon film formed on the surface of artificial crystalline lenses made of other suitable materials.
- Intraocular lens samples were fabricated by forming diamond-like carbon films in varying thicknesses (5 nm, 10 nm, 40 nm, 100 nm and 750 nm) on artificial crystalline lenses of PMMA resin by a RF decomposition technique that was performed under the conditions shown in Table 1.
- the artificial crystalline lens coated with a diamond-like carbon film in a thickness of 5 nm is not satisfactory as an intraocular lens since it admits some transmission of ultraviolet light harmful to the optic nerve and retina.
- a diamond-like carbon film of 10 nm thick the absorption edge exceeds 300 nm and the artificial crystalline lens substantially blocks the light in the near ultraviolet region while admitting high transmission of visible light. If the carbon film thickness is 100 nm, the lens completely blocks the light in the near ultraviolet region and yet retains the high transmission of visible light. As the film thickness exceeds 100 nm, transparency to visible light is gradually decreased and the intraocular lens will lose its function as an artificial crystalline lens.
- the appropriate thickness of the diamond-like carbon film to be deposited on the artificial crystalline film made of a PMMA resin is within the range of 10 - 100 nm.
- an artificial crystalline lens made of a PMMA resin or some other suitable material that is coated with a diamond-like carbon film according to the present invention provides an intraocular lens that effectively blocks rays of light in the ultraviolet and near ultraviolet regions to produce visual sensation of color that is close to what is attainable by the natural eye's crystalline lens. Therefore, the intraocular lens of the present invention can be used without any potential damage to the retina by ultraviolet radiation.
- the diamond-like carbon film is hard and resistant to scratching that may occur during handling of the lens.
- the intraocular lens of the present invention has the additional advantage of affording high biocompatibility without causing an problem such as carcinogenicity.
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP36681/87 | 1987-02-19 | ||
| JP62036681A JPS63203163A (ja) | 1987-02-19 | 1987-02-19 | 眼内レンズ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP0280215A1 true EP0280215A1 (fr) | 1988-08-31 |
| EP0280215B1 EP0280215B1 (fr) | 1991-12-18 |
Family
ID=12476586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP88102485A Expired - Lifetime EP0280215B1 (fr) | 1987-02-19 | 1988-02-19 | Lentille intraoculaire |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US4822359A (fr) |
| EP (1) | EP0280215B1 (fr) |
| JP (1) | JPS63203163A (fr) |
| DE (1) | DE3866894D1 (fr) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0567627A4 (en) * | 1991-11-14 | 1994-06-22 | Stanley Poler | Secondary eye growth impeding device and method |
| US5346507A (en) * | 1989-07-27 | 1994-09-13 | Fedorov Svjatoslav N | Intraocular lens and a polymer composition for making same |
| WO1999016390A3 (fr) * | 1997-09-26 | 1999-10-07 | Mark A Babizhayev | Dispositifs ophtalmiques implantables a revetement et leurs procedes de fabrication |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01301723A (ja) * | 1988-05-31 | 1989-12-05 | Canon Inc | 眼内レンズの表面機能性膜形成方法 |
| JPH01300959A (ja) * | 1988-05-31 | 1989-12-05 | Canon Inc | 表面機能性膜を有する眼内レンズ |
| JP2793274B2 (ja) * | 1989-07-26 | 1998-09-03 | ホーヤ株式会社 | 眼内レンズの製造方法 |
| US5171267A (en) * | 1989-08-31 | 1992-12-15 | The Board Of Regents Of The University Of Washington | Surface-modified self-passivating intraocular lenses |
| US5984962A (en) * | 1996-01-22 | 1999-11-16 | Quantum Vision, Inc. | Adjustable intraocular lens |
| US5728155A (en) * | 1996-01-22 | 1998-03-17 | Quantum Solutions, Inc. | Adjustable intraocular lens |
| US6749813B1 (en) | 2000-03-05 | 2004-06-15 | 3M Innovative Properties Company | Fluid handling devices with diamond-like films |
| US6795636B1 (en) | 2000-03-05 | 2004-09-21 | 3M Innovative Properties Company | Radiation-transmissive films on glass articles |
| US20020051286A1 (en) * | 2000-10-27 | 2002-05-02 | Honeywell, Inc. | Wavlength specific coating for mirrored optics and method for reducing reflection of white light |
| DE10064096B4 (de) * | 2000-12-21 | 2006-08-24 | Wöhlk Contact-Linsen GmbH | Verfahren zur dauerstabilen Hydrophilisierung einer Kontaktlinsenoberfläche und beschichtete Silikon-Kontaktlinse |
| US7106939B2 (en) | 2001-09-19 | 2006-09-12 | 3M Innovative Properties Company | Optical and optoelectronic articles |
| DE10152055A1 (de) * | 2001-10-25 | 2003-05-08 | Nttf Gmbh | Mechanisch und thermodynamisch stabile amorphe Kohlenstoffschichten für temperaturempfindliche Oberflächen |
| JP2006517136A (ja) * | 2003-02-07 | 2006-07-20 | オプトバイオニックス コーポレイション | ダイヤモンド状カーボン被覆を使用する埋め込み可能な装置 |
| EP3123980A1 (fr) * | 2005-09-08 | 2017-02-01 | Calhoun Vision, Inc. | Éléments optiques réglables présentant une protection accrue contre les ultraviolets |
| DE102008010674A1 (de) * | 2008-02-22 | 2009-08-27 | Fachhochschule Ansbach | Lichtschutzbeschichtung und Verfahren zur Herstellung derselben |
| WO2014066802A1 (fr) * | 2012-10-26 | 2014-05-01 | Board Of Regents, The University Of Texas System | Capteurs de contrainte flexibles |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2271589A1 (en) * | 1974-05-13 | 1975-12-12 | Korjukin Alexandr | Variable density optical filter manufacture - involves application of light filtering coating by vapour deposition |
| US4045125A (en) * | 1974-06-27 | 1977-08-30 | Etat Francias | Band filters for use in protective glasses |
| US4240163A (en) * | 1979-01-31 | 1980-12-23 | Galin Miles A | Medicament coated intraocular lens |
| EP0030792A2 (fr) * | 1979-11-20 | 1981-06-24 | National Research Development Corporation | Réflecteurs infrarouge |
| EP0161765A1 (fr) * | 1984-04-11 | 1985-11-21 | Pharmacia Ab | Implants intraoculaires pour absorber la lumière ultraviolette |
| DE3428895A1 (de) * | 1984-08-04 | 1986-02-13 | Dr. K. Schmidt-Apparatebau, 5205 St Augustin | Intraokularlinse |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2705234A1 (de) * | 1977-02-08 | 1978-08-17 | Hennig Gerhard | Keratoprothese |
-
1987
- 1987-02-19 JP JP62036681A patent/JPS63203163A/ja active Granted
-
1988
- 1988-02-18 US US07/156,752 patent/US4822359A/en not_active Expired - Lifetime
- 1988-02-19 EP EP88102485A patent/EP0280215B1/fr not_active Expired - Lifetime
- 1988-02-19 DE DE8888102485T patent/DE3866894D1/de not_active Expired - Lifetime
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2271589A1 (en) * | 1974-05-13 | 1975-12-12 | Korjukin Alexandr | Variable density optical filter manufacture - involves application of light filtering coating by vapour deposition |
| US4045125A (en) * | 1974-06-27 | 1977-08-30 | Etat Francias | Band filters for use in protective glasses |
| US4240163A (en) * | 1979-01-31 | 1980-12-23 | Galin Miles A | Medicament coated intraocular lens |
| EP0030792A2 (fr) * | 1979-11-20 | 1981-06-24 | National Research Development Corporation | Réflecteurs infrarouge |
| EP0161765A1 (fr) * | 1984-04-11 | 1985-11-21 | Pharmacia Ab | Implants intraoculaires pour absorber la lumière ultraviolette |
| DE3428895A1 (de) * | 1984-08-04 | 1986-02-13 | Dr. K. Schmidt-Apparatebau, 5205 St Augustin | Intraokularlinse |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5346507A (en) * | 1989-07-27 | 1994-09-13 | Fedorov Svjatoslav N | Intraocular lens and a polymer composition for making same |
| EP0567627A4 (en) * | 1991-11-14 | 1994-06-22 | Stanley Poler | Secondary eye growth impeding device and method |
| WO1999016390A3 (fr) * | 1997-09-26 | 1999-10-07 | Mark A Babizhayev | Dispositifs ophtalmiques implantables a revetement et leurs procedes de fabrication |
| US6613088B1 (en) | 1997-09-26 | 2003-09-02 | Mark A. Babizhayev | Coated ophthalmic and implantable devices and methods for producing same |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0448059B2 (fr) | 1992-08-05 |
| EP0280215B1 (fr) | 1991-12-18 |
| DE3866894D1 (de) | 1992-01-30 |
| JPS63203163A (ja) | 1988-08-23 |
| US4822359A (en) | 1989-04-18 |
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