EP0259485A4 - Heavy metal salts of hyaluronic acid useful as antimicrobial agents. - Google Patents

Heavy metal salts of hyaluronic acid useful as antimicrobial agents.

Info

Publication number: EP0259485A4
Authority: EP; European Patent Office
Prior art keywords: metal salts; heavy metal; hyaluronic acid; antimicrobial agents; acid useful
Prior art date: 1986-03-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

EP19870902255

Other languages

German (de)

French (fr)

Other versions

EP0259485A1 (en

Inventor

Abraham Nimrod

Benjamin Greenman

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Savient Pharmaceuticals Inc

Original Assignee

Savient Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-03-14

Filing date

1987-03-13

Publication date

1988-07-29

1986-03-14 Priority claimed from US06/840,419 external-priority patent/US4746504A/en

1987-03-09 Priority claimed from US07/023,666 external-priority patent/US4784991A/en

1987-03-13 Application filed by Savient Pharmaceuticals Inc filed Critical Savient Pharmaceuticals Inc

1988-03-16 Publication of EP0259485A1 publication Critical patent/EP0259485A1/en

1988-07-29 Publication of EP0259485A4 publication Critical patent/EP0259485A4/en

Status Ceased legal-status Critical Current

Links

KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title 1
239000004599 antimicrobial Substances 0.000 title 1
229910001385 heavy metal Inorganic materials 0.000 title 1
229920002674 hyaluronan Polymers 0.000 title 1
229960003160 hyaluronic acid Drugs 0.000 title 1
150000003839 salts Chemical class 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Materials Engineering (AREA)
Polymers & Plastics (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Agronomy & Crop Science (AREA)
Pest Control & Pesticides (AREA)
Plant Pathology (AREA)
Dentistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Environmental Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

EP19870902255 1986-03-14 1987-03-13 Heavy metal salts of hyaluronic acid useful as antimicrobial agents. Ceased EP0259485A4 (en)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US06/840,419 US4746504A (en)	1986-03-14	1986-03-14	Heavy metal salts of hyaluronic acid and their use as antimicrobial agents
US840419		1986-03-14
US1947487A	1987-02-26	1987-02-26
US19474		1987-02-26
US23666		1987-03-09
US07/023,666 US4784991A (en)	1986-03-14	1987-03-09	Heavy metal salts of hyaluronic acid and their use as antimicrobial agents

Publications (2)

Publication Number	Publication Date
EP0259485A1 EP0259485A1 (en)	1988-03-16
EP0259485A4 true EP0259485A4 (en)	1988-07-29

Family

ID=27361231

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP19870902255 Ceased EP0259485A4 (en)	1986-03-14	1987-03-13	Heavy metal salts of hyaluronic acid useful as antimicrobial agents.

Country Status (4)

Country	Link
EP (1)	EP0259485A4 (en)
AU (1)	AU600483B2 (en)
CA (1)	CA1291123C (en)
WO (1)	WO1987005517A1 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0356435B1 (en) *	1987-03-19	1995-10-18	Arthropharm Pty. Limited	Anti-inflammatory compounds and compositions
HU203372B (en)	1989-02-24	1991-07-29	Richter Gedeon Vegyeszet	Process for producing hyaluronic associates and pharmaceutical compositions and cosmetics comprising such active ingredient
DE4115454A1 (en) *	1991-05-11	1992-11-12	Basf Ag	Iron (III) -HYALURONATE
AU719365B2 (en) *	1995-09-28	2000-05-04	Sangstat Medical Corporation	Use of hyaluronic acid as an immunosuppressant
HU225329B1 (en) *	1996-09-12	2006-09-28	Richter Gedeon Vegyeszet	Use of zinc or cobalt hyaluronate associate for the manufacture of pharmaceutical compositions of antimicrobial activity
HU225991B1 (en) *	1997-04-29	2008-02-28	Richter Gedeon Nyrt	Use of the zinc hyaluronate associate (complex) for the preparation of pharmaceutical compositions for oral use against peptic ulcer
JP2003089647A (en)	1999-03-10	2003-03-28	Takada Seiyaku Kk	Agent for treating joint diseases
US7879824B2 (en)	2001-07-31	2011-02-01	Dermal Research Laboratories, Inc.	Methods of preventing or treating diseases and conditions using complex carbohydrates
AU8136801A (en) *	2000-07-31	2002-02-13	Dermal Res Lab Inc	Methods of preventing or treating diseases and conditions using complex carbohydrates
DK1536845T3 (en)	2002-09-11	2007-06-11	Johnson & Johnson Medical Ltd	Wound dressing materials containing complexes of silver anionic polysaccharides
GB2392913B (en) *	2002-09-11	2007-04-04	Johnson & Johnson Medical Ltd	Wound dressings comprising complexes of oxidised celluloses with silver
GB2408206B (en) *	2003-11-18	2007-11-28	Johnson & Johnson Medical Ltd	Antioxidant and antimicrobial wound dressing materials
CA2529413C (en) *	2003-06-20	2014-05-27	Johnson & Johnson Medical Limited	Antioxidant wound dressing materials
GB2402880B (en) *	2003-06-20	2008-01-23	Johnson & Johnson Medical Ltd	Antimicrobial compositions comprising silver
US8425926B2 (en)	2003-07-16	2013-04-23	Yongxing Qiu	Antimicrobial medical devices
CA2705850C (en) *	2007-11-13	2016-07-19	Bio-Technology General (Israel) Ltd.	Dilute filtration sterilization process for viscoelastic biopolymers
TWI516269B (en)	2009-08-14	2016-01-11	禾伸堂生技股份有限公司	Mixture of hyaluronic acid for treating and preventing inflammatory bowel disease
TWI383796B (en)	2009-08-14	2013-02-01	Holy Stone Healthcare Co Ltd	Use of hyaluronic acid mixture for the treatment and prevention of peptic ulcer and duodenal ulcer
US8575130B2 (en)	2010-01-04	2013-11-05	Holy Stone Healthcare Co., Ltd.	Mixture of hyaluronic acid for treating and preventing inflammatory bowel disease
US8722644B2 (en)	2010-01-04	2014-05-13	Holy Stone Healthcare Co., Ltd.	Mixture of hyaluronic acid for treating and preventing peptic ulcer and duodenal ulcer
US9029347B2 (en)	2010-08-05	2015-05-12	Holy Stone Healthcare Co., Ltd.	Method and mixture for treating and preventing inflammatory bowel disease
IT1402786B1 (en) *	2010-11-19	2013-09-18	Fidia Farmaceutici	PHARMACEUTICAL COMPOSITIONS WITH ANTIBACTERIAL AND CICATRIZING ACTIVITIES
CN102552309B (en) *	2010-12-15	2013-06-05	北京理工大学	Application and preparation method of gold hyaluronic acid
EP2545925B1 (en)	2011-07-12	2018-02-14	Holy Stone Healthcare Co.,Ltd.	Compositions comprising hyaluronic acid for treating and preventing mucosa related diseases
EP2543357B1 (en)	2011-07-07	2018-03-21	Holy Stone Healthcare Co.,Ltd.	Composition for use in treating and preventing inflammation related disorder
FR2978664B1 (en)	2011-08-04	2014-01-10	Petcare Innovation	ANTISEPTIC COMPOSITION
CZ303722B6 (en) *	2012-01-16	2013-04-03	Contipro Biotech S.R.O.	Tritium-labeled hyaluronic acid, method of labeling hyaluronic acid by tritium and use thereof
US20150011501A1 (en)	2012-02-17	2015-01-08	Kimflexor, S.L.	Partially depolymerized glycosaminoglycan silver and gold salts
FR3002452B1 (en)	2013-02-28	2016-02-12	Dermaconcept Jmc	TOPIC ANTIMICROBIAL DERMATOLOGICAL COMPOSITION
CN112500505A (en) *	2020-11-19	2021-03-16	徐州医科大学	Polymer silver compound and preparation method and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0197718A2 (en) *	1985-04-05	1986-10-15	FIDIA S.p.A.	New medicaments for topical use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4172128A (en) *	1975-03-26	1979-10-23	Erhard Thiele	Process of degrading and regenerating bone and tooth material and products
US4211769A (en) *	1977-08-24	1980-07-08	Takeda Chemical Industries, Ltd.	Preparations for vaginal administration
US4487865A (en) *	1983-12-15	1984-12-11	Biomatrix, Inc.	Polymeric articles modified with hyaluronate
US4605691A (en) *	1984-12-06	1986-08-12	Biomatrix, Inc.	Cross-linked gels of hyaluronic acid and products containing such gels

1987
- 1987-03-13 WO PCT/US1987/000549 patent/WO1987005517A1/en not_active Ceased
- 1987-03-13 AU AU72068/87A patent/AU600483B2/en not_active Ceased
- 1987-03-13 EP EP19870902255 patent/EP0259485A4/en not_active Ceased
- 1987-03-13 CA CA000531936A patent/CA1291123C/en not_active Expired - Fee Related

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0197718A2 (en) *	1985-04-05	1986-10-15	FIDIA S.p.A.	New medicaments for topical use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO8705517A1 *

Also Published As

Publication number	Publication date
WO1987005517A1 (en)	1987-09-24
CA1291123C (en)	1991-10-22
AU600483B2 (en)	1990-08-16
AU7206887A (en)	1987-10-09
EP0259485A1 (en)	1988-03-16

Publication	Publication Date	Title
EP0259485A4 (en)	1988-07-29	Heavy metal salts of hyaluronic acid useful as antimicrobial agents.
IL81877A0 (en)	1987-10-20	Heavy metal salts of hyaluronic acid and their use as antimicrobial agents
IE872696L (en)	1988-04-08	1-tertiary-alkyl-substituted naphthyridine-and¹quinoline-carboxylic acid antibacterial agents
PH25491A (en)	1991-07-24	Substituted basic 2-aminotetralin useful as cardiotonic agents
AU557313B2 (en)	1986-12-18	Aqueous acid metal cleaning composition
AU2371588A (en)	1989-04-20	Conversion coating solution for treating metal surfaces
ZA88342B (en)	1988-07-04	Polymer complexes of metals useful as pharmaceutical agents
GB8705305D0 (en)	1987-04-08	Antimicrobial agents
EP0288519A4 (en)	1992-04-15	1-tertiary-alkyl-substituted naphthyridine- and quinoline-carboxylic acid antibacterial agents
GB2207866B (en)	1991-07-24	Use of metal chelates as mulluscicides
ZA88678B (en)	1988-08-03	Photoactivating additive for polymer compositions,in the form of a metal salt of an oxidized wax
GB8611942D0 (en)	1986-06-25	Preventing steel corrosion
HU912010D0 (en)	1991-12-30	Utilization of macroring amino-phosphonic acid complexes as transformation agents
GB9310859D0 (en)	1993-07-14	Bisdithiophosphoric acid derivatives as lubricant additives
EP0245072A3 (en)	1989-05-10	Nylon containing metal salts
EP0276151A3 (en)	1988-12-14	Dissolved composition of ûbenzo-1,2,4-thiadiazine¨-1,1-dioxide
HUT49271A (en)	1989-09-28	Aqueous biocide composition
AU2320888A (en)	1989-03-31	Hyaluronic acid lubricating compounds
AU610592B2 (en)	1991-05-23	Aqueous alkali metal halogenite compositions
PT83141A (en)	1986-09-01	Process for the preparation of 3,7-disubstituted-3-cephem compounds useful as antimicrobial agents
OA08421A (en)	1988-06-30	A process for the preparation of an azetidine-3-carboxylic acid or salt thereof.
AU1508388A (en)	1988-10-27	Mineral salt tanning agent
GB8702620D0 (en)	1987-03-11	Pf-102 & salt
GB2189501B (en)	1990-01-17	Anti-corrosion composition
GB8812332D0 (en)	1988-06-29	Aqueous halogenite compositions

Legal Events

Date	Code	Title	Description
1988-01-30	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1988-03-16	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE
1988-05-11	17P	Request for examination filed	Effective date: 19880314
1988-09-14	A4	Supplementary search report drawn up and despatched	Effective date: 19880729
1990-02-28	17Q	First examination report despatched	Effective date: 19900112
1991-10-09	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED
1991-11-27	18R	Application refused	Effective date: 19910528
2007-08-08	RIN1	Information on inventor provided before grant (corrected)	Inventor name: NIMROD, ABRAHAM Inventor name: GREENMAN, BENJAMIN