EP0129998A3 - A composition for controlling hemophilia in mammals - Google Patents

A composition for controlling hemophilia in mammals Download PDF

Info

Publication number: EP0129998A3
Authority: EP; European Patent Office
Prior art keywords: mammals; composition; hemophilia; controlling; controlling hemophilia
Prior art date: 1983-06-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

EP84303800A

Other versions

EP0129998A2 (en

EP0129998B1 (en

Inventor

Alan R. Giles

Kenneth G. Mann

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Queens University at Kingston

Original Assignee

Queens University at Kingston

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-06-27

Filing date

1984-06-05

Publication date

1986-11-12

1984-06-05 Application filed by Queens University at Kingston filed Critical Queens University at Kingston

1985-01-02 Publication of EP0129998A2 publication Critical patent/EP0129998A2/en

1986-11-12 Publication of EP0129998A3 publication Critical patent/EP0129998A3/en

1995-09-27 Application granted granted Critical

1995-09-27 Publication of EP0129998B1 publication Critical patent/EP0129998B1/en

2004-06-05 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Hematology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Diabetes (AREA)
Dispersion Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

EP84303800A 1983-06-27 1984-06-05 A composition for controlling hemophilia in mammals Expired - Lifetime EP0129998B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/508,213 US4536392A (en)	1983-06-27	1983-06-27	Method for controlling hemophilia in mammals
US508213		1983-06-27

Publications (3)

Publication Number	Publication Date
EP0129998A2 EP0129998A2 (en)	1985-01-02
EP0129998A3 true EP0129998A3 (en)	1986-11-12
EP0129998B1 EP0129998B1 (en)	1995-09-27

Family

ID=24021827

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP84303800A Expired - Lifetime EP0129998B1 (en)	1983-06-27	1984-06-05	A composition for controlling hemophilia in mammals

Country Status (6)

Country	Link
US (1)	US4536392A (en)
EP (1)	EP0129998B1 (en)
JP (1)	JPH064541B2 (en)
AU (1)	AU568542B2 (en)
CA (1)	CA1223204A (en)
DE (1)	DE3486407T2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4721618A (en) *	1983-06-27	1988-01-26	Queen's University At Kingston	Method for controlling bleeding
DE3625090A1 (en) *	1986-07-24	1988-01-28	Behringwerke Ag	AGENT FOR THE THERAPY FACTOR VIII-RESISTANT HAEMOPHILY A AND METHOD FOR THE PRODUCTION THEREOF
DE4325872C1 (en) *	1993-08-02	1994-08-04	Immuno Ag	Virus inactivated factor Xa preparation
SE0104388D0 (en)	2001-12-27	2001-12-27	Pharmacia Ab	New formulation and use and manufacture thereof
WO2005081870A2 (en) *	2004-02-20	2005-09-09	Isto Technologies, Inc.	Intervertebral disc repair, methods and devices therefor
JP2007091599A (en) *	2005-09-27	2007-04-12	Shino Test Corp	Blood coagulation reaction promoter
EP3590528A1 (en) *	2018-07-06	2020-01-08	Octapharma AG	Fx activation process and its use in the preparation of a fxa composition

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5746921A (en) *	1980-09-02	1982-03-17	Green Cross Corp:The	Oral preparation of human blood coagulation factor
JPS5770814A (en) *	1980-10-17	1982-05-01	Isamu Horikoshi	Oral preparation of blood clotting eighth factor

1983
- 1983-06-27 US US06/508,213 patent/US4536392A/en not_active Expired - Lifetime
1984
- 1984-05-30 CA CA000455424A patent/CA1223204A/en not_active Expired
- 1984-06-05 EP EP84303800A patent/EP0129998B1/en not_active Expired - Lifetime
- 1984-06-05 DE DE3486407T patent/DE3486407T2/en not_active Expired - Fee Related
- 1984-06-12 AU AU29268/84A patent/AU568542B2/en not_active Ceased
- 1984-06-26 JP JP59130204A patent/JPH064541B2/en not_active Expired - Lifetime

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BIOLOGICAL ABSTRACTS, vol. 70, no. 2, 1980, page 780, ref.no. 7436; Philadelphia, (US) M.F. LECOMPTE et al: "Structural dynamics of prothrombin interacting with mixed monolayers of phosphatidylserine and phosphatidylcholine."; & BIOELECTROCHEM BIOENERG. 6(4), 537-542 1979 *
CHEMICAL ABSTRACTS, vol. 82, no. 11, March 17, 1975 page 268, ref.no. 70918x; Columbus, Ohio, (US) CH.T. ESMON et al: "Plausible mechanism for prothrombin activation by factor Xa, factor V, phospholipid, and calcium ions; & J. BIOL. CHEM. 1974, 249(24), 8045-7 *
CHEMICAL ABSTRACTS, vol. 82, no. 11, March 17, 1975, Columbus, Ohio, (US) CH.T. ESMON et al: "Conversion of prothrombin to thrombin. V. Activation of prothrombin by factor Xa in the presence of phospholipid."; & J. BIOL. CHEM. 1974, 249(24), 7798-807 *
CHEMICAL ABSTRACTS, vol. 92, no. 11, November 17, 1980, page 375, ref.no. 91778y; Columbus, Ohio, (US) J. ROSING et al: "The role of phospholipids, and factor Va in the prothrombinase complex."; & J. BIOL. CHEM. 1980, 255(1), 274-83 *
CHEMICAL ABSTRACTS, vol. 92, no. 9, March 3, 1980, page 418, ref.no. 73470n; Columbus, Ohio, (US) C.L. ORTHNER et al: "Activation of human prothrombin: kinetics and regulation."; & VITAM. K METAB. VITAM. K-DEPENDENT PROTEINS, (Proc. Steenbock Symp.) 8th, 1979 (Publ. 1980), 106-9 *
CHEMICAL ABSTRACTS, vol. 96, no. 15, April 12, 1982, page 444, ref.no. 119892q; Columbus, Ohio, (US) A.R. GILES et al: "The coagulantactive phospholipid content is a major determinant of in vivo thrombogenicity of prothrombin complex (factor IX) concentrates in rabbits"; & BLOOD 1982, 59(2), 401-7 *

Also Published As

Publication number	Publication date
JPH064541B2 (en)	1994-01-19
AU2926884A (en)	1985-01-03
DE3486407T2 (en)	1996-03-07
EP0129998A2 (en)	1985-01-02
US4536392A (en)	1985-08-20
AU568542B2 (en)	1988-01-07
DE3486407D1 (en)	1995-11-02
CA1223204A (en)	1987-06-23
EP0129998B1 (en)	1995-09-27
JPS6069027A (en)	1985-04-19

Publication	Publication Date	Title
DE3476068D1 (en)	1989-02-16	Photopolymerizable composition
ZA842864B (en)	1984-11-28	Molding composition
GB8404431D0 (en)	1984-03-28	Taping machine
DE3463985D1 (en)	1987-07-02	A composition for plastic magnets
EP0117493A3 (en)	1987-05-06	Digital controller
GB8422628D0 (en)	1984-10-10	Compositions for vesicles
DE3476809D1 (en)	1989-03-30	Moulding composition
EP0139234A3 (en)	1986-10-01	Resin composition
GB8334423D0 (en)	1984-02-01	Composition
GB8411555D0 (en)	1984-06-13	Controlling cutting machines
EP0131824A3 (en)	1987-04-29	Photopolymerizable composition
EP0136916A3 (en)	1987-02-04	Anthithrombic resin composition
GB8323987D0 (en)	1983-10-12	Work-clamp pallet
DE3474452D1 (en)	1988-11-10	Photopolymerizable composition
DE3475969D1 (en)	1989-02-09	Light-sensitive composition
GB8428358D0 (en)	1984-12-19	Emulsifier composition
EP0135887A3 (en)	1985-05-08	Photocurable composition
EP0129998A3 (en)	1986-11-12	A composition for controlling hemophilia in mammals
GB8334422D0 (en)	1984-02-01	Composition
GB8400676D0 (en)	1984-02-15	Solid resin composition
DE3473291D1 (en)	1988-09-15	Methacrylic resin composition
EP0134039A3 (en)	1986-06-04	Edge-protecting border
DE3470318D1 (en)	1988-05-11	Blowing agents for thermoplastic compositions
GB8422239D0 (en)	1984-10-10	Termite controlling composition
DE3479897D1 (en)	1989-11-02	Resin composition

Legal Events

Date	Code	Title	Description
1984-11-02	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1985-01-02	AK	Designated contracting states	Designated state(s): CH DE FR GB IT LI SE
1986-09-22	PUAL	Search report despatched	Free format text: ORIGINAL CODE: 0009013
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1987-06-24	17P	Request for examination filed	Effective date: 19870424
1988-12-14	17Q	First examination report despatched	Effective date: 19881027
1995-07-12	ITF	It: translation for a ep patent filed
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1996-09-18	26N	No opposition filed
1997-05-28	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: SE Payment date: 19970528 Year of fee payment: 14
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