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EP0189322A3 - Enzymatic synthesis of s-adenosylmethionine - Google Patents

Enzymatic synthesis of s-adenosylmethionine Download PDF

Info

Publication number
EP0189322A3
EP0189322A3 EP86300448A EP86300448A EP0189322A3 EP 0189322 A3 EP0189322 A3 EP 0189322A3 EP 86300448 A EP86300448 A EP 86300448A EP 86300448 A EP86300448 A EP 86300448A EP 0189322 A3 EP0189322 A3 EP 0189322A3
Authority
EP
European Patent Office
Prior art keywords
adenosylmethionine
enzymatic synthesis
adenosyltrans
radioenzymatic
ferase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP86300448A
Other languages
German (de)
French (fr)
Other versions
EP0189322A2 (en
Inventor
Ronald Reed Bowsher
David Patterson Ii Henry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of EP0189322A2 publication Critical patent/EP0189322A2/en
Publication of EP0189322A3 publication Critical patent/EP0189322A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The present invention provides an improved process for enzymatically preparing purified S-adenosylmethionine em­ ploying substantially purified methionine adenosyltrans­ ferase as the enzyme catalyst. The S-adenosylmethionine thus prepared is ideally suited for use in radioenzymatic as­ says.
EP86300448A 1985-01-25 1986-01-23 Enzymatic synthesis of s-adenosylmethionine Withdrawn EP0189322A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69504085A 1985-01-25 1985-01-25
US695040 1985-01-25

Publications (2)

Publication Number Publication Date
EP0189322A2 EP0189322A2 (en) 1986-07-30
EP0189322A3 true EP0189322A3 (en) 1986-10-08

Family

ID=24791308

Family Applications (1)

Application Number Title Priority Date Filing Date
EP86300448A Withdrawn EP0189322A3 (en) 1985-01-25 1986-01-23 Enzymatic synthesis of s-adenosylmethionine

Country Status (2)

Country Link
EP (1) EP0189322A3 (en)
JP (1) JPS61227792A (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6312920B1 (en) 1996-11-13 2001-11-06 Eli Lilly And Company SAM operon
WO2007083631A1 (en) 2006-01-17 2007-07-26 Mitsubishi Gas Chemical Company, Inc. Method of stabilizing s-adenosyl-l-methionine and stabilized composition
CN101437935B (en) 2006-05-16 2012-06-20 三菱瓦斯化学株式会社 Method of producing s-adenosyl-l-methionine-containing dry yeast having excellent storage stability, the product thereof and composition for oral intake
JP2008013509A (en) * 2006-07-07 2008-01-24 Fujifilm Corp Method for preserving S-adenosylmethionine
CA2675970C (en) 2007-01-25 2016-01-05 Mitsubishi Gas Chemical Company, Inc. Method for production of dry yeast containing s-adenosyl-l-methionine and having excellent storage stability, product produced by the method, and molded composition of the dry yeast
WO2013151975A1 (en) * 2012-04-02 2013-10-10 Northeastern University Compositions and methods for the inhibition of methyltransferases
CN120594719B (en) * 2025-08-08 2025-11-25 杭州煌森生物科技有限公司 A method for the separation and detection of components in a S-adenosylmethionine disulfate preparation.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4028183A (en) * 1973-06-27 1977-06-07 Bioresearch Limited Process of preparing double salts of S-adenosyl-L-methionine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4028183A (en) * 1973-06-27 1977-06-07 Bioresearch Limited Process of preparing double salts of S-adenosyl-L-methionine

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 100, no. 17, 23th April 1984, page 237, abstract no. 63874s, Columbus, Ohio, US; J.L. HOFFMAN: "Fractionation of methionine adenosyltransferase isozymes (rat liver)", & METHODS ENZYMOL 1983, 94(Polyamines), 223-8 *
CHEMICAL ABSTRACTS, vol. 100, no. 9, 27th February 1984, page 327, abstract no. 135336t, Columbus, Ohio, US; A. GROSS et al.: "Enzymic synthesis of S-adenosyl-L-methionine from L-methionine and ATP", & APPL. BIOCHEM. BIOTECHNOL. 1983, 8(5), 415-22 *
CHEMICAL ABSTRACTS, vol. 96, no. 15, 12th April 1982, page 320, abstract no. 118506e, Columbus, Ohio, US; & JP - A - 81 145 299 (KANEGAFUCHI CHEMICAL INDUSTRY CO. LTD.) 11-11-1981 *

Also Published As

Publication number Publication date
EP0189322A2 (en) 1986-07-30
JPS61227792A (en) 1986-10-09

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Inventor name: HENRY, DAVID PATTERSON, II

Inventor name: BOWSHER, RONALD REED