EP0166439A3 - 4h-pyrimidoû2,1-a¨isoquinolin-4-one derivatives - Google Patents

4h-pyrimidoû2,1-a¨isoquinolin-4-one derivatives Download PDF

Info

Publication number: EP0166439A3
Authority: EP; European Patent Office
Prior art keywords: isoquinolin; derivatives
Prior art date: 1984-06-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

EP85107949A

Other versions

EP0166439B1 (en

EP0166439A2 (en

Inventor

Arthur Lee Campbell

Suzanne Evans-Radak

Melanie Jane Loots

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

GD Searle LLC

Original Assignee

GD Searle LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-06-27

Filing date

1985-06-27

Publication date

1987-05-20

1985-06-27 Application filed by GD Searle LLC filed Critical GD Searle LLC

1986-01-02 Publication of EP0166439A2 publication Critical patent/EP0166439A2/en

1987-05-20 Publication of EP0166439A3 publication Critical patent/EP0166439A3/en

1990-05-09 Application granted granted Critical

1990-05-09 Publication of EP0166439B1 publication Critical patent/EP0166439B1/en

2005-06-27 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Toxicology (AREA)
Child & Adolescent Psychology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

EP85107949A 1984-06-27 1985-06-27 4H-pyrimido[2,1-a]isoquinolin-4-one derivatives Expired - Lifetime EP0166439B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/625,061 US4661592A (en)	1984-06-27	1984-06-27	4H-pyrimido[2,1-a]isoquinolin-4-one derivatives
US625061		1984-06-27

Publications (3)

Publication Number	Publication Date
EP0166439A2 EP0166439A2 (en)	1986-01-02
EP0166439A3 true EP0166439A3 (en)	1987-05-20
EP0166439B1 EP0166439B1 (en)	1990-05-09

Family

ID=24504413

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP85107949A Expired - Lifetime EP0166439B1 (en)	1984-06-27	1985-06-27	4H-pyrimido[2,1-a]isoquinolin-4-one derivatives

Country Status (7)

Country	Link
US (1)	US4661592A (en)
EP (1)	EP0166439B1 (en)
JP (1)	JPS6124593A (en)
AU (1)	AU4417985A (en)
DE (1)	DE3577559D1 (en)
ES (2)	ES8703872A1 (en)
ZA (1)	ZA854877B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NO162019C (en) *	1983-11-23	1989-10-25	Fujisawa Pharmaceutical Co	ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PYRIMIDOISKINOLIN DERIVATIVES.
JPH0619904Y2 (en) *	1988-09-16	1994-05-25	株式会社クボタ	Pipe fitting
JPH0726632Y2 (en) *	1990-09-28	1995-06-14	徳厚小島	Pipe fitting
WO2008148074A2 (en) *	2007-05-24	2008-12-04	Research Foundation Of State University Of New York	Inhibitors of mtor and methods of treatment using same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4127720A (en) *	1977-09-21	1978-11-28	Bristol-Myers Company	Pyrimido[2,1-a]isoquinoline derivatives having antiallergy activity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU168014B (en) *	1973-03-30	1976-02-28
US4348396A (en) *	1978-01-23	1982-09-07	Hoffmann-La Roche Inc.	Substituted 11-oxo-11H-pyrido[2,1-b]quinazolines and method of inhibiting allergic reactions with them
NO162019C (en) *	1983-11-23	1989-10-25	Fujisawa Pharmaceutical Co	ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PYRIMIDOISKINOLIN DERIVATIVES.

1984
- 1984-06-27 US US06/625,061 patent/US4661592A/en not_active Expired - Fee Related
1985
- 1985-06-26 ES ES544581A patent/ES8703872A1/en not_active Expired
- 1985-06-26 JP JP13809485A patent/JPS6124593A/en active Pending
- 1985-06-26 AU AU44179/85A patent/AU4417985A/en not_active Abandoned
- 1985-06-27 EP EP85107949A patent/EP0166439B1/en not_active Expired - Lifetime
- 1985-06-27 ZA ZA854877A patent/ZA854877B/en unknown
- 1985-06-27 DE DE8585107949T patent/DE3577559D1/en not_active Expired - Fee Related
1986
- 1986-10-31 ES ES557171A patent/ES8801267A1/en not_active Expired

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4127720A (en) *	1977-09-21	1978-11-28	Bristol-Myers Company	Pyrimido[2,1-a]isoquinoline derivatives having antiallergy activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 102, no. 13, 1st April 1985, page 718, abstract no. 113529x, Columbus, Ohio, US; & JP-A-59 172 490 (FUJISAWA PHARMACEUTICAL CO., LTD) 29-09-1984 *

Also Published As

Publication number	Publication date
AU4417985A (en)	1986-01-02
ES8801267A1 (en)	1988-01-01
ES8703872A1 (en)	1987-03-01
ES544581A0 (en)	1987-03-01
JPS6124593A (en)	1986-02-03
ES557171A0 (en)	1988-01-01
EP0166439B1 (en)	1990-05-09
ZA854877B (en)	1986-08-27
US4661592A (en)	1987-04-28
DE3577559D1 (en)	1990-06-13
EP0166439A2 (en)	1986-01-02

Publication	Publication Date	Title
IL80463A (en)	1988-07-31	2-desoxy-2,2-difluoro-furanose derivatives
GB2152033B (en)	1987-11-18	Sulfonamido-benzamide derivatives
GB2155925B (en)	1987-11-25	Pyrimidylpiperazine derivatives
EP0163324A3 (en)	1986-11-12	Aminoalkylphenoxy derivatives
GB2164644B (en)	1988-04-27	Benzonorbornene derivatives
ZA851281B (en)	1985-11-27	Pyrazolopyridine derivatives
EP0159856A3 (en)	1986-03-19	9a-aza-9a-homoerythromycin derivatives
ZA851279B (en)	1986-05-28	Pyrazolopyridine derivatives
DE3574380D1 (en)	1989-12-28	1,8-naphthyridine derivatives
DE3675784D1 (en)	1991-01-10	Photochromische 3-pyrryl-fulgide und fulgimide.
NZ214823A (en)	1989-08-29	2-substituted-3,4-dihydroxyphenethylamino derivatives
GB2159814B (en)	1987-09-16	Iminothiazolidine derivatives
EP0166439A3 (en)	1987-05-20	4h-pyrimidoû2,1-a¨isoquinolin-4-one derivatives
GB2165845B (en)	1988-01-06	Dioxinopyridine derivatives
GB8505028D0 (en)	1985-03-27	3-exomethylenecepham derivatives
GB2165247B (en)	1988-08-10	Azabicycloheptene derivatives
GB2162178B (en)	1988-03-23	4-cyano-3-oxo-hexahydro-isoquinoline derivatives
GB8507660D0 (en)	1985-05-01	Thiatriazine derivatives
EP0174271A3 (en)	1989-03-29	Anthraceme derivatives
GB2158066B (en)	1988-04-07	Apovincaminol derivatives
GB8503123D0 (en)	1985-03-13	Phenylpropargylamine derivatives
GB8422379D0 (en)	1984-10-10	Derivatives
GB2169290B (en)	1988-03-30	Pyrone -3- carboxamide derivatives
IE850147L (en)	1985-07-25	Pyrazolopyridine derivatives
GB8401010D0 (en)	1984-02-15	Thioketene derivatives

Legal Events

Date	Code	Title	Description
1985-11-01	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1986-01-02	AK	Designated contracting states	Designated state(s): BE CH DE FR GB IT LI NL SE
1987-03-30	PUAL	Search report despatched	Free format text: ORIGINAL CODE: 0009013
1987-05-20	AK	Designated contracting states	Kind code of ref document: A3 Designated state(s): BE CH DE FR GB IT LI NL SE
1987-12-23	17P	Request for examination filed	Effective date: 19871026
1989-03-29	17Q	First examination report despatched	Effective date: 19890209
1990-03-24	GRAA	(expected) grant	Free format text: ORIGINAL CODE: 0009210
1990-03-30	ITF	It: translation for a ep patent filed
1990-05-09	AK	Designated contracting states	Kind code of ref document: B1 Designated state(s): BE CH DE FR GB IT LI NL SE
1990-05-09	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: SE Effective date: 19900509 Ref country code: NL Effective date: 19900509 Ref country code: LI Effective date: 19900509 Ref country code: CH Effective date: 19900509 Ref country code: BE Effective date: 19900509
1990-06-08	ET	Fr: translation filed
1990-06-13	REF	Corresponds to:	Ref document number: 3577559 Country of ref document: DE Date of ref document: 19900613
1990-08-22	R20	Corrections of a patent specification	Effective date: 19900618
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1990-10-16	NLV1	Nl: lapsed or annulled due to failure to fulfill the requirements of art. 29p and 29m of the patents act
1991-03-07	PLBE	No opposition filed within time limit	Free format text: ORIGINAL CODE: 0009261
1991-03-07	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT
1991-04-24	26N	No opposition filed
1991-05-23	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: FR Payment date: 19910523 Year of fee payment: 7 Ref country code: DE Payment date: 19910523 Year of fee payment: 7
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1993-02-24	GBPC	Gb: european patent ceased through non-payment of renewal fee	Effective date: 19920627
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