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EP0009865A1 - Process for the stereoselective synthesis of the E isomer of aryl alkyl oximes - Google Patents

Process for the stereoselective synthesis of the E isomer of aryl alkyl oximes Download PDF

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Publication number
EP0009865A1
EP0009865A1 EP79301528A EP79301528A EP0009865A1 EP 0009865 A1 EP0009865 A1 EP 0009865A1 EP 79301528 A EP79301528 A EP 79301528A EP 79301528 A EP79301528 A EP 79301528A EP 0009865 A1 EP0009865 A1 EP 0009865A1
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Prior art keywords
isomer
ketoxime
aryl alkyl
isopropyl
anhydrous
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EP79301528A
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German (de)
French (fr)
Inventor
Jill Helaine Paul
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Bayer CropScience Inc USA
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Rhone Poulenc Industries SA
Rhone Poulenc Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/02—Seven-membered rings
    • C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms

Definitions

  • This invention relates to a process for the conversion of mixtures of E and Z isomers of certain ketoximes to 98% or greater pure E isomer.
  • This invention provides a process for producing 98% or greater pure E isomer of an aryl alkyl ketoxime having the formula: wherein Ar is phenyl; phenyl substituted in the 2- to 6- position with 1-5 halogen (Cl, Br, F, I), C 1 - C 4 alkyl, C l - C 4 alkoxy, C l - C 4 alkylthio, methylenedioxy, ethylenedioxy, isopropylenedioxy, trifluoromethyl, C l -C 4 haloalkyl, C 1 - C 4 alkylthioalkyl, C 2 - C 4 alkenyl, C 2 - C 4 alkynyl, cyano, C 2 - C 4 cyanoalkyl, C 2 - C 4 carboalkoxy, C 1 - C 4 alkylsulfonyl, C 2 - C 8 alkoxyalkyl, C 2 - C 4 haloalkenyl,
  • aryl alkyl ketoximes treated in accordance with this invention include:
  • mixtures of E and Z isomers of the aryl alkyl ketoximes are precipitated as the E isomer immonium complex by treating a solution of the mixture in an anhydrous solvent with anhydrous protic or Lewis-acids. It has been found that, unexpectedly, the E isomer in the mixture is preciptated as an immonium salt and the Z isomer isomerizes to the E isomer. Upon neutralization about 98% of the original mixture of isomers is recovered in the form of E isomer.
  • the organic solvent used can be any of the well known solvents used in organic synthesis operations, so long as the solvent is anhydrous.
  • Typical utilizable anhydrous organic solvents include hydrocarbons, such as hexane, cyclohexane, toluene, and xylene; chlorinated hydrocarbons, such as chloroform and carbon tetrachloride; ethers, such as diethyl ether, tetrahydrofuran and dioxane; and ketones, such as acetone and 2-butanone.
  • the amount of solvent used is not a critical factor, as it simply serves as a medium for the acid treatment. In general, between about one part and about 10 parts solvent per part aryl alkyl ketoxime can be used.
  • the acid used to precipitate the immonium salt of the aryl alkyl ketoxime will be an anhydrous organic or inorganic protic or Lewis acid.
  • Typical acids include Lewis acids, such as boron trifluoride and aluminum chloride; mineral acids, such as sulfuric acid, orthophosphoric acid and polyphosphoric acids; hydrogen halide acids, such as hydrobromic acid and hydrochloric acid.
  • HC1 and BF 3 are preferred because they are gases and easily handled. At least a stoichiometric amount of .the acid must be used, although an excess over the stoichiometric up to the point of saturation of the ketoxime solution is not detrimental.
  • the reaction of the aryl alkyl ketoxime with the acid to form the immonium complex or salt can be carried out at temperatures between about -20°C. and about 150°C., although temperatures between about 10°C. and about 40 o C. are preferred. The reaction is carried out until precipitation is complete, usually within one hour.
  • the solid immonium complex is isolated, as by filtration, and washed with solvent, preferably the same as used in the initial solution. Then, the E ketoxime isomer immonium complex is neutralized to obtain the free E ketoxime. Neutralization is readily carried out using dilute aqueous solutions of alkali metal salts, particularly Na and K, of weakly ionized organic acids, such as carbonic acid and oxalic acid, e.g., sodium carbonate, potassium carbonate, sodium bicarbonate, sodium oxalate, and potassium oxalate. In general, the concentration of the aqueous solution can be between 10 weight per cent and 15 weight per cent and usually 10 weight per cent. A large excess of the aqueous solution is used, in the order of 3 parts per part immonium complex.
  • alkali metal salts particularly Na and K
  • weakly ionized organic acids such as carbonic acid and oxalic acid
  • the concentration of the aqueous solution can be between 10 weight per cent and
  • the aryl alkyl ketoximes are prepared from aryl alkyl ketones and excess hydroxylamine hydrochloride in the presence of a base, in a manner familiar to those skilled in the art. In practice, the aryl alkyl ketoximes usually are obtained as a mixture of E and Z isomers.
  • the ketoximes are precursors for preparing active insecticides by converting them to ketoximinoethers for example, by reacting the sodium ketoximate with substituted alkyl bromides, such as m-phenoxybenzylbromide.
  • ketoxime ratios are ascertained using two corroborative methods: (1) comparison of the E/Z isomer ratio of the thermally stable trimethyl silyl derivative of the oxime before and after acid (HC1) treatment, by gas chromatograph analysis and (2) comparison of the relative integration in the H 1 HMR of the separate resonances for the E and Z isopropyl methine protons, before and after the acid (HC1) treatment.
  • the E stereochemistry was concluded from both H l and C13 chemical shift data. References: J. Am. Chem. Soc. 86, 4373 (1964); Tet. 23, 1079-1095 (1967); J. Am. Chem. Soc. 94, 4897 (1972); J.O.C. 39(8), 1017 (1974).
  • a 60:40 E/Z isomeric mixture of p-chloro- isobutyrophenone oxime (151g., 0.76m) was dissolved in 50.0 ml of anhydrous diethyl ether. The solution was saturated with anhydrous HC1, whereupon a voluminous amount of pure E oxime hydrochloride precipitated. The solid was filtered and washed well with dry ether. The dried hydrochloride salt was then added in portions to a vigorously stirring solution of 2500 ml. of 10% Na 2 C0 3 . The free oxime was filtered; washed with H 2 0 until washings were neutral,, and dried, under reduced pressure to yield 145g. of 98% E p-chlorophenyl isopropyl ketoxime.
  • Example 6 is a typical illustration of a sterospecific synthesis of an insecticidally active ketoximinoether using the E oxime of Example 1.

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Mixtures of the E and Z isomers of aryl alkyl oximes are converted to 98% or greater E isomer by a process comprising treating a solution of a mixture of E and Z isomers in an organic solvent with a protic or Lewis acid, under anhydrous conditions, to precipitate >98% pure E isomer of an immonium complex and neutralizing the precipitate with an excess of dilute organic/inorganic base, such as Na2CO3 or NaHCO3. The E isomer of the ketoxime is precursor for highly insecticidal ketoximinoethers.

Description

  • This invention relates to a process for the conversion of mixtures of E and Z isomers of certain ketoximes to 98% or greater pure E isomer.
  • The isomerization of E aromatic aldoximes to Z aldoximes via the hydrochloride salt has been described in Ann. 260, 63 (1890). For example, the E isomer of p-chlorobenzaldoxime (I) was converted to the Z isomer III by saturating an ether solution of the E aldoxime with dry HC1 and treating the resultant precipitate with sodium carbonate:
    Figure imgb0001
  • Hauser and Hoffenberg have reported, in J.O.C.-20, 1941 (1955), such isomerization utilizing the Lewis acid, BF3.. A benzene solution of the E isomer of p-chlorobenzaldoxime (I) is treated with BF3 to form a BF3 complex (IV) which is treated with NaHC03 solution to obtain the Z isomer (V).
    Figure imgb0002
  • As reported in J. Med. Chem. 20, No. 9, 1199. (1977) the E isomer of an oximinoether (VI) in diethyl ether was treated with anhydrous HC1. A precipitate was isolated and suspended in water and extracted with ether to yield 37% of the Z isomer VII.
    Figure imgb0003
  • It is the surprising discovery of this invention that, contrary to the teaching of the prior art, mixtures of the E and isomers of aryl alkyl ketoximes, as contrasted to aldoximes, are converted to 98% E isomer.
  • This invention provides a process for producing 98% or greater pure E isomer of an aryl alkyl ketoxime having the formula:
    Figure imgb0004
    wherein Ar is phenyl; phenyl substituted in the 2- to 6- position with 1-5 halogen (Cl, Br, F, I), C1 - C4 alkyl, Cl - C4 alkoxy, Cl - C4 alkylthio, methylenedioxy, ethylenedioxy, isopropylenedioxy, trifluoromethyl, Cl-C4 haloalkyl, C1 - C4 alkylthioalkyl, C2 - C4 alkenyl, C2 - C4 alkynyl, cyano, C2 - C4 cyanoalkyl, C2 - C4 carboalkoxy, C1 - C4 alkylsulfonyl, C2 - C8 alkoxyalkyl, C2 - C4 haloalkenyl, or C1 - C4 acyl; indanyl; naphthyl; benzofuryl; benzodihydrofuryl; benzothienyl; thienyl; R is C2 - C6 alkyl, C3 - C6 cycloalkyl, or C2 - C6 alkenyl, any of which can be substituted by halogen, hydroxy,
    C1 - C4 alkoxy, C1 - C4 alkylsulfonyl, cyano, nitro, C2 - C4 carboalkoxy, or C1 - C4 acyl which comprises contacting a solution of mixed E and Z isomers of the aryl alkyl ketoxime in an anhydrous organic solvent with at least a stoichiometric amount of anhydrous protic or Lewis acid at between -20oC. and 150°C, thereby precipitating the E isomer of an immonium complex of the aryl alkyl ketoxime, separating the precipitate, neutralizing the precipitate with an excess of dilute aqueous Na2C03 or NaHC03, and separating the E 'isomer.
  • In addition to the ketoximes set forth in the specific examples, non-limiting examples of aryl alkyl ketoximes treated in accordance with this invention include:
    • p-trifluoromethylisobutyrophenone oxime;
    • p-methylthioisobutyrophenone oxime;
    • 3,4-methylenedioxy phenyl propiophenone;
    • 2,4-dichloroisobutyrophenone oxime;
    • p-cyanoisobutyrophenone oxime;
    • 4-(α,α-dichloroethenyl) isobutyrophenone oxime;
    • p-ethynylisobutyrophenone oxime;
    • m-carbomethoxyisobutyrophenone oxime;
    • p-methylsulfonylpropiophenone oxime;
    • p-chloromethylpropiophenone oxime;
    • 2-(5-nitrothienyl) isopropyl ketoxime;
    • 2-(4-chloro-5-bromomethylthienyl) isopropyl ketoxime;
    • 2-(5-ethoxythienyl) isopropyl ketoxime;
    • 2-(4-chlorothienyl) isopropyl ketoxime;
    • 4-chlorophenyl cyclobutyl ketoxime;
    • 4-chlorophenyl cyclohexyl ketoxime;
    • 3,4,5-trichloroisobutyrophenone oxime;
    • 3,4-dichloroisobutyrophenone oxime;
    • 2,4,5-trichloroisobutyrophenone oxime 3-chloro-4-bromoisobutyrophenone oxime; and
    • 4-benzothienyl isopropyl ketoxime.
  • In accordance with this.invention, mixtures of E and Z isomers of the aryl alkyl ketoximes are precipitated as the E isomer immonium complex by treating a solution of the mixture in an anhydrous solvent with anhydrous protic or Lewis-acids. It has been found that, unexpectedly, the E isomer in the mixture is preciptated as an immonium salt and the Z isomer isomerizes to the E isomer. Upon neutralization about 98% of the original mixture of isomers is recovered in the form of E isomer.
  • The organic solvent used can be any of the well known solvents used in organic synthesis operations, so long as the solvent is anhydrous. Typical utilizable anhydrous organic solvents include hydrocarbons, such as hexane, cyclohexane, toluene, and xylene; chlorinated hydrocarbons, such as chloroform and carbon tetrachloride; ethers, such as diethyl ether, tetrahydrofuran and dioxane; and ketones, such as acetone and 2-butanone. The amount of solvent used is not a critical factor, as it simply serves as a medium for the acid treatment. In general, between about one part and about 10 parts solvent per part aryl alkyl ketoxime can be used.
  • The acid used to precipitate the immonium salt of the aryl alkyl ketoxime will be an anhydrous organic or inorganic protic or Lewis acid. Typical acids include Lewis acids, such as boron trifluoride and aluminum chloride; mineral acids, such as sulfuric acid, orthophosphoric acid and polyphosphoric acids; hydrogen halide acids, such as hydrobromic acid and hydrochloric acid. HC1 and BF3 are preferred because they are gases and easily handled. At least a stoichiometric amount of .the acid must be used, although an excess over the stoichiometric up to the point of saturation of the ketoxime solution is not detrimental.
  • The reaction of the aryl alkyl ketoxime with the acid to form the immonium complex or salt can be carried out at temperatures between about -20°C. and about 150°C., although temperatures between about 10°C. and about 40oC. are preferred. The reaction is carried out until precipitation is complete, usually within one hour.
  • After the reaction is complete, the solid immonium complex is isolated, as by filtration, and washed with solvent, preferably the same as used in the initial solution. Then, the E ketoxime isomer immonium complex is neutralized to obtain the free E ketoxime. Neutralization is readily carried out using dilute aqueous solutions of alkali metal salts, particularly Na and K, of weakly ionized organic acids, such as carbonic acid and oxalic acid, e.g., sodium carbonate, potassium carbonate, sodium bicarbonate, sodium oxalate, and potassium oxalate. In general, the concentration of the aqueous solution can be between 10 weight per cent and 15 weight per cent and usually 10 weight per cent. A large excess of the aqueous solution is used, in the order of 3 parts per part immonium complex.
  • The aryl alkyl ketoximes are prepared from aryl alkyl ketones and excess hydroxylamine hydrochloride in the presence of a base, in a manner familiar to those skilled in the art. In practice, the aryl alkyl ketoximes usually are obtained as a mixture of E and Z isomers. The ketoximes are precursors for preparing active insecticides by converting them to ketoximinoethers for example, by reacting the sodium ketoximate with substituted alkyl bromides, such as m-phenoxybenzylbromide. These insecticidal compounds have the general structure:
    Figure imgb0005
  • Because of the oximino function, the existence of both E and Z geometrical isomers of the ketoximinoethers is possible. Indeed, a mixture of both isomers is obtained when the starting ketoxime is itself a mixture of geometrical isomers. It has been found, however, that the overall insecticidal activity of the E isomer of the ketoximinoether is superior to that of the Z isomer. It has also been found that the E isomer of the ketoxime can be converted to the E isomer of the ketoximinoether with complete retention of stereochemistry. Accordingly, the process of this invention to convert mixtures of E and Z isomers of the ketoxime to the E isomer is highly desirable and significant.
  • The following examples demonstrate the process of this invention and the conversion of the resultant E ketoximes to the oximinoethers. In the Examples, the ketoxime ratios are ascertained using two corroborative methods: (1) comparison of the E/Z isomer ratio of the thermally stable trimethyl silyl derivative of the oxime before and after acid (HC1) treatment, by gas chromatograph analysis and (2) comparison of the relative integration in the H1 HMR of the separate resonances for the E and Z isopropyl methine protons, before and after the acid (HC1) treatment. The E stereochemistry was concluded from both Hl and C13 chemical shift data. References: J. Am. Chem. Soc. 86, 4373 (1964); Tet. 23, 1079-1095 (1967); J. Am. Chem. Soc. 94, 4897 (1972); J.O.C. 39(8), 1017 (1974).
    • Example 1
  • A 60:40 E/Z isomeric mixture of p-chloro- isobutyrophenone oxime (151g., 0.76m) was dissolved in 50.0 ml of anhydrous diethyl ether. The solution was saturated with anhydrous HC1, whereupon a voluminous amount of pure E oxime hydrochloride precipitated. The solid was filtered and washed well with dry ether. The dried hydrochloride salt was then added in portions to a vigorously stirring solution of 2500 ml. of 10% Na2C03. The free oxime was filtered; washed with H20 until washings were neutral,, and dried, under reduced pressure to yield 145g. of 98% E p-chlorophenyl isopropyl ketoxime.
    • Example 2
  • A 50:50 isomeric mixture of p-bromoisobutyro- phenone oxime was isomerized to >98% E oxime via the procedure of Example 1.
    • Example 3
  • An 80:20 E/Z isomeric mixture of 3-methyl, 4- ethoxyisobutyrophenone oxime was isomerized to >98% E oxime via the procedure of Example 1.
    • Example 4
  • A 50;50 E/Z isomeric mixture of 3,4 indanyl, isopropyl ketoxime was isomerized to >98% E oxime via the procedure of Example 1.
    • Example 5
  • A 70:30 E/Z mixture of p-chlorophenyl cyclopropyl ketoxime was isomerized to >98% E isomer via the procedure of Example 1.
  • Example 6 is a typical illustration of a sterospecific synthesis of an insecticidally active ketoximinoether using the E oxime of Example 1.
    • Example 6
  • A solution of 0.02 mole of >98% E p-chloro- isobutyrophenone oxime in 20 ml. of ethanol was added to a freshly prepared ethanolic.solution of 0.02 mole NaOEt. The mixture was stirred at room temperature for 30 minutes and concentrated under reduced pressure to dryness. The resulting sodium oximate salt was dissolved in a minimum volume of DMP; whereupon 0.02 mole of m-phenoxybenzyl bromide was added dropwise, causing an exotherm of 80..
  • The reaction mixture was stirred overnight at room temperature and poured into H20. The resulting oil was extracted two times into toluene. The combined organic layers were washed twice with H20, dried over MgSO4; and concentrated under reduced pressure to yield 0.019 mole of >98% E-1-(4-chloropheny)-2-methyl 1-propanone, 0-(3-phenoxyphenyl) methyl oxime.
    • Example 7
  • The >98% E isomer of 1-(4-bromophenyl)-2-methyl 1-propanone, 0-(3-phenoxyphenyl) methyl oxime was prepared via the procedure of Example 6.
    • Example 8
  • The >98% E isomer of 1-(3-methyl, 4-ethoxyphenyl)- 2-methyl 1 propanone, 0-(3-phenoxyhenyl) methyl oxime was prepared via the procedure of Example 6.
    • Example 9
  • The >98% E isomer of 1-(2,3-dihydro-1H-indenyl 5-yl)-2-methyl-1-propanone, 0-(3-phenoxyphenyl) methyl oxime was prepared via the procedure of Example 6.
    • Example 10
  • The 98% E isomer of cyclopropyl (p-chlorophenyl) methanone, 0-(3-phenoxyphenyl) methyl oxime was prepared via the procedure of Example 6.

Claims (7)

1. A process for producing 98% or greater pure E isomer of an aryl alkyl ketoxime having the formula:
Figure imgb0006
wherein Ar is phenyl; phenyl substituted in the 2- to 6- position with 1-5 halogen (Cl, Br, F, I), C1 - C4 alkyl, Cl - C4 alkoxy, C1 - C4 alkylthio, methylenedioxy, ethylenedioxy, isopropylenedioxy, trifluoromethyl, C1 -C4 haloalkyl, C1 - C4 alkylthioalkyl, C2 - C4 alkenyl, C2 - C4 alkynyl, cyano, C2 - C4 cyanoalkyl; C2 - C4 carboalkoxy, C1 - C4 alkylsulfonyl; C2 - C8 alkoxyalkyl, C2 - C4 haloalkenyl, or C1 - C4 acyl; indanyl; naphthyl; benzofuryl; benzodihydrofuryl; benzothienyl; thienyl; R is C2 - C6 alkyl, C3 - C6 cycloalkyl, or C2 - C6 alkenyl, any of which can be substituted by halogen, hydroxy, C1 - C4 alkoxy, C1 - C4 alkylsulfonyl, cyano, nitro, C2 - C4 carboalkoxy, or C1 - C4 acyl which comprises contacting a solution of mixed E and Z isomers of the aryl alkyl ketoxime in an anhydrous organic solvent with at least a stoichiometric amount of anhydrous protic or Lewis acid at between -20°C and 150°C, thereby precipitating the E isomer of an immonium complex of the aryl alkyl ketoxime, separating the precipitate, neutralizing the precipitate with an excess of dilute aqueous Na2C03 or NaHCO3, and separating the E isomer.
.2. The process of Claim 1, wherein the solvent is anhydrous diethyl ether, the temperature is between 10°C and 40°C and the protic acid is anhydrous HC1.
3. The process of Claim 1 or 2, wherein Ar is p- chlorophenyl and R is isopropyl.
4. The process of Claim 1 or 2, wherein Ar is p- bromophenyl and R is isopropyl.
5. The process of Claim 1 or 2, wherein Ar is 3-methyl-4-ethoxyphenyl and R is isopropyl.
6. The process of Claim 1 or 2, wherein Ar is 3,4-indanyl and R is isopropyl.
7. The process of Claim 1 or 2, wherein Ar is p-chlorophenyl and R is cyclopropyl.
EP79301528A 1978-08-16 1979-07-31 Process for the stereoselective synthesis of the E isomer of aryl alkyl oximes Withdrawn EP0009865A1 (en)

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EP0596692A3 (en) * 1992-11-02 1995-03-08 Shionogi & Co Process for the preparation of (E) -alkoximino or hydroxyiminoacetamide compounds and intermediates.
US5627284A (en) * 1992-11-02 1997-05-06 Shionogi & Co., Ltd. Process for producing (E)-alkoxyimino or hydroxyiminoacetamide compounds and intermediates therefor
US6670382B2 (en) 2000-06-15 2003-12-30 Taisho Pharmaceutical Co., Ltd. Hydroxyformamidine derivatives and medicines containing the same
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US5442063A (en) * 1992-11-02 1995-08-15 Shionogi & Co., Ltd. Process for producing (E)-alkoxyimino or hydroxyimino-acetamide compounds and intermediates therefor
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CN103497129A (en) * 2013-09-05 2014-01-08 湖南海利化工股份有限公司 Preparation method for trans-sufluoxime
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CN109996793B (en) * 2017-02-08 2022-02-25 日产化学株式会社 Process for producing geometric isomer of oxime compound
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US4158015A (en) 1979-06-12
ZA794299B (en) 1981-03-25

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