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EP0000541A3 - 1h-pyrimido-(4,5-c)-1,2-diazepines, methods for their preparation and compositions containing them; their use as intermediates for heterocyclic transformations. - Google Patents

1h-pyrimido-(4,5-c)-1,2-diazepines, methods for their preparation and compositions containing them; their use as intermediates for heterocyclic transformations. Download PDF

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Publication number
EP0000541A3
EP0000541A3 EP78100435A EP78100435A EP0000541A3 EP 0000541 A3 EP0000541 A3 EP 0000541A3 EP 78100435 A EP78100435 A EP 78100435A EP 78100435 A EP78100435 A EP 78100435A EP 0000541 A3 EP0000541 A3 EP 0000541A3
Authority
EP
European Patent Office
Prior art keywords
diazepines
pyrimido
transformations
intermediates
heterocyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP78100435A
Other versions
EP0000541A2 (en
EP0000541B1 (en
Inventor
Robert William Morrison Jr.
William Revill Mallory
Virgil Lee Styles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of EP0000541A2 publication Critical patent/EP0000541A2/en
Publication of EP0000541A3 publication Critical patent/EP0000541A3/en
Application granted granted Critical
Publication of EP0000541B1 publication Critical patent/EP0000541B1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP78100435A 1977-07-20 1978-07-19 1h-pyrimido-(4,5-c)-1,2-diazepines, methods for their preparation and compositions containing them; their use as intermediates for heterocyclic transformations. Expired EP0000541B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB3038077 1977-07-20
GB3038077 1977-07-20

Publications (3)

Publication Number Publication Date
EP0000541A2 EP0000541A2 (en) 1979-02-07
EP0000541A3 true EP0000541A3 (en) 1979-07-11
EP0000541B1 EP0000541B1 (en) 1982-02-03

Family

ID=10306770

Family Applications (1)

Application Number Title Priority Date Filing Date
EP78100435A Expired EP0000541B1 (en) 1977-07-20 1978-07-19 1h-pyrimido-(4,5-c)-1,2-diazepines, methods for their preparation and compositions containing them; their use as intermediates for heterocyclic transformations.

Country Status (5)

Country Link
US (4) US4235905A (en)
EP (1) EP0000541B1 (en)
JP (1) JPS5422393A (en)
DE (1) DE2861598D1 (en)
DK (1) DK323278A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5419996A (en) * 1977-07-08 1979-02-15 Wellcome Found Pyrimido*4*55c*pyridazines
EP0075267B1 (en) * 1981-09-19 1986-01-15 Sumitomo Chemical Company, Limited 4-(2-fluoro-4-halo-5-substituted phenyl)urazols, and their production and use
WO1993020075A1 (en) * 1992-04-01 1993-10-14 The University Of Sydney 8-substituted-n5-deazapterins as antifolates
WO2008117047A1 (en) * 2007-03-27 2008-10-02 Astrazeneca Ab Pyrazolo[3, 4-d]pyrimidine derivatives as antibacterial compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB798646A (en) * 1955-08-10 1958-07-23 Wellcome Found Improvements in and relating to derivatives of pyrimidine and the manufacture thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB447094A (en) 1934-06-22 1936-05-12 Anonima Eternit Pietra Artific Improvements in lead-packed couplings for pipe lines
GB774095A (en) 1953-01-02 1957-05-08 Wellcome Found Improvements in or relating to pyrimidine compounds
GB1129084A (en) 1965-02-18 1968-10-02 Wellcome Found Novel pyrido[2,3-d]pyrimidines
US3947442A (en) * 1969-11-20 1976-03-30 The Sherwin-Williams Company Method for producing heterocyclic acid anhydrides and pyrimidinediones
DE2038035A1 (en) * 1970-07-31 1972-02-03 Boehringer Mannheim GmbH, 6800 Mannheim-Waldhof 2-Amino-pyrido square brackets on 2,3-square brackets to pyrimidin-4 (3H) one derivatives
BE790014A (en) 1971-10-12 1973-04-12 Woods Hamish C S PYRIDO (2,3-D) PYRIMIDINES FOR THERAPEUTIC USE
US4113859A (en) * 1972-10-12 1978-09-12 Burroughs Wellcome Co. Certain pyrido-pyrimidines for treating mammalian and avian infections
JPS5419996A (en) * 1977-07-08 1979-02-15 Wellcome Found Pyrimido*4*55c*pyridazines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB798646A (en) * 1955-08-10 1958-07-23 Wellcome Found Improvements in and relating to derivatives of pyrimidine and the manufacture thereof

Also Published As

Publication number Publication date
DE2861598D1 (en) 1982-03-11
US4237289A (en) 1980-12-02
US4288365A (en) 1981-09-08
EP0000541A2 (en) 1979-02-07
EP0000541B1 (en) 1982-02-03
DK323278A (en) 1979-01-21
JPS5422393A (en) 1979-02-20
US4235905A (en) 1980-11-25
US4315932A (en) 1982-02-16

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