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EP0000332A3 - Benzophenone anti-oximes, diazepin-n-oxides, their preparations and their use as pharmaceutical agents and as intermediates for the preparation of diazepines - Google Patents

Benzophenone anti-oximes, diazepin-n-oxides, their preparations and their use as pharmaceutical agents and as intermediates for the preparation of diazepines Download PDF

Info

Publication number
EP0000332A3
EP0000332A3 EP78100164A EP78100164A EP0000332A3 EP 0000332 A3 EP0000332 A3 EP 0000332A3 EP 78100164 A EP78100164 A EP 78100164A EP 78100164 A EP78100164 A EP 78100164A EP 0000332 A3 EP0000332 A3 EP 0000332A3
Authority
EP
European Patent Office
Prior art keywords
preparation
diazepin
intermediates
oxides
diazepines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP78100164A
Other languages
German (de)
French (fr)
Other versions
EP0000332A2 (en
Inventor
William Joseph Middleton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of EP0000332A2 publication Critical patent/EP0000332A2/en
Publication of EP0000332A3 publication Critical patent/EP0000332A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C07D239/76—N-oxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

N-Fluorohaloacetyl-N-methylaminobenzophenone antioxime, the corresponding diazepin-N-oxides, their preparation and their use as tranquilizers, muscle relaxants and sedatives, and their use as intermediates in the preparation of 3-fluorobenzodiazepines, which are also useful as tranquilizers, muscle relaxants and sedatives.
EP78100164A 1977-06-16 1978-06-15 Benzophenone anti-oximes, diazepin-n-oxides, their preparations and their use as pharmaceutical agents and as intermediates for the preparation of diazepines Withdrawn EP0000332A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/807,075 US4182760A (en) 1977-06-16 1977-06-16 Benzophenone anti-oximes, diazepin-N-oxides, and their use as pharmaceutical agents and as intermediates for pharmaceutical agents
US807075 1977-06-16

Publications (2)

Publication Number Publication Date
EP0000332A2 EP0000332A2 (en) 1979-01-24
EP0000332A3 true EP0000332A3 (en) 1979-05-30

Family

ID=25195504

Family Applications (1)

Application Number Title Priority Date Filing Date
EP78100164A Withdrawn EP0000332A3 (en) 1977-06-16 1978-06-15 Benzophenone anti-oximes, diazepin-n-oxides, their preparations and their use as pharmaceutical agents and as intermediates for the preparation of diazepines

Country Status (4)

Country Link
US (1) US4182760A (en)
EP (1) EP0000332A3 (en)
JP (1) JPS545956A (en)
IT (1) IT1098339B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4472435A (en) * 1980-07-31 1984-09-18 Hoffman-La Roche Inc. Benzophenone derivatives useful in treating heart failure
US4374067A (en) * 1981-12-23 1983-02-15 Hoechst-Roussel Pharmaceuticals, Inc. Intermediates for the preparation of 4-phenyl-1,3-benzodiazepins and methods for preparing the intermediates
US4461728A (en) * 1981-12-23 1984-07-24 Hoechst Roussel Pharmaceuticals Inc. Preparation of 4-phenyl-1,3-benzodiazepins
JP2020023441A (en) * 2016-11-02 2020-02-13 国立大学法人九州大学 Novel compounds useful for EGFR inhibition and tumor treatment
RU2687556C1 (en) * 2018-12-24 2019-05-15 Акционерное общество "Федеральный научно-производственный центр "Алтай" Method of producing 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2h-1,4-benzodiazepin-2-one

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE656226A (en) * 1963-11-27 1965-05-25
US3398139A (en) * 1964-04-10 1968-08-20 Hoffmann La Roche Process for preparing 2-amino-benzodiazepines
DE2460360A1 (en) * 1974-12-20 1976-06-24 Merck Patent Gmbh 3-Fluoro-2,3-dihydro 1H-1,4-benzo-diazepin-2-one derivs - prepd. e.g. by fluorinating 3-unsubstd. cpds.
FR2318643A1 (en) * 1975-07-21 1977-02-18 Du Pont NEW BENZODIAZEPINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DE2542251A1 (en) * 1975-09-23 1977-03-31 Merck Patent Gmbh CNS depressant 3-fluoro-benzodiazepines - viz 7-substd 5-aryl-3-fluoro-2,3-dihydro-1H-1,4benzodiazepin-2-ones

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3453279A (en) * 1963-11-27 1969-07-01 Hoffmann La Roche 2-dihalo lower alkyl-4-phenyl-quinazoline 3-oxide
US3453326A (en) * 1963-11-27 1969-07-01 Hoffmann La Roche 2'-benzoyl-2,2-dihaloacetanilide oxime

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE656226A (en) * 1963-11-27 1965-05-25
US3398139A (en) * 1964-04-10 1968-08-20 Hoffmann La Roche Process for preparing 2-amino-benzodiazepines
DE2460360A1 (en) * 1974-12-20 1976-06-24 Merck Patent Gmbh 3-Fluoro-2,3-dihydro 1H-1,4-benzo-diazepin-2-one derivs - prepd. e.g. by fluorinating 3-unsubstd. cpds.
FR2318643A1 (en) * 1975-07-21 1977-02-18 Du Pont NEW BENZODIAZEPINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DE2542251A1 (en) * 1975-09-23 1977-03-31 Merck Patent Gmbh CNS depressant 3-fluoro-benzodiazepines - viz 7-substd 5-aryl-3-fluoro-2,3-dihydro-1H-1,4benzodiazepin-2-ones

Also Published As

Publication number Publication date
US4182760A (en) 1980-01-08
EP0000332A2 (en) 1979-01-24
JPS545956A (en) 1979-01-17
IT1098339B (en) 1985-09-07
IT7824616A0 (en) 1978-06-15

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Designated state(s): BE CH DE FR GB LU NL SE

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Designated state(s): BE CH DE FR GB LU NL SE

17P Request for examination filed
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN

18W Application withdrawn

Withdrawal date: 19810424

RIN1 Information on inventor provided before grant (corrected)

Inventor name: MIDDLETON, WILLIAM JOSEPH