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EE200300373A - Meetod kamptotetsiini analoogide sünteesimiseks kasutatavate ühendite valmistamiseks ning kamptotetsiini analoogide terviksüntees - Google Patents

Meetod kamptotetsiini analoogide sünteesimiseks kasutatavate ühendite valmistamiseks ning kamptotetsiini analoogide terviksüntees

Info

Publication number
EE200300373A
EE200300373A EEP200300373A EEP200300373A EE200300373A EE 200300373 A EE200300373 A EE 200300373A EE P200300373 A EEP200300373 A EE P200300373A EE P200300373 A EEP200300373 A EE P200300373A EE 200300373 A EE200300373 A EE 200300373A
Authority
EE
Estonia
Prior art keywords
synthesis
camptothecin analogs
preparation
compounds used
integral
Prior art date
Application number
EEP200300373A
Other languages
English (en)
Inventor
Ogawa Takanori
Nishiyama Hiroyuki
Uchida Miyuki
Sawada Seigo
Original Assignee
Kabushiki Kaisha Yakult Honsha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabushiki Kaisha Yakult Honsha filed Critical Kabushiki Kaisha Yakult Honsha
Publication of EE200300373A publication Critical patent/EE200300373A/et
Publication of EE05361B1 publication Critical patent/EE05361B1/et

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/64One oxygen atom attached in position 2 or 6
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/20Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/21Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C205/22Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring having one nitro groups bound to the ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14Ortho-condensed systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
EEP200300373A 2001-02-21 2002-02-21 Meetod kamptotetsiini analoogide snteesimiseks kasutatavate hendite valmistamiseks ning kamptotetsiini analoogide terviksntees EE05361B1 (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001045430 2001-02-21
JP2001309322 2001-10-05
PCT/JP2002/001538 WO2002066416A1 (fr) 2001-02-21 2002-02-21 Procede de synthese de composes se rapportant a la camptothecine (cpt)

Publications (2)

Publication Number Publication Date
EE200300373A true EE200300373A (et) 2003-10-15
EE05361B1 EE05361B1 (et) 2010-12-15

Family

ID=26609837

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200300373A EE05361B1 (et) 2001-02-21 2002-02-21 Meetod kamptotetsiini analoogide snteesimiseks kasutatavate hendite valmistamiseks ning kamptotetsiini analoogide terviksntees

Country Status (23)

Country Link
US (2) US7126000B2 (et)
EP (1) EP1378505B1 (et)
JP (2) JP4210119B2 (et)
KR (2) KR100858972B1 (et)
CN (1) CN100408550C (et)
AR (2) AR035684A1 (et)
AU (1) AU2002237527B2 (et)
BG (2) BG108031A (et)
BR (1) BR0207470A (et)
CA (2) CA2437702C (et)
CZ (1) CZ20032470A3 (et)
EE (1) EE05361B1 (et)
HU (1) HUP0302755A3 (et)
IL (2) IL156949A0 (et)
MX (1) MXPA03007528A (et)
NO (2) NO328628B1 (et)
NZ (2) NZ527615A (et)
PL (2) PL218065B1 (et)
RO (2) RO125158A2 (et)
RU (1) RU2308447C2 (et)
SK (2) SK288073B6 (et)
TW (1) TWI245768B (et)
WO (1) WO2002066416A1 (et)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ299329B6 (cs) * 2003-08-26 2008-06-18 Pliva-Lachema A.S. Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
CZ299593B6 (cs) * 2003-12-16 2008-09-10 Pliva-Lachema A. S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
US20080182990A1 (en) * 2004-08-09 2008-07-31 Shilpa Medicare Limited Process for the Preparation of Irinotecan Hydrochloride Trihydrate
WO2006049447A1 (en) * 2004-11-05 2006-05-11 Samyang Corporation Pharmaceutical formulation for increasing solubility of 10-hydroxycamptothecin compounds in non-aqueous polar solvents
ES2333462T3 (es) * 2005-02-07 2010-02-22 Fermion Oy Procedimiento para la preparacion de 7-etil-10-hidroxi camptotecina.
JP5133703B2 (ja) 2005-02-08 2013-01-30 フェルミオン オサケ ユキチュア [1,4’]ビピペリジニル−1’−カルボニルクロリドまたはその塩酸塩の製造方法
US7767813B2 (en) 2005-02-08 2010-08-03 Fermion Oy Preparation method
US8112154B2 (en) * 2005-04-13 2012-02-07 The Cleveland Clinic Foundation Systems and methods for neuromodulation using pre-recorded waveforms
TWI375678B (en) * 2005-06-09 2012-11-01 Yakult Honsha Kk A method of preparation of a tricyclic ketone
WO2007015259A2 (en) * 2005-08-03 2007-02-08 Avra Laboratories Pvt. Ltd. Method of synthesizing key intermediates for the production of camptothecin derivatives
EP1803725A1 (en) * 2005-12-13 2007-07-04 W.C. Heraeus GmbH Methods for preparing irinotecan
US9220889B2 (en) 2008-02-11 2015-12-29 Intelect Medical, Inc. Directional electrode devices with locating features
CN101824038B (zh) * 2009-03-06 2013-08-21 复旦大学 喜树碱及其类似物的制备方法
WO2011025865A1 (en) 2009-08-27 2011-03-03 The Cleveland Clinic Foundation System and method to estimate region of tissue activation
JP5599094B2 (ja) * 2010-05-20 2014-10-01 国立大学法人 千葉大学 ニトリル化合物の製造方法
JP5830090B2 (ja) 2010-06-14 2015-12-09 ボストン サイエンティフィック ニューロモデュレイション コーポレイション 脊髄神経調節のためのプログラミングインターフェイス
AU2012294364A1 (en) 2011-08-09 2014-03-20 Boston Scientific Neuromodulation Corporation Remote control for blind clinical trials of electrical stimulation
WO2014036075A1 (en) 2012-08-28 2014-03-06 Boston Scientific Neuromodulation Corporation Point-and-click programming for deep brain stimulation using real-time monopolar review trendlines
WO2014070290A2 (en) 2012-11-01 2014-05-08 Boston Scientific Neuromodulation Corporation Systems and methods for voa model generation and use
US8722886B1 (en) * 2012-11-13 2014-05-13 Bionumerik Pharmaceuticals, Inc. Methods for the total chemical synthesis of enantiomerically-pure 7-(2′-trimethylsilyl)ethyl camptothecin
US9959388B2 (en) 2014-07-24 2018-05-01 Boston Scientific Neuromodulation Corporation Systems, devices, and methods for providing electrical stimulation therapy feedback
US10265528B2 (en) 2014-07-30 2019-04-23 Boston Scientific Neuromodulation Corporation Systems and methods for electrical stimulation-related patient population volume analysis and use
US10272247B2 (en) 2014-07-30 2019-04-30 Boston Scientific Neuromodulation Corporation Systems and methods for stimulation-related volume analysis, creation, and sharing with integrated surgical planning and stimulation programming
WO2016057544A1 (en) 2014-10-07 2016-04-14 Boston Scientific Neuromodulation Corporation Systems, devices, and methods for electrical stimulation using feedback to adjust stimulation parameters
WO2016064900A1 (en) * 2014-10-22 2016-04-28 Arno Therapeutics, Inc. Methods and systems for camptothecin analog synthesis
US9956419B2 (en) 2015-05-26 2018-05-01 Boston Scientific Neuromodulation Corporation Systems and methods for analyzing electrical stimulation and selecting or manipulating volumes of activation
US10780283B2 (en) 2015-05-26 2020-09-22 Boston Scientific Neuromodulation Corporation Systems and methods for analyzing electrical stimulation and selecting or manipulating volumes of activation
ES2940303T3 (es) 2015-06-29 2023-05-05 Boston Scient Neuromodulation Corp Sistemas de selección de parámetros de estimulación por uso de dianas y direccionamiento
US20160375248A1 (en) 2015-06-29 2016-12-29 Boston Scientific Neuromodulation Corporation Systems and methods for selecting stimulation parameters based on stimulation target region, effects, or side effects
EP3359252B1 (en) 2015-10-09 2020-09-09 Boston Scientific Neuromodulation Corporation System and methods for clinical effects mapping for directional stimulations leads
US10716942B2 (en) 2016-04-25 2020-07-21 Boston Scientific Neuromodulation Corporation System and methods for directional steering of electrical stimulation
EP3458152B1 (en) 2016-06-24 2021-04-21 Boston Scientific Neuromodulation Corporation Systems and methods for visual analytics of clinical effects
WO2018044881A1 (en) 2016-09-02 2018-03-08 Boston Scientific Neuromodulation Corporation Systems and methods for visualizing and directing stimulation of neural elements
US10780282B2 (en) 2016-09-20 2020-09-22 Boston Scientific Neuromodulation Corporation Systems and methods for steering electrical stimulation of patient tissue and determining stimulation parameters
CN109803719B (zh) 2016-10-14 2023-05-26 波士顿科学神经调制公司 用于闭环确定电模拟系统的刺激参数设置的系统和方法
JP6834005B2 (ja) 2017-01-03 2021-02-24 ボストン サイエンティフィック ニューロモデュレイション コーポレイション Mri適合刺激パラメータを選択するためのシステム及び方法
ES2821752T3 (es) 2017-01-10 2021-04-27 Boston Scient Neuromodulation Corp Sistemas y procedimientos para crear programas de estimulación en base a áreas o volúmenes definidos por el usuario
US10625082B2 (en) 2017-03-15 2020-04-21 Boston Scientific Neuromodulation Corporation Visualization of deep brain stimulation efficacy
US11357986B2 (en) 2017-04-03 2022-06-14 Boston Scientific Neuromodulation Corporation Systems and methods for estimating a volume of activation using a compressed database of threshold values
US10716505B2 (en) 2017-07-14 2020-07-21 Boston Scientific Neuromodulation Corporation Systems and methods for estimating clinical effects of electrical stimulation
US10960214B2 (en) 2017-08-15 2021-03-30 Boston Scientific Neuromodulation Corporation Systems and methods for controlling electrical stimulation using multiple stimulation fields
WO2019210214A1 (en) 2018-04-27 2019-10-31 Boston Scientific Neuromodulation Corporation Systems for visualizing and programming electrical stimulation
EP3784331B1 (en) 2018-04-27 2023-01-18 Boston Scientific Neuromodulation Corporation Multi-mode electrical stimulation systems and methods of making and using
US11434196B2 (en) * 2019-01-15 2022-09-06 Laurus Labs Limited Process for preparation of 2-Amino-5-hydroxy propiophenone
EP4291294A1 (en) 2021-04-27 2023-12-20 Boston Scientific Neuromodulation Corporation Systems and methods for automated programming of electrical stimulation
EP4313269A1 (en) 2021-06-15 2024-02-07 Boston Scientific Neuromodulation Corporation Methods and systems for estimating neural activation by stimulation using a stimulation system
EP4415809A2 (en) 2021-12-10 2024-08-21 Boston Scientific Neuromodulation Corporation Systems and methods for generating and using response maps for electrical stimulation
CN118108705A (zh) * 2024-01-29 2024-05-31 浙江工业大学 一种富马酸沃诺拉赞的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2061678C1 (ru) * 1992-05-14 1996-06-10 Валерий Павлович Севодин Способ получения 2-амино-5-нитробензофенона
US5391745A (en) 1992-07-23 1995-02-21 Sloan-Kettering Institute For Cancer Research Methods of preparation of camptothecin analogs
JPH07101956A (ja) * 1993-10-05 1995-04-18 Tanabe Seiyaku Co Ltd ヒドロキシカンプトテシン化合物の製法
KR960029336A (ko) * 1995-01-09 1996-08-17 김충환 캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제
JPH08225482A (ja) * 1995-02-22 1996-09-03 Dai Ichi Seiyaku Co Ltd テトラロン関連化合物及びその製法
IL117684A (en) * 1995-04-07 2002-02-10 Pharmacia & Upjohn Inc Intermediates and Process for Production of History of Kempotocin (CPT-11) and Related Compounds
SG50747A1 (en) * 1995-08-02 1998-07-20 Tanabe Seiyaku Co Comptothecin derivatives
EP0876373B1 (en) 1995-11-02 2005-08-10 OSI Pharmaceuticals, Inc. Method for preparing camptothecin derivatives
SG104284A1 (en) * 1996-10-30 2004-06-21 Tanabe Seiyaku Co S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof

Also Published As

Publication number Publication date
EP1378505B1 (en) 2014-11-05
SK288073B6 (sk) 2013-05-03
AU2002237527B2 (en) 2007-01-04
CA2683768C (en) 2013-05-28
KR100858972B1 (ko) 2008-09-17
JP2008273952A (ja) 2008-11-13
NZ527615A (en) 2004-12-24
PL363440A1 (en) 2004-11-15
JP4210119B2 (ja) 2009-01-14
RU2308447C2 (ru) 2007-10-20
KR20080012383A (ko) 2008-02-11
MXPA03007528A (es) 2003-12-11
AR035684A1 (es) 2004-06-23
BG111453A (en) 2013-09-30
BG108031A (bg) 2005-04-30
RO125158A2 (ro) 2010-01-29
EP1378505A4 (en) 2006-09-27
US7378555B2 (en) 2008-05-27
HUP0302755A3 (en) 2008-03-28
US20070010674A1 (en) 2007-01-11
CN1492851A (zh) 2004-04-28
IL156949A (en) 2009-09-01
PL217238B1 (pl) 2014-06-30
TWI245768B (en) 2005-12-21
EP1378505A1 (en) 2004-01-07
PL218065B1 (pl) 2014-10-31
EE05361B1 (et) 2010-12-15
HUP0302755A2 (hu) 2003-12-29
BR0207470A (pt) 2008-04-08
US20040106830A1 (en) 2004-06-03
NO20093402L (no) 2003-10-10
RU2003128530A (ru) 2005-03-27
KR100864692B1 (ko) 2008-10-23
AR082663A2 (es) 2012-12-26
NO331656B1 (no) 2012-02-13
RO122639B9 (ro) 2014-03-28
IL156949A0 (en) 2004-02-08
CZ20032470A3 (cs) 2004-02-18
RO122639B1 (ro) 2009-10-30
US7126000B2 (en) 2006-10-24
JP4805967B2 (ja) 2011-11-02
NO20033579D0 (no) 2003-08-13
NZ534374A (en) 2004-12-24
CA2437702A1 (en) 2002-08-29
SK288149B6 (sk) 2013-12-02
KR20030077631A (ko) 2003-10-01
NO20033579L (no) 2003-10-10
NO328628B1 (no) 2010-04-12
CN100408550C (zh) 2008-08-06
SK11472003A3 (sk) 2004-03-02
CA2437702C (en) 2010-04-06
JPWO2002066416A1 (ja) 2004-09-24
PL399009A1 (pl) 2012-09-10
WO2002066416A1 (fr) 2002-08-29
CA2683768A1 (en) 2002-08-29

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