EE04276B1 - Kinoliini derivaadid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad farmatseutilised kompositsioonid - Google Patents

Kinoliini derivaadid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad farmatseutilised kompositsioonid

Info

Publication number: EE04276B1
Authority: EE; Estonia
Prior art keywords: pharmaceuticals; preparation; pharmaceutical compositions; compositions containing; quinoline derivatives
Prior art date: 1998-07-15

Application number

EEP200100007A

Other languages

English (en)

Inventor

Bj�rk Anders

J�nsson Stig

Fex Tomas

Hedlund Gunnar

Original Assignee

Active Biotech Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-15

Filing date

1999-07-14

Publication date

2004-04-15

1999-07-14 Application filed by Active Biotech Ab filed Critical Active Biotech Ab

2002-06-17 Publication of EE200100007A publication Critical patent/EE200100007A/et

2004-04-15 Publication of EE04276B1 publication Critical patent/EE04276B1/et

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Obesity (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)

EEP200100007A 1998-07-15 1999-07-14 Kinoliini derivaadid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad farmatseutilised kompositsioonid EE04276B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9802550A SE9802550D0 (sv)	1998-07-15	1998-07-15	Quinoline derivatives
PCT/SE1999/001271 WO2000003992A1 (en)	1998-07-15	1999-07-14	Quinoline derivatives

Publications (2)

Publication Number	Publication Date
EE200100007A EE200100007A (et)	2002-06-17
EE04276B1 true EE04276B1 (et)	2004-04-15

Family

ID=20412094

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200100007A EE04276B1 (et)	1998-07-15	1999-07-14	Kinoliini derivaadid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad farmatseutilised kompositsioonid

Country Status (30)

Country	Link
EP (1)	EP1097139B1 (et)
JP (1)	JP4082865B2 (et)
KR (1)	KR100551611B1 (et)
CN (1)	CN1114597C (et)
AP (1)	AP1425A (et)
AT (1)	ATE229005T1 (et)
AU (1)	AU745915B2 (et)
BR (1)	BR9912104B1 (et)
CA (1)	CA2334718C (et)
DE (1)	DE69904333T2 (et)
DK (1)	DK1097139T3 (et)
EE (1)	EE04276B1 (et)
ES (1)	ES2187176T3 (et)
HR (1)	HRP20010038A2 (et)
HU (1)	HUP0103634A3 (et)
ID (1)	ID27547A (et)
IL (1)	IL140009A0 (et)
IS (1)	IS2187B (et)
NO (1)	NO317545B1 (et)
NZ (1)	NZ508924A (et)
OA (1)	OA11580A (et)
PL (1)	PL200147B1 (et)
PT (1)	PT1097139E (et)
RU (1)	RU2213734C2 (et)
SE (1)	SE9802550D0 (et)
TR (1)	TR200100086T2 (et)
UA (1)	UA70944C2 (et)
WO (1)	WO2000003992A1 (et)
YU (1)	YU1401A (et)
ZA (1)	ZA200007493B (et)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE0002320D0 (sv) *	1999-10-25	2000-06-21	Active Biotech Ab	Malignant tumors
DE60128936T2 (de)	2000-10-12	2008-04-10	Merck & Co, Inc.	Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer
NZ525088A (en)	2000-10-12	2004-11-26	Merck & Co Inc	Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors
AU2003220170B2 (en)	2002-03-15	2008-12-11	Merck Sharp & Dohme Corp.	N-(Substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as HIV integrase inhibitors
SE0201778D0 (sv) *	2002-06-12	2002-06-12	Active Biotech Ab	Process for the manufacture of quinoline derivatives
SE0400235D0 (sv)	2004-02-06	2004-02-06	Active Biotech Ab	New composition containing quinoline compounds
US8314124B2 (en)	2004-02-06	2012-11-20	Active Biotech Ab	Crystalline salts of quinoline compounds and methods for preparing them
SE0401578D0 (sv) *	2004-06-18	2004-06-18	Active Biotech Ab	Novel compounds
KR101440982B1 (ko)	2005-10-19	2014-09-17	테바 파마슈티컬 인더스트리즈 리미티드	라퀴니모드 나트륨의 결정 및 이의 제조방법
US7989473B2 (en)	2006-06-12	2011-08-02	Teva Pharmaceutical Industries, Ltd.	Stable laquinimod preparations
US8178127B2 (en)	2007-12-20	2012-05-15	Teva Pharmaceuticals Industries, Ltd.	Stable laquinimod preparations
JP2012502038A (ja)	2008-09-03	2012-01-26	テバファーマシューティカルインダストリーズリミティド	免疫機能の２−オキソ−１，２−ジヒドロ−キノリンモジュレーター
MX2012001333A (es)	2009-07-30	2012-06-01	Teva Pharma	Tratamiento de la enfermedad de crohn con la laquinimod.
PT2467372T (pt)	2009-08-10	2016-08-23	Teva Pharma	Tratamento de distúrbios relacionados com bdnf usando laquinimod
KR20160129093A (ko)	2010-03-03	2016-11-08	테바 파마슈티컬 인더스트리즈 리미티드	라퀴니모드를 이용한 루푸스 신장염의 치료
SG183513A1 (en)	2010-03-03	2012-09-27	Teva Pharma	Treatment of rheumatoid arthritis with a combination of laquinimod and methotrexate
CN104610144A (zh)	2010-07-09	2015-05-13	泰华制药工业有限公司	氘化的n-乙基-n-苯基-1,2-二氢-4-羟基-5-氯-1-甲基-2-氧代喹啉-3-甲酰胺、其盐和用途
EP2627638B1 (en)	2010-10-14	2017-07-12	Immunahr AB	1,2-dihydro-4-hydroxy-2-oxo-quinoline-3-carboxanilides as ahr activators.
EP2766020A4 (en)	2011-10-12	2015-04-01	Teva Pharma	TREATMENT OF MULTIPLE SCLEROSIS BY COMBINING LAQUINIMOD AND FINGOLIMOD
JP2015505564A (ja)	2012-02-03	2015-02-23	テバファーマシューティカルインダストリーズリミティド	第一選択の抗ＴＮＥα療法に失敗したクローン病患者を治療するためのラキニモドの使用
JP6215238B2 (ja)	2012-02-16	2017-10-18	テバファーマシューティカルインダストリーズリミティド	Ｎ−エチル−ｎ−フェニル−１，２−ジヒドロ−４，５−ジ−ヒドロキシ−１−メチル−２−オキソ−３−キノリンカルボキサミド、その製剤、および使用
TW201350467A (zh)	2012-05-08	2013-12-16	Teva Pharma	Ｎ－乙基－４－羥基－１－甲基－５－（甲基（２，３，４，５，６－五羥基己基）胺基）－２－側氧－ｎ－苯基－１，２－二氫喹啉－３－甲醯胺
TW201400117A (zh)	2012-06-05	2014-01-01	Teva Pharma	使用拉喹莫德治療眼發炎疾病
TW201410244A (zh)	2012-08-13	2014-03-16	Teva Pharma	用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ）
HK1215210A1 (zh)	2012-11-07	2016-08-19	Teva Pharmaceutical Industries Ltd.	拉喹莫德胺盐
US9233927B2 (en)	2013-03-14	2016-01-12	Teva Pharmaceutical Industries, Ltd.	Crystals of laquinimod sodium and improved process for the manufacture thereof
AU2015253330A1 (en)	2014-04-29	2016-12-01	Teva Pharmaceutical Industries Ltd.	Laquinimod for the treatment of relapsing-remitting multiple sclerosis (RRMS) patients with a high disability status
WO2021237112A1 (en) *	2020-05-21	2021-11-25	Stemsynergy Therapeutics, Inc.	Notch inhibitors and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE52670B1 (en) *	1981-03-03	1988-01-20	Leo Ab	Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation
GB9108547D0 (en) *	1991-04-22	1991-06-05	Fujisawa Pharmaceutical Co	Quinoline derivatives
DE4120646A1 (de) *	1991-06-22	1992-12-24	Bayer Ag	7-isoindolinyl-chinolon- und naphthyridoncarbonsaeure-derivate
SE469368B (sv) *	1991-10-09	1993-06-28	Kabi Pharmacia Ab	Ny anvaendning av linomide foer tillverkning av laekemedel foer behandling av multiple sclerosis (ms)
CN1063686A (zh) *	1992-03-12	1992-08-19	华西医科大学药物研究所	用活性酯法合成维司力农
SE9201076L (sv) *	1992-04-06	1993-10-07	Shimon Slavin	Användningen av gamla läkemedel för behandling av diabetes
JPH07224040A (ja) *	1994-02-07	1995-08-22	Fujisawa Pharmaceut Co Ltd	キノリン誘導体
GB9404378D0 (en) *	1994-03-07	1994-04-20	Fujisawa Pharmaceutical Co	Quinoline derivatives
SE9400809D0 (sv) *	1994-03-10	1994-03-10	Pharmacia Ab	New use of quinoline-3-carboxamide compounds
SE9400810D0 (sv) *	1994-03-10	1994-03-10	Pharmacia Ab	New use of Quinoline-3-carboxamide compounds
GB2290786A (en) *	1994-06-30	1996-01-10	Fujisawa Pharmaceutical Co	Quinoline derivatives

1998
- 1998-07-15 SE SE9802550A patent/SE9802550D0/xx unknown
1999
- 1999-07-14 YU YU1401A patent/YU1401A/sh unknown
- 1999-07-14 HU HU0103634A patent/HUP0103634A3/hu unknown
- 1999-07-14 EP EP99935261A patent/EP1097139B1/en not_active Expired - Lifetime
- 1999-07-14 UA UA2000127137A patent/UA70944C2/uk unknown
- 1999-07-14 NZ NZ508924A patent/NZ508924A/xx not_active IP Right Cessation
- 1999-07-14 ES ES99935261T patent/ES2187176T3/es not_active Expired - Lifetime
- 1999-07-14 OA OA1200100012A patent/OA11580A/en unknown
- 1999-07-14 CN CN99808597A patent/CN1114597C/zh not_active Expired - Fee Related
- 1999-07-14 IL IL14000999A patent/IL140009A0/xx not_active IP Right Cessation
- 1999-07-14 DK DK99935261T patent/DK1097139T3/da active
- 1999-07-14 WO PCT/SE1999/001271 patent/WO2000003992A1/en not_active Ceased
- 1999-07-14 HR HR20010038A patent/HRP20010038A2/hr not_active Application Discontinuation
- 1999-07-14 TR TR2001/00086T patent/TR200100086T2/xx unknown
- 1999-07-14 AU AU50775/99A patent/AU745915B2/en not_active Ceased
- 1999-07-14 AP APAP/P/2001/002040A patent/AP1425A/en active
- 1999-07-14 RU RU2001104344/04A patent/RU2213734C2/ru not_active IP Right Cessation
- 1999-07-14 ID IDW20010360A patent/ID27547A/id unknown
- 1999-07-14 KR KR1020007014281A patent/KR100551611B1/ko not_active Expired - Fee Related
- 1999-07-14 JP JP2000560099A patent/JP4082865B2/ja not_active Expired - Fee Related
- 1999-07-14 BR BRPI9912104-2A patent/BR9912104B1/pt not_active IP Right Cessation
- 1999-07-14 DE DE69904333T patent/DE69904333T2/de not_active Expired - Lifetime
- 1999-07-14 PT PT99935261T patent/PT1097139E/pt unknown
- 1999-07-14 EE EEP200100007A patent/EE04276B1/et not_active IP Right Cessation
- 1999-07-14 AT AT99935261T patent/ATE229005T1/de not_active IP Right Cessation
- 1999-07-14 PL PL345389A patent/PL200147B1/pl unknown
- 1999-07-14 CA CA002334718A patent/CA2334718C/en not_active Expired - Fee Related
2000
- 2000-12-05 IS IS5753A patent/IS2187B/is unknown
- 2000-12-14 ZA ZA200007493A patent/ZA200007493B/en unknown
2001
- 2001-01-12 NO NO20010210A patent/NO317545B1/no unknown

Also Published As

Publication number	Publication date
WO2000003992A1 (en)	2000-01-27
IS5753A (is)	2000-12-05
CN1309640A (zh)	2001-08-22
IS2187B (is)	2006-12-15
DE69904333D1 (de)	2003-01-16
DK1097139T3 (da)	2002-12-30
PL345389A1 (en)	2001-12-17
IL140009A0 (en)	2002-02-10
YU1401A (sh)	2003-10-31
ES2187176T3 (es)	2003-05-16
HK1035716A1 (en)	2001-12-07
BR9912104B1 (pt)	2010-07-13
ZA200007493B (en)	2001-06-19
HUP0103634A3 (en)	2002-03-28
EP1097139B1 (en)	2002-12-04
AU5077599A (en)	2000-02-07
TR200100086T2 (tr)	2001-05-21
JP2002520396A (ja)	2002-07-09
AP2001002040A0 (en)	2001-03-31
SE9802550D0 (sv)	1998-07-15
KR100551611B1 (ko)	2006-02-13
EE200100007A (et)	2002-06-17
CA2334718C (en)	2006-11-21
HRP20010038A2 (en)	2001-12-31
NO20010210D0 (no)	2001-01-12
NZ508924A (en)	2002-09-27
JP4082865B2 (ja)	2008-04-30
OA11580A (en)	2004-07-01
UA70944C2 (uk)	2004-11-15
EP1097139A1 (en)	2001-05-09
NO20010210L (no)	2001-03-15
PL200147B1 (pl)	2008-12-31
PT1097139E (pt)	2003-04-30
BR9912104A (pt)	2001-05-02
HUP0103634A2 (hu)	2002-02-28
CA2334718A1 (en)	2000-01-27
CN1114597C (zh)	2003-07-16
AP1425A (en)	2005-06-06
RU2213734C2 (ru)	2003-10-10
AU745915B2 (en)	2002-04-11
ID27547A (id)	2001-04-12
DE69904333T2 (de)	2003-10-16
ATE229005T1 (de)	2002-12-15
NO317545B1 (no)	2004-11-15
KR20010071491A (ko)	2001-07-28

Publication	Publication Date	Title
EE04673B1 (et)	2006-08-15	Kinoliini derivaadid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad farmatseutilised kompositsioonid
EE04276B1 (et)	2004-04-15	Kinoliini derivaadid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad farmatseutilised kompositsioonid
EE04275B1 (et)	2004-04-15	Kinoliini derivaadid, nende valmistamismeetodid, kasutamine ja farmatseutilised kompositsioonid
EE200000168A (et)	2001-04-16	Karboksamidotiasoolderivaadid, nende valmistamine ja neid sisaldavad farmatseutilised kompositsioonid
EE200300046A (et)	2004-10-15	Asabitsüklilised ühendid, nende valmistamine ja kasutamine ravimitena ning neid sisaldav farmatseutiline kompositsioon
EE200200138A (et)	2003-06-16	Kinolüülpropüülpiperidiini derivaadid, nende valmistamine ja neid sisaldavad kompositsioonid
EE200200065A (et)	2003-04-15	3-aminopürasooli derivaadid, nende valmistamine ja kasutamine vähivastaste toimeainetena ning neid sisaldav farmatseutiline kompositsioon
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