EE03594B1 - Depooravimiks sobiv farmatseutiline kompositsioon, selle valmistamismeetod ja kasutamine - Google Patents

Depooravimiks sobiv farmatseutiline kompositsioon, selle valmistamismeetod ja kasutamine

Info

Publication number: EE03594B1
Authority: EE; Estonia
Prior art keywords: preparation; pharmaceutical composition; composition suitable; depot administration; depot
Prior art date: 1996-05-20

Application number

EE9800136A

Other languages

English (en)

Estonian (et)

Other versions

EE9800136A (et

Inventor

Karel Jozef Fran�ois Marc

Carolus Augusta Embrechts Roger

Karel Borghijs Herman

Monbaliu Johan

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-20

Filing date

1997-05-12

Publication date

2002-02-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8224016&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE03594(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-05-12 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

1998-10-15 Publication of EE9800136A publication Critical patent/EE9800136A/xx

2002-02-15 Publication of EE03594B1 publication Critical patent/EE03594B1/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

EE9800136A 1996-05-20 1997-05-12 Depooravimiks sobiv farmatseutiline kompositsioon, selle valmistamismeetod ja kasutamine EE03594B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP96201429		1996-05-20
PCT/EP1997/002504 WO1997044039A1 (fr)	1996-05-20	1997-05-12	Suspensions aqueuses d'esters d'acides gras de 9-hydroxyrisperidone

Publications (2)

Publication Number	Publication Date
EE9800136A EE9800136A (et)	1998-10-15
EE03594B1 true EE03594B1 (et)	2002-02-15

Family

ID=8224016

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9800136A EE03594B1 (et)	1996-05-20	1997-05-12	Depooravimiks sobiv farmatseutiline kompositsioon, selle valmistamismeetod ja kasutamine

Country Status (37)

Country	Link
US (1)	US6077843A (fr)
EP (1)	EP0904081B1 (fr)
JP (1)	JP3274687B2 (fr)
KR (1)	KR100358373B1 (fr)
CN (1)	CN1093762C (fr)
AR (1)	AR007194A1 (fr)
AT (1)	ATE208619T1 (fr)
AU (1)	AU715572B2 (fr)
BG (1)	BG62684B1 (fr)
BR (1)	BR9706824B8 (fr)
CA (1)	CA2236691C (fr)
CY (2)	CY2270B1 (fr)
CZ (1)	CZ291284B6 (fr)
DE (2)	DE122011100027I1 (fr)
DK (1)	DK0904081T3 (fr)
EA (1)	EA000536B1 (fr)
EE (1)	EE03594B1 (fr)
ES (1)	ES2167745T3 (fr)
FR (1)	FR11C0035I2 (fr)
HR (1)	HRP970276B1 (fr)
HU (2)	HU224025B1 (fr)
ID (1)	ID16927A (fr)
IL (1)	IL124551A (fr)
LU (1)	LU91842I2 (fr)
MX (1)	MX9804816A (fr)
MY (1)	MY126302A (fr)
NO (2)	NO315931B1 (fr)
NZ (1)	NZ330369A (fr)
PL (1)	PL188309B1 (fr)
PT (1)	PT904081E (fr)
SI (1)	SI0904081T1 (fr)
SK (1)	SK284013B6 (fr)
TR (1)	TR199800923T2 (fr)
TW (1)	TW487572B (fr)
UA (1)	UA61898C2 (fr)
WO (1)	WO1997044039A1 (fr)
ZA (1)	ZA974331B (fr)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA72189C2 (uk) *	1997-11-17	2005-02-15	Янссен Фармацевтика Н.В.	Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот
AU753278B2 (en) *	1998-02-25	2002-10-10	Abbott Laboratories	Butorphanol sustained release formulations
US6342488B1 (en)	1998-08-18	2002-01-29	Sepracor, Inc.	Phosphonorisperidone and sulforisperidone compositions and methods
ES2688273T3 (es)	1999-03-31	2018-10-31	Janssen Pharmaceutica Nv	Almidón pregelatinizado en una formulación de liberación controlada
US6495164B1 (en)	2000-05-25	2002-12-17	Alkermes Controlled Therapeutics, Inc. I	Preparation of injectable suspensions having improved injectability
ATE401313T1 (de) *	2000-08-14	2008-08-15	Teva Pharma	Herstellung von risperidon
US7666445B2 (en) *	2000-10-20	2010-02-23	The Trustees Of The University Of Pennsylvania	Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use
GB0216416D0 (en) *	2002-07-15	2002-08-21	Novartis Ag	Organic compounds
DK1539115T3 (da) *	2002-07-29	2008-01-28	Alza Corp	Fremgangsmåder og doseringsformer til kontrolleret levering af paliperidon
US20050232995A1 (en)	2002-07-29	2005-10-20	Yam Nyomi V	Methods and dosage forms for controlled delivery of paliperidone and risperidone
GB0322994D0 (en) *	2003-10-01	2003-11-05	Novartis Ag	Organic compounds
PL1675573T4 (pl)	2003-10-23	2016-04-29	Otsuka Pharma Co Ltd	Sterylny preparat do wstrzykiwań arypiprazolu o kontrolowanym uwalnianiu i sposób
EP2633853A1 (fr) *	2004-01-12	2013-09-04	The Trustees of The University of Pennsylvania	Formulations d'administration à long terme et leurs procédés d'utilisation
US8329203B2 (en) *	2004-01-12	2012-12-11	The Trustees Of The University Of Pennsylvania	Drug-containing implants and methods of use thereof
US8221778B2 (en)	2005-01-12	2012-07-17	The Trustees Of The University Of Pennsylvania	Drug-containing implants and methods of use thereof
ES2245252B1 (es) *	2004-06-15	2007-03-01	Farmalider, S.A.	Solucion acuosa de risperidona para administracion oral.
US11246913B2 (en)	2005-02-03	2022-02-15	Intarcia Therapeutics, Inc.	Suspension formulation comprising an insulinotropic peptide
US20080214808A1 (en)	2005-04-25	2008-09-04	Thomas Frederik Ernestine Spittaels	Preparation of Aseptic 3-[2-[4-((6-Fluoro-1,2-Benzisoxazol-3-Yl)-1-Piperidinyl]-6,7,8,9-Tetrahydro-9-Hydroxy-2-Methyl-4H-Pyrido[1,2-a]Pyrimidin-4-One Palmitate Ester
PL116330U1 (en) *	2005-10-31	2007-04-02	Alza Corp	Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation
AU2007284759B2 (en)	2006-08-09	2010-10-28	Intarcia Therapeutics, Inc.	Osmotic delivery systems and piston assemblies
WO2008128436A1 (fr) *	2007-04-19	2008-10-30	Youxin Li	Nouveaux composés pour le traitement de troubles psychotiques, procédés d'élaboration, et leurs utilisations
RU2440097C2 (ru)	2007-04-23	2012-01-20	Интарсия Терапьютикс, Инк.	Способ лечения диабета ii типа и ожирения, осмотическое устройство для доставки и способ его изготовления
US20090076035A1 (en) *	2007-09-15	2009-03-19	Protia, Llc	Deuterium-enriched paliperidone
AU2008340101C1 (en)	2007-12-19	2025-03-06	Janssen Pharmaceutica Nv	Dosing regimen associated with long acting injectable paliperidone esters
US20090209757A1 (en) *	2008-01-10	2009-08-20	Santiago Ini	Processes for the preparation and purification of paliperidone palmitate
US8343140B2 (en)	2008-02-13	2013-01-01	Intarcia Therapeutics, Inc.	Devices, formulations, and methods for delivery of multiple beneficial agents
SMT202000405T1 (it)	2008-09-04	2020-09-10	Amylin Pharmaceuticals Llc	Formulazioni a rilascio prolungato usando veicolanti non acquosi
WO2011037623A1 (fr)	2009-09-28	2011-03-31	Intarcia Therapeutics, Inc.	Établissement rapide et/ou arrêt rapide d'une administration constante substantielle de médicament
EP2493473A1 (fr)	2009-10-30	2012-09-05	Janssen Pharmaceutica NV	Posologie associée à des esters de palipéridone injectables à action prolongée
US20120259116A1 (en) *	2009-12-17	2012-10-11	Rajiv Kumar	Novel Process for the Preparation of Paliperidone
TWI577377B (zh)	2010-09-16	2017-04-11	Ｖｉｉｖ醫療保健公司	醫藥組合物
JP5893616B2 (ja)	2010-10-18	2016-03-23	大日本住友製薬株式会社	注射用徐放性製剤
US20120208755A1 (en)	2011-02-16	2012-08-16	Intarcia Therapeutics, Inc.	Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
PL2683717T3 (pl) *	2011-05-31	2016-11-30		Wytwarzanie 3-[2-[4-((6-fluoro-1,2-benzoizoksazol-3-ilo)-1-piperydynylo)-6,7,8,9-tetrahydro-9- hydroksy-2-metylo-4H-pirydo[1,2-a]pirymidyn-4-onu (paliperydonu) i palmitynianu paliperydonu
WO2013046225A2 (fr) *	2011-08-10	2013-04-04	Glenmark Generics Limited	Procédé de préparation de palmitate de palipéridone
CN102993200B (zh) *	2011-09-10	2016-02-03	鲁翠涛	帕潘立酮氨基酸酯及其制备方法
EP2919788A4 (fr)	2012-11-14	2016-05-25	Univ Johns Hopkins	Méthodes et compositions pour le traitement de la schizophrénie
US10525057B2 (en)	2013-09-24	2020-01-07	Otsuka Pharmaceutical Co., Ltd.	Method of providing aripiprazole to patients having impaired CYP2D6 or CYP3A4 enzyme function
US9889085B1 (en)	2014-09-30	2018-02-13	Intarcia Therapeutics, Inc.	Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
FI3744326T3 (fi)	2015-04-07	2024-02-02	Janssen Pharmaceutica Nv	Annosteluohjelma pitkävaikutteisten injektoitavien paliperidoniestereiden ottamatta jääneille annoksille
ES2968262T3 (es)	2015-06-03	2024-05-08	I2O Therapeutics Inc	Sistemas de colocación de implantes
CA3024479A1 (fr)	2016-05-16	2017-11-23	Intarcia Therapeutics, Inc.	Polypeptides selectifs du recepteur du glucagon et methodes pour les employer
USD840030S1 (en)	2016-06-02	2019-02-05	Intarcia Therapeutics, Inc.	Implant placement guide
USD860451S1 (en)	2016-06-02	2019-09-17	Intarcia Therapeutics, Inc.	Implant removal tool
JP7286542B2 (ja)	2017-01-03	2023-06-05	インターシアセラピューティクス，インコーポレイティド	Ｇｌｐ－１受容体アゴニストの持続的投与及び薬物の同時投与を含む方法
IL303252A (en)	2020-11-30	2023-07-01	Janssen Pharmaceutica Nv	Dosing regimens associated with extended release paliperidone injectable formulations
KR102794804B1 (ko)	2020-11-30	2025-04-10	얀센 파마슈티카 엔브이	서방형 팔리페리돈 주사용 제형과 관련된 투약 요법
EP4025187B1 (fr)	2020-11-30	2024-01-03	Janssen Pharmaceutica NV	Schémas posologiques associés à des formulations injectables de palipéridone à libération prolongée
CA3203567A1 (fr)	2020-11-30	2022-06-02	Janssen Pharmaceutica Nv	Procedes destines a assurer la resuspension de formulations de palmitate de paliperidone
HUP2100259A1 (hu)	2021-07-07	2023-01-28	Richter Gedeon Nyrt	Cariprazine tartalmú szabályozott hatóanyag-leadású injekciós készítmények
MX2024002215A (es)	2021-08-20	2024-05-10	Janssen Pharmaceutica Nv	Regímenes de dosificación asociados con formulaciones inyectables de paliperidona de liberación prolongada.

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US5158952A (en) *	1988-11-07	1992-10-27	Janssen Pharmaceutica N.V.	3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use
US5254556A (en) *	1988-11-07	1993-10-19	Janssen Pharmaceutica N.V.	3-piperidinyl-1,2-benzisoxazoles
CA2000786C (fr) *	1988-11-07	1999-01-26	Cornelus G. M. Janssen	3-piperidinyl-1,2-benzisoxazoles
TW376319B (en) *	1993-04-28	1999-12-11	Janssen Pharmaceutica Nv	Pharmaceutical composition containing risperidone pamoate and having a long acting activity for treating psychoses induced by the release of dopamine
ES2236700T3 (es) *	1993-11-19	2005-07-16	Janssen Pharmaceutica N.V.	1,2-benzazoles microencapsulados.
US5650173A (en) *	1993-11-19	1997-07-22	Alkermes Controlled Therapeutics Inc. Ii	Preparation of biodegradable microparticles containing a biologically active agent
EP2275089A1 (fr) *	1993-11-19	2011-01-19	Alkermes Controlled Therapeutics, Inc.	Préparastion de microparticules biodégradables contentant un agent biologiquement actif
ES2157442T3 (es) *	1995-06-06	2001-08-16	Aventis Pharma Inc	Derivados de benzoisoxazol y de indazol, utilizados como agentes neurolepticos.
US5792477A (en) *	1996-05-07	1998-08-11	Alkermes Controlled Therapeutics, Inc. Ii	Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent

1997
- 1997-05-01 TW TW086105768A patent/TW487572B/zh not_active IP Right Cessation
- 1997-05-12 EA EA199800531A patent/EA000536B1/ru not_active IP Right Cessation
- 1997-05-12 DE DE201112100027 patent/DE122011100027I1/de active Pending
- 1997-05-12 DE DE69708284T patent/DE69708284T2/de not_active Expired - Lifetime
- 1997-05-12 EP EP97923912A patent/EP0904081B1/fr not_active Expired - Lifetime
- 1997-05-12 EE EE9800136A patent/EE03594B1/xx active Protection Beyond IP Right Term
- 1997-05-12 SK SK620-98A patent/SK284013B6/sk not_active IP Right Cessation
- 1997-05-12 ES ES97923912T patent/ES2167745T3/es not_active Expired - Lifetime
- 1997-05-12 DK DK97923912T patent/DK0904081T3/da active
- 1997-05-12 AU AU29559/97A patent/AU715572B2/en not_active Expired
- 1997-05-12 HU HU9901319A patent/HU224025B1/hu active Protection Beyond IP Right Term
- 1997-05-12 JP JP54150097A patent/JP3274687B2/ja not_active Expired - Lifetime
- 1997-05-12 NZ NZ330369A patent/NZ330369A/xx not_active IP Right Cessation
- 1997-05-12 IL IL12455197A patent/IL124551A/xx not_active IP Right Cessation
- 1997-05-12 SI SI9730272T patent/SI0904081T1/xx unknown
- 1997-05-12 TR TR1998/00923T patent/TR199800923T2/xx unknown
- 1997-05-12 BR BRPI9706824-1B8A patent/BR9706824B8/pt not_active IP Right Cessation
- 1997-05-12 PT PT97923912T patent/PT904081E/pt unknown
- 1997-05-12 WO PCT/EP1997/002504 patent/WO1997044039A1/fr not_active Ceased
- 1997-05-12 KR KR10-1998-0703629A patent/KR100358373B1/ko not_active Expired - Lifetime
- 1997-05-12 AT AT97923912T patent/ATE208619T1/de active
- 1997-05-12 CZ CZ19981401A patent/CZ291284B6/cs not_active IP Right Cessation
- 1997-05-12 PL PL97327995A patent/PL188309B1/pl unknown
- 1997-05-12 CN CN97191494A patent/CN1093762C/zh not_active Expired - Lifetime
- 1997-05-12 CA CA002236691A patent/CA2236691C/fr not_active Expired - Lifetime
- 1997-05-12 US US09/180,659 patent/US6077843A/en not_active Expired - Lifetime
- 1997-05-19 ID IDP971649A patent/ID16927A/id unknown
- 1997-05-19 MY MYPI97002172A patent/MY126302A/en unknown
- 1997-05-19 AR ARP970102112A patent/AR007194A1/es active IP Right Grant
- 1997-05-19 ZA ZA974331A patent/ZA974331B/xx unknown
- 1997-05-20 HR HR970276A patent/HRP970276B1/xx not_active IP Right Cessation
- 1997-12-05 UA UA98052747A patent/UA61898C2/uk unknown
1998
- 1998-04-30 NO NO19981984A patent/NO315931B1/no not_active IP Right Cessation
- 1998-05-12 BG BG102443A patent/BG62684B1/bg unknown
- 1998-06-15 MX MX9804816A patent/MX9804816A/es unknown
2002
- 2002-04-25 CY CY0200021A patent/CY2270B1/xx unknown
2011
- 2011-07-20 LU LU91842C patent/LU91842I2/fr unknown
- 2011-08-18 HU HUS1100013C patent/HUS1100013I1/hu unknown
- 2011-08-18 CY CY2011011C patent/CY2011011I1/el unknown
- 2011-08-29 NO NO2011015C patent/NO2011015I2/no unknown
- 2011-09-02 FR FR11C0035C patent/FR11C0035I2/fr active Active

Also Published As

Publication number	Publication date
EE9800136A (et)	1998-10-15
DE69708284T2 (de)	2002-07-25
PL188309B1 (pl)	2005-01-31
CN1093762C (zh)	2002-11-06
CZ140198A3 (cs)	1999-04-14
HUP9901319A2 (hu)	1999-08-30
JP2000513718A (ja)	2000-10-17
DE122011100027I1 (de)	2011-11-17
BR9706824B8 (pt)	2015-02-18
HK1017852A1 (en)	1999-12-03
ID16927A (id)	1997-11-20
IL124551A0 (en)	1998-12-06
DE69708284D1 (de)	2001-12-20
LU91842I2 (fr)	2011-09-20
HUP9901319A3 (en)	1999-11-29
NZ330369A (en)	2000-04-28
JP3274687B2 (ja)	2002-04-15
ATE208619T1 (de)	2001-11-15
UA61898C2 (en)	2003-12-15
ZA974331B (en)	1998-11-19
EA000536B1 (ru)	1999-10-28
CY2011011I2 (el)	2016-12-14
ES2167745T3 (es)	2002-05-16
NO2011015I2 (no)	2013-03-11
SK284013B6 (sk)	2004-08-03
SK62098A3 (en)	2000-04-10
NO2011015I1 (no)	2011-09-19
IL124551A (en)	2001-08-26
CN1206347A (zh)	1999-01-27
MY126302A (en)	2006-09-29
BG102443A (en)	1999-06-30
AU715572B2 (en)	2000-02-03
CY2011011I1 (el)	2016-12-14
PT904081E (pt)	2002-04-29
US6077843A (en)	2000-06-20
CY2270B1 (en)	2003-07-04
AR007194A1 (es)	1999-10-13
NO981984D0 (no)	1998-04-30
NO315931B1 (no)	2003-11-17
HU224025B1 (hu)	2005-05-30
KR100358373B1 (ko)	2003-02-11
WO1997044039A1 (fr)	1997-11-27
BR9706824A (pt)	1999-03-23
TW487572B (en)	2002-05-21
CA2236691A1 (fr)	1997-11-27
FR11C0035I1 (fr)	2011-07-10
NO981984L (no)	1998-11-19
TR199800923T2 (xx)	1999-09-21
DK0904081T3 (da)	2002-02-25
AU2955997A (en)	1997-12-09
KR19990067603A (ko)	1999-08-25
HRP970276B1 (en)	2002-04-30
EP0904081A1 (fr)	1999-03-31
CA2236691C (fr)	2007-01-02
MX9804816A (es)	1998-10-31
FR11C0035I2 (fr)	2013-08-16
HRP970276A2 (en)	1998-04-30
HUS1100013I1 (hu)	2017-03-28
BG62684B1 (bg)	2000-05-31
SI0904081T1 (en)	2002-04-30
EP0904081B1 (fr)	2001-11-14
PL327995A1 (en)	1999-01-04
CZ291284B6 (cs)	2003-01-15
EA199800531A1 (ru)	1998-12-24

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EE05214B1 (et)	2009-10-15	Polool-IFN- β konjugaat, selle valmistamismeetod ja farmatseutiline kompositsioon
EE9500064A (et)	1996-06-17	Asendatud 1H-imidasoolid, nende valmistamismeetodid ja farmatseutilised kompositsioonid
EE03380B1 (et)	2001-04-16	Farmatseutiline aerosoolpreparaat ja selle valmistamismeetod
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EE9900147A (et)	1999-12-15	Oksadiasoolid, nende saamismeetodid ja kasutamine ravimitena
HUP9900974A3 (en)	2000-09-28	Heterocycle-condensed morphinoid derivatives, process for the preparation thereof, their use and pharmaceutical compositions containing them
HUP0004024A3 (en)	2001-10-29	Azabenzimidazole-based compounds, process for their preparation and pharmaceutical composition thereof
IL135920A0 (en)	2001-05-20	2-aryl -8-oxodihydropurine derivative, process for the preparation thereof, pharmaceutical composition containing the same and intermediate therefor
HUP0001508A3 (en)	2003-01-28	4-arylmethylene-2-imino-2,3-dihydrothiazole derivatives, their use, process for the preparation thereof and pharmaceutical compositions containing them
EE200000225A (et)	2001-06-15	Arüüloksüalküüldialküülamiinid, nende valmistamismeetodid ja farmatseutiline kompositsioon
HUP0000426A3 (en)	2001-04-28	Novel benzonaphthyridines, pharmaceutical compositions and use thereof and process for their preparation
EE9800302A (et)	1999-02-15	Arüülglütsiinamiidi derivaadid, nende valmistamismeetod ja kasutamine ning farmatseutiline preparaat
KR100547921B1 (ko)	2006-10-19	설폰아미드-치환된크로만,이의제조방법및이를포함하는약제학적조성물
EE03825B1 (et)	2002-08-15	2-tsüanoiminoimidasooli derivaadid, nende valmistamismeetod, kasutamine ja farmatseutilised kompositsioonid
EE9800200A (et)	1998-12-15	Bensoüülguanidiini derivaadid, nende valmistamismeetod, kasutamine ja farmatseutiline kompositsioon
EE04119B1 (et)	2003-08-15	Külmkuivatamiseks sobiv ravimkoostis ja selle valmistamise meetod
EE04681B1 (et)	2006-08-15	3,6-poolketaalid 9a-asaliidide klassist, nende valmistamismeetod ja farmatseutiline kompositsioon
EE9900034A (et)	1999-08-16	Arüültsükloalkaankarboksüülestrid, nende kasutamine, farmatseutilised kompositsioonid ja valmistamine
EE03691B1 (et)	2002-04-15	1,2,3,4-tetrahüdrobensofuro[3,4-c]püridiini derivaadid, nende valmistamismeetod, kasutamine, farmatseutiline kompositsioon ja selle valmistamismeetod
AU2837089A (en)	1989-07-20	New indolylpiperidine compounds, processes for the preparation thereof and pharmaceutical composition comprising the same
GB8917687D0 (en)	1989-09-20	Aminopiperazine derivatives,processes for preparation thereof and pharmaceutical composition comprising the same
EE03387B1 (et)	2001-04-16	Kombineeritud ravimpreparaat, selle kasutamine ja meetod selle valmistamiseks
FI972988L (fi)	1997-09-11	Menetelmiä ja farmaseuttisia koostumuksia, joissa käytetään desmetyyliselegiliiniä
GB9123353D0 (en)	1991-12-18	New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same

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