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ECSP17032341A - COAGONISTS OF GLUCAGON AND GLP-1 RECEPTORS - Google Patents

COAGONISTS OF GLUCAGON AND GLP-1 RECEPTORS

Info

Publication number
ECSP17032341A
ECSP17032341A ECIEPI201732341A ECPI201732341A ECSP17032341A EC SP17032341 A ECSP17032341 A EC SP17032341A EC IEPI201732341 A ECIEPI201732341 A EC IEPI201732341A EC PI201732341 A ECPI201732341 A EC PI201732341A EC SP17032341 A ECSP17032341 A EC SP17032341A
Authority
EC
Ecuador
Prior art keywords
glucagon
glp
receptor
coagonists
peptide
Prior art date
Application number
ECIEPI201732341A
Other languages
Spanish (es)
Inventor
Paul Carrington
Sas Sofibel
Aktiebolag Aga
Development Industries Co Ltd Italpharma
Seguridad S L U Ifam
S A Tecnoquimicas
Qiaolin Deng
Chemical Co Ltd Sumitomo
S P A Freddy
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of ECSP17032341A publication Critical patent/ECSP17032341A/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Se describen análogos peptídicos de glucagón, que se han modificado para que sean resistentes a la escisión e inactivación por dipeptidilpeptidasa IV (DPP-IV) y para incrementar la semivida in vivo del análogo peptídico mientras que permite que el análogo peptídico tenga una actividad agonista relativamente equilibrada en el receptor del péptido similar al glucagón 1 (GLP-1) y en el receptor de glucagón (GCG), y al uso de dichos coagonistas de receptor de GLP-1/receptor de GCG para el tratamiento de trastornos metabólicos tales como diabetes, hesteatosis hepática no alcohólica (NAFLD), esteatohepatitis no alcohólica (NASH) y obesidad.Glucagon peptide analogs are described, which have been modified to be resistant to cleavage and inactivation by dipeptidylpeptidase IV (DPP-IV) and to increase the in vivo half-life of the peptide analog while allowing the peptide analog to have relatively agonist activity. balanced on glucagon-like peptide 1 (GLP-1) and glucagon receptor (GCG), and the use of these GLP-1 receptor / GCG receptor coagonists for the treatment of metabolic disorders such as diabetes , nonalcoholic hepatic hesteatosis (NAFLD), nonalcoholic steatohepatitis (NASH) and obesity.

ECIEPI201732341A 2014-10-24 2017-05-24 COAGONISTS OF GLUCAGON AND GLP-1 RECEPTORS ECSP17032341A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462068157P 2014-10-24 2014-10-24

Publications (1)

Publication Number Publication Date
ECSP17032341A true ECSP17032341A (en) 2017-09-29

Family

ID=58698765

Family Applications (1)

Application Number Title Priority Date Filing Date
ECIEPI201732341A ECSP17032341A (en) 2014-10-24 2017-05-24 COAGONISTS OF GLUCAGON AND GLP-1 RECEPTORS

Country Status (2)

Country Link
AR (1) AR102406A1 (en)
EC (1) ECSP17032341A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114349828B (en) * 2020-11-27 2023-12-08 江苏师范大学 GLP-1/glucagon receptor dual agonist and application thereof

Also Published As

Publication number Publication date
AR102406A1 (en) 2017-02-22

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