ECSP13012629A - COMPUESTOS 3-FENILSULFANILMETIL-BICICLO[3.1.0]HEXANO 4-SUSTITUIDOS COMO ANTAGONISTAS DE mGluR 2/3 - Google Patents
COMPUESTOS 3-FENILSULFANILMETIL-BICICLO[3.1.0]HEXANO 4-SUSTITUIDOS COMO ANTAGONISTAS DE mGluR 2/3Info
- Publication number
- ECSP13012629A ECSP13012629A ECSP13012629A ECSP13012629A EC SP13012629 A ECSP13012629 A EC SP13012629A EC SP13012629 A ECSP13012629 A EC SP13012629A EC SP13012629 A ECSP13012629 A EC SP13012629A
- Authority
- EC
- Ecuador
- Prior art keywords
- phenylsulphanylme
- mglur
- antagonists
- hexane
- substituted
- Prior art date
Links
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 title 3
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 title 1
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 101001071429 Homo sapiens Metabotropic glutamate receptor 2 Proteins 0.000 abstract 1
- 102100036837 Metabotropic glutamate receptor 2 Human genes 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a un antagonista del receptor mGlu2/3 de la fórmula:se describen sus usos, y métodos para su preparación.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41512110P | 2010-11-18 | 2010-11-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP13012629A true ECSP13012629A (es) | 2013-07-31 |
Family
ID=45099188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP13012629 ECSP13012629A (es) | 2010-11-18 | 2013-05-17 | COMPUESTOS 3-FENILSULFANILMETIL-BICICLO[3.1.0]HEXANO 4-SUSTITUIDOS COMO ANTAGONISTAS DE mGluR 2/3 |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US8629169B2 (es) |
| EP (1) | EP2640697B1 (es) |
| JP (1) | JP5877847B2 (es) |
| KR (2) | KR20130101094A (es) |
| CN (1) | CN103228625B (es) |
| AR (1) | AR083845A1 (es) |
| AU (1) | AU2011329076B2 (es) |
| BR (1) | BR112013012118A2 (es) |
| CA (1) | CA2818116C (es) |
| CL (1) | CL2013001345A1 (es) |
| CO (1) | CO6761385A2 (es) |
| CR (1) | CR20130178A (es) |
| DK (1) | DK2640697T3 (es) |
| DO (1) | DOP2013000099A (es) |
| EA (1) | EA021724B1 (es) |
| EC (1) | ECSP13012629A (es) |
| ES (1) | ES2650139T3 (es) |
| GT (1) | GT201300126A (es) |
| HR (1) | HRP20171649T1 (es) |
| HU (1) | HUE037457T2 (es) |
| IL (1) | IL225843A (es) |
| LT (1) | LT2640697T (es) |
| MA (1) | MA34663B1 (es) |
| MX (1) | MX339973B (es) |
| NO (1) | NO2640697T3 (es) |
| NZ (1) | NZ609816A (es) |
| PE (1) | PE20140997A1 (es) |
| PH (1) | PH12013500991A1 (es) |
| PL (1) | PL2640697T3 (es) |
| PT (1) | PT2640697T (es) |
| RS (1) | RS56535B1 (es) |
| SG (1) | SG189959A1 (es) |
| SI (1) | SI2640697T1 (es) |
| TW (1) | TWI520935B (es) |
| UA (1) | UA110039C2 (es) |
| WO (1) | WO2012068067A1 (es) |
| ZA (1) | ZA201302918B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR079343A1 (es) * | 2009-12-21 | 2012-01-18 | Lilly Co Eli | Compuesto de acido 2-amino-4-(4h-1,2,4-triazol-3-ilsulfanil)biciclo[3.1.0]hexano-2,6-dicarboxilico, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar un trastorno psiquiatrico |
| EP3000814A1 (en) | 2014-09-26 | 2016-03-30 | Domain Therapeutics | Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors |
| HRP20211277T1 (hr) | 2016-04-18 | 2021-11-12 | Taisho Pharmaceutical Co., Ltd. | Predlijek derivata aminokiseline |
| CN110191709A (zh) | 2017-01-17 | 2019-08-30 | 德州大学系统董事会 | 可用作吲哚胺2,3-双加氧酶和/或色氨酸双加氧酶抑制剂的化合物 |
| WO2020018670A1 (en) * | 2018-07-17 | 2020-01-23 | Board Of Regents, The University Of Texas System | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0669928B2 (ja) | 1987-10-06 | 1994-09-07 | 宇部興産株式会社 | 光重合性歯科材料 |
| JP2589812B2 (ja) | 1989-07-05 | 1997-03-12 | 松下電器産業株式会社 | スチームアイロン |
| ZA969485B (en) | 1995-11-16 | 1998-05-12 | Lilly Co Eli | Excitatory amino acid receptor antagonists. |
| KR19990067597A (ko) * | 1995-11-16 | 1999-08-25 | 피터 지. 스트링거 | 흥분성 아미노산 수용체 길항제 |
| ZA983930B (en) * | 1997-05-14 | 1999-11-08 | Lilly Co Eli | Excitatory amino acid receptor modulators. |
| CN1231461C (zh) * | 1998-03-17 | 2005-12-14 | 辉瑞产品公司 | 二环并[2.2.1]庚烷和有关化合物 |
| GB9815542D0 (en) | 1998-07-17 | 1998-09-16 | Lilly Co Eli | Bicyclohexane derivatives |
| CH694053A5 (de) | 1998-09-03 | 2004-06-30 | Hoffmann La Roche | Verfahren zur Herstellung von 2-Amino-bicyclo[3.1.0]hexan-2,6-dicarbonsäure-Derivaten. |
| EP1370519A1 (en) * | 2001-02-22 | 2003-12-17 | Eli Lilly And Company | Synthetic excitatory amino acids |
| MXPA04006322A (es) | 2001-12-27 | 2004-10-04 | Taisho Pharmaceutical Co Ltd | Derivados de 6-fluorobiciclo[3.1.0]hexano. |
| ATE421526T1 (de) * | 2002-06-11 | 2009-02-15 | Lilly Co Eli | Prodrugs von exzitatorischen aminosäuren |
| JP2007063129A (ja) | 2003-06-26 | 2007-03-15 | Taisho Pharmaceut Co Ltd | ２−アミノ−３−アルコキシビシクロ［３．１．０］ヘキサン誘導体 |
| HRP20100619T1 (hr) | 2003-06-26 | 2011-01-31 | Taisho Pharmaceutical Co. | Derivat 2-aminobiciklo[3.1.0]heksan-2,6-dikarboksilnog estera |
| US7381746B2 (en) * | 2003-06-26 | 2008-06-03 | Taisho Pharmaceutical Co., Ltd. | 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative |
| AR079343A1 (es) * | 2009-12-21 | 2012-01-18 | Lilly Co Eli | Compuesto de acido 2-amino-4-(4h-1,2,4-triazol-3-ilsulfanil)biciclo[3.1.0]hexano-2,6-dicarboxilico, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar un trastorno psiquiatrico |
-
2011
- 2011-11-11 AR ARP110104219A patent/AR083845A1/es unknown
- 2011-11-11 TW TW100141326A patent/TWI520935B/zh not_active IP Right Cessation
- 2011-11-15 UA UAA201305835A patent/UA110039C2/ru unknown
- 2011-11-15 MX MX2013005622A patent/MX339973B/es active IP Right Grant
- 2011-11-15 WO PCT/US2011/060730 patent/WO2012068067A1/en not_active Ceased
- 2011-11-15 KR KR1020137012697A patent/KR20130101094A/ko not_active Abandoned
- 2011-11-15 EA EA201390498A patent/EA021724B1/ru not_active IP Right Cessation
- 2011-11-15 EP EP11791692.4A patent/EP2640697B1/en active Active
- 2011-11-15 BR BR112013012118A patent/BR112013012118A2/pt not_active IP Right Cessation
- 2011-11-15 KR KR1020157034547A patent/KR20150140876A/ko not_active Ceased
- 2011-11-15 SG SG2013030507A patent/SG189959A1/en unknown
- 2011-11-15 AU AU2011329076A patent/AU2011329076B2/en not_active Ceased
- 2011-11-15 JP JP2013539938A patent/JP5877847B2/ja active Active
- 2011-11-15 RS RS20171082A patent/RS56535B1/sr unknown
- 2011-11-15 NZ NZ609816A patent/NZ609816A/en not_active IP Right Cessation
- 2011-11-15 DK DK11791692.4T patent/DK2640697T3/en active
- 2011-11-15 PE PE2013001215A patent/PE20140997A1/es not_active Application Discontinuation
- 2011-11-15 CN CN201180055263.7A patent/CN103228625B/zh active Active
- 2011-11-15 ES ES11791692.4T patent/ES2650139T3/es active Active
- 2011-11-15 PH PH1/2013/500991A patent/PH12013500991A1/en unknown
- 2011-11-15 HR HRP20171649TT patent/HRP20171649T1/hr unknown
- 2011-11-15 SI SI201131304T patent/SI2640697T1/sl unknown
- 2011-11-15 CA CA2818116A patent/CA2818116C/en active Active
- 2011-11-15 LT LTEP11791692.4T patent/LT2640697T/lt unknown
- 2011-11-15 NO NO11791692A patent/NO2640697T3/no unknown
- 2011-11-15 US US13/296,384 patent/US8629169B2/en active Active
- 2011-11-15 PT PT117916924T patent/PT2640697T/pt unknown
- 2011-11-15 HU HUE11791692A patent/HUE037457T2/hu unknown
- 2011-11-15 PL PL11791692T patent/PL2640697T3/pl unknown
-
2013
- 2013-04-18 IL IL225843A patent/IL225843A/en not_active IP Right Cessation
- 2013-04-22 ZA ZA2013/02918A patent/ZA201302918B/en unknown
- 2013-04-24 CR CR20130178A patent/CR20130178A/es unknown
- 2013-05-08 DO DO2013000099A patent/DOP2013000099A/es unknown
- 2013-05-13 MA MA35898A patent/MA34663B1/fr unknown
- 2013-05-15 CL CL2013001345A patent/CL2013001345A1/es unknown
- 2013-05-15 GT GT201300126A patent/GT201300126A/es unknown
- 2013-05-17 EC ECSP13012629 patent/ECSP13012629A/es unknown
- 2013-05-30 CO CO13133036A patent/CO6761385A2/es unknown
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