ECSP11011107A - Derivados bicíclicos de morfina-6-glucurónido, su preparación y su aplicación en terapéutica - Google Patents
Derivados bicíclicos de morfina-6-glucurónido, su preparación y su aplicación en terapéuticaInfo
- Publication number
- ECSP11011107A ECSP11011107A EC2011011107A ECSP11011107A ECSP11011107A EC SP11011107 A ECSP11011107 A EC SP11011107A EC 2011011107 A EC2011011107 A EC 2011011107A EC SP11011107 A ECSP11011107 A EC SP11011107A EC SP11011107 A ECSP11011107 A EC SP11011107A
- Authority
- EC
- Ecuador
- Prior art keywords
- therapeutics
- application
- group
- preparation
- glucurónido
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000004001 thioalkyl group Chemical group 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/06—Heterocyclic radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Abstract
La presente invención tiene por objeto los compuestos que responden a la fórmula (I) en la que : R1 representa un átomo de hidrógeno o un grupo alquilo(C1-C4), R2 representa un grupo hidroxilo, un grupo tiol, un grupo alquiloxi(C1-C4) o un grupo tioalquilo(C1-C4), y n es un número entero igual a 1 ó 2, en el estado de base o de sal de adición a un ácido así como en el estado de hidrato o de solvato. La presente invención pretende igualmente su procedimiento de preparación y su aplicación en terapéutica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0806974A FR2939796B1 (fr) | 2008-12-11 | 2008-12-11 | Derives bicycliques de morphine-6-glucuronide, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP11011107A true ECSP11011107A (es) | 2011-07-29 |
Family
ID=41037668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2011011107A ECSP11011107A (es) | 2008-12-11 | 2011-06-03 | Derivados bicíclicos de morfina-6-glucurónido, su preparación y su aplicación en terapéutica |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US8440634B2 (es) |
| EP (1) | EP2376511B1 (es) |
| JP (1) | JP5616355B2 (es) |
| KR (1) | KR20110091536A (es) |
| CN (1) | CN102317302B (es) |
| AR (1) | AR074578A1 (es) |
| AU (1) | AU2009326907B2 (es) |
| BR (1) | BRPI0923368A2 (es) |
| CA (1) | CA2746701A1 (es) |
| CL (1) | CL2011001401A1 (es) |
| CO (1) | CO6382159A2 (es) |
| CR (1) | CR20110317A (es) |
| EA (1) | EA201170791A1 (es) |
| EC (1) | ECSP11011107A (es) |
| ES (1) | ES2470684T3 (es) |
| FR (1) | FR2939796B1 (es) |
| HN (1) | HN2011001614A (es) |
| IL (1) | IL213380A (es) |
| MA (1) | MA32954B1 (es) |
| ME (1) | ME01147B (es) |
| MX (1) | MX2011006251A (es) |
| MY (1) | MY153779A (es) |
| NI (1) | NI201100113A (es) |
| NZ (1) | NZ593340A (es) |
| PE (1) | PE20120231A1 (es) |
| SG (1) | SG172070A1 (es) |
| SV (1) | SV2011003937A (es) |
| TN (1) | TN2011000277A1 (es) |
| TW (1) | TW201026313A (es) |
| UA (1) | UA104445C2 (es) |
| WO (1) | WO2010067008A2 (es) |
| ZA (1) | ZA201104389B (es) |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3766188A (en) | 1971-06-28 | 1973-10-16 | Yamanouchi Pharma Co Ltd | Carbonyldioxymorphinan derivatives |
| GB9116909D0 (en) | 1991-08-06 | 1991-09-18 | Salford Ultrafine Chem & Res | Morphine derivatives |
| GB2282758A (en) | 1993-08-23 | 1995-04-19 | Euro Celtique Sa | Oral morphine-6-glucuronide compositions |
| EP0975648B1 (en) * | 1997-04-14 | 2003-06-04 | Ufc Limited | Morphine derivatives |
| AU756816B2 (en) * | 1998-02-02 | 2003-01-23 | Cenes Limited | Glycosidation of 4,5-epoxymorphinan-6-ols |
| PT1086114E (pt) | 1998-06-06 | 2003-02-28 | Cenes Ltd | Sintese da morfina-6-glucuronido |
| DE10161963A1 (de) * | 2001-12-17 | 2003-07-03 | Johannes Schuetz | 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung |
| DE10229842A1 (de) * | 2002-07-03 | 2004-02-05 | Helmut Prof. Dr. Schmidhammer | Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung |
| GB0218811D0 (en) * | 2002-08-14 | 2002-09-18 | Cenes Ltd | Salts of morphine-6-glucuronide |
| FR2864082B1 (fr) * | 2003-12-22 | 2006-03-10 | Synt Em | Nouveau derive de la morphine-6-glucuronide, composition pharmaceutique le contenant et son utilisation pour le traitement de la douleur |
| WO2005117589A1 (en) * | 2004-05-28 | 2005-12-15 | Human Biomolecular Research Institute | Synthesis of metabolically stable analgesics, pain medications and other agents |
| FR2907121B1 (fr) * | 2006-10-12 | 2012-05-04 | Neorphys | Nouveaux derives morphiniques |
-
2008
- 2008-12-11 FR FR0806974A patent/FR2939796B1/fr not_active Expired - Fee Related
-
2009
- 2009-12-08 JP JP2011540162A patent/JP5616355B2/ja not_active Expired - Fee Related
- 2009-12-08 CN CN200980156458.3A patent/CN102317302B/zh not_active Expired - Fee Related
- 2009-12-08 BR BRPI0923368A patent/BRPI0923368A2/pt not_active IP Right Cessation
- 2009-12-08 AU AU2009326907A patent/AU2009326907B2/en not_active Ceased
- 2009-12-08 UA UAA201108555A patent/UA104445C2/uk unknown
- 2009-12-08 MX MX2011006251A patent/MX2011006251A/es active IP Right Grant
- 2009-12-08 MA MA34001A patent/MA32954B1/fr unknown
- 2009-12-08 PE PE2011001206A patent/PE20120231A1/es not_active Application Discontinuation
- 2009-12-08 WO PCT/FR2009/052446 patent/WO2010067008A2/fr not_active Ceased
- 2009-12-08 EA EA201170791A patent/EA201170791A1/ru unknown
- 2009-12-08 EP EP09801747.8A patent/EP2376511B1/fr active Active
- 2009-12-08 SG SG2011042330A patent/SG172070A1/en unknown
- 2009-12-08 CA CA2746701A patent/CA2746701A1/fr not_active Abandoned
- 2009-12-08 KR KR1020117013251A patent/KR20110091536A/ko not_active Abandoned
- 2009-12-08 ME MEP-2011-104A patent/ME01147B/me unknown
- 2009-12-08 ES ES09801747.8T patent/ES2470684T3/es active Active
- 2009-12-08 MY MYPI2011002645A patent/MY153779A/en unknown
- 2009-12-08 NZ NZ593340A patent/NZ593340A/xx not_active IP Right Cessation
- 2009-12-10 AR ARP090104785A patent/AR074578A1/es unknown
- 2009-12-11 TW TW098142583A patent/TW201026313A/zh unknown
-
2011
- 2011-05-30 TN TN2011000277A patent/TN2011000277A1/fr unknown
- 2011-06-03 EC EC2011011107A patent/ECSP11011107A/es unknown
- 2011-06-05 IL IL213380A patent/IL213380A/en not_active IP Right Cessation
- 2011-06-07 CR CR20110317A patent/CR20110317A/es unknown
- 2011-06-08 SV SV2011003937A patent/SV2011003937A/es unknown
- 2011-06-08 NI NI201100113A patent/NI201100113A/es unknown
- 2011-06-08 US US13/155,727 patent/US8440634B2/en not_active Expired - Fee Related
- 2011-06-09 CL CL2011001401A patent/CL2011001401A1/es unknown
- 2011-06-10 HN HN2011001614A patent/HN2011001614A/es unknown
- 2011-06-10 CO CO11072131A patent/CO6382159A2/es not_active Application Discontinuation
- 2011-06-13 ZA ZA2011/04389A patent/ZA201104389B/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI1011683B8 (pt) | derivados de isoquinolina substituída, suas composições farmacêuticas e seus usos | |
| CO6362007A2 (es) | Derivados de azaspiranil-alquilcarbamatos de heterociclos de 5 eslabones, su preparación y su aplicación en terapeútica | |
| UY30603A1 (es) | Derivados de 2-aril-6-fenil-imidazo[1, 2-a]piridinas, su preparacion y su aplicacion en terapéutica | |
| CO6351789A2 (es) | Derivados de carbamatos de alquiltiazoles, su preparacion y su aplicacion en terapeutica | |
| HN2010001460A (es) | Derivados biciclicos de carboxamidas aza-biciclicas, su preparacion y su aplicacion terapeutica | |
| ECSP099330A (es) | Compuesto de indol | |
| BR112014001018A2 (pt) | derivado de azabenzimidazol tendo atividade de ativação de ampk | |
| UY29047A1 (es) | Derivados de sulfonamidas, su preparación y su aplicación en terapéutica | |
| DOP2010000213A (es) | Derivados de carboxamidas azabiciclicas, su preparacion y su aplicacion en terapeutica | |
| BRPI1009212B8 (pt) | Composto de piperazina capaz de inibir a prostaglandina d sintase, seus usos e composição farmacêutica | |
| UY32308A (es) | Nucleótidos uracil ciclopropílicos | |
| ECSP099216A (es) | Nuevos derivados de diosmetina, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
| CR11327A (es) | Derivados de quinazolinadiona, su preparacion y sus aplicaciones terapeuticas | |
| CO6251235A2 (es) | Compuestos derivados de azetidinas su preparacion y su aplicacion en terapeutica | |
| CU20100157A7 (es) | Nuevos derivados dihidroindolonas, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
| BRPI1016069A8 (pt) | Misturas de ésteres e composições compreendendo tais misturas de ésteres | |
| CO6150157A2 (es) | Derivados de 7-alquinil-1,8- naftiridonas su preparacion y su aplicacion en terapeutica | |
| UY29857A1 (es) | Derivados de la 4-amino-quinazolina, su preparación y su aplicación en terapéutica. | |
| CR9565A (es) | Derivados del 4,5-diarilpirrol, su preparacion y su aplicacion en terapeutica | |
| BR112012020703A2 (pt) | composição para o controle de pragas | |
| CO6382159A2 (es) | Derivados bicíclicos de morfina-6-glucurónido, su preparación y su aplicación en terapéuticaqq | |
| HN2009001484A (es) | Derivados de azabicicloalcano, su preparacion y su aplicacion en terapeutica | |
| CO6190551A2 (es) | Derivado de alquilsulfona | |
| AR074514A1 (es) | Derivados de morfina-6-glucuronido, su preparacion y su aplicacion en terapeutica | |
| CU20120041A7 (es) | Nuevos derivados dihidro-oxazolobenzodiazepinonas, su procedimiento de preparación y las composiciones farmacéuticas que los contienen |