ECSP099765A - Novedosas moléculas de anticuerpos y ácidos nucleicos que se enlazan con la proteina de tension fungica hsp90 - Google Patents
Novedosas moléculas de anticuerpos y ácidos nucleicos que se enlazan con la proteina de tension fungica hsp90Info
- Publication number
- ECSP099765A ECSP099765A EC2009009765A ECSP099765A ECSP099765A EC SP099765 A ECSP099765 A EC SP099765A EC 2009009765 A EC2009009765 A EC 2009009765A EC SP099765 A ECSP099765 A EC SP099765A EC SP099765 A ECSP099765 A EC SP099765A
- Authority
- EC
- Ecuador
- Prior art keywords
- fungical
- novels
- antibodies
- nucleic
- molecules
- Prior art date
Links
- 101710113864 Heat shock protein 90 Proteins 0.000 title 1
- 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/14—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from fungi, algea or lichens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Plant Pathology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Se da a conocer un péptido scFv, el cual comprende un dominio VH y un dominio VL enlazados por un espaciador de aminoácidos. El dominio VH comprende una secuencia con una identidad de secuencia de cuando menos el 80 por ciento con la secuencia de la SEQ ID NO:64. El dominio VL comprende una secuencia con una identidad de secuencia de cuando menos el 80 por ciento con la secuencia de la SEQ ID NO:66. El péptido scFv también comprende la sustitución o la supresión de un aminoácido en el dominio VH en la posición correspondiente a C28.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07107140 | 2007-04-27 | ||
| EP07113353 | 2007-07-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP099765A true ECSP099765A (es) | 2009-12-28 |
Family
ID=39717534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2009009765A ECSP099765A (es) | 2007-04-27 | 2009-11-27 | Novedosas moléculas de anticuerpos y ácidos nucleicos que se enlazan con la proteina de tension fungica hsp90 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US20100113355A1 (es) |
| EP (2) | EP2144932A1 (es) |
| JP (1) | JP2010524485A (es) |
| KR (1) | KR20100017387A (es) |
| CN (1) | CN101679517A (es) |
| AR (1) | AR066311A1 (es) |
| AU (1) | AU2008244308A1 (es) |
| BR (1) | BRPI0810827A2 (es) |
| CA (1) | CA2685136A1 (es) |
| CL (1) | CL2008001202A1 (es) |
| CR (1) | CR11059A (es) |
| EA (1) | EA200901441A1 (es) |
| EC (1) | ECSP099765A (es) |
| GT (1) | GT200900276A (es) |
| IL (1) | IL201445A0 (es) |
| MA (1) | MA31384B1 (es) |
| MX (1) | MX2009011595A (es) |
| PE (1) | PE20090728A1 (es) |
| TN (1) | TN2009000442A1 (es) |
| TW (1) | TW200902714A (es) |
| WO (2) | WO2008132152A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100113355A1 (en) | 2007-04-27 | 2010-05-06 | Naresh Chennamsetty | Novel antibody molecules and nucleic acids binding to fungal stress protein hsp90 |
| CA2956161A1 (en) * | 2014-07-23 | 2016-01-28 | Ohio State Innovation Foundation | Methods and compositions related to antibody fragments that bind to tumor-associated glycoprotein 72 (tag-72) |
| CN105652011B (zh) * | 2014-11-20 | 2017-09-22 | 深圳市安群生物工程有限公司 | 检测人HSP90α‑2蛋白的荧光免疫层析试纸及其制备方法 |
| CN111116743B (zh) * | 2018-10-30 | 2022-01-28 | 迈威(上海)生物科技股份有限公司 | Hsp90抗体及其在抗真菌感染中的应用 |
| EP4572772A1 (en) | 2022-08-17 | 2025-06-25 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
| WO2024249954A1 (en) | 2023-05-31 | 2024-12-05 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| WO2025076127A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| WO2025076113A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Ionizable cationic lipids with conserved spacing and lipid nanoparticles |
| WO2025217452A1 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| WO2025217454A2 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Ionizable cationic lipids and lipid nanoparticles |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4732852A (en) * | 1981-11-20 | 1988-03-22 | Cetus Corporation | Site directed peptidase cleavage |
| US4670382A (en) | 1983-12-02 | 1987-06-02 | Temple University--of the Commonwealth System of Higher Education | Monoclonal antibody to Candida albicans cytoplasmic antigens and methods of preparing same |
| US4806465A (en) * | 1984-01-16 | 1989-02-21 | Temple University Of The Commonwealth System Of Higher Education | Cytoplasmic antigens of candida albicans and methods of using the same |
| GB8506373D0 (en) | 1985-03-12 | 1985-04-11 | Axon Healthcare Ltd | Antigens antibodies |
| GB8915019D0 (en) | 1989-06-30 | 1989-08-23 | Matthews Ruth C | Medicaments |
| EP0604580A1 (en) | 1991-09-19 | 1994-07-06 | Genentech, Inc. | EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab') 2? ANTIBODIES |
| GB2270076A (en) | 1992-08-18 | 1994-03-02 | Univ Manchester | Human HSP 90 Epitopes |
| WO2000061578A1 (en) | 1999-04-09 | 2000-10-19 | Sloan-Kettering Institute For Cancer Research | Methods and compositions for degradation and/or inhibition of her-family tyrosine kinases |
| ES2287044T3 (es) | 2000-01-25 | 2007-12-16 | Oklahoma Medical Research Foundation | Procedimiento universal para el replegamiento de proteinas recombinantes. |
| GB0008305D0 (en) * | 2000-04-06 | 2000-05-24 | Neutec Pharma Plc | Treatment of fungal infections |
| AU2001272001A1 (en) | 2000-07-14 | 2002-01-30 | Healthcite, Inc. | Method and system for providing medical information |
| AU2002252179A1 (en) * | 2001-03-01 | 2002-09-19 | Conforma Therapeutics Corp. | Methods for treating genetically-defined proliferative disorders with hsp90 inhibitors |
| GB0127983D0 (en) | 2001-11-22 | 2002-01-16 | Neutec Pharma Plc | Treatment of micro-organism infection |
| GB0315111D0 (en) * | 2003-06-27 | 2003-07-30 | Cancer Rec Tech Ltd | Substituted 5-membered ring compounds and their use |
| GB0409077D0 (en) | 2004-04-23 | 2004-05-26 | Neutec Pharma Plc | Treatment of fungal infections |
| KR20070050918A (ko) * | 2004-07-02 | 2007-05-16 | 뉴텍 파마 피엘씨 | 암의 치료 |
| US20100113355A1 (en) | 2007-04-27 | 2010-05-06 | Naresh Chennamsetty | Novel antibody molecules and nucleic acids binding to fungal stress protein hsp90 |
| WO2008132174A1 (en) | 2007-04-27 | 2008-11-06 | Novartis Ag | An immunoglobulin composition |
-
2006
- 2006-04-24 US US12/597,229 patent/US20100113355A1/en not_active Abandoned
-
2008
- 2008-04-24 CA CA002685136A patent/CA2685136A1/en not_active Abandoned
- 2008-04-24 US US12/150,076 patent/US7722869B2/en not_active Expired - Fee Related
- 2008-04-24 BR BRPI0810827-7A2A patent/BRPI0810827A2/pt not_active Application Discontinuation
- 2008-04-24 WO PCT/EP2008/055037 patent/WO2008132152A1/en not_active Ceased
- 2008-04-24 MX MX2009011595A patent/MX2009011595A/es unknown
- 2008-04-24 KR KR1020097024646A patent/KR20100017387A/ko not_active Withdrawn
- 2008-04-24 EA EA200901441A patent/EA200901441A1/ru unknown
- 2008-04-24 EP EP08736541A patent/EP2144932A1/en not_active Withdrawn
- 2008-04-24 JP JP2010504689A patent/JP2010524485A/ja active Pending
- 2008-04-24 EP EP08749716A patent/EP2152746A1/en not_active Withdrawn
- 2008-04-24 WO PCT/EP2008/055006 patent/WO2008132134A1/en not_active Ceased
- 2008-04-24 CN CN200880013913A patent/CN101679517A/zh active Pending
- 2008-04-24 AU AU2008244308A patent/AU2008244308A1/en not_active Abandoned
- 2008-04-25 PE PE2008000709A patent/PE20090728A1/es not_active Application Discontinuation
- 2008-04-25 TW TW097115380A patent/TW200902714A/zh unknown
- 2008-04-25 AR ARP080101768A patent/AR066311A1/es unknown
- 2008-04-25 CL CL2008001202A patent/CL2008001202A1/es unknown
-
2009
- 2009-10-09 CR CR11059A patent/CR11059A/es not_active Application Discontinuation
- 2009-10-11 IL IL201445A patent/IL201445A0/en unknown
- 2009-10-23 GT GT200900276A patent/GT200900276A/es unknown
- 2009-10-23 TN TNP2009000442A patent/TN2009000442A1/fr unknown
- 2009-11-20 MA MA32355A patent/MA31384B1/fr unknown
- 2009-11-27 EC EC2009009765A patent/ECSP099765A/es unknown
-
2010
- 2010-03-08 US US12/719,049 patent/US20100166758A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0810827A2 (pt) | 2014-10-29 |
| IL201445A0 (en) | 2010-06-16 |
| PE20090728A1 (es) | 2009-07-02 |
| EP2152746A1 (en) | 2010-02-17 |
| EP2144932A1 (en) | 2010-01-20 |
| WO2008132134A9 (en) | 2009-07-09 |
| MA31384B1 (fr) | 2010-05-03 |
| AU2008244308A1 (en) | 2008-11-06 |
| AR066311A1 (es) | 2009-08-12 |
| TN2009000442A1 (en) | 2011-03-31 |
| WO2008132134A1 (en) | 2008-11-06 |
| CR11059A (es) | 2009-11-20 |
| KR20100017387A (ko) | 2010-02-16 |
| TW200902714A (en) | 2009-01-16 |
| US20100166758A1 (en) | 2010-07-01 |
| CL2008001202A1 (es) | 2008-12-19 |
| MX2009011595A (es) | 2009-12-08 |
| JP2010524485A (ja) | 2010-07-22 |
| EA200901441A1 (ru) | 2010-04-30 |
| CA2685136A1 (en) | 2008-11-06 |
| US20090136484A1 (en) | 2009-05-28 |
| CN101679517A (zh) | 2010-03-24 |
| US7722869B2 (en) | 2010-05-25 |
| US20100113355A1 (en) | 2010-05-06 |
| GT200900276A (es) | 2010-05-21 |
| WO2008132152A1 (en) | 2008-11-06 |
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