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ECSP088437A - Compuestos y métodos para inhibir la replicación viral de hepatitis c - Google Patents

Compuestos y métodos para inhibir la replicación viral de hepatitis c

Info

Publication number
ECSP088437A
ECSP088437A EC2008008437A ECSP088437A ECSP088437A EC SP088437 A ECSP088437 A EC SP088437A EC 2008008437 A EC2008008437 A EC 2008008437A EC SP088437 A ECSP088437 A EC SP088437A EC SP088437 A ECSP088437 A EC SP088437A
Authority
EC
Ecuador
Prior art keywords
compounds
hepatitis
inhibit
methods
viral replication
Prior art date
Application number
EC2008008437A
Other languages
English (en)
Inventor
Lawrence M Blatt
Steven Wade Andrews
Scott D Seiwert
Leonid Beigelman
Julia Haas
Original Assignee
Intermune Inc
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intermune Inc, Array Biopharma Inc filed Critical Intermune Inc
Publication of ECSP088437A publication Critical patent/ECSP088437A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Los compuestos macrocíclicos que tienen las estructuras descritas en la presente son útiles para inhibir la replicación del virus de hepatitis C (VHC). En modalidades preferidas, los compuestos son activos tanto contra la NS3 proteasa como la NS3 helicasa de VHC.
EC2008008437A 2005-10-11 2008-05-08 Compuestos y métodos para inhibir la replicación viral de hepatitis c ECSP088437A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72556405P 2005-10-11 2005-10-11

Publications (1)

Publication Number Publication Date
ECSP088437A true ECSP088437A (es) 2008-06-30

Family

ID=37943551

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008437A ECSP088437A (es) 2005-10-11 2008-05-08 Compuestos y métodos para inhibir la replicación viral de hepatitis c

Country Status (26)

Country Link
US (1) US8119592B2 (es)
EP (1) EP1999129B1 (es)
JP (1) JP2009511595A (es)
KR (1) KR20080056295A (es)
CN (1) CN101415705B (es)
AT (1) ATE493409T1 (es)
AU (1) AU2006301966A1 (es)
BR (1) BRPI0617274A2 (es)
CA (1) CA2624333A1 (es)
CU (1) CU23781B7 (es)
DE (1) DE602006019323D1 (es)
DK (1) DK1999129T3 (es)
EA (1) EA200801050A1 (es)
EC (1) ECSP088437A (es)
ES (1) ES2356776T3 (es)
GE (1) GEP20104956B (es)
IL (1) IL190404A0 (es)
MA (1) MA29924B1 (es)
MX (1) MX2008004754A (es)
NI (1) NI200800114A (es)
NO (1) NO20081999L (es)
NZ (1) NZ568135A (es)
TN (1) TNSN08160A1 (es)
UA (1) UA93990C2 (es)
WO (1) WO2007044893A2 (es)
ZA (1) ZA200803797B (es)

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