ECSP088431A - Derivados de pirazolo - Google Patents
Derivados de pirazoloInfo
- Publication number
- ECSP088431A ECSP088431A EC2008008431A ECSP088431A ECSP088431A EC SP088431 A ECSP088431 A EC SP088431A EC 2008008431 A EC2008008431 A EC 2008008431A EC SP088431 A ECSP088431 A EC SP088431A EC SP088431 A ECSP088431 A EC SP088431A
- Authority
- EC
- Ecuador
- Prior art keywords
- alkyl
- derivatives
- pirazolo
- halogen
- independently represent
- Prior art date
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un compuesto de fórmula (I) (consta gráfico) o uno de sus derivados farmacéuticamente aceptables, en donde R1 y R3 representan, de modo independiente, H, alquilo C1-6, cicloalquilo C3-8 o halógeno; R2 representa alquilo C1-6, CF3 o arilo;a representa 1 ó 2; R4, R5, R7 y R8 representan, de modo independiente, H, alquilo C1-6, alquil C1-6oxi, CN o halógeno, o R4 y R5, o R7 y R8, junto con el anillo al que están unidos, forman un arilo o sistema de anillos heterocíclicos fusionados;X representa C o N; Y representa CH2 u O; y R6 representa H, CN o halo, pero cuando X representa N, entonces R6 representa H.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73509105P | 2005-11-08 | 2005-11-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP088431A true ECSP088431A (es) | 2008-06-30 |
Family
ID=37909834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2008008431A ECSP088431A (es) | 2005-11-08 | 2008-05-06 | Derivados de pirazolo |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US7309712B2 (es) |
| EP (1) | EP1948615B1 (es) |
| JP (1) | JP4234786B1 (es) |
| KR (1) | KR100997595B1 (es) |
| CN (1) | CN101304974A (es) |
| AP (1) | AP2008004463A0 (es) |
| AR (1) | AR056780A1 (es) |
| AT (1) | ATE537150T1 (es) |
| AU (1) | AU2006313478A1 (es) |
| BR (1) | BRPI0618630A2 (es) |
| CA (1) | CA2628844C (es) |
| CR (1) | CR9959A (es) |
| CY (1) | CY1112286T1 (es) |
| DK (1) | DK1948615T3 (es) |
| DO (1) | DOP2006000245A (es) |
| EA (1) | EA014693B1 (es) |
| EC (1) | ECSP088431A (es) |
| ES (1) | ES2376252T3 (es) |
| GT (1) | GT200600478A (es) |
| HN (1) | HN2006037713A (es) |
| IL (1) | IL190806A0 (es) |
| MA (1) | MA29940B1 (es) |
| NL (1) | NL2000299C2 (es) |
| NO (1) | NO20082504L (es) |
| PE (1) | PE20070642A1 (es) |
| PL (1) | PL1948615T3 (es) |
| PT (1) | PT1948615E (es) |
| RS (1) | RS20080191A (es) |
| SI (1) | SI1948615T1 (es) |
| TN (1) | TNSN08202A1 (es) |
| TW (1) | TWI321563B (es) |
| UA (1) | UA90763C2 (es) |
| UY (1) | UY29904A1 (es) |
| WO (1) | WO2007054770A2 (es) |
| ZA (1) | ZA200803670B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE241351T1 (de) | 1996-07-24 | 2003-06-15 | Warner Lambert Co | Isobutylgaba und dessen derivate zur schmerzbehandlung |
| CN101304974A (zh) * | 2005-11-08 | 2008-11-12 | 辉瑞有限公司 | 吡唑衍生物和它们的医药用途 |
| JP5448164B2 (ja) | 2006-07-28 | 2014-03-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を変調する化合物 |
| US7928123B2 (en) | 2006-09-25 | 2011-04-19 | Boehringer Ingelheim International Gmbh | Compounds which modulate the CB2 receptor |
| WO2008135824A1 (en) * | 2007-05-02 | 2008-11-13 | Pfizer Limited | Oxyalkylpyrazole compounds useful in therapy |
| WO2009061652A1 (en) | 2007-11-07 | 2009-05-14 | Boehringer Ingelheim International Gmbh | Compounds which modulate the cb2 receptor |
| SG176464A1 (en) * | 2008-05-09 | 2011-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
| CA2724232A1 (en) * | 2008-05-13 | 2009-11-19 | Boehringer Ingelheim International Gmbh | Sulfone compounds which modulate the cb2 receptor |
| WO2010005782A1 (en) | 2008-07-10 | 2010-01-14 | Boehringer Ingelheim International Gmbh | Sulfone compounds which modulate the cb2 receptor |
| AP2011005674A0 (en) | 2008-09-25 | 2011-04-30 | Boehringer Ingelheim Int | Sulfonyl compounds which selectively modulate the CB2 receptor. |
| US8299103B2 (en) | 2009-06-15 | 2012-10-30 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the CB2 receptor |
| US8383615B2 (en) | 2009-06-16 | 2013-02-26 | Boehringer Ingelheim International Gmbh | Azetidine 2-carboxamide derivatives which modulate the CB2 receptor |
| US8383651B2 (en) | 2009-09-22 | 2013-02-26 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the CB2 receptor |
| US10610528B2 (en) | 2009-12-08 | 2020-04-07 | Intelgenx Corp. | Solid oral film dosage forms and methods for making same |
| US20110136815A1 (en) | 2009-12-08 | 2011-06-09 | Horst Zerbe | Solid oral film dosage forms and methods for making same |
| EP2523936A1 (en) | 2010-01-15 | 2012-11-21 | Boehringer Ingelheim International GmbH | Compounds which modulate the cb2 receptor |
| US8329735B2 (en) | 2010-03-05 | 2012-12-11 | Boehringer Ingelheim International Gmbh | Tetrazole compounds which selectively modulate the CB2 receptor |
| US20110263606A1 (en) * | 2010-04-26 | 2011-10-27 | Horst Zerbe | Solid oral dosage forms comprising tadalafil |
| EP2595959B1 (en) | 2010-07-22 | 2015-11-04 | Boehringer Ingelheim International GmbH | Sulfonyl compounds which modulate the cb2 receptor |
| EP2803668A1 (en) | 2013-05-17 | 2014-11-19 | Boehringer Ingelheim International Gmbh | Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles |
| WO2020078402A1 (zh) * | 2018-10-18 | 2020-04-23 | 南京圣和药业股份有限公司 | 作为TGF-βR1抑制剂的化合物及其应用 |
| RU2711615C1 (ru) * | 2019-09-12 | 2020-01-17 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт акушерства, гинекологии и репродуктологии имени Д.О. Отта" | Способ лечения эндометриоза на основании экспериментальной модели у крыс |
| CN111269097B (zh) * | 2020-04-02 | 2023-02-17 | 苏州爱玛特生物科技有限公司 | 一种多元环双取代的1,3-丙二酮类化合物的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6281638A (ja) * | 1985-10-07 | 1987-04-15 | Fuji Photo Film Co Ltd | ハロゲン化銀カラ−写真感光材料 |
| JPS63313784A (ja) * | 1987-03-12 | 1988-12-21 | Zeria Shinyaku Kogyo Kk | 新規ピラゾール誘導体およびその製造法ならびにこれを有効成分とする抗潰瘍剤 |
| DE4414792A1 (de) * | 1993-08-11 | 1995-02-16 | Bayer Ag | Arzneimittel enthaltend 1-Thiocarbamoyl-5-hydroxypyrazolen und deren Verwendung als Mittel zur Bekämpfung des septischen Schocks |
| PT1377556E (pt) * | 2001-04-10 | 2007-06-06 | Pfizer Ltd | Derivados de pirazole para tratamento do hiv |
| GB0229618D0 (en) * | 2002-12-19 | 2003-01-22 | Cancer Rec Tech Ltd | Pyrazole compounds |
| CN101304974A (zh) * | 2005-11-08 | 2008-11-12 | 辉瑞有限公司 | 吡唑衍生物和它们的医药用途 |
-
2006
- 2006-10-26 CN CNA2006800416684A patent/CN101304974A/zh active Pending
- 2006-10-26 JP JP2008539519A patent/JP4234786B1/ja not_active Expired - Fee Related
- 2006-10-26 AT AT06809167T patent/ATE537150T1/de active
- 2006-10-26 RS RSP-2008/0191A patent/RS20080191A/sr unknown
- 2006-10-26 DK DK06809167.7T patent/DK1948615T3/da active
- 2006-10-26 PT PT06809167T patent/PT1948615E/pt unknown
- 2006-10-26 KR KR1020087010982A patent/KR100997595B1/ko not_active Expired - Fee Related
- 2006-10-26 BR BRPI0618630-0A patent/BRPI0618630A2/pt not_active IP Right Cessation
- 2006-10-26 PL PL06809167T patent/PL1948615T3/pl unknown
- 2006-10-26 UA UAA200805973A patent/UA90763C2/ru unknown
- 2006-10-26 CA CA2628844A patent/CA2628844C/en not_active Expired - Fee Related
- 2006-10-26 AP AP2008004463A patent/AP2008004463A0/xx unknown
- 2006-10-26 ES ES06809167T patent/ES2376252T3/es active Active
- 2006-10-26 SI SI200631237T patent/SI1948615T1/sl unknown
- 2006-10-26 EA EA200801053A patent/EA014693B1/ru not_active IP Right Cessation
- 2006-10-26 EP EP06809167A patent/EP1948615B1/en active Active
- 2006-10-26 AU AU2006313478A patent/AU2006313478A1/en not_active Abandoned
- 2006-10-26 WO PCT/IB2006/003080 patent/WO2007054770A2/en not_active Ceased
- 2006-11-02 NL NL2000299A patent/NL2000299C2/nl not_active IP Right Cessation
- 2006-11-03 US US11/592,574 patent/US7309712B2/en not_active Expired - Fee Related
- 2006-11-06 PE PE2006001366A patent/PE20070642A1/es not_active Application Discontinuation
- 2006-11-07 TW TW095141158A patent/TWI321563B/zh active
- 2006-11-07 AR ARP060104881A patent/AR056780A1/es unknown
- 2006-11-07 HN HN2006037713A patent/HN2006037713A/es unknown
- 2006-11-07 GT GT200600478A patent/GT200600478A/es unknown
- 2006-11-08 DO DO2006000245A patent/DOP2006000245A/es unknown
- 2006-11-08 UY UY29904A patent/UY29904A1/es not_active Application Discontinuation
-
2007
- 2007-10-11 US US11/870,451 patent/US7425569B2/en not_active Expired - Fee Related
-
2008
- 2008-04-10 IL IL190806A patent/IL190806A0/en unknown
- 2008-04-25 ZA ZA200803670A patent/ZA200803670B/xx unknown
- 2008-05-06 EC EC2008008431A patent/ECSP088431A/es unknown
- 2008-05-07 TN TNP2008000202A patent/TNSN08202A1/fr unknown
- 2008-05-08 CR CR9959A patent/CR9959A/es not_active Application Discontinuation
- 2008-05-08 MA MA30910A patent/MA29940B1/fr unknown
- 2008-06-05 NO NO20082504A patent/NO20082504L/no not_active Application Discontinuation
-
2012
- 2012-01-27 CY CY20121100096T patent/CY1112286T1/el unknown
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