ECSP066718A - Derivados de pirazolo[1,5-a]pirimidin-7-il-amina para usar en el tratamiento de enfermedades dependientes de la proteina quinasa - Google Patents

Derivados de pirazolo[1,5-a]pirimidin-7-il-amina para usar en el tratamiento de enfermedades dependientes de la proteina quinasa

Info

Publication number: ECSP066718A
Authority: EC; Ecuador
Prior art keywords: treatment; pirazolo; pirimidin; amina; derivatives
Prior art date: 2004-01-22

Application number

EC2006006718A

Other languages

English (en)

Spanish (es)

Inventor

Pascal Furet

Keiichi Masuya

Guido Bold

Andreas Floersheimer

Patricia Imbach

Joseph Schoepfer

Georg Martiny-Baron

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-01-22

Filing date

2006-07-21

Publication date

2006-10-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34807167&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP066718(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-07-21 Application filed by Novartis Ag filed Critical Novartis Ag

2006-10-31 Publication of ECSP066718A publication Critical patent/ECSP066718A/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Ophthalmology & Optometry (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Oncology (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Hematology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EC2006006718A 2004-01-22 2006-07-21 Derivados de pirazolo[1,5-a]pirimidin-7-il-amina para usar en el tratamiento de enfermedades dependientes de la proteina quinasa ECSP066718A (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US53822004P	2004-01-22	2004-01-22

Publications (1)

Publication Number	Publication Date
ECSP066718A true ECSP066718A (es)	2006-10-31

Family

ID=34807167

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EC2006006718A ECSP066718A (es)	2004-01-22	2006-07-21	Derivados de pirazolo[1,5-a]pirimidin-7-il-amina para usar en el tratamiento de enfermedades dependientes de la proteina quinasa

Country Status (17)

Country	Link
EP (1)	EP1708710A1 (no)
JP (1)	JP2007519662A (no)
KR (1)	KR20070009546A (no)
CN (1)	CN1909908A (no)
AR (1)	AR049769A1 (no)
AU (1)	AU2005205915B2 (no)
BR (1)	BRPI0507071A (no)
CA (1)	CA2552885A1 (no)
EC (1)	ECSP066718A (no)
IL (1)	IL176737A0 (no)
MA (1)	MA28400B1 (no)
NO (1)	NO20063758L (no)
PE (1)	PE20051089A1 (no)
RU (1)	RU2006130003A (no)
TN (1)	TNSN06226A1 (no)
TW (1)	TW200528103A (no)
WO (1)	WO2005070431A1 (no)

Families Citing this family (44)

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US7563798B2 (en) *	2002-09-04	2009-07-21	Schering Corporation	Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
US7605155B2 (en) *	2002-09-04	2009-10-20	Schering Corporation	Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
US7196078B2 (en) *	2002-09-04	2007-03-27	Schering Corpoartion	Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
GB0515026D0 (en) *	2005-07-21	2005-08-31	Novartis Ag	Organic compounds
US7776865B2 (en) *	2005-10-06	2010-08-17	Schering Corporation	Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
TWI421078B (zh) *	2005-10-06	2014-01-01	Merck Sharp & Dohme	關卡激酶抑制劑及其用途
DK1973545T3 (da)	2005-12-23	2013-02-25	Ariad Pharma Inc	Bicykliske heteroarylforbindelser
US20090069315A1 (en) *	2006-03-08	2009-03-12	Rajeev Sivasankaran	Use of Pyrazolo(1,5A)Pyrimidin-7-YL Amine Derivatives in the Treatment of Neurological Disorders
WO2007109183A2 (en) *	2006-03-20	2007-09-27	Novartis Ag	Mutations and polymorphisms of fms-related tyrosine kinase 1
GB0606804D0 (en) *	2006-04-04	2006-05-17	Novartis Ag	Organic Compounds
GB0606805D0 (en) *	2006-04-04	2006-05-17	Novartis Ag	Organic compounds
KR20090073120A (ko) *	2006-09-28	2009-07-02	노파르티스 아게	피라졸로[1,5-ａ]피리미딘 유도체 및 이들의 치료 용도
KR20090073121A (ko)	2006-09-29	2009-07-02	노파르티스 아게	Ｐｉ3ｋ 지질 키나제 억제제로서의 피라졸로피리미딘
EP1918291A1 (en) *	2006-10-30	2008-05-07	Novartis AG	3-Aminocarbonyl-substituted fused pyrazolo-derivatives as protein kinase modulators
CA2689667A1 (en) *	2007-06-07	2008-12-18	Schering Corporation	Synthesis of substituted-3-aminopyrazoles
WO2010118207A1 (en)	2009-04-09	2010-10-14	Schering Corporation	Pyrazolo [1, 5-a] pyrimidine derivatives as mtor inhibitors
AU2010300925A1 (en)	2009-09-30	2012-03-29	Merck Sharp & Dohme Corp.	Novel compounds that are ERK inhibitors
UY33227A (es) *	2010-02-19	2011-09-30	Novartis Ag	Compuestos de pirrolopirimidina como inhibidores de la cdk4/6
CN105693720B (zh)	2010-05-20	2019-01-18	阵列生物制药公司	作为trk激酶抑制剂的大环化合物
CN103097380B (zh) *	2010-08-09	2015-06-03	株式会社创药分子设计	酪蛋白激酶1δ及酪蛋白激酶1ε抑制剂
WO2012023143A1 (en)	2010-08-19	2012-02-23	E. I. Du Pont De Nemours And Company	Fungicidal pyrazoles
EP2615916B1 (en)	2010-09-16	2017-01-04	Merck Sharp & Dohme Corp.	Fused pyrazole derivatives as novel erk inhibitors
WO2013077579A1 (ko) *	2011-11-25	2013-05-30	가톨릭대학교 산학협력단	안과 질환의 예방 및 치료용 약학 조성물
CN105906630B (zh) *	2015-04-06	2018-10-23	四川百利药业有限责任公司	用作fgfr抑制剂的n-(1h-吡唑-5-基)嘧啶并吡唑-4,6-二取代胺类化合物
EP3322706B1 (en)	2015-07-16	2020-11-11	Array Biopharma, Inc.	Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
TWI704148B (zh)	2016-10-10	2020-09-11	美商亞雷生物製藥股份有限公司	作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
JOP20190077A1 (ar)	2016-10-10	2019-04-09	Array Biopharma Inc	مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret
CN106588893A (zh) *	2016-12-01	2017-04-26	北京万全德众医药生物技术有限公司	维拉佐酮双氧化物的制备
CN110267960B (zh)	2017-01-18	2022-04-26	阿雷生物药品公司	作为RET激酶抑制剂的取代的吡唑并[1,5-a]吡嗪化合物
WO2018136663A1 (en)	2017-01-18	2018-07-26	Array Biopharma, Inc.	Ret inhibitors
JOP20190213A1 (ar)	2017-03-16	2019-09-16	Array Biopharma Inc	مركبات حلقية ضخمة كمثبطات لكيناز ros1
TWI791053B (zh)	2017-10-10	2023-02-01	美商亞雷生物製藥股份有限公司	6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
TWI812649B (zh)	2017-10-10	2023-08-21	美商絡速藥業公司	6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
TW201938169A (zh)	2018-01-18	2019-10-01	美商亞雷生物製藥股份有限公司	作為RET激酶抑制劑之經取代吡唑并[3,4-d]嘧啶化合物
WO2019143994A1 (en)	2018-01-18	2019-07-25	Array Biopharma Inc.	Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors
CN111971286B (zh)	2018-01-18	2023-04-14	阿雷生物药品公司	作为RET激酶抑制剂的取代的吡咯并[2,3-d]嘧啶化合物
IL312674A (en)	2018-01-29	2024-07-01	Merck Patent Gmbh	GCN2 inhibitors and uses thereof
EP3746075B1 (en) *	2018-01-29	2025-09-03	Merck Patent GmbH	Gcn2 inhibitors and uses thereof
ES2922314T3 (es)	2018-09-10	2022-09-13	Array Biopharma Inc	Compuestos heterocíclicos condensados como inhibidores de cinasa RET
CN109836428A (zh) *	2019-02-27	2019-06-04	华东师范大学	具有免疫抑制活性的吡唑[4,3-d]嘧啶衍生物及用途
US20210008173A1 (en) *	2019-07-10	2021-01-14	Musc Foundation For Research Development	Endostatin peptides for the treatment of tumors, fibrosis and acute lung injury
KR20230154292A (ko)	2019-11-25	2023-11-07	암젠 인크	델타-5 불포화효소 억제제로서의 헤테로시클릭 화합물 및 사용 방법
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2005
- 2005-01-20 AR ARP050100208A patent/AR049769A1/es unknown
- 2005-01-20 PE PE2005000080A patent/PE20051089A1/es not_active Application Discontinuation
- 2005-01-21 WO PCT/EP2005/000602 patent/WO2005070431A1/en not_active Ceased
- 2005-01-21 BR BRPI0507071-6A patent/BRPI0507071A/pt not_active IP Right Cessation
- 2005-01-21 EP EP05706961A patent/EP1708710A1/en not_active Withdrawn
- 2005-01-21 KR KR1020067014683A patent/KR20070009546A/ko not_active Withdrawn
- 2005-01-21 TW TW094101852A patent/TW200528103A/zh unknown
- 2005-01-21 JP JP2006550056A patent/JP2007519662A/ja active Pending
- 2005-01-21 CA CA002552885A patent/CA2552885A1/en not_active Abandoned
- 2005-01-21 AU AU2005205915A patent/AU2005205915B2/en not_active Ceased
- 2005-01-21 CN CNA2005800030379A patent/CN1909908A/zh active Pending
- 2005-01-21 RU RU2006130003/15A patent/RU2006130003A/ru not_active Application Discontinuation
2006
- 2006-07-06 IL IL176737A patent/IL176737A0/en unknown
- 2006-07-10 MA MA29182A patent/MA28400B1/fr unknown
- 2006-07-21 EC EC2006006718A patent/ECSP066718A/es unknown
- 2006-07-21 TN TNP2006000226A patent/TNSN06226A1/en unknown
- 2006-08-22 NO NO20063758A patent/NO20063758L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NO20063758L (no)	2006-10-23
AU2005205915A1 (en)	2005-08-04
AR049769A1 (es)	2006-09-06
RU2006130003A (ru)	2008-04-10
IL176737A0 (en)	2006-10-31
WO2005070431A1 (en)	2005-08-04
EP1708710A1 (en)	2006-10-11
JP2007519662A (ja)	2007-07-19
AU2005205915B2 (en)	2009-05-21
CN1909908A (zh)	2007-02-07
KR20070009546A (ko)	2007-01-18
CA2552885A1 (en)	2005-08-04
PE20051089A1 (es)	2006-01-25
MA28400B1 (fr)	2007-01-02
TNSN06226A1 (en)	2007-12-03
BRPI0507071A (pt)	2007-06-19
TW200528103A (en)	2005-09-01

Publication	Publication Date	Title
ECSP066718A (es)	2006-10-31	Derivados de pirazolo[1,5-a]pirimidin-7-il-amina para usar en el tratamiento de enfermedades dependientes de la proteina quinasa
CR8102A (es)	2006-08-09	Derivados de pirazolo- quinazolina, procedimiento para preparacion y su uso como inhibidores de quinasa
ECSP088350A (es)	2008-05-30	Pirazolopirimidinas como inhibidores de protein quinasas
MX2007005644A (es)	2007-06-05	Pirazolo-pirimidinas 1,4-sustituidas como inhibidores de cinasa.
ATE405564T1 (de)	2008-09-15	1h-imidazoä4,5-cüchinolinderivate zur behandlung von protein kinase-abhängigen krankheiten
CR8171A (es)	2006-08-09	Derivados de pirrolo[3,4-c] pyrazol activos como inhibidores de quinasa
UY27755A1 (es)	2003-11-28	Nuevas composiciones farmacéuticas basadas en anticolinérgicos e inhibidores.
ATE400573T1 (de)	2008-07-15	1h-imidazochinolinderivate als proteinkinaseinhibitoren
TW200745128A (en)	2007-12-16	Pyrazolopyrimidines as protein kinase inhibitors
BRPI0519567A2 (pt)	2009-01-27	heterociclos tricÍclicos, sua fabricaÇço e uso como agentes farmacÊuticos
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