ECSP003399A - DERIVATIVES FROM 1- ARENOSULFONIL - 2- ARYL - PIRROLIDINE AND PIPERIDINE - Google Patents
DERIVATIVES FROM 1- ARENOSULFONIL - 2- ARYL - PIRROLIDINE AND PIPERIDINEInfo
- Publication number
- ECSP003399A ECSP003399A ECSP003399A ECSP003399A EC SP003399 A ECSP003399 A EC SP003399A EC SP003399 A ECSP003399 A EC SP003399A EC SP003399 A ECSP003399 A EC SP003399A
- Authority
- EC
- Ecuador
- Prior art keywords
- lower alkyl
- phenyl
- toluen
- pyrrolidine
- sulfonyl
- Prior art date
Links
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Natural products C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- OOVSRCPGHGCJAM-UHFFFAOYSA-N 1-(4-methylphenyl)sulfonyl-2-phenylpyrrolidine Chemical compound C1=CC(C)=CC=C1S(=O)(=O)N1C(C=2C=CC=CC=2)CCC1 OOVSRCPGHGCJAM-UHFFFAOYSA-N 0.000 abstract 1
- WRLSSXDFVXDSKD-UHFFFAOYSA-N 2-(4-methylphenyl)-1-(4-methylphenyl)sulfonylpyrrolidine Chemical compound C1=CC(C)=CC=C1C1N(S(=O)(=O)C=2C=CC(C)=CC=2)CCC1 WRLSSXDFVXDSKD-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 abstract 1
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 abstract 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 239000003823 glutamate receptor agonist Substances 0.000 abstract 1
- 239000003825 glutamate receptor antagonist Substances 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención se refiere a compuestos de fórmula general (gráfico), en donde R1 significa hidrógeno, alquilo inferior o hidroxilo-alquilo inferior; R2 significa furilo, tienilo, piridilo o fenilo, el cual está opcionalmente sustituido por 1 a 3 substituyentes, seleccionados de alquilo inferior, alcoxilo inferior, halógeno, ciano, CF3 ó -N(R4)2, R3 significa naftilo o fenilo, el cual está opcionalmente substituido con 1 a 3 substituyentes, seleccionado de alquilo inferior, alcoxilo inferior, halógeno, acetilo, ciano, hidroxilo-alquilo inferior, -CH2-morfolin-4-ilo, alquilo inferior-oxi-alquilo inferior, alquilo inferior-N(R4)2 ó CF3; R4 significa, independientemente entre si, hidrógeno o alquilo inferior, con la excepción de la (RS)-2-fenil-1-(toluen-4-sulfonil)-pirrolidina y (RS)-1-(toluen-4-sulfonil)-2-p-tolil-pirrolidina asi como sus sales farmacéuticamente aceptables. Los compuestos discretos más arriba son antagonistas o agonistas del receptor metabotrópico de glutamato, y porlo tanto son de utilidad en el tratamiento de los correspondientes trastornos del SNC.The invention relates to compounds of the general formula (graph), wherein R1 signifies hydrogen, lower alkyl or hydroxyl-lower alkyl; R2 signifies furyl, thienyl, pyridyl or phenyl, which is optionally substituted by 1 to 3 substituents, selected from lower alkyl, lower alkoxy, halogen, cyano, CF3 or -N (R4) 2, R3 means naphthyl or phenyl, which is optionally substituted with 1 to 3 substituents, selected from lower alkyl, lower alkoxy, halogen, acetyl, cyano, hydroxyl-lower alkyl, -CH2-morpholin-4-yl, lower alkyl-oxy-lower alkyl, lower alkyl-N ( R4) 2 or CF3; R4 means, independently of each other, hydrogen or lower alkyl, with the exception of (RS) -2-phenyl-1- (toluen-4-sulfonyl) -pyrrolidine and (RS) -1- (toluen-4-sulfonyl) -2-p-tolyl-pyrrolidine as well as its pharmaceutically acceptable salts. The discrete compounds above are metabotropic glutamate receptor antagonists or agonists, and are therefore useful in the treatment of corresponding CNS disorders.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003399 ECSP003399A (en) | 2000-03-24 | 2000-03-24 | DERIVATIVES FROM 1- ARENOSULFONIL - 2- ARYL - PIRROLIDINE AND PIPERIDINE |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003399 ECSP003399A (en) | 2000-03-24 | 2000-03-24 | DERIVATIVES FROM 1- ARENOSULFONIL - 2- ARYL - PIRROLIDINE AND PIPERIDINE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP003399A true ECSP003399A (en) | 2000-11-24 |
Family
ID=42041029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP003399 ECSP003399A (en) | 2000-03-24 | 2000-03-24 | DERIVATIVES FROM 1- ARENOSULFONIL - 2- ARYL - PIRROLIDINE AND PIPERIDINE |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP003399A (en) |
-
2000
- 2000-03-24 EC ECSP003399 patent/ECSP003399A/en unknown
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