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EA201790186A1 - Замещенные азаспиро(4.5)декановые производные - Google Patents

Замещенные азаспиро(4.5)декановые производные

Info

Publication number
EA201790186A1
EA201790186A1 EA201790186A EA201790186A EA201790186A1 EA 201790186 A1 EA201790186 A1 EA 201790186A1 EA 201790186 A EA201790186 A EA 201790186A EA 201790186 A EA201790186 A EA 201790186A EA 201790186 A1 EA201790186 A1 EA 201790186A1
Authority
EA
Eurasian Patent Office
Prior art keywords
decane derivatives
substituted azaspiro
substituted
compounds
preparation
Prior art date
Application number
EA201790186A
Other languages
English (en)
Inventor
Анита Вегерт
Берт Нольте
Клаус Линц
Штефани Харльфингер
Бабетте-Ивонне Кёгель
Пол Рэтклифф
Фритц Тайль
Ольга Грёгер
Биргит Браун
Original Assignee
Грюненталь Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Грюненталь Гмбх filed Critical Грюненталь Гмбх
Publication of EA201790186A1 publication Critical patent/EA201790186A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретение относится к замещенным спироциклическим циклогексановым производным, которые обладают аффинностью к μопиоидному рецептору и ORL1 рецептору, способам их получения, лекарственным средствам, содержащим такие соединения, и применению таких соединений для получения лекарственных средств.
EA201790186A 2014-07-15 2015-07-14 Замещенные азаспиро(4.5)декановые производные EA201790186A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14002438 2014-07-15
PCT/EP2015/001446 WO2016008583A1 (de) 2014-07-15 2015-07-14 Substituierte aza-spiro(4.5)decan-derivate

Publications (1)

Publication Number Publication Date
EA201790186A1 true EA201790186A1 (ru) 2017-07-31

Family

ID=51211483

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201790186A EA201790186A1 (ru) 2014-07-15 2015-07-14 Замещенные азаспиро(4.5)декановые производные

Country Status (22)

Country Link
US (1) US10202345B2 (ru)
EP (1) EP3169665B1 (ru)
JP (1) JP6490187B2 (ru)
CN (1) CN106536514A (ru)
AU (1) AU2015291468B2 (ru)
BR (1) BR112017000766A2 (ru)
CA (1) CA2955073A1 (ru)
CY (1) CY1120443T1 (ru)
DK (1) DK3169665T3 (ru)
EA (1) EA201790186A1 (ru)
ES (1) ES2680820T3 (ru)
HR (1) HRP20180940T1 (ru)
HU (1) HUE039604T2 (ru)
LT (1) LT3169665T (ru)
MX (1) MX2017000519A (ru)
PL (1) PL3169665T3 (ru)
PT (1) PT3169665T (ru)
RS (1) RS57388B1 (ru)
SI (1) SI3169665T1 (ru)
TR (1) TR201809663T4 (ru)
TW (1) TW201607923A (ru)
WO (1) WO2016008583A1 (ru)

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Also Published As

Publication number Publication date
HRP20180940T1 (hr) 2018-07-27
PL3169665T3 (pl) 2018-12-31
EP3169665A1 (de) 2017-05-24
MX2017000519A (es) 2017-05-01
BR112017000766A2 (pt) 2017-11-21
AU2015291468B2 (en) 2019-01-24
WO2016008583A8 (de) 2016-03-31
AU2015291468A1 (en) 2017-03-02
SI3169665T1 (en) 2018-08-31
CY1120443T1 (el) 2019-07-10
HUE039604T2 (hu) 2019-01-28
US10202345B2 (en) 2019-02-12
LT3169665T (lt) 2018-07-10
US20160016903A1 (en) 2016-01-21
WO2016008583A1 (de) 2016-01-21
PT3169665T (pt) 2018-07-12
DK3169665T3 (en) 2018-06-25
ES2680820T3 (es) 2018-09-11
EP3169665B1 (de) 2018-05-09
CA2955073A1 (en) 2016-01-21
CN106536514A (zh) 2017-03-22
JP2017520599A (ja) 2017-07-27
RS57388B1 (sr) 2018-09-28
TR201809663T4 (tr) 2018-07-23
JP6490187B2 (ja) 2019-03-27
TW201607923A (zh) 2016-03-01

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