EA201700518A3 - ANTIMICROBIAL COMBINATION WITH RESPECT TO THE SUSTAINABLE CARBAPENES OF THE GRAMORATORY BACTERIA OF ACINETOBACTER BAUMANNII KIND, PRODUCING METAL-β-LACTAMAZ - Google Patents
ANTIMICROBIAL COMBINATION WITH RESPECT TO THE SUSTAINABLE CARBAPENES OF THE GRAMORATORY BACTERIA OF ACINETOBACTER BAUMANNII KIND, PRODUCING METAL-β-LACTAMAZInfo
- Publication number
- EA201700518A3 EA201700518A3 EA201700518A EA201700518A EA201700518A3 EA 201700518 A3 EA201700518 A3 EA 201700518A3 EA 201700518 A EA201700518 A EA 201700518A EA 201700518 A EA201700518 A EA 201700518A EA 201700518 A3 EA201700518 A3 EA 201700518A3
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- carbapenems
- lactamase
- respect
- metallo
- acinetobacter baumannii
- Prior art date
Links
- 241000588626 Acinetobacter baumannii Species 0.000 title abstract 3
- 230000000845 anti-microbial effect Effects 0.000 title abstract 2
- 241000894006 Bacteria Species 0.000 title 1
- 229940041011 carbapenems Drugs 0.000 abstract 3
- 102000020235 metallo-beta-lactamase Human genes 0.000 abstract 3
- 108060004734 metallo-beta-lactamase Proteins 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- 229940122361 Bisphosphonate Drugs 0.000 abstract 1
- 241000588724 Escherichia coli Species 0.000 abstract 1
- WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 150000004663 bisphosphonates Chemical class 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- ZSKVGTPCRGIANV-ZXFLCMHBSA-N imipenem Chemical compound C1C(SCC\N=C\N)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 ZSKVGTPCRGIANV-ZXFLCMHBSA-N 0.000 abstract 1
- 229960002182 imipenem Drugs 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 229960002260 meropenem Drugs 0.000 abstract 1
- DMJNNHOOLUXYBV-PQTSNVLCSA-N meropenem Chemical compound C=1([C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)S[C@@H]1CN[C@H](C(=O)N(C)C)C1 DMJNNHOOLUXYBV-PQTSNVLCSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Изобретение относится к области медицины, в частности к клинической микробиологии, и может быть использовано для преодоления устойчивости грамотрицательных микроорганизмов вида Acinetobacter baumannii, продуцирующих металло-β-лактамазу (МβЛ), к карбапенемам. Указанный технический результат достигается тем, что клодроновая или этидроновая кислоты из группы бисфосфонатов ингибируют стандартный реактив - металло-β-лактамазу P.aeruginosa, рекомбинантную, экспрессированную в Escherichia coli. Достигнутый результат позволил выявить антимикробный эффект комбинации клодроновой или этидроновой кислот с карбапенемами (имипенемом или меропенемом) в отношении референс-штамма A.baumannii ATCC BAA-747, резистентного к карбапенемам, в присутствии стандартного реактива МβЛ, инактивирующего эти антибиотики. Предложенное техническое решение позволяет моделировать получение штаммов грамотрицательных микроорганизмов с различным уровнем резистентности к карбапенемам и оценивать эффективность ингибирования металло-β-лактамаз.The invention relates to the field of medicine, in particular to clinical microbiology, and can be used to overcome the resistance of Gram-negative microorganisms of the species Acinetobacter baumannii, producing metallo-β-lactamase (МβЛ), to carbapenems. This technical result is achieved by the fact that clodronic or etidronovy acid from the group of bisphosphonates inhibit the standard reagent - metallo-β-lactamase P. aeruginosa, recombinant, expressed in Escherichia coli. The achieved result allowed to reveal the antimicrobial effect of the combination of clodronic or etidronic acids with carbapenems (imipenem or meropenem) with respect to the reference A.baumannii ATCC BAA-747 resistant antibiotic The proposed solution allows to simulate the production of strains of gram-negative microorganisms with different levels of resistance to carbapenems and to assess the effectiveness of inhibition of metallo-β-lactamase.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2016147239A RU2666619C2 (en) | 2016-12-01 | 2016-12-01 | ANTIMICROBIAL COMBINATION FOR CARBAPENEM-RESISTANT GRAM-NEGATIVE BACTERIA OF THE SPECIES ACINETOBACTER BAUMANNII PRODUCING METAL-β-LACTAMASE |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EA201700518A2 EA201700518A2 (en) | 2018-07-31 |
| EA201700518A3 true EA201700518A3 (en) | 2018-11-30 |
| EA033885B1 EA033885B1 (en) | 2019-12-05 |
Family
ID=62557456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201700518A EA033885B1 (en) | 2016-12-01 | 2017-11-23 | ANTIMICROBIAL COMBINATION FOR CARBAPENEM-RESISTANT GRAM-NEGATIVE BACTERIA OF THE SPECIES ACINETOBACTER BAUMANNII PRODUCING METAL-β-LACTAMASE |
Country Status (2)
| Country | Link |
|---|---|
| EA (1) | EA033885B1 (en) |
| RU (1) | RU2666619C2 (en) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5888998A (en) * | 1997-04-24 | 1999-03-30 | Synphar Laboratories, Inc. | 2-oxo-1-azetidine sulfonic acid derivatives as potent β-lactamase inhibitors |
| JP4122049B2 (en) * | 2005-09-22 | 2008-07-23 | 明治製菓株式会社 | Metallo-β-lactamase inhibitor |
| RU2488394C2 (en) * | 2007-03-23 | 2013-07-27 | Базилеа Фармацойтика Аг | Combined therapeutic agents for treating bacterial infections |
| PL2512461T3 (en) * | 2009-12-18 | 2014-06-30 | Colgate Palmolive Co | Chalcones as enhancer of antimicrobial agents |
-
2016
- 2016-12-01 RU RU2016147239A patent/RU2666619C2/en active
-
2017
- 2017-11-23 EA EA201700518A patent/EA033885B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2016147239A (en) | 2018-06-05 |
| RU2666619C2 (en) | 2018-09-11 |
| EA033885B1 (en) | 2019-12-05 |
| RU2016147239A3 (en) | 2018-06-05 |
| EA201700518A2 (en) | 2018-07-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112019003427A2 (en) | antibiotic compounds | |
| BR112017010132A2 (en) | combination therapy for treatment of resistant bacterial infections | |
| BR112017020935A2 (en) | "compounds, pharmaceutical composition and assembly" | |
| BR112018005318A2 (en) | ? lysine polypeptides active against gram-negative bacteria? | |
| MY179292A (en) | Monobactam organic compounds for the treatment of bacterial infections | |
| EA201991523A1 (en) | COMBINED THERAPY BY AMIDINE-SUBSTITUTED BETA-LACTAMIC COMPOUNDS AND INHIBITORS OF BETA-LACTAMASE IN INFECTIONS CAUSED BY BACTERIAL STRAINS RESISTANT TO ANTIBIOTICS | |
| IN2014MN02438A (en) | ||
| TW201613575A (en) | Treatment of polybacterial infections | |
| BR112014004704A2 (en) | antibacterial compounds and methods of use | |
| MY191276A (en) | Use of antimicrobial agent combination in preparing composition for vagina, composition for vagina and method for preparing the same | |
| ZA202002093B (en) | Antibacterial compounds | |
| PH12017500338B1 (en) | Anti-diarrhea formulation which avoids antimicrobial resistance | |
| BR112017023359A2 (en) | "compounds, pharmaceutical compositions and kits" | |
| PH12016501532A1 (en) | Antibacterial combinations comprising polymyxin | |
| BR112017021225A2 (en) | antibacterial composition, quasi-antibacterial drug, antibacterial food additive against carbapenem-resistant gram-negative bacteria, pharmaceutical composition and food composition | |
| AU2012335397A8 (en) | Novel bacteriophages | |
| EA201791948A1 (en) | BETA SPILLARY PEPTIDOMYMETICS | |
| EA201700518A3 (en) | ANTIMICROBIAL COMBINATION WITH RESPECT TO THE SUSTAINABLE CARBAPENES OF THE GRAMORATORY BACTERIA OF ACINETOBACTER BAUMANNII KIND, PRODUCING METAL-β-LACTAMAZ | |
| CN106029894A8 (en) | Method for producing L-amino acid using Enterobacteriaceae bacteria with overexpressed yajL gene | |
| EA201700519A3 (en) | ANTIMICROBIAL COMBINATION WITH RESPECT TO SUSTAINABLE CARBAPENES OF GRAMORATORAL BACTERIA OF KLEBSIELLA PNEUMONIAE KIND, PRODUCING METAL-β-LACTAMAZ | |
| MY180113A (en) | Use of patchouli extract in the preparation of compositions with an anti-microorganism effect | |
| MY170829A (en) | Fulvic acid and antibiotic combination for the inhibition or treatment of multi-drug resistant bacteria | |
| BR112019001163A2 (en) | nitroimidazole crystal and salt and method of manufacture thereof | |
| RU2015133469A (en) | Antimicrobial combination against carbapenem-resistant gram-negative microorganisms producing metallo-β-lactamase | |
| Ebrahimi et al. | ANTIBACTERIAL EFFECT OF RHEUM RIBES ON ESCHERICHIA COLI |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM RU |