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EA201201300A1 - Производные пиридина и пиридазина, предназначенные для лечения мв (муковисцидоза) - Google Patents

Производные пиридина и пиридазина, предназначенные для лечения мв (муковисцидоза)

Info

Publication number
EA201201300A1
EA201201300A1 EA201201300A EA201201300A EA201201300A1 EA 201201300 A1 EA201201300 A1 EA 201201300A1 EA 201201300 A EA201201300 A EA 201201300A EA 201201300 A EA201201300 A EA 201201300A EA 201201300 A1 EA201201300 A1 EA 201201300A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyridine
treatment
derivatives
mucoviscidosis
pyridazin
Prior art date
Application number
EA201201300A
Other languages
English (en)
Other versions
EA028305B1 (ru
Inventor
Урс Беттиг
Камлеш Джагдис Бала
Эмма Бадд
Ли Эдуардс
Кэтрин Хаушем
Глин Хьюз
Даррен Марк Легранд
Катрин Шпигель
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44647718&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201201300(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201201300A1 publication Critical patent/EA201201300A1/ru
Publication of EA028305B1 publication Critical patent/EA028305B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

В заявке описаны производные пиридина и пиразина, которые восстанавливают или усиливают функцию мутантного МВТР и/или МВТР дикого типа, предназначенные для лечения муковисцидоза, первичной цилиарной дискинезии, хронического бронхита, хронического обструктивного заболевания легких, астмы, инфекции дыхательных путей, карциномы легких, ксеростомии и сухого кератоконъюнктивита, или констипации (СРК, ВБК, вызванной опиоидом). В заявке также описаны фармацевтические композиции, содержащие такие производные.
EA201201300A 2010-03-19 2011-03-17 Производные пиридина и пиридазина, предназначенные для лечения воспалительного или обструктивного заболевания дыхательных путей или мв (муковисцидоза) EA028305B1 (ru)

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