[go: up one dir, main page]

EA200970126A1 - METHOD OF OBTAINING PREGABALIN AND ITS ENANTIOMER - Google Patents

METHOD OF OBTAINING PREGABALIN AND ITS ENANTIOMER

Info

Publication number
EA200970126A1
EA200970126A1 EA200970126A EA200970126A EA200970126A1 EA 200970126 A1 EA200970126 A1 EA 200970126A1 EA 200970126 A EA200970126 A EA 200970126A EA 200970126 A EA200970126 A EA 200970126A EA 200970126 A1 EA200970126 A1 EA 200970126A1
Authority
EA
Eurasian Patent Office
Prior art keywords
enantiomer
pregabalin
obtaining
obtaining pregabalin
prepare
Prior art date
Application number
EA200970126A
Other languages
Russian (ru)
Inventor
Амир Авдагич
Зденко Хамерсак
Original Assignee
Плива Хрватска Д.О.О.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Плива Хрватска Д.О.О. filed Critical Плива Хрватска Д.О.О.
Publication of EA200970126A1 publication Critical patent/EA200970126A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C265/00—Derivatives of isocyanic acid
    • C07C265/02—Derivatives of isocyanic acid having isocyanate groups bound to acyclic carbon atoms
    • C07C265/04—Derivatives of isocyanic acid having isocyanate groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Настоящее изобретение относится к получению прегабалина и его энантиомера или фармацевтически приемлемой соли любого из них и к промежуточным соединениям, которые использовали для их получения.The present invention relates to the preparation of pregabalin and its enantiomer or pharmaceutically acceptable salt of any of them, and to the intermediate compounds that were used to prepare them.

EA200970126A 2006-07-15 2007-07-11 METHOD OF OBTAINING PREGABALIN AND ITS ENANTIOMER EA200970126A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0614133A GB0614133D0 (en) 2006-07-15 2006-07-15 Process for preparing a pharmaceutical compound
PCT/GB2007/002607 WO2008009897A1 (en) 2006-07-15 2007-07-11 Process for preparing pregabalin and its opposite enantiomer

Publications (1)

Publication Number Publication Date
EA200970126A1 true EA200970126A1 (en) 2009-06-30

Family

ID=36955756

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970126A EA200970126A1 (en) 2006-07-15 2007-07-11 METHOD OF OBTAINING PREGABALIN AND ITS ENANTIOMER

Country Status (4)

Country Link
EP (1) EP2046728A1 (en)
EA (1) EA200970126A1 (en)
GB (1) GB0614133D0 (en)
WO (1) WO2008009897A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1866275A1 (en) 2005-04-06 2007-12-19 Teva Pharmaceutical Industries Ltd. Crystalline forms of pregabalin
US7488846B2 (en) 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
CA2604624A1 (en) 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid
KR100893312B1 (en) 2005-05-10 2009-04-15 테바 파마슈티컬 인더스트리즈 리미티드 Method for the preparation of pregabalin and salts thereof
JP2008505980A (en) 2005-05-10 2008-02-28 テバ ファーマシューティカル インダストリーズ リミティド Pregabalin free from isobutyl glutaric acid and method for preparing the same
CA2619473C (en) 2005-09-19 2012-04-17 Teva Pharmaceutical Industries Ltd. An asymmetric synthesis of (s)-(+)-3-(aminomethyl)-5-methylhexanoic acid
US7462738B2 (en) 2006-05-24 2008-12-09 Teva Pharmaceutical Industries Ltd. Processes for the preparation of R-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
BRPI0803092A2 (en) 2007-03-22 2011-08-30 Teva Pharma Synthesis of - (+) - 3- (Aminomethyl) -5-methyl hexanoic acid, (s) pregabalin
CN101333165B (en) * 2008-08-05 2011-05-04 浙江大学 Method for synthesizing monomethyl glutarate
IT1394292B1 (en) * 2009-05-07 2012-06-06 Dipharma Francis Srl PROCEDURE FOR THE SYNTHESIS OF PREGABALINA
WO2012059797A1 (en) * 2010-11-04 2012-05-10 Lupin Limited Process for synthesis of (s) - pregabalin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616793A (en) * 1995-06-02 1997-04-01 Warner-Lambert Company Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid

Also Published As

Publication number Publication date
EP2046728A1 (en) 2009-04-15
WO2008009897A1 (en) 2008-01-24
GB0614133D0 (en) 2006-08-23

Similar Documents

Publication Publication Date Title
EA200970126A1 (en) METHOD OF OBTAINING PREGABALIN AND ITS ENANTIOMER
EA200970581A1 (en) CRISTAL TREATMENT BASIS BACKGROUND
EA201190217A1 (en) SUBSTITUTED 2-ACETAMIDO-5-ARIL-1,2,4-TRIAZOLONES AND THEIR APPLICATION
EA201000642A1 (en) 2'-FLUOR-2'-DEOXYTETRAHYDROUridine AS CYTIDINDE DIAMINASE INHIBITORS
EA201001639A1 (en) COMPOSITIONS AND METHODS FOR THEIR PRODUCTION AND APPLICATION
EA201001680A1 (en) COMPOUNDS OF BENZOLSULPHONAMIDTIAOSOL AND OXAZOL
EA201490132A1 (en) ANTI-VIRUS COMPOUNDS
EA201001847A1 (en) COMPOUNDS AND COMPOSITIONS APPLICABLE FOR THE TREATMENT OF MALARIA
EA201171151A1 (en) CRYSTALLINE TRIPEPTIDE EPOXYKETON-PROTEASE INHIBITORS
EA201170227A1 (en) ИМИДАЗОЛКАРБОКСАМИДЫ
EA200900959A1 (en) MEK INHIBITORS
NO345046B1 (en) Oral dosage form
EA200970737A1 (en) OXABICYCLOPTANES AND OXABICYCLOPTENS
EA201390803A1 (en) Bromodomain inhibitors and their use
EA200970580A1 (en) TANNA BROADBAND
EA201200669A1 (en) PYRIDOPYRIMIDINONE INHIBITORS PI3Kα
EA201070786A1 (en) BENZOFUROPYRIMIDINONES
EA200970247A1 (en) METHOD OF OPTIMIZATION
EA201290642A1 (en) CONNECTIONS AND METHODS
EA200702586A1 (en) CRYSTAL MODIFICATIONS OF PIRACLOSTROBIN
EA201190293A1 (en) TRIPOLIDA SPIRITS
EA201070009A1 (en) DERIVATIVES OF 7-ALKINYL-1,8-NAFTYRIDONES, THEIR RECEIVING AND THEIR APPLICATION IN THERAPY
EA201490756A1 (en) CITRAMID RAZAGLININA
EA201200046A1 (en) NEW COMPOUNDS, PHARMACEUTICAL COMPOSITION AND RELATED METHODS
EA201270256A1 (en) DERIVATIVES OF T1-SUBSTITUTED 5-FLUOR-2-OXOPYRIMIDINON-1 (2H) -KARBOXAMID