[go: up one dir, main page]

EA200901299A1 - Композиции олигогулуроната и олигогалактуроната - Google Patents

Композиции олигогулуроната и олигогалактуроната

Info

Publication number
EA200901299A1
EA200901299A1 EA200901299A EA200901299A EA200901299A1 EA 200901299 A1 EA200901299 A1 EA 200901299A1 EA 200901299 A EA200901299 A EA 200901299A EA 200901299 A EA200901299 A EA 200901299A EA 200901299 A1 EA200901299 A1 EA 200901299A1
Authority
EA
Eurasian Patent Office
Prior art keywords
oligoguluronate
oligogalacturonate
composition
compositions
fraction
Prior art date
Application number
EA200901299A
Other languages
English (en)
Other versions
EA018776B1 (ru
Inventor
Кэтрин Тэйлор
Курт Ингар Драгет
Олав Асмунд Смидсрод
Original Assignee
ЭнТиЭнЮ ТЕКНОЛОДЖИ ТРАНСФЕР АС
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ЭнТиЭнЮ ТЕКНОЛОДЖИ ТРАНСФЕР АС filed Critical ЭнТиЭнЮ ТЕКНОЛОДЖИ ТРАНСФЕР АС
Publication of EA200901299A1 publication Critical patent/EA200901299A1/ru
Publication of EA018776B1 publication Critical patent/EA018776B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

В изобретении предложена фармацевтическая композиция, содержащая макромолекулярное лекарственное вещество и олигогулуронат или олигогалактуронат, в частности, имеющие средне-численную степень полимеризации в интервале от 5 до 18, фракцию гулуроната (или галактуроната) (FG) по меньшей мере 0,80, фракцию маннуроната (FM) не более 0,20, и имеющие по меньшей мере 95 мол.% со степенью полимеризации менее 20. Эту композицию можно применять в способе лечения, включающем введение этой композиции на поверхность слизистой оболочки субъекта, являющегося человеком или позвоночным животным.
EA200901299A 2007-04-12 2008-04-11 Фармацевтическая композиция, содержащая олигогулуронат или галактуронат, способы лечения с ее использованием, ее применение и содержащий ее спрей-аппликатор EA018776B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0707096.4A GB0707096D0 (en) 2007-04-12 2007-04-12 Method
PCT/GB2008/001287 WO2008125828A2 (en) 2007-04-12 2008-04-11 Oligo-guluronate and galacturonate compositions

Publications (2)

Publication Number Publication Date
EA200901299A1 true EA200901299A1 (ru) 2010-06-30
EA018776B1 EA018776B1 (ru) 2013-10-30

Family

ID=38116633

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200901299A EA018776B1 (ru) 2007-04-12 2008-04-11 Фармацевтическая композиция, содержащая олигогулуронат или галактуронат, способы лечения с ее использованием, ее применение и содержащий ее спрей-аппликатор

Country Status (14)

Country Link
US (1) US8841279B2 (ru)
EP (2) EP2500025B1 (ru)
JP (2) JP5649443B2 (ru)
KR (2) KR101336459B1 (ru)
CN (1) CN101711159B (ru)
AU (1) AU2008237710B2 (ru)
BR (1) BRPI0810179B8 (ru)
CA (2) CA2817754C (ru)
DK (2) DK2155211T3 (ru)
EA (1) EA018776B1 (ru)
ES (2) ES2655102T3 (ru)
GB (1) GB0707096D0 (ru)
MX (2) MX352972B (ru)
WO (1) WO2008125828A2 (ru)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2430881B (en) 2005-10-06 2010-10-13 Ntnu Technology Transfer As Oligoelectrolyte polyols for the treatment of mucosal hyperviscosity
GB0707096D0 (en) 2007-04-12 2007-05-23 Ntnu Technology Transfer As Method
SI2268142T1 (sl) 2007-11-27 2017-09-29 Algipharma As Uporaba alginiranih oligomerov v boju proti biofilmom
GB0904942D0 (en) * 2009-03-23 2009-05-06 Ntnu Technology Transfer As Composition
GB0904941D0 (en) * 2009-03-23 2009-05-06 Ntnu Technology Transfer As Composition
GB0909557D0 (en) 2009-06-03 2009-07-15 Algipharma Ipr As Anti-microbial alginate oligomers
GB0909529D0 (en) 2009-06-03 2009-07-15 Algipharma Ipr As Alginate oligomers for the inhibition of microbial adherence to surfaces
CN102497883B (zh) 2009-06-03 2014-06-11 阿尔吉法玛公司 用于克服细菌多重抗药性的藻酸盐低聚物
JO3676B1 (ar) * 2009-07-27 2020-08-27 Arc Medical Devices Inc مركبات صيدلانية تضم فوكانات معدلة وطرق تتعلق بها
GB201116010D0 (en) 2011-09-15 2011-10-26 Algipharma As Use of alginate oligomers to enhance the effects of antifungal agents
GB201322777D0 (en) 2013-12-20 2014-02-05 Algipharma As Use of alginate oligomers as blood anticoagulants
JP2017501221A (ja) * 2013-12-23 2017-01-12 ノルウェージャン ユニバーシティ オブ サイエンス アンド テクノロジー（エヌティーエヌユー） がん治療におけるオリゴウロン酸塩の使用
EP3110426A1 (en) * 2014-02-28 2017-01-04 Algipharma As Use of alginate oligomers in the treatment of cystic fibrosis and other conditions associated with defective cftr ion channel function
FR3024358B1 (fr) * 2014-08-01 2017-11-10 Soc De Courtage Et De Diffusion Codif Int Compositions cosmetiques et complements alimentaires neuro-protecteurs comprenant de l'oligoalginate ayant un degre de polymerisation de 10 pour lutter contre le vieillissement de la peau.
GB201415381D0 (en) 2014-08-29 2014-10-15 Algipharma As Inhalable powder formulations of alginate oligomers
GB201504878D0 (en) 2015-03-23 2015-05-06 Algipharma As Use of alginate oligomers and CFTR modulators in the treatment of conditions associated with CFTR dysfuntion
GB201517639D0 (en) 2015-10-06 2015-11-18 Algipharma As Use of alginate oligomers to treat or prevent microbial overgrowth in the intestinal tract
US11072668B2 (en) 2017-01-03 2021-07-27 The University Of North Carolina At Chapel Hill Nitric oxide-releasing alginates as biodegradable antibacterial scaffolds and methods pertaining thereto
CN110461338A (zh) 2017-03-28 2019-11-15 北卡罗来纳大学查佩尔希尔分校 作为可生物降解抗菌支架的释放一氧化氮的聚氨基糖苷类和其制备方法
EP3710514B1 (en) 2017-11-15 2023-06-07 The University of North Carolina at Chapel Hill Nitric oxide-releasing hyperbranched compounds as antibacterial scaffolds and methods pertaining thereto
EP3762039A4 (en) 2018-03-06 2021-12-22 The University of North Carolina at Chapel Hill NITROGEN OXIDE RELEASING CYCLODEXTRIN AS BIODEGRADABLE ANTIBACTERIAL SCAFFOLDINGS AND RELATED PROCEDURES
GB201812473D0 (en) 2018-07-31 2018-09-12 Algipharma As Method for the qualitative and quantitative detection of alginate oligomers in body fluids
EP3902841B1 (en) 2018-12-28 2025-01-29 The University of North Carolina at Chapel Hill Nitric oxide-releasing antibacterial polymers and scaffolds fabricated therefrom and methods pertaining thereto
US11684597B2 (en) 2019-01-28 2023-06-27 The United States Of America As Represented By The Secretary Of The Army Administration of tailored feedstock to increase nitro-containing amphenicol antibiotic susceptibility
GB201908639D0 (en) 2019-06-17 2019-07-31 Algipharma Ipr As Use of alginate oligomers in the anticoagulation therapy of subjects at risk of blood clots which have an abnormally dense microstructure
WO2024141760A1 (en) 2022-12-30 2024-07-04 Algipharma As Compositions and methods to increase the systemic bioavailability of a polypeptide therapeutic agent undergoing oral administration

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL297511A (ru) 1956-12-20
FR7576M (ru) 1968-03-27 1970-01-05
HU172831B (hu) 1976-03-31 1978-12-28 Egyt Gyogyszervegyeszeti Gyar Sposob poluchenija kompleksov oligo- i poligalakturonnyk kislot s ionami zhiznenno vazhnykh metallov
JPS6176413A (ja) 1984-09-21 1986-04-18 Junzo Sunamoto 吸水性高分子によりカプセル化されたリポソ−ムの製造法
DD268865A1 (de) 1987-01-16 1989-06-14 Adw Ddr Verfahren zur herstellung eines pharmazeutischen praeparates
US4898852A (en) 1987-06-02 1990-02-06 Walsh William E Cyclopolgalcturonic acid composition and treatment
US4855128A (en) 1988-01-14 1989-08-08 Warner-Lambert Company Saccharide inhibition of dental plaque
JP2641472B2 (ja) 1988-01-30 1997-08-13 日本レダリー株式会社 感染症治療剤
WO1991007951A1 (en) 1989-12-05 1991-06-13 Trancel Corporation Homologous guluronic acid alginate coating composition for in-vivo application and implantation and method of using same
US5459054A (en) 1989-12-05 1995-10-17 Neocrin Company Cells encapsulated in alginate containing a high content of a- l- guluronic acid
AU7221691A (en) 1990-01-23 1991-08-21 Terje Espevik Mannuronic acid containing alginate wound healing composition and method
US5166137A (en) 1991-03-27 1992-11-24 Nobipols Forskningsstiftelse Guluronic acid polymers and use of same for inhibition of cytokine production
US5460957A (en) 1992-04-28 1995-10-24 Maruha Corporation Calcium alginate oligosaccharide and method for producing the same from potassium or sodium alginate
HU213872B (en) 1993-09-08 1997-11-28 Mta Koezponti Kemiai Kutato In Oligo- and polygalacturonate mixed complex, pharmaceutical and food compositions containing them, further process for preparing these compounds
DE4330773A1 (de) 1993-09-10 1995-03-16 Laevosan Gmbh & Co Kg Blockierung der Anlagerung von Keimen an menschliche Zellen
JP2828391B2 (ja) 1993-10-29 1998-11-25 東燃株式会社 オリゴ糖を表面に有するリポソーム
AUPM322393A0 (en) 1993-12-24 1994-01-27 Austin Research Institute, The Mucin carbohydrate compounds and their use in immunotherapy
US5795587A (en) 1995-01-23 1998-08-18 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
CA2235069C (en) 1995-10-19 2010-12-14 Advanced Reproduction Technologies, Inc. Methods and compositions to improve germ cell and embryo survival and function
JP3512553B2 (ja) 1996-01-30 2004-03-29 ポーラ化成工業株式会社 便秘抑制剤及びそれを含有する組成物
FR2747045B1 (fr) 1996-04-05 1998-06-26 Hooreman Michel Nouveau medicament optimisant la viscosite des mucus et ameliorant le fonctionnement de l'intestin
NO305441B1 (no) 1996-07-12 1999-05-31 Norsk Hydro As Anvendelse av G-blokk polysakkarider
WO1998013024A2 (en) 1996-09-27 1998-04-02 Hyal Pharmaceutical Corporation Hyaluronic drug delivery system
US20070185032A1 (en) * 1996-12-11 2007-08-09 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
NO305033B1 (no) * 1997-05-09 1999-03-22 Algipharma As Fremgangsmate for fremstilling av uronsyreblokker fra alginat
US6339075B1 (en) 1997-06-30 2002-01-15 The University Of British Columbia Use of dextran and other polysaccharides to improve mucus clearance
KR100219918B1 (ko) 1997-07-03 1999-09-01 김윤 대장선택적 약물전달용 조성물
US6868121B2 (en) * 1997-12-31 2005-03-15 Sony Corporation Coded data output device and method
JP3932679B2 (ja) * 1998-07-21 2007-06-20 セイコーエプソン株式会社 ポリグルロン酸の製造法
US6290987B1 (en) 1998-09-27 2001-09-18 Generex Pharmaceuticals, Inc. Mixed liposome pharmaceutical formulation with amphiphiles and phospholipids
US20040224922A1 (en) 1999-08-26 2004-11-11 Malcolm King Use of charged dextran as a mucoactive agent and methods and pharmaceutical compositions relating thereto
AU6679300A (en) 1999-08-26 2001-03-26 Governors Of The University Of Alberta, The Use of charged dextran as a mucoactive agent and methods and pharmaceutical compositions relating thereto
US6458387B1 (en) 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
JP2001155905A (ja) * 1999-11-24 2001-06-08 Nec Corp 半導体装置およびトリミング方法ならびに記録媒体
US7785625B2 (en) 2000-01-14 2010-08-31 Lg Life Sciences, Limited Lipophilic-coated microparticle containing a protein drug and formulation comprising same
KR100501584B1 (ko) 2000-02-03 2005-07-18 (주)케이비피 저분자 폴리만유로네이트의 제조방법, 혈청지질개선제로서의 이의 신규 용도 및 이를 함유하는 기능성식품 및 건강 보조 식품
DE10006989A1 (de) 2000-02-16 2001-08-23 Nutricia Nv Antiadhäsive Kohlenhydratmischung
ES2357474T3 (es) 2000-03-07 2011-04-26 Rush-Presbyterian-St.Luke's Medical Center Composiciones y su uso para atrapar e inactivar microbios patógenos y espermatoziodes.
AU4445201A (en) 2000-03-30 2001-10-08 Generex Pharmaceuticals Inc. Method for administering insulin to the buccal region
DE10019076A1 (de) 2000-04-06 2001-10-18 Lang Christine Verwendung von Polygalakturoniden als Lebensmittelzusatzstoffe
JP2002338493A (ja) 2000-10-23 2002-11-27 Genaera Corp ムチン合成インヒビター
DE10057976B4 (de) 2000-11-22 2005-02-03 Südzucker AG Mannheim/Ochsenfurt Verfahren zur Herstellung von Pektinhydrolyseprodukten
US6440314B1 (en) * 2001-01-03 2002-08-27 Vulcan Chemical Technologies, Inc. Method for destroying chlorite in solution
ITMI20010347A1 (it) 2001-02-21 2002-08-21 Grisotech S A Complessi di immunoglobuline e polisaccaridi per assorbimento orale etrans-mucosale
US6610331B1 (en) 2002-05-30 2003-08-26 Scott M. Sweazy Fertility kit
JP2005145885A (ja) * 2003-11-14 2005-06-09 Japan Science & Technology Agency アルギン酸オリゴマーからなる免疫機構賦活剤
US7279457B2 (en) 2004-03-12 2007-10-09 Biodel, Inc. Rapid acting drug delivery compositions
CA2569645C (en) 2004-06-07 2014-10-28 Protiva Biotherapeutics, Inc. Cationic lipids and methods of use
JP2006028041A (ja) 2004-07-13 2006-02-02 Ltt Bio-Pharma Co Ltd 核酸含有ナノ粒子
EP1714660A1 (en) 2005-04-21 2006-10-25 N.V. Nutricia Uronic acid and probiotics
US7621036B2 (en) 2005-06-21 2009-11-24 Cardiomems, Inc. Method of manufacturing implantable wireless sensor for in vivo pressure measurement
EP1745705A1 (en) 2005-07-20 2007-01-24 N.V. Nutricia Process for preparing uronic acid oligosaccharides by extrusion
GB2430881B (en) * 2005-10-06 2010-10-13 Ntnu Technology Transfer As Oligoelectrolyte polyols for the treatment of mucosal hyperviscosity
CN101312736B (zh) 2005-10-21 2013-03-20 生命细胞产品有限公司 包囊体系
GB0707096D0 (en) 2007-04-12 2007-05-23 Ntnu Technology Transfer As Method
US20110130444A1 (en) 2007-05-04 2011-06-02 Stefan Moisyadi Methods and compositions for targeted delivery of gene therapeutic vectors
US8389768B2 (en) 2008-05-19 2013-03-05 The University Of North Carolina At Chapel Hill Methods and compositions comprising novel cationic lipids

Also Published As

Publication number Publication date
EP2155211A2 (en) 2010-02-24
EA018776B1 (ru) 2013-10-30
AU2008237710A1 (en) 2008-10-23
CA2683914C (en) 2013-08-13
CA2683914A1 (en) 2008-10-23
KR20130106446A (ko) 2013-09-27
ES2655102T3 (es) 2018-02-16
JP2014129401A (ja) 2014-07-10
WO2008125828A2 (en) 2008-10-23
ES2553962T3 (es) 2015-12-15
BRPI0810179B8 (pt) 2021-05-25
US20100152122A1 (en) 2010-06-17
CN101711159B (zh) 2012-06-27
BRPI0810179A2 (pt) 2014-12-30
WO2008125828A3 (en) 2009-06-04
GB0707096D0 (en) 2007-05-23
EP2500025A1 (en) 2012-09-19
KR101336459B1 (ko) 2013-12-04
DK2500025T3 (en) 2018-01-15
MX2009010889A (es) 2009-10-28
KR101472245B1 (ko) 2014-12-11
EP2500025B1 (en) 2017-10-18
JP2010523636A (ja) 2010-07-15
MX352972B (es) 2017-12-15
CN101711159A (zh) 2010-05-19
KR20100016492A (ko) 2010-02-12
AU2008237710B2 (en) 2014-02-06
US8841279B2 (en) 2014-09-23
BRPI0810179B1 (pt) 2019-12-10
DK2155211T3 (en) 2015-12-14
CA2817754C (en) 2014-12-09
EP2155211B1 (en) 2015-08-26
JP5649443B2 (ja) 2015-01-07
CA2817754A1 (en) 2008-10-23

Similar Documents

Publication Publication Date Title
EA200901299A1 (ru) Композиции олигогулуроната и олигогалактуроната
NO20074980L (no) Sammensetninger og fremgangsmater for topisk paforing og transdermal avlevering av botulinumtoksiker.
BR112014010275A2 (pt) formulações para tratamento de diabetes
DE502005010615D1 (de) Mittel zur behandlung von entzündlichen erkrankungen
DK1696904T3 (da) Anvendelse af rotigotin til behandling eller forebyggelse af dopaminergt neurontab
PL385586A1 (pl) Nowe analogi insuliny o przedłużonym działaniu
ATE475716T1 (de) Zusammenstellungen zur behandlung von neurodegenerativen erkrankungen
EA200700684A1 (ru) Полиаминные композиции
BR112013020005A8 (pt) peptídeo de fórmula geral r1-wn-xm-aa1-aa2-aa3-aa4-aa5-aa6-yp-zq-r2, seus estereoisômeros, misturas dos mesmos e/ou seus sais cosmética ou farmaceuticamente aceitáveis e composição cosmética ou farmacêutica
GB2465677B (en) Non-systemic delivery of satiogens for use in the treatment of obesity and/or diabetes
EA201200519A1 (ru) Стабилизированные жидкие и лиофилизированные композиции adamts13
EA201070121A1 (ru) Лекарственная форма, содержащая слитый белок glp-1-fc
MX2010004613A (es) Composicion topica.
BR112012017054A2 (pt) "análogo de peptídeo de oxintomodulina, seu uso, bem como composição farmacêutica"
ATE395905T1 (de) Pharmazeutische zusammensetzungen in form fester dispersionen zur behandlung von krebs
NZ591057A (en) Complement antagonists and uses thereof
ATE390142T1 (de) Synergistische zusammensetzung zur behandlung von diabetes mellitus
EA201100393A1 (ru) Применение усиливающих агентов, возможно связанных с рибофлавином, а также соответствующих офтальмологических композиций для перекрестного сшивания роговицы при лечении кератоконуса или других эктазийных расстройств роговицы
MY155299A (en) Oral dosage composition
MY149505A (en) Hyaluronic acid binary mixtures and therapeutic use thereof
NZ740615A (en) A pharmaceutical composition comprising electrohydrodynamically obtained fibres, the composition having improved residence time on the application site
EA201691420A1 (ru) Композиции енолазы 1 (eno1) и их применение
WO2018005801A3 (en) Novel non-systemic tgr5 agonists
EA201391063A1 (ru) Аполипопротеин a-iv в качестве антидиабетического пептида
ES2345882T3 (es) Nuevos compuestos y su uso como moduladores de ppar.