[go: up one dir, main page]

EA200901148A1 - Подкожные имплантаты, высвобождающие активные компоненты в течение длительного периода времени - Google Patents

Подкожные имплантаты, высвобождающие активные компоненты в течение длительного периода времени

Info

Publication number
EA200901148A1
EA200901148A1 EA200901148A EA200901148A EA200901148A1 EA 200901148 A1 EA200901148 A1 EA 200901148A1 EA 200901148 A EA200901148 A EA 200901148A EA 200901148 A EA200901148 A EA 200901148A EA 200901148 A1 EA200901148 A1 EA 200901148A1
Authority
EA
Eurasian Patent Office
Prior art keywords
freedoming
subcutane
implants
time
long period
Prior art date
Application number
EA200901148A
Other languages
English (en)
Other versions
EA017473B1 (ru
Inventor
Патрис Морьяк
Пьер Марьон
Original Assignee
Медиоланум Фармасьютикалз Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Медиоланум Фармасьютикалз Лтд. filed Critical Медиоланум Фармасьютикалз Лтд.
Publication of EA200901148A1 publication Critical patent/EA200901148A1/ru
Publication of EA017473B1 publication Critical patent/EA017473B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Подкожные имплантаты, полученные с помощью экструзии, содержащие активный ингредиент и гидрофильный эксципиент, диспергированные в PLGA-матриксе, при массовом отношении:(Активный ингредиент (AI) + Эксципиент (E))/PLGA больше чем 0,05 и меньше чем 1.
EA200901148A 2006-08-02 2007-08-01 Подкожные имплантаты, высвобождающие активные компоненты в течение длительного периода времени EA017473B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001539A ITMI20061539A1 (it) 2006-08-02 2006-08-02 Impianti sottocutanei in grado di rilasciare il principio attivo per un periodo prolungato di tempo
PCT/EP2007/057961 WO2008015232A1 (en) 2006-08-02 2007-08-01 Subcutaneous implants releasing an active principle over an extended period of time

Publications (2)

Publication Number Publication Date
EA200901148A1 true EA200901148A1 (ru) 2010-02-26
EA017473B1 EA017473B1 (ru) 2012-12-28

Family

ID=37765841

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200901148A EA017473B1 (ru) 2006-08-02 2007-08-01 Подкожные имплантаты, высвобождающие активные компоненты в течение длительного периода времени

Country Status (15)

Country Link
US (1) US20090246245A1 (ru)
EP (1) EP2054028B9 (ru)
JP (1) JP2009545351A (ru)
KR (1) KR20090046837A (ru)
CN (1) CN101522169B (ru)
AU (1) AU2007280391A1 (ru)
BR (1) BRPI0714818A2 (ru)
CA (1) CA2658592A1 (ru)
EA (1) EA017473B1 (ru)
ES (1) ES2389981T3 (ru)
IT (1) ITMI20061539A1 (ru)
MX (1) MX2009001231A (ru)
PL (1) PL2054028T3 (ru)
PT (1) PT2054028E (ru)
WO (1) WO2008015232A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10753023B2 (en) 2010-08-13 2020-08-25 Kimberly-Clark Worldwide, Inc. Toughened polylactic acid fibers
US8936740B2 (en) 2010-08-13 2015-01-20 Kimberly-Clark Worldwide, Inc. Modified polylactic acid fibers
WO2012088304A2 (en) * 2010-12-22 2012-06-28 Psivida Us, Inc. Two-piece injectable drug delivery device with heat-cured seal
WO2014076703A1 (en) 2012-11-14 2014-05-22 Silenseed Ltd. Methods and compositions for treating cancer
SG10202103998RA (en) * 2015-06-18 2021-05-28 Acuitybio Corp Implantable drug delivery compositions and methods of use thereof
WO2020006000A1 (en) * 2018-06-25 2020-01-02 Titan Pharmaceuticals, Inc. Implants for release of lipophilic or amphiphilic pharmaceutical substances

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1304152B1 (it) * 1998-12-10 2001-03-08 Mediolanum Farmaceutici Srl Composizioni comprendenti un peptide ed acido polilattico-glicolicoatte alla preparazione di impianti sottocutanei aventi un prolungato
ATE478656T1 (de) * 2001-06-22 2010-09-15 Univ Johns Hopkins Med Biologisch abbaubare polymerzusammensetzungen, zusammensetzungen und damit in beziehung stehende verwendungen
CN100592904C (zh) * 2003-06-26 2010-03-03 梅迪奥拉努姆制药有限公司 具有有效成分的有限起始释放及随后线性变化延长释放的皮下植入物
ITMI20031302A1 (it) * 2003-06-26 2004-12-27 Mediolanum Pharmaceuticals Ltd Uso di etanolo come plasticizzante per preparare impianti sottocutanei contenenti principi attivi termolabili dispersi in una matrice di plga.
WO2005110374A1 (en) * 2004-04-30 2005-11-24 Allergan, Inc. Intraocular drug delivery systems containing a therapeutic component, a cyclodextrin, and a polymeric component

Also Published As

Publication number Publication date
CN101522169B (zh) 2013-02-20
WO2008015232A1 (en) 2008-02-07
AU2007280391A1 (en) 2008-02-07
HK1131546A1 (en) 2010-01-29
KR20090046837A (ko) 2009-05-11
PT2054028E (pt) 2012-10-10
US20090246245A1 (en) 2009-10-01
MX2009001231A (es) 2009-04-28
EP2054028B1 (en) 2012-06-27
ES2389981T3 (es) 2012-11-05
BRPI0714818A2 (pt) 2013-05-21
EP2054028B9 (en) 2012-09-26
EP2054028A1 (en) 2009-05-06
WO2008015232A8 (en) 2008-05-22
CA2658592A1 (en) 2008-02-07
EA017473B1 (ru) 2012-12-28
PL2054028T3 (pl) 2013-02-28
JP2009545351A (ja) 2009-12-24
CN101522169A (zh) 2009-09-02
ITMI20061539A1 (it) 2008-02-03

Similar Documents

Publication Publication Date Title
ATE367803T1 (de) Subcutane implantate mit begrenzter initialer wirkstoff-freisetzung und deren anschliessende lineare veränderliche verlängerte freisetzung
CL2003002277A1 (es) Composicion farmaceutica inyectable, de deposito de liberacion prolongada, que comprende un agente beneficioso disuelto o disperso en un gel constituido por un polimero bioerosionable y biocompatible; y un solvente.
ATE302616T1 (de) Oral anzuwendende arzneizusammensetzungen mit gesteuerter wirkstoffabgabe
BRPI0415639A (pt) formas de dosagem de oxicodona de liberação controlada, oral, uma vez por dia
EA200901148A1 (ru) Подкожные имплантаты, высвобождающие активные компоненты в течение длительного периода времени
AR047540A1 (es) Particulados
DE60124294D1 (de) Proinsulin c-peptid enthaltende arzneizubereitung mit verzögerter wirkstofffreigabe
EA200900246A1 (ru) Подкожные имплантаты, высвобождающие активный компонент в течение продолжительного периода времени
ATE284698T1 (de) Aktivierung natürlicher killerzellen durch adenosin-a3-rezeptoragonisten
AR044248A1 (es) Agentes para combatir parasitos en animales
EA200501821A1 (ru) Фармацевтическая комбинация, содержащая модафинил и другой лекарственный препарат
DE602006016127D1 (de) Zusammensetzung und dosierform mit einer festen oder halbfesten matrix
ATE392889T1 (de) Orale antimikrobielle pharmazeutische zusammensetzungen
AR041573A1 (es) Uso de ihidromidazolonas para la preparacion demedicamentos para caninos
MX2007007099A (es) Implante formado in situ para animales.
RU2007122391A (ru) S-миртазапин для лечения приливов
DE602006009259D1 (de) Pharmazeutische zusammensetzung mit einem organopoirkstoff
SE0403014D0 (sv) New protein formulation
EA200900247A1 (ru) Подкожные имплантаты, высвобождающие активный компонент в течение длительного времени
SE0203817D0 (sv) New composition
AR037543A1 (es) Metodo para la terapia del cancer y composicion farmaceutica
ATE262898T1 (de) Formulierung mit gesteuerter wirkstoffabgabe enthaltend bupropion-hci als wirkstoff
CL2024000812A1 (es) Sistema de administración de principios activos.
ATE484288T1 (de) Pharmazeutische zusammensetzungen zur linderung von übermässig hohen zuckerspiegeln bei diabetikern
WO2005000239A3 (en) Lyase treatment for p. carinii

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU