[go: up one dir, main page]

EA200900991A1 - NEW ANTIBODIES AGAINST IGF-1R - Google Patents

NEW ANTIBODIES AGAINST IGF-1R

Info

Publication number
EA200900991A1
EA200900991A1 EA200900991A EA200900991A EA200900991A1 EA 200900991 A1 EA200900991 A1 EA 200900991A1 EA 200900991 A EA200900991 A EA 200900991A EA 200900991 A EA200900991 A EA 200900991A EA 200900991 A1 EA200900991 A1 EA 200900991A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibodies against
antibodies
new antibodies
against igf
antigen
Prior art date
Application number
EA200900991A
Other languages
Russian (ru)
Inventor
Майкл Нейл Берден
Джонатан Генри Эллис
Пол Эндрю Хэмблин
Алан Питер Льюис
Радха Шах
Original Assignee
Глаксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0702888.9A external-priority patent/GB0702888D0/en
Application filed by Глаксо Груп Лимитед filed Critical Глаксо Груп Лимитед
Publication of EA200900991A1 publication Critical patent/EA200900991A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Настоящее изобретение относится к антителам или их антигенсвязывающим фрагментам, которые специфически связываются с IGF-1R (рецептором инсулиноподобного фактора роста), в частности с hlGF-1R. Также раскрыты препараты антител, содержащие антитела или антигенсвязывающие фрагменты по изобретению. Также в объем настоящего изобретения включены способы продуцирования таких антител или антигенсвязывающих фрагментов и их применения.The present invention relates to antibodies or antigen-binding fragments thereof that specifically bind to IGF-1R (insulin-like growth factor receptor), in particular to hlGF-1R. Also disclosed are antibody preparations containing the antibodies or antigen-binding fragments of the invention. Also within the scope of the present invention are methods for the production of such antibodies or antigennegative fragments and their use.

EA200900991A 2007-02-14 2008-02-12 NEW ANTIBODIES AGAINST IGF-1R EA200900991A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0702888.9A GB0702888D0 (en) 2007-02-14 2007-02-14 Novel Antibodies
US95321007P 2007-08-01 2007-08-01
PCT/EP2008/051655 WO2008098917A2 (en) 2007-02-14 2008-02-12 Novel antibodies against igf-ir

Publications (1)

Publication Number Publication Date
EA200900991A1 true EA200900991A1 (en) 2010-02-26

Family

ID=42025950

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200900991A EA200900991A1 (en) 2007-02-14 2008-02-12 NEW ANTIBODIES AGAINST IGF-1R

Country Status (5)

Country Link
JP (1) JP2010518140A (en)
KR (1) KR20090114449A (en)
EA (1) EA200900991A1 (en)
MX (1) MX2009008754A (en)
PE (1) PE20090107A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2015102845A (en) * 2010-02-23 2015-06-10 Санофи ANTIBODIES TO α2 INTEGRIN AND THEIR APPLICATIONS
UY33578A (en) 2010-08-31 2012-03-30 Sanofi Sa PEPTIDE PEPTIDE OR COMPLEX THAT JOINS INTEGRINE TO (ALPHA) AND METHODS AND USES THAT INVOLVE THE SAME
KR20150031217A (en) * 2011-12-15 2015-03-23 더 로얄 인스티튜션 포 디 어드밴스먼트 오브 러닝/맥길 유니버시티 Soluble igf receptor fc fusion proteins and uses thereof
AU2016341402B2 (en) * 2015-10-23 2020-08-27 Apogenix Ag Single-chain GITR-receptor agonist proteins

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY27087A1 (en) * 2001-01-05 2002-06-20 Pfizer ANTIBODIES AGAINST THE RECEIVER OF THE SIMILAR TO INSULIN GROWTH FACTOR
US7538195B2 (en) * 2002-06-14 2009-05-26 Immunogen Inc. Anti-IGF-I receptor antibody
US8034904B2 (en) * 2002-06-14 2011-10-11 Immunogen Inc. Anti-IGF-I receptor antibody
EP2365001A3 (en) * 2003-05-01 2012-03-28 Imclone LLC Fully human antibodies directed against the human insulin-like growth factor-1 receptor
WO2005058967A2 (en) * 2003-12-16 2005-06-30 Pierre Fabre Medicament Novel anti-insulin/igf-i hybrid receptor or anti-insulin/igf-i hybrid receptor and igf-ir antibodies and uses thereof
FR2873699B1 (en) * 2004-07-29 2009-08-21 Pierre Fabre Medicament Sa NOVEL ANTI-IGF ANTIBODIES IR RT USES THEREOF
WO2007000328A1 (en) * 2005-06-27 2007-01-04 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Antibodies that bind to an epitope on insulin-like growth factor 1 receptor and uses thereof
FR2888850B1 (en) * 2005-07-22 2013-01-11 Pf Medicament NOVEL ANTI-IGF-IR ANTIBODIES AND THEIR APPLICATIONS

Also Published As

Publication number Publication date
JP2010518140A (en) 2010-05-27
KR20090114449A (en) 2009-11-03
MX2009008754A (en) 2009-11-02
PE20090107A1 (en) 2009-03-20

Similar Documents

Publication Publication Date Title
MX2018013008A (en) Soluble human st-2 antibodies and assays.
EA201000053A1 (en) NEW ANTIBODIES
UA106070C2 (en) Antibody that specifically binds to egfr and her3
MX2011011754A (en) COMPOSITIONS AND METHODS FOR ANTIBODIES THAT GO TO THE COMPLEMENT PROTEIN C3B.
MX369148B (en) Kir3dl2 binding agents.
PH12016501691A1 (en) Antibodies to matrix metalloproteinase 9
EA201070695A1 (en) MOLECULES OF HUMANIZED ANTIBODIES SPECIFIC TO IL-31
WO2013188693A8 (en) Antigen binding constructs to cd3
AU2009260320A8 (en) Antibodies to IL-6 and their uses
EP2352523A4 (en) ANTI-CD19 ENHANCED ANTIBODIES
EA201490053A1 (en) ANTIBODIES THAT ARE BIND OX40 AND THEIR APPLICATION
EA200802168A1 (en) HUMANIZED ANTIBODY TO C-KIT
EA201290570A1 (en) CONSTRUCTIONS CONNECTING WITH RON AND METHODS OF THEIR USE
MX382398B (en) ST2 ANTIGEN BINDING PROTEINS.
BR112012023010A2 (en) "antibody or antigen binding fragment thereof which specifically binds to cd37, immunoconjugate comprising them, use of said antibody, fragment and immunoconjugate, composition comprising them, kit, isolated cell, as well as in vitro method for inhibiting growth" of a cell expressing cd37 "
EA201000471A1 (en) ANTIGENSELVATING PROTEINS, ABLE TO CONNECT TYMUS STROMAL LYMPHOPOETHINE
MX2018007630A (en) Antibodies to matrix metalloproteinase 9.
EP2579895A4 (en) Anti-vegf antibodies and uses thereof
EA201591153A1 (en) ANTIBODIES CONNECTING TL1A AND THEIR APPLICATION
SG178886A1 (en) Humanized anti-cdcp1 antibodies
ES2639026T3 (en) Totally human antibodies specific for CADM1
WO2008098917A3 (en) Novel antibodies against igf-ir
PH12014501931A1 (en) Antibodies to matrix metalloproteinase 9
UA113623C2 (en) TISSUE FACTOR FACTOR (TFPI) MONOCLONAL ANTIBODY AGAINST TISSUE FACTOR INHIBITOR
AU2018338322A1 (en) A33 antibody compositions and methods of using the same in radioimmunotherapy