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EA200900797A1 - Способ синтеза производных 3-аминотетрагидрофуран-3-карбоновой кислоты и их применение в качестве лекарственных средств - Google Patents

Способ синтеза производных 3-аминотетрагидрофуран-3-карбоновой кислоты и их применение в качестве лекарственных средств

Info

Publication number
EA200900797A1
EA200900797A1 EA200900797A EA200900797A EA200900797A1 EA 200900797 A1 EA200900797 A1 EA 200900797A1 EA 200900797 A EA200900797 A EA 200900797A EA 200900797 A EA200900797 A EA 200900797A EA 200900797 A1 EA200900797 A1 EA 200900797A1
Authority
EA
Eurasian Patent Office
Prior art keywords
synthesis
aminothetrohydrofuran
medicines
derivatives
application
Prior art date
Application number
EA200900797A
Other languages
English (en)
Inventor
Чжэнсюй Хань
Кай Герлах
Дхилипкумар Кришнамурти
Буркхард Маттес
Герберт Нар
Роланд Пфау
Хеннинг Припке
Аннетте Шулер-Метц
Крис Х. Сенанаяки
Петер Зигер
Вэньюнь Тан
Вольфганг Винен
Ибо Сюй
Натан К. И
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA200900797A1 publication Critical patent/EA200900797A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

В заявке описан способ получения замещенных амидов 3-аминотетрагидрофуран-3-карбоновой кислоты общей формулы (I) и их предшественников высокой оптической чистотыпредшественников синтеза замещенных амидов 3-аминотетрагидрофуран-3-карбоновой кислоты общей формулы (I) высокой оптической чистоты и таутомеров, энантиомеров, диастереоизомеров, смесей и солей замещенных амидов 3-аминотетрагидрофуран-3-карбоновой кислоты общей формулы (I) высокой оптической чистоты, предпочтительно их физиологически приемлемых солей с неорганическими или органическими кислотами или основаниями, которые обладают ценными свойствами.
EA200900797A 2006-12-31 2007-12-21 Способ синтеза производных 3-аминотетрагидрофуран-3-карбоновой кислоты и их применение в качестве лекарственных средств EA200900797A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88293706P 2006-12-31 2006-12-31
PCT/EP2007/064406 WO2008080891A2 (en) 2006-12-31 2007-12-21 Process for the synthesis of derivatives of 3-amino-tetrahydrofuran-3-carboxylic acid and use thereof as medicaments

Publications (1)

Publication Number Publication Date
EA200900797A1 true EA200900797A1 (ru) 2009-12-30

Family

ID=39253961

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200900797A EA200900797A1 (ru) 2006-12-31 2007-12-21 Способ синтеза производных 3-аминотетрагидрофуран-3-карбоновой кислоты и их применение в качестве лекарственных средств

Country Status (23)

Country Link
US (2) US20100317848A1 (ru)
EP (1) EP2114909A2 (ru)
JP (1) JP2010514729A (ru)
KR (1) KR20090097208A (ru)
CN (1) CN101573346B (ru)
AR (1) AR064708A1 (ru)
AU (1) AU2007341335A1 (ru)
BR (1) BRPI0720748A2 (ru)
CA (1) CA2674168A1 (ru)
CL (1) CL2007003875A1 (ru)
EA (1) EA200900797A1 (ru)
EC (1) ECSP099406A (ru)
MA (1) MA31116B1 (ru)
MY (1) MY148769A (ru)
NO (1) NO20091782L (ru)
NZ (1) NZ578715A (ru)
PE (1) PE20081834A1 (ru)
TN (1) TN2009000276A1 (ru)
TW (1) TW200846345A (ru)
UA (1) UA96973C2 (ru)
UY (1) UY30851A1 (ru)
WO (1) WO2008080891A2 (ru)
ZA (1) ZA200902451B (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20070171A1 (es) 2005-06-30 2007-03-08 Boehringer Ingelheim Int GLICINAMIDAS SUSTITUIDAS CON EFECTO ANTITROMBOTICO E INHIBIDOR DEL FACTOR Xa
EP2220079A2 (en) 2007-11-15 2010-08-25 Boehringer Ingelheim International GmbH Substituted amides, manufacturing and use thereof as medicaments
US9352016B2 (en) 2011-03-09 2016-05-31 Csl Behring Gmbh Factor XII inhibitors for the administration with medical procedures comprising contact with artificial surfaces
EP2497489A1 (en) 2011-03-09 2012-09-12 CSL Behring GmbH Factor XII inhibitors for the treatment of silent brain ischemia and ischemia of other organs
US9096579B2 (en) 2012-04-20 2015-08-04 Boehringer Ingelheim International Gmbh Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
WO2014060575A2 (en) * 2012-10-19 2014-04-24 Medichem S.A. Process for the enantioselective synthesis of a tetrahydrobenzazepine compound
RU2520134C1 (ru) * 2013-02-27 2014-06-20 Общество с ограниченной ответственностью "Авионко" (ООО "Авионко") Замещенные (r)-3-(4-метилкарбамоил-3-фторфениламино)-тетрагидро-фуран-3-енкарбоновые кислоты и их эфиры, способ их получения и применения
CA2901225C (en) 2013-03-08 2023-09-19 Csl Behring Gmbh Treatment and prevention of remote ischemia-reperfusion injury
CN105431415A (zh) * 2013-05-20 2016-03-23 斯洛文尼亚莱柯制药股份有限公司 通过烯烃的弗瑞德-克来福特烷基化进行的8-氯-3-苯并[d]氮杂*的新合成方法
CN104530029B (zh) * 2014-12-09 2017-04-12 广东东阳光药业有限公司 作为Xa因子抑制剂的杂环化合物及其使用方法和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007537179A (ja) * 2004-05-13 2007-12-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換チオフェン−２−カルボン酸アミド、その製法及び薬物としての使用
WO2005111029A1 (de) * 2004-05-13 2005-11-24 Boehringer Ingelheim International Gmbh Neue substituierte thiophencarbonsäureamide, deren herstellung und deren verwendung als arzneimittel
WO2005111014A1 (de) * 2004-05-13 2005-11-24 Boehringer Ingelheim International Gmbh Substituierte thiophencarbonsäureamide, deren herstellung und deren verwendung als arzneimittel
DE102004047840A1 (de) * 2004-09-29 2006-03-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue substituierte Thiophencarbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel
PE20070171A1 (es) * 2005-06-30 2007-03-08 Boehringer Ingelheim Int GLICINAMIDAS SUSTITUIDAS CON EFECTO ANTITROMBOTICO E INHIBIDOR DEL FACTOR Xa

Also Published As

Publication number Publication date
CN101573346A (zh) 2009-11-04
ZA200902451B (en) 2010-05-26
ECSP099406A (es) 2009-07-31
MY148769A (en) 2013-05-31
CN101573346B (zh) 2013-01-09
CA2674168A1 (en) 2008-07-10
TW200846345A (en) 2008-12-01
EP2114909A2 (en) 2009-11-11
PE20081834A1 (es) 2009-01-16
KR20090097208A (ko) 2009-09-15
MA31116B1 (fr) 2010-01-04
US20100317848A1 (en) 2010-12-16
AU2007341335A1 (en) 2008-07-10
UY30851A1 (es) 2008-07-31
TN2009000276A1 (fr) 2010-10-18
JP2010514729A (ja) 2010-05-06
AR064708A1 (es) 2009-04-22
CL2007003875A1 (es) 2008-04-18
NO20091782L (no) 2009-06-10
BRPI0720748A2 (pt) 2015-05-19
UA96973C2 (ru) 2011-12-26
US20130005962A1 (en) 2013-01-03
WO2008080891A2 (en) 2008-07-10
WO2008080891A3 (en) 2008-10-02
NZ578715A (en) 2012-06-29

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