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EA200801481A1 - 5-(арилсульфонил)пиразолопиперидины - Google Patents

5-(арилсульфонил)пиразолопиперидины

Info

Publication number
EA200801481A1
EA200801481A1 EA200801481A EA200801481A EA200801481A1 EA 200801481 A1 EA200801481 A1 EA 200801481A1 EA 200801481 A EA200801481 A EA 200801481A EA 200801481 A EA200801481 A EA 200801481A EA 200801481 A1 EA200801481 A1 EA 200801481A1
Authority
EA
Eurasian Patent Office
Prior art keywords
formula
compounds
pyrazolopiperides
arosulfonyl
alzheimer
Prior art date
Application number
EA200801481A
Other languages
English (en)
Other versions
EA014906B1 (ru
Inventor
Альберт В. Гарофэло
Яцек Дж. Ягодзинский
Андрей В. Конради
Кристофер М. Семко
Дженифер Л. Смит
Йинг-зи Ксу
Сяоцун Майкл Е
Original Assignee
Элан Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Элан Фармасьютикалз, Инк. filed Critical Элан Фармасьютикалз, Инк.
Publication of EA200801481A1 publication Critical patent/EA200801481A1/ru
Publication of EA014906B1 publication Critical patent/EA014906B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретение относится к N-циклическим сульфонамидным соединениям формулы I в которой A, B, R, R, R, R, Rи Rявляются такими, как описано в описании. Соединения формулы I могут быть использованы в лечении или профилактике когнитивных нарушений, таких как болезнь Альцгеймера. Изобретение также охватывает фармацевтические композиции, включающие соединения формулы I, способы получения соединений формулы I и способы лечения когнитивных нарушений, таких как болезнь Альцгеймера.
EA200801481A 2005-12-01 2006-12-01 5-(арилсульфонил)пиразолопиперидины EA014906B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74136605P 2005-12-01 2005-12-01
PCT/US2006/046039 WO2007064914A2 (en) 2005-12-01 2006-12-01 5-(arylsulfonyl)-pyrazolopiperidines

Publications (2)

Publication Number Publication Date
EA200801481A1 true EA200801481A1 (ru) 2009-02-27
EA014906B1 EA014906B1 (ru) 2011-02-28

Family

ID=38092841

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801481A EA014906B1 (ru) 2005-12-01 2006-12-01 5-(арилсульфонил)пиразолопиперидины

Country Status (18)

Country Link
US (2) US7732609B2 (ru)
EP (1) EP1957458A2 (ru)
JP (1) JP2009518301A (ru)
KR (1) KR20080073359A (ru)
CN (1) CN101370776A (ru)
AR (1) AR057959A1 (ru)
AU (1) AU2006320423B2 (ru)
BR (1) BRPI0619633A2 (ru)
CA (1) CA2632227A1 (ru)
EA (1) EA014906B1 (ru)
EC (1) ECSP088593A (ru)
IL (1) IL190608A0 (ru)
MA (1) MA30089B1 (ru)
MY (1) MY149422A (ru)
NZ (1) NZ568109A (ru)
PE (1) PE20071090A1 (ru)
TW (1) TW200736255A (ru)
WO (1) WO2007064914A2 (ru)

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WO2007138072A2 (en) * 2006-05-31 2007-12-06 Galapagos N.V. Triazolopyrazine compounds useful for the treatment of degenerative & inflammatory diseases
ES2373253T3 (es) * 2007-05-25 2012-02-01 Elan Pharmaceuticals Inc. Pirazolopirrolidinos como inhibidores de gamma secretasa.
EP2271625B1 (en) 2008-04-01 2012-09-12 Abbott GmbH & Co. KG Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy
AR075442A1 (es) 2009-02-16 2011-03-30 Abbott Gmbh & Co Kg Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia
TW201038569A (en) * 2009-02-16 2010-11-01 Abbott Gmbh & Co Kg Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy
JP2012521993A (ja) * 2009-03-25 2012-09-20 エラン ファーマシューティカルズ，インコーポレイテッド 縮合三環式スルホンアミドの製造プロセス
US8846743B2 (en) 2010-08-13 2014-09-30 Abbott Laboratories Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8877794B2 (en) 2010-08-13 2014-11-04 Abbott Laboratories Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9045459B2 (en) 2010-08-13 2015-06-02 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9051280B2 (en) 2010-08-13 2015-06-09 AbbVie Deutschland GmbH & Co. KG Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8883839B2 (en) 2010-08-13 2014-11-11 Abbott Laboratories Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
WO2013020930A1 (en) 2011-08-05 2013-02-14 Abbott Gmbh & Co. Kg Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US8846741B2 (en) 2011-11-18 2014-09-30 Abbvie Inc. N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9656955B2 (en) 2013-03-15 2017-05-23 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9650334B2 (en) 2013-03-15 2017-05-16 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
CA2924689A1 (en) 2013-10-17 2015-04-23 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
CN105764895A (zh) 2013-10-17 2016-07-13 艾伯维德国有限责任两合公司 氨基四氢化萘及氨基二氢化茚衍生物，包含其的药物组合物及其在治疗中的用途
CN104059063A (zh) * 2014-04-03 2014-09-24 丽水绿氟科技有限公司 7,7-二氟-4,5,6,7-四氢吡唑并[4,3-c]吡啶及其衍生物的制备方法
CN112074505B (zh) 2018-03-08 2024-04-05 因赛特公司 作为PI3K-γ抑制剂的氨基吡嗪二醇化合物
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996012720A1 (en) * 1994-10-20 1996-05-02 Pfizer Inc. Bicyclic tetrahydro pyrazolopyridines and their use as medicaments
DE60143041D1 (de) * 2000-08-10 2010-10-21 Pfizer Italia Srl Bizyklische pyrazole wirksam als kinase inhibitoren, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
MXPA04003330A (es) * 2001-10-09 2004-07-08 Kyorin Seiyaku Kk 4-(2-furoil) aminopiperidinas novedosas, compuestos intermedios en la sintesis de las mismas, proceso para producirlas y su uso medicinal.
AU2003292724A1 (en) 2002-12-27 2004-07-29 Japan Tobacco Inc. Fused n-containing heterocyclic compounds and medicinal use thereof
EP1758884A2 (en) * 2004-05-20 2007-03-07 Elan Pharmaceuticals, Inc. N-cyclic sulfonamido inhibitors of gamma secretase
DE602005026037D1 (de) * 2004-10-27 2011-03-03 Janssen Pharmaceutica Nv Tetrahydro pyridinyl pyrazole cannabinoid modulatoren
DE102005002500A1 (de) * 2005-01-19 2006-07-27 Sanofi-Aventis Deutschland Gmbh Tetrahydrofuranderivate als Inhibitoren von Matrix-Metalloproteinasen
JP2008534496A (ja) * 2005-03-22 2008-08-28 アストラゼネカ・アクチエボラーグ ＣＢ１’受容体リガンドとしての新規なテトラヒドロ−１Ｈ−ピリド［４，３−ｂ］インドール誘導体
DE102005016170A1 (de) * 2005-04-07 2006-10-12 Grünenthal GmbH 4,5,6,7- Tetrahydro-isoxazolo(4,5c)pyridin-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
WO2007024651A2 (en) 2005-08-19 2007-03-01 Elan Pharmaceuticals, Inc. Bridged n-bicyclic sulfonamido inhibitors of gamma secretase

Also Published As

Publication number Publication date
EP1957458A2 (en) 2008-08-20
CA2632227A1 (en) 2007-06-07
US20100267747A1 (en) 2010-10-21
CN101370776A (zh) 2009-02-18
MY149422A (en) 2013-08-30
AU2006320423A1 (en) 2007-06-07
US20070155753A1 (en) 2007-07-05
PE20071090A1 (es) 2007-10-24
JP2009518301A (ja) 2009-05-07
NZ568109A (en) 2011-07-29
AU2006320423B2 (en) 2012-06-21
ECSP088593A (es) 2008-08-29
WO2007064914A8 (en) 2008-05-15
TW200736255A (en) 2007-10-01
WO2007064914A2 (en) 2007-06-07
KR20080073359A (ko) 2008-08-08
WO2007064914A3 (en) 2007-12-27
US7732609B2 (en) 2010-06-08
EA014906B1 (ru) 2011-02-28
MA30089B1 (fr) 2008-12-01
BRPI0619633A2 (pt) 2011-10-04
IL190608A0 (en) 2008-11-03
AR057959A1 (es) 2007-12-26

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU