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EA200801171A1 - Биспецифичные лиганды, обладающие специфичностью связывания с поверхностными клеточными мишенями, и способы их применения - Google Patents

Биспецифичные лиганды, обладающие специфичностью связывания с поверхностными клеточными мишенями, и способы их применения

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Publication number
EA200801171A1
EA200801171A1 EA200801171A EA200801171A EA200801171A1 EA 200801171 A1 EA200801171 A1 EA 200801171A1 EA 200801171 A EA200801171 A EA 200801171A EA 200801171 A EA200801171 A EA 200801171A EA 200801171 A1 EA200801171 A1 EA 200801171A1
Authority
EA
Eurasian Patent Office
Prior art keywords
binding
methods
ligands
surface cell
cell targets
Prior art date
Application number
EA200801171A
Other languages
English (en)
Inventor
Елена Де Анджелис
Стив Холмс
Айан М. Томлинсон
Эрик Йи-чун Хуанг
Люси Дж. Холт
Клэр И. Эверетт
Original Assignee
Домантис Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Домантис Лимитед filed Critical Домантис Лимитед
Publication of EA200801171A1 publication Critical patent/EA200801171A1/ru

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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Abstract

Раскрыты лиганды, содержащие первый полипептидный домен, имеющий связывающий участок со специфичностью связывания с первой поверхностной клеточной мишенью, и второй полипептидный домен, имеющий связывающий участок со специфичностью связывания со второй поверхностной клеточной мишенью, где каждая мишень отличается от другой, и они находятся на одной и той же клетке. В некоторых воплощениях указанные лиганды далее содержат токсин. В других воплощениях указанные лиганды дополнительно содержат группировки, удлиняющие период полувыведения. Также раскрыты способы применения указанных лигандов. В частности, описано применение указанных лигандов для лечения рака.
EA200801171A 2005-12-06 2006-12-05 Биспецифичные лиганды, обладающие специфичностью связывания с поверхностными клеточными мишенями, и способы их применения EA200801171A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74299205P 2005-12-06 2005-12-06
PCT/GB2006/004565 WO2007066109A1 (en) 2005-12-06 2006-12-05 Bispecific ligands with binding specificity to cell surface targets and methods of use therefor

Publications (1)

Publication Number Publication Date
EA200801171A1 true EA200801171A1 (ru) 2008-12-30

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EA200801171A EA200801171A1 (ru) 2005-12-06 2006-12-05 Биспецифичные лиганды, обладающие специфичностью связывания с поверхностными клеточными мишенями, и способы их применения

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Country Link
US (1) US20100021473A1 (ru)
EP (1) EP1963370A1 (ru)
JP (1) JP2009518025A (ru)
KR (1) KR20080090414A (ru)
CN (2) CN101379088A (ru)
AU (1) AU2006323415A1 (ru)
BR (1) BRPI0619460A2 (ru)
CA (1) CA2632424A1 (ru)
CR (1) CR10100A (ru)
EA (1) EA200801171A1 (ru)
MA (1) MA30020B1 (ru)
NO (1) NO20082381L (ru)
TW (1) TW200738750A (ru)
WO (1) WO2007066109A1 (ru)
ZA (1) ZA200804307B (ru)

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