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EA200701843A1 - 2-оксо-1,2,4,5-тетрагидро-1,3-бензодиазепин-3-илпиперидины в качестве cgrp-антагонистов - Google Patents

2-оксо-1,2,4,5-тетрагидро-1,3-бензодиазепин-3-илпиперидины в качестве cgrp-антагонистов

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Publication number
EA200701843A1
EA200701843A1 EA200701843A EA200701843A EA200701843A1 EA 200701843 A1 EA200701843 A1 EA 200701843A1 EA 200701843 A EA200701843 A EA 200701843A EA 200701843 A EA200701843 A EA 200701843A EA 200701843 A1 EA200701843 A1 EA 200701843A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cgrp
antagonists
ilpiperidines
benzodiazepin
tetrahydro
Prior art date
Application number
EA200701843A
Other languages
English (en)
Other versions
EA012590B1 (ru
Inventor
Штефан Георг Мюллер
Клаус Рудольф
Филипп Лустенбергер
Дирк Штенкамп
Марко Сантагостино
Фабио Палеари
Александер Дрейер
Кирстен Арндт
Хенри Додс
Герхард Шэнцле
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2005/003094 external-priority patent/WO2005092880A1/de
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA200701843A1 publication Critical patent/EA200701843A1/ru
Publication of EA012590B1 publication Critical patent/EA012590B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P39/02—Antidotes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Addiction (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)

Abstract

В заявке описаны CGRP-антагонисты общей формулы (I)в которой В, Rи Rимеют указанные в п. 1 формулы изобретения значения, их таутомеры, их изомеры, их диастереомеры, их энантиомеры, их гидраты, их смеси и их соли, а также гидраты солей, прежде всего их физиологически совместимые соли с неорганическими или органическими кислотами или основаниями, содержащие эти соединения лекарственные средства, их применение и способ их получения.
EA200701843A 2005-03-23 2006-03-21 2-оксо-1,2,4,5-тетрагидро-1,3-бензодиазепин-3-илпиперидины в качестве cgrp-антагонистов EA012590B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2005/003094 WO2005092880A1 (de) 2004-03-29 2005-03-23 Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
PCT/EP2006/002557 WO2006100026A1 (de) 2005-03-23 2006-03-21 2-oxo-1,2,4,5-tetrahydro-1,3-benzdiazepin-3-yl-piperidine als cgrp-antagonisten

Publications (2)

Publication Number Publication Date
EA200701843A1 true EA200701843A1 (ru) 2008-02-28
EA012590B1 EA012590B1 (ru) 2009-10-30

Family

ID=36406232

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701843A EA012590B1 (ru) 2005-03-23 2006-03-21 2-оксо-1,2,4,5-тетрагидро-1,3-бензодиазепин-3-илпиперидины в качестве cgrp-антагонистов

Country Status (19)

Country Link
EP (2) EP1863791B1 (ru)
JP (1) JP4210322B2 (ru)
KR (1) KR20070113317A (ru)
CN (2) CN101146799A (ru)
AU (1) AU2006226544A1 (ru)
CA (1) CA2600189A1 (ru)
DE (1) DE502006002066D1 (ru)
DK (1) DK1863791T5 (ru)
EA (1) EA012590B1 (ru)
ES (1) ES2317512T3 (ru)
HR (1) HRP20090011T3 (ru)
MY (1) MY144635A (ru)
NO (1) NO20073758L (ru)
PL (1) PL1863791T3 (ru)
PT (1) PT1863791E (ru)
RS (1) RS50722B (ru)
SI (1) SI1863791T1 (ru)
WO (1) WO2006100026A1 (ru)
ZA (1) ZA200705852B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10250082A1 (de) 2002-10-25 2004-05-13 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
DE102004015723A1 (de) * 2004-03-29 2005-10-20 Boehringer Ingelheim Pharma Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
US7696195B2 (en) 2004-04-22 2010-04-13 Boehringer Ingelheim International Gmbh Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
EP1770086A1 (de) * 2005-09-29 2007-04-04 Boehringer Ingelheim Pharma GmbH & Co. KG Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
MX2008015562A (es) * 2006-06-08 2008-12-17 Boehringer Ingelheim Int Tratamiento de trastornos gastrointestinales con antagonistas de cgrp.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10250080A1 (de) * 2002-10-25 2004-05-13 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
DE10250082A1 (de) * 2002-10-25 2004-05-13 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
EP1644332A1 (en) 2003-07-03 2006-04-12 Poseidon Pharmaceuticals A/S Diarylmethyl derivatives as potassium channel modulators
TW200533398A (en) 2004-03-29 2005-10-16 Bristol Myers Squibb Co Novel therapeutic agents for the treatment of migraine
EP1619187A1 (de) 2004-07-23 2006-01-25 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von 3-(4-Piperidinyl)- 2,3,4,5-tetrahydro-1,3-benzodiazepin-2(1H)-on

Also Published As

Publication number Publication date
ES2317512T3 (es) 2009-04-16
EP1992349B8 (de) 2013-10-09
PT1863791E (pt) 2008-12-15
WO2006100026A8 (de) 2007-02-08
EP1992349B1 (de) 2013-07-31
RS50722B (sr) 2010-08-31
NO20073758L (no) 2007-10-19
ZA200705852B (en) 2009-12-30
EA012590B1 (ru) 2009-10-30
SI1863791T1 (sl) 2009-04-30
PL1863791T3 (pl) 2009-04-30
KR20070113317A (ko) 2007-11-28
HRP20090011T3 (hr) 2009-02-28
EP1863791A1 (de) 2007-12-12
DK1863791T3 (da) 2009-02-16
CA2600189A1 (en) 2006-09-28
EP1863791B1 (de) 2008-11-12
CN101146790A (zh) 2008-03-19
JP2008533083A (ja) 2008-08-21
EP1992349A1 (de) 2008-11-19
CN101146799A (zh) 2008-03-19
MY144635A (en) 2011-10-14
DE502006002066D1 (de) 2008-12-24
WO2006100026A1 (de) 2006-09-28
DK1863791T5 (da) 2010-10-04
AU2006226544A1 (en) 2006-09-28
JP4210322B2 (ja) 2009-01-14

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