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EA200701052A1 - NEW DERIVATIVES OF THE SUBSTITUTED ARYLPIPERAZINE - Google Patents

NEW DERIVATIVES OF THE SUBSTITUTED ARYLPIPERAZINE

Info

Publication number
EA200701052A1
EA200701052A1 EA200701052A EA200701052A EA200701052A1 EA 200701052 A1 EA200701052 A1 EA 200701052A1 EA 200701052 A EA200701052 A EA 200701052A EA 200701052 A EA200701052 A EA 200701052A EA 200701052 A1 EA200701052 A1 EA 200701052A1
Authority
EA
Eurasian Patent Office
Prior art keywords
disorders
new derivatives
arylpiperazine
derivatives
substituted arylpiperazine
Prior art date
Application number
EA200701052A
Other languages
Russian (ru)
Inventor
Мариа Люс Лопес Родригес
Беллинда Бенхаму Залама
Маргарита Вальхондо Фалькон
Original Assignee
Шварц Фарма, С.Л.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Шварц Фарма, С.Л. filed Critical Шварц Фарма, С.Л.
Publication of EA200701052A1 publication Critical patent/EA200701052A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Описываются новые производные арилпиперазина с активностью как у лигандов подтипа 1А рецептора 5-гидрокситриптамин (5-HT), их стереоизомеры, способы их получения, их использование, а также фармацевтические композиции, содержащие эти производные, применяемые для лечения болезни Паркинсона, церебральных нарушений, вызванных тромбоэмолическим инсультом, черепно-мозговых травм, депрессий, мигрени. болей, психоза, патологических состояний тревоги, агрессивных нарушений или нарушений функции мочевыводящих путей.Describes new derivatives of arylpiperazine with activity like ligands of subtype 1A of the 5-hydroxytryptamine receptor (5-HT), their stereoisomers, methods for their preparation, their use, as well as pharmaceutical compositions containing these derivatives used to treat Parkinson's disease, cerebral disorders caused by thromboembolic stroke, traumatic brain injury, depression, migraine. pain, psychosis, pathological conditions of anxiety, aggressive disorders or disorders of the urinary tract.

EA200701052A 2004-12-27 2005-12-27 NEW DERIVATIVES OF THE SUBSTITUTED ARYLPIPERAZINE EA200701052A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04106998A EP1674103A1 (en) 2004-12-27 2004-12-27 Arylpiperazine derivatives and use thereof as 5-HT1A receptor ligands
PCT/EP2005/057175 WO2006069993A1 (en) 2004-12-27 2005-12-27 Arylpiperazine derivatives and use thereof as 5-ht1a receptor ligands

Publications (1)

Publication Number Publication Date
EA200701052A1 true EA200701052A1 (en) 2008-02-28

Family

ID=34930175

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701052A EA200701052A1 (en) 2004-12-27 2005-12-27 NEW DERIVATIVES OF THE SUBSTITUTED ARYLPIPERAZINE

Country Status (14)

Country Link
US (1) US20090036455A1 (en)
EP (2) EP1674103A1 (en)
JP (1) JP2008525384A (en)
KR (1) KR20070097419A (en)
CN (1) CN101087610A (en)
AU (1) AU2005321228A1 (en)
BR (1) BRPI0519269A2 (en)
CA (1) CA2582663A1 (en)
EA (1) EA200701052A1 (en)
IL (1) IL181955A0 (en)
MX (1) MX2007006842A (en)
NO (1) NO20073732L (en)
WO (1) WO2006069993A1 (en)
ZA (1) ZA200702457B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2199086B1 (en) 2002-07-31 2005-06-01 Cepa Schwarz Pharma Sl NEW DERIVATIVES OF CYCLLOCANODIONAS, PROCEDURE FOR ITS PREPARATION AND ITS PHARMACOLOGICAL APPLICATIONS.
JP2025504406A (en) * 2022-01-11 2025-02-12 スヴェン・ライフ・サイエンシーズ・リミテッド Heteroalicyclic derivatives and their use in the treatment of CNS disorders - Patents.com

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996006846A1 (en) * 1994-09-01 1996-03-07 Universidad Complutense De Madrid New arylpiperazine derivatives

Also Published As

Publication number Publication date
AU2005321228A1 (en) 2006-07-06
WO2006069993A1 (en) 2006-07-06
CN101087610A (en) 2007-12-12
EP1674103A1 (en) 2006-06-28
US20090036455A1 (en) 2009-02-05
CA2582663A1 (en) 2006-07-06
NO20073732L (en) 2007-09-18
IL181955A0 (en) 2007-07-04
EP1830854A1 (en) 2007-09-12
BRPI0519269A2 (en) 2009-01-06
JP2008525384A (en) 2008-07-17
ZA200702457B (en) 2008-04-30
MX2007006842A (en) 2007-08-08
KR20070097419A (en) 2007-10-04

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