EA200700601A1 - Производные фениламинопиримидина как ингибиторы bcr-abl - Google Patents
Производные фениламинопиримидина как ингибиторы bcr-ablInfo
- Publication number
- EA200700601A1 EA200700601A1 EA200700601A EA200700601A EA200700601A1 EA 200700601 A1 EA200700601 A1 EA 200700601A1 EA 200700601 A EA200700601 A EA 200700601A EA 200700601 A EA200700601 A EA 200700601A EA 200700601 A1 EA200700601 A1 EA 200700601A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- derivatives
- phenylaminopyrimidine
- bcr
- abl inhibitors
- phenylaminopyrimidines
- Prior art date
Links
- XGXNTJHZPBRBHJ-UHFFFAOYSA-N n-phenylpyrimidin-2-amine Chemical class N=1C=CC=NC=1NC1=CC=CC=C1 XGXNTJHZPBRBHJ-UHFFFAOYSA-N 0.000 title abstract 4
- WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 abstract 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 abstract 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/66—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Настоящее изобретение относится к промежуточным соединениям, применимым для получения производных фениламинопиримидинов и к производным фениламинопиримидинов, содержащим их фармацевтическим композициям и способам их получения, в частности, изобретение относится к производным фениламинопиримидинов формулы IЭти соединения можно применять при лечении хронической миелоидной лейкемии.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN908CH2004 | 2004-09-09 | ||
| PCT/IN2005/000243 WO2006027795A1 (en) | 2004-09-09 | 2005-07-19 | Novel phenylaminopyrimidine derivatives as inhibitors of bcr-abl kinase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200700601A1 true EA200700601A1 (ru) | 2008-02-28 |
| EA013328B1 EA013328B1 (ru) | 2010-04-30 |
Family
ID=35395645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200700601A EA013328B1 (ru) | 2004-09-09 | 2005-07-19 | Производные фениламинопиримидина как ингибиторы bcr-abl |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US7910598B2 (ru) |
| EP (2) | EP1786799B1 (ru) |
| JP (1) | JP5184887B2 (ru) |
| KR (1) | KR100948453B1 (ru) |
| CN (1) | CN101068805B (ru) |
| AP (1) | AP2470A (ru) |
| AU (1) | AU2005281299B2 (ru) |
| BR (1) | BRPI0515081B8 (ru) |
| CA (1) | CA2591321C (ru) |
| CY (1) | CY1113617T1 (ru) |
| DK (1) | DK1786799T3 (ru) |
| EA (1) | EA013328B1 (ru) |
| ES (1) | ES2390227T3 (ru) |
| HR (1) | HRP20070146B1 (ru) |
| IL (1) | IL181811A (ru) |
| MA (1) | MA28922B1 (ru) |
| MX (1) | MX2007002819A (ru) |
| NO (1) | NO337598B1 (ru) |
| NZ (1) | NZ554361A (ru) |
| PL (1) | PL1786799T3 (ru) |
| PT (1) | PT1786799E (ru) |
| SI (1) | SI1786799T1 (ru) |
| UA (1) | UA94570C2 (ru) |
| WO (1) | WO2006027795A1 (ru) |
| ZA (2) | ZA200701942B (ru) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6667300B2 (en) * | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
| RS55546B1 (sr) | 2004-05-13 | 2017-05-31 | Icos Corp | Hinazolinoni kao inhibitori humane fosfatidilonozitol 3-delta kinaze |
| US8735415B2 (en) | 2004-09-09 | 2014-05-27 | Natco Pharma Limited | Acid addition salts of (3,5-Bis trifluoromethyl)-N-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide |
| EA013328B1 (ru) | 2004-09-09 | 2010-04-30 | Натко Фарма Лимитед | Производные фениламинопиримидина как ингибиторы bcr-abl |
| US7939541B2 (en) * | 2004-09-09 | 2011-05-10 | Natco Pharma Limited | Intermediates and a process employing the intermediates for the preparation of (3-trifluoromethylsulfonyl)-N-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide |
| US20110190328A1 (en) * | 2004-09-09 | 2011-08-04 | Natco Pharma Limited | Acid addition salts of (3,5-bis trifluoromethyl)-n-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide |
| EP2069287A1 (en) * | 2006-09-11 | 2009-06-17 | Syngeta Participations AG | Insecticidal compounds |
| RU2009120882A (ru) * | 2006-11-03 | 2010-12-10 | Айрм Ллк (Bm) | Соединения и композиции, как ингибиторы протеинкиназы |
| CN101558040B (zh) * | 2006-12-14 | 2013-03-27 | 拜耳先灵医药股份有限公司 | 用作蛋白激酶抑制剂的二氢吡啶衍生物 |
| US8338417B2 (en) | 2007-05-04 | 2012-12-25 | Irm Llc | Compounds and compositions as c-kit and PDGFR kinase inhibitors |
| KR101122481B1 (ko) * | 2007-05-04 | 2012-02-29 | 아이알엠 엘엘씨 | Ｃ-ｋｉｔ 및 ｐｄｇｆｒ 키나제 억제제로서의 피리미딘 유도체 및 조성물 |
| BRPI0815572A2 (pt) | 2007-08-22 | 2015-02-18 | Irm Llc | Compostos e composições como inibidores de quinases |
| WO2009026276A1 (en) | 2007-08-22 | 2009-02-26 | Irm Llc | 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors |
| WO2009109867A2 (en) * | 2008-03-04 | 2009-09-11 | Natco Pharma Limited | Crystal form of phenylamino pyrimidine derivatives |
| US8067422B2 (en) | 2008-03-04 | 2011-11-29 | Natco Pharma Limited | Crystal form of phenylamino pyrimidine derivatives |
| WO2012004801A1 (en) * | 2010-07-07 | 2012-01-12 | Hetero Research Foundation | Process for imatinib mesylate |
| GB2488788B (en) * | 2011-03-07 | 2013-07-10 | Natco Pharma Ltd | Oral formulation of phenylaminopyrymidine compound with enhanced bioavailability and pharmacological response |
| BR112014004560A2 (pt) | 2011-09-01 | 2017-04-04 | Irm Llc | compostos e composições como inibidores de c-kit quinase |
| US9061028B2 (en) | 2012-02-15 | 2015-06-23 | Natco Pharma Limited | Process for the preparation of Nilotinib |
| CA2876539A1 (en) * | 2012-06-15 | 2013-12-19 | Basf Se | Multicomponent crystals comprising dasatinib and selected co-crystal formers |
| RS62422B1 (sr) | 2015-12-18 | 2021-10-29 | Natco Pharma Ltd | Farmaceutske kompozicije koje sadrže derivat fenilaminopirimidina |
| WO2017156350A1 (en) | 2016-03-09 | 2017-09-14 | K-Gen, Inc. | Methods of cancer treatment |
| JP2023534963A (ja) | 2020-07-15 | 2023-08-15 | サード ハーモニック バイオ， インコーポレイテッド | 選択的ｃ－ｋｉｔキナーゼ阻害剤の結晶質形態 |
| JP2023551434A (ja) | 2020-11-19 | 2023-12-08 | サード ハーモニック バイオ， インコーポレイテッド | 選択的ｃ－ｋｉｔキナーゼ阻害剤の医薬組成物ならびにその作製および使用のための方法 |
| CN113125689B (zh) * | 2021-03-29 | 2022-02-22 | 创芯国际生物科技(广州)有限公司 | 一种新型mtt细胞活力检测试剂盒及其应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW225528B (ru) | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| US5516775A (en) | 1992-08-31 | 1996-05-14 | Ciba-Geigy Corporation | Further use of pyrimidine derivatives |
| AU693475B2 (en) | 1993-10-01 | 1998-07-02 | Novartis Ag | Pyrimidineamine derivatives and processes for the preparation thereof |
| CN1047776C (zh) | 1993-10-01 | 1999-12-29 | 诺瓦蒂斯有限公司 | 具有药理学活性的吡啶类衍生物及其制备方法 |
| AU693114B2 (en) | 1993-10-01 | 1998-06-25 | Novartis Ag | Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof |
| CO4940418A1 (es) | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
| ES2188005T3 (es) * | 1997-09-23 | 2003-06-16 | Astrazeneca Ab | Derivados de amidas para el tratamiento de enfermedades mediadas por citoquinas. |
| TR200100300T2 (tr) * | 1998-08-04 | 2001-07-23 | Astrazeneca Ab | Sitokinlerin üretiminde engelleyici olarak kullanışlı amid türevleri |
| GB0022438D0 (en) | 2000-09-13 | 2000-11-01 | Novartis Ag | Organic Compounds |
| US7494997B2 (en) * | 2002-06-28 | 2009-02-24 | Nippon Shinyaku Co., Ltd. | Amide derivative |
| GB0222514D0 (en) * | 2002-09-27 | 2002-11-06 | Novartis Ag | Organic compounds |
| WO2004108699A1 (en) * | 2003-06-06 | 2004-12-16 | Natco Pharma Limited | Process for the preparation of the anti-cancer drug imatinib and its analogues |
| JP2006527230A (ja) * | 2003-06-13 | 2006-11-30 | ノバルティス アクチエンゲゼルシャフト | Ｒａｆキナーゼ阻害剤としての２−アミノピリミジン誘導体 |
| EA013328B1 (ru) | 2004-09-09 | 2010-04-30 | Натко Фарма Лимитед | Производные фениламинопиримидина как ингибиторы bcr-abl |
| RU2009120882A (ru) * | 2006-11-03 | 2010-12-10 | Айрм Ллк (Bm) | Соединения и композиции, как ингибиторы протеинкиназы |
-
2005
- 2005-07-19 EA EA200700601A patent/EA013328B1/ru unknown
- 2005-07-19 WO PCT/IN2005/000243 patent/WO2006027795A1/en not_active Ceased
- 2005-07-19 EP EP05779775A patent/EP1786799B1/en not_active Expired - Lifetime
- 2005-07-19 UA UAA200703971A patent/UA94570C2/ru unknown
- 2005-07-19 PT PT05779775T patent/PT1786799E/pt unknown
- 2005-07-19 BR BRPI0515081A patent/BRPI0515081B8/pt not_active IP Right Cessation
- 2005-07-19 DK DK05779775.5T patent/DK1786799T3/da active
- 2005-07-19 HR HRP20070146AA patent/HRP20070146B1/hr not_active IP Right Cessation
- 2005-07-19 KR KR1020077008040A patent/KR100948453B1/ko not_active Expired - Fee Related
- 2005-07-19 CA CA2591321A patent/CA2591321C/en not_active Expired - Fee Related
- 2005-07-19 ES ES05779775T patent/ES2390227T3/es not_active Expired - Lifetime
- 2005-07-19 SI SI200531589T patent/SI1786799T1/sl unknown
- 2005-07-19 AP AP2007003944A patent/AP2470A/xx active
- 2005-07-19 JP JP2007530854A patent/JP5184887B2/ja not_active Expired - Fee Related
- 2005-07-19 EP EP10184904.0A patent/EP2295424B1/en not_active Expired - Lifetime
- 2005-07-19 MX MX2007002819A patent/MX2007002819A/es active IP Right Grant
- 2005-07-19 CN CN2005800300912A patent/CN101068805B/zh not_active Expired - Fee Related
- 2005-07-19 AU AU2005281299A patent/AU2005281299B2/en not_active Ceased
- 2005-07-19 PL PL05779775T patent/PL1786799T3/pl unknown
- 2005-07-19 NZ NZ554361A patent/NZ554361A/en not_active IP Right Cessation
-
2007
- 2007-03-05 US US11/714,565 patent/US7910598B2/en not_active Expired - Fee Related
- 2007-03-06 ZA ZA200701942A patent/ZA200701942B/xx unknown
- 2007-03-08 IL IL181811A patent/IL181811A/en active IP Right Grant
- 2007-03-22 NO NO20071521A patent/NO337598B1/no not_active IP Right Cessation
- 2007-04-06 MA MA29808A patent/MA28922B1/fr unknown
- 2007-04-12 ZA ZA200703123A patent/ZA200703123B/en unknown
-
2008
- 2008-03-04 US US12/042,235 patent/US8183253B2/en not_active Expired - Fee Related
-
2012
- 2012-09-28 CY CY20121100895T patent/CY1113617T1/el unknown
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